TALANTA
·
2018
·
IF 4.244
Jia Jiang,Shuang Zang,Dan Li,Kun Wang,Sizhu Tian,Aimin Yu,Ziwei Zhang
Electron spin resonance spectroscopy was applied to determining the antioxidant capacity of eight thiol-containing compounds, including reduced glutathione , N-acetyl-L-cycsteine, methimazole, captopril , and tiopronin with one thiol group , 1,4-dithioerythritol and 2,3-dimercapto-1-propanol with two thiol groups, as well as L-cystine with no free thiol group. Cu 2+ ion gives an electron spin resonance signal and is reduced to Cu + ion with no electron spin resonance signal by the free thiol group in the compounds. Trolox equivalent antioxidant capacity (TEAC) was used to evaluate the reducing ability of the thiol-containing compounds and the TEAC values were found to be relevant to the number of thiol groups contained in the compounds. For the purpose of comparison, the UV-vis spectrophotometry , cupric reducing antioxidant capacity (CUPRAC) method, and Ellman assay were applied to the determination of the antioxidant capacity of the thiol-containing compounds. The TEAC values obtained by the present method were very close to those obtained by UV-vis method. However, compared with CUPRAC method, for methimazole the present method gave a more reasonable TEAC value. The present method was also applied to the quantification of N-acetyl-L-cycsteine, methimazole, captopril, and tiopronin in their pharmaceutical formulations.
研究领域:
分析化学
·
药物分析
·
生物化学
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Hui Qiao,Wenxia Zhang,Dongmei Zhang,Wenjun Yan,Jianguo Li,Yingqi Li
The redox homeostasis in tumor cells is an innate defense barrier for reactive oxygen species (ROS)-mediated tumor therapy. Herein, an intratumoral cascade-responsive multifunctional nanodiamond-based platform (NPCD) with a hydrodynamic diameter of 191 ± 5 nm triggering redox dyshomeostasis is fabricated by Cu2+-mediated coordination for polylysinated nanodiamond and doxorubicin (DOX) to achieve cancer-specific diagnosis and therapy. The NPCD nanoplatform enables precise tumor fluorescence localization and chemotherapy through a “turn on” effect due to being specifically activated by GSH to trigger DOX release at a low-pH tumor-specific environment instead of normal cells. Furthermore, NPCD realizes Cu+-based chemodynamic therapy (CDT) and induces GSH depletion by Cu2+ reduction to support CDT. These cause intracellular redox dyshomeostasis, making tumor cells more sensitive to the NPCD nanoparticles. Additionally, NPCD also possesses the intrinsic ability to reverse drug resistance. Of note, NPCD mainly accumulates in the tumor site in 4T1 tumor-bearing mice and enhances the efficacy of therapeutic interventions with negligible side effects. More interestingly, combined with programmed cell death ligand 1 antibody (anti-PD-L1) and imiquimod (R837), NPCD significantly suppresses distant tumor growth, indicating a good immune response. Therefore, this work opens perspectives for the further development of synergistic therapy through a Cu2+-mediated intratumoral cascade reaction.
研究领域:
纳米技术
·
癌症治疗
·
氧化还原生物学
·
药物递送系统
·
免疫肿瘤学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Qian Long,Hanfeng Cui,Jing Zhang,Qiqi Fan,Ting Huang,Hai Shuai,Xiaocui Yin,Guobing Wei,Huanwen Chen,Hao Fan
Cu 2+ serves as a significant biomarker in various physiological processes. This study presents the development of a novel Ru-UiO-TPEA functionalized metal-organic framework (MOFs) probe for Cu 2+ detection, employing both electrochemiluminescence (ECL) and electrochemical (EC) methods. Employing a dual ligand-assisted energy transfer approach, we synthesized Ru-UiO with optimal ECL and EC properties by adjusting the synthesis ratio of biphenyldicarboxylic acid to Ru(dcbpy) 3 2+ . This was followed by its conjugation with N-(2-aminoethyl)-N, N′, N′-tris(pyridin-2-ylmethyl) ethane-1,2-diamine (AE-TPEA) to form the highly conjugated Ru-UiO-TPEA probe for Cu 2+ detection. As the Cu 2+ concentration increased, the probe exhibited a diminished ECL signal and an enhanced differential pulse voltammetry (DPV) signal. The dual-mode detection method enabled cross-validation of the ECL and EC signals, enhancing accuracy and effectively minimizing errors. The ECL and EC methods had detection limits of 0.26 nM (range: 1 nM to 10 μM) and 0.65 nM (range: 2 nM to 80 μM), respectively. Meanwhile, these two methods can effectively detect Cu 2+ in rat brain microdialysis fluid. Notably, the measured concentrations correlated well with those determined by Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), highlighting its potential in biological and clinical bioelectronic sensing applications.
研究领域:
分析化学
·
生物化学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROANALYSIS
·
2019
·Vol. 32
·期 3
·620-625
·
IF 2.691
Xiangyu Ma,Kun Qian,Martha Kandawa-Schulz,Weimin Miao,Yihong Wang
Copper ion (Cu 2+ ) is one of the heavy metal ions which has been considered as a severe pollutant affecting the environment and human health. Therefore, it is necessary to detect Cu 2+ sensitively and conveniently in food and drinks. However, the gold standard method that inductively coupled plasma mass spectrometry (ICP-MS) is expensive equipment required and time-consuming. In this work, a highly sensitive and facile electrochemical method was studied to directly determine the concentration of Cu 2+ without cumbersome modification on the surface of glassy carbon electrode (GCE). In the presence of ferric ion (Fe 3+ ), Cu 2+ could play a role of catalyst in the detection system, and the electrochemical signal of differential pulse voltammetry (DPV) response to Cu 2+ could be amplified obviously. Under the optimal conditions, a good linear relationship was obtained in the range of 1 nM to 5 μM with a detection limit of 57.5 pM (S/N=3) were obtained. Besides, the proposed method has good applicability for the detection of Cu 2+ in tap water. Furthermore, the copper complex was detected and the results were indicated the proposed method was effective and sensitive.
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 90
·74126-74131
·
IF 3.84
Jun Zhu,Xiufang Xu,Jinglei Liu,Yiqun Zheng,Shifeng Hou
We report a facile method for the synthesis of oleylamine-capped silver (Ag) nanowires in high purity. For the first time, Ag nanowires could be produced in high purity via a simple one-pot approach in a hydrophobic phase. The success of this synthesis relies on the use of Cu2+ to mediate the reduction of silver bromide (AgBr) by oleylamine at an elevated temperature, which promoted the high-yield formation of Ag products with a wire-like shape. These Ag nanowires were washed and deposited on PET films to form a transparent conductive electrode (TCE), which showed a sheet resistance of 34.0 Ω sq−1 and an optical transmittance of 70–80% at visible wavelengths. In addition to TCEs, these nanowires could also find important applications in the fields of conductive ink, and wearable electronics, among others.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Zizheng Liu,Jiawei Liu,Haike Yang,Jingyi Guo,Yiqun Chen,Qing Shao,Shuxian Gao,Liting Luo
Arsenic is categorized as a class I carcinogen due to its strong biological toxicity. In this study, a novel treatment process with Cu 2 (OH) 2 CO 3 as catalyst is proposed, whereby As(III) in water is oxidized by activating sulfite to generate SO 4 − and SO 5 − radicals. Under conditions of [Cu 2 (OH) 2 CO 3 ] 0 = 0.01 g·L −1 , [sulfite] 0 = 0.3 mmol·L −1 , and initial pH 8.0, 94% of As(III) was converted into As(V) within 20 min, whereby dissolved oxygen had a pivotal impact on the reaction. However, HCO 3 − , humic acid, and fulvic acid all significantly inhibited the oxidation. Heterogeneous electron transfer on the catalyst surface and homogeneous dissolved Cu 2+ jointly activated sulfite in the Cu 2 (OH) 2 CO 3 /sulfite system, with the heterogeneous process predominating. Density functional theory (DFT) calculations disclose a dominate physical adsorption of sulfite on Cu 2 (OH) 2 CO 3 surface with 1.74 electrons transferred. >90% of As(III) was still oxidized after recycling the material five times, indicating excellent reusability. Overall, it shows good potential for application in the removal of As(III) from real water samples.
研究领域:
环境科学
·
化学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Zitong Yang,Yunkai Sun,Zexi Hou,Haiyan Yu,Mingxue Li,Yanwei Li,Yude Li,Baoyu Gao,Shiping Xu
Although the effect of Cu 2+ on antibiotic removal during photocatalytic reaction has been studied in depth, there is less known about the effect of antibiotics on Cu 2+ removal. In this study, we report for the first time that, during the photocatalytic purification of sulfamerazine (SMZ) and Cu 2+ combined pollution, Cu 2+ concentration showed an obvious five-stage fluctuation, which was completely different from the simple promotion or inhibition reported in previous studies. By employing HPLC-MS analysis and density functional theory (DFT) calculation, the repeated fluctuation of Cu 2+ concentration was found to be closely related to the SMZ degradation process, mainly resulting from solution pH drop and formation of Cu-containing intermediates which acted as sacrificial agents for Cu 2+ reduction. In addition, compared with the SMZ-free system, the presence of SMZ can greatly enhance the deep removal of Cu 2+ (minimum Cu 2+ concentration was only 0.17 mg/L vs. 1.28 mg/L without SMZ), and there was a wide time interval to ensure the efficient recovery of Cu metal. More interestingly, the in-situ obtained Cu-decorated TiO 2 photocatalyst performed well in water splitting, nitrogen fixation and bacterial sterilization. Results of this study confirmed the great potential of photocatalytic technology in purifying antibiotic-heavy metal combined pollution.
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产品关联
DOI
PubMed
高影响因子
Journal of Materiomics
·
2019
·Vol. 5
·期 4
·626-633
·
IF 0
Zhiming Geng,Dongliang Shi,Lu Shi,Ying Li,G. Jeffrey Snyder,Kwok-ho Lam
As the featured material of the superionic thermoelectric (TE) material family, copper-chalcogenide Cu 2- x Se is attracting growing research interest for its excellent TE performance derived from the satisfactory power factor and the ultra-low thermal conductivity induced by the superionic effect. Various efforts have been made and proved to be effective to further enhance the TE performance for Cu 2- x Se. However, this material is still far from the application stage, which is mainly due to concerns regarding control of the properties and the costly complex fabrication technology. Here we report a scalable pathway to achieve high-performance and tunable Cu 2- x Se, utilizing conventional sintering technology and copper (Cu)-vacancy engineering with an effective mass model. The figure of merit zT is a competitive value of 1.0 at 800 K for the optimized binary Cu 2- x Se, based on the precise modeling prediction and Cu-vacancy engineering. The changes in TE properties of Cu 2- x Se under heating-cooling cycle tests are also revealed. Our work offers the referable method along with the decent parent material for further enhancement of TE performance, paving a possible route for the application and industrialization of Cu 2- x Se TE materials.
研究领域:
材料科学
·
热电学
·
固体物理
·
能源材料
✓ 已验证
DOI
CHEMOSPHERE
·
2020
·
IF 5.778
Chuang Fu,Xianliang Yi,Yang Liu,Hao Zhou
Sulfonamide antibiotics (SAs) are widely used in veterinary medicine but are poorly metabolized in biological systems; thus, they can cause a selective pressure to promote the proliferation of antibiotic resistant pathogens and threaten human health. Persulfate (PS)-based advanced oxidation processes (AOPs) have been applied for SA degradation, but using transition metal ions as PS activators is relatively limited. In this study, sulfamethazine (SMZ) was used as a model SA to evaluate the performance of a Cu 2+ -activated PS system. Cu 2+ -PS exhibited better SMZ removal than other metal ions, and 25 mg/L SMZ can be degraded in the presence of 0.2 mM Cu 2+ and 2.5 g L −1 PS within 120 min. Various anions inhibited SMZ degradation to different degrees except HCO 3 − . Among the cations, Fe 3+ significantly inhibited SMZ removal, while Ni 2+ increased the removal rate. High concentrations of humic acid and protein also increased the degradation rate of SMZ. Radical and singlet oxygen quenching experiments, together with the results of electron spin-resonance spectroscopy (ESR), showed that the main active species generated from Cu 2+ -PS are SO 4 · - and ·OH. The degradation pathway of SMZ was identified through HPLC-HRMS. Direct SO 4 · - and ·OH oxidation products of SMZ were not found, suggesting that the complex formed between Cu 2+ and SMZ may affect the fate of SMZ. On the other hand, the efficiency and selectivity of Cu 2+ -PS against different SAs were confirmed. Overall, this study provides a facile and effective method for SMZ and other SA removal.
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Na Xiao,Jiang Xue Dong,Shi Gang Liu,Na Li,Yu Zhu Fan,Yan Jun Ju,Nian Bing Li,Hong Qun Luo
Selective and sensitive detection of multiple metal ions is significant for biological researches and environmental monitoring, because the abnormal metal ions levels have potential damage to the human body and environment. In this study, a fluorescent sensing platform based on Ag nanoclusters has been established for independent detection of Hg 2+ , Cu 2+ , and Fe 3+ ions in a solution. The interference of the fluorescence induced by coexistent metal ions was removed by altering buffers with different pH and using different masking agents. Moreover, the detection mechanism is discussed in detail, which provides a valuable reference for the detection of heavy metal ions with metal nanomaterials. This sensor exhibits a high selectivity and sensitivity, and the linear ranges for Hg 2+ , Cu 2+ , and Fe 3+ detection are 0.05-9, 0.05-18, and 0.1–18 μM with the corresponding detection limits of 12, 27, and 50 nM, respectively. Furthermore, this method was successfully used for analyzing the three metal ions in environmental and biological samples.
研究领域:
分析化学
·
环境科学
·
生物传感
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2014
·Vol. 25
·期 12
·1391-1395
·
IF 1.964
Q. Huang,G. Chen,J. Liu
Polyanilines (PANIs) doped with Zn 2+ and Cu 2+ were synthesized by H 2 O 2 oxidative polymerization of aniline in the presence of corresponding metal chloride in solution. The products were characterized by elemental analysis, UV-Vis-NIR, FTIR and Raman spectroscopies. Scanning electron micrograph was employed to examine the morphology of PANIs fabricated in the presence of different transition metals. Experimental results showed that transition metal ions had been successfully incorporated into the polymer, and there was a strong interaction between the transition metal ions and the PANI chains. The electrical conductivity of PANI doped with Zn 2+ and Cu 2+ is 0.37 and 0.21 S/cm, respectively, which is higher than that of HCl doping PANI corresponding to 0.052 S/cm. The cyclic voltammetric study has indicated that incorporation of metal ions in PANI backbone results in increasing of specific capacitance compared to that of HCl doping PANI. Copyright © 2014 John Wiley & Sons, Ltd.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2015
·
IF 4.762
Jing Liu,Jian Liu,Weisheng Liu,Haoli Zhang,Zhengyin Yang,Baodui Wang,Fengjuan Chen,Haotai Chen
The combination of different fluorescent species into one nanostructure to develop fluorescent nanoparticles with multiple emission signatures by a single wavelength excitation has become a very popular research area in the field of multiplex bioanalysis, diagnostics, and multicolor imaging. However, these novel hybrids must be elaborately designed to ensure that the unique properties of each component are conveyed, i.e., fluorescent species and nanoparticles, and are maximized without serious interactions with each other. Herein, a first triple-fluorescence dumbbell nanoprobe with large Stokes shift based on incorporating fluorescein isothiocyanate (FITC) and lanthanide complexes onto Au–Fe3O4 NPs was synthesized. This hybrid displays well-resolved triple fluorescence emission, with FITC at 515 nm, Tb(III) complex at 545 nm, and Eu(III) complex at 616 nm under a single-excitation wavelength and is used for highly selective and sensitive colorimetric detection of Cu2+ with a detection limit of 30 nM. Under different Cu2+ concentrations, this hybrid exhibited distinguishable multiple colors under UV light, and the color could change in the presence of different concentrations of Cu2+. This sensor for ratio/multianalyte microscopic imaging of Cu2+ in HeLa cells and BHK cells was also demonstrated. Target molecules, such as folic acid, can be covalently attached to the fluorescent nanoparticle surface to serve as an effective probe for simultaneous multicolor imaging folate receptor-overexpressing HeLa cell lines in vitro.
研究领域:
生物分析
·
诊断学
·
成像技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）