CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Rong Zhang,Teng Jin,Yue Zhang,Xueqing Sui,Shiman Wu,Yue Wu,Dapeng Hao,Zhenwei Yao,Zhengze Yu,Xuejun Liu,Hua Zhang
Immunotherapy holds significant promise to completely eliminate tumor, yet lack of timely evaluation of immune responses, which challenged by inherent lagging and pseudoprogression during immunotherapy. Immune-vascular crosstalk (IVC), an enhancement ring for the mutual regulation linking tumor vascular normalization with immune remodeling forms, emerging as a systematic indicator for immunotherapy outcomes, necessitates timely, non-invasive, and early detection of its status to enhance clinical benefits. Herein, positive and negative loop models of tumor IVC were established using different degree of photothermal therapy (PTT) based on NaBiF 4 :Gd@PDA@PEG nanoprobes. Multi-functional magnetic resonance imaging, including fast spoiled gradient-recalled (FSPGR), time-resolved imaging of contrast kinetics (TRICKs) and dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI), was applied to dynamically reflect normalized/ablated tumor vasculature, well-matched increased/decreased immune response corresponding to different status of IVC, confirmed by pathology results. This study proposes a novel biological method to noninvasively detect the positive/negative IVC loop, paving the visualized way for immunotherapy assessed benefits, which is expected to be extended to clinical translation.
研究领域:
肿瘤学
·
免疫学
·
医学影像学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2012
·
IF 5.856
Fengshan Shen,Hyundoo Hwang,Young Ki Hahn,Je-Kyun Park
This paper describes a new label-free cell separation method using a magnetic repulsion force resulting from the magnetic susceptibility difference between cells and a paramagnetic buffer solution in a microchannel. The difference in the magnetic forces acting on different-sized cells is enhanced by adjusting the magnetic susceptibility of the surrounding medium, which depends on the concentration of paramagnetic salts, such as biocompatible gadolinium diethylenetriamine pentaacetic acid (Gd–DTPA), dissolved therein. As a proof-of-concept demonstration, Gd–DTPA solutions at concentrations of 0–80 mM were applied to separate U937 cells from red blood cells (RBCs) and to distinguish two different-sized polystyrene (PS) beads (8 and 10 μm in diameter). By increasing the Gd–DTPA concentration from 0 to 40 mM, the separation resolution of PS beads was increased from 0.08 to 0.91. Additionally, we successfully achieved label-free separation of U937 cells from RBCs with >90% purity and 1 × 105 cells/h throughput using a 40 mM Gd–DTPA solution.
研究领域:
生物医学工程
·
细胞生物学
·
微流控技术
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
Biomaterials Science
·
2018
·Vol. 6
·期 8
·2209-2218
·
IF 5.831
Siqi Wang,Wenzhi Ren,Jianhua Wang,Zhenqi Jiang,Madiha Saeed,Lili Zhang,Aiguo Li,Aiguo Wu
At present, transmembrane glycoprotein CD133 highly expressed pancreatic cancer stem cells (PCSCs), with the features of chemotherapeutic/radiotherapeutic resistance and exclusive tumorigenic potential, are considered as the primary cause of metastasis and recurrence in pancreatic cancer, and therefore are an effective target in the disease treatment. Furthermore, with the launch of precision medicine, multifunctional nanoprobes have been applied as an efficient strategy for the magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) of pancreatic cancer. In this research, with the aim of achieving precise MRI-guided PTT in CD133 highly expressed PCSCs, novel bTiO2-Gd-CD133mAb nanoprobes were designed and successfully prepared by loading Gd-DOTA and CD133 monoclonal antibodies on black TiO2 nanoparticles. It was very interesting to find that the r1 relaxivity value of the nanoprobes was 34.394 mM−1 s−1, about 7.5 times that of commercial Magnevist (4.5624 mM−1 s−1), which indicates that the nanoprobes have good potential as MRI T1 contrast agents with excellent performance. Herein, CD133 highly expressed PANC-1 cells were selected and verified as PCSCs model. In vitro experiments demonstrated that the nanoprobes exhibited active-targeting ability in PANC-1 cells, and consequently could specially enhance T1-weighted MR imaging and 808 nm near-infrared (NIR)-triggered PTT efficiency in the PCSCs model. Our study not only provides a new strategy for the effective treatment of pancreatic cancer and its’ stem cells, but also further broadens the application of black TiO2 in the field of cancer theranostics.
研究领域:
癌症研究
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纳米技术
·
医学成像
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诊疗一体化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Qin Zhang,Jiaqi Yang,Bo An,Ke Wang,Dongxing Song,Huijuan Su
Gd 0.1 Ce 0.9-x Ga x O 2-δ (x = 0, 0.04,0.07, 0.12) are synthesized via the citric acid-EDTA combustion method as an electrolyte material for intermediate-temperature solid oxide fuel cells. XRD and Rietveld refinement revealed that the material exhibits a single-phase cubic fluorite structure. SEM and EDS analyses demonstrated that the incorporation of Ga ions improved the sample's density, increased the grain size, and provided better element dispersion. XPS analysis confirms that Ga-Gd co-doping leads to increased oxygen vacancy concentration and modifies the oxidation states of Ce. Impedance spectroscopy results indicated that Ga-Gd co-doped ceria has higher ionic conductivity and lower activation energy compared to Gd single-doped ceria. In comparison to Gd 0.1 Ce 0.9 O 1.95 , the best-performing Gd 0.1 Ce 0.83 Ga 0.07 O 2-δ achieved nearly a 26-fold increase in ionic conductivity and a 66 % reduction in activation energy. The clearance coefficient of Gd 0.1 Ce 0.83 Ga 0.07 O 2-δ reached 100.95, while the blocking factor decreased by nearly 73 % compared to Gd 0.1 Ce 0.9 O 1.95 . The incorporation of Ga ions led to a nearly one order of magnitude reduction in the dissipation of oxygen vacancy concentration in the space charge layer, with the potential decreasing from 0.3971V (Gd 0.1 Ce 0.9 O 1.95 ) to 0.3117V (Gd 0.1 Ce 0.83 Ga 0.07 O 2-δ ). Dielectric studies clarified the contribution of the Gd-Ga synergistic effect on interfacial polarization. In terms of single-cell performance, the NiO-GDC| Gd 0.1 Ce 0.83 Ga 0.07 O 2-δ |LSCF cell exhibited higher power density and current density, particularly showing a 42.9 % performance improvement at 650 °C compared to NiO-GDC|Gd 0.1 Ce 0.9 O 1.95 |LSCF. Density functional theory calculations indicated that the incorporation of Ga ions effectively suppresses the electronic conductivity of CeO 2 and significantly reduces the formation energy, binding energy, and migration barrier of oxygen vacancies. Therefore, Ga-Gd co-doping can be regarded as an effective strategy for enhancing the performance of ceria-based electrolytes in IT-SOFCs.
研究领域:
材料科学
·
能源工程
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Nano Research
·
2014
·Vol. 7
·期 11
·1581-1591
·
IF 6.963
Guo Weisheng,Yang Weitao,Wang Yu,Sun Xiaolian,Liu Zhongyun,Zhang Bingbo,Chang Jin,Chen Xiaoyuan
Inorganic nanoparticles have been introduced into biological systems as useful probes for in vitro diagnosis and in vivo imaging, due to their relatively small size and exceptional physical and chemical properties. A new kind of colortunable Gd-Zn-Cu-In-S/ZnS (GZCIS/ZnS) quantum dots (QDs) with stable crystal structure has been successfully synthesized and utilized for magnetic resonance (MR) and fluorescence dual modality imaging. This strategy allows successful fabrication of GZCIS/ZnS QDs by incorporating Gd into ZCIS/ZnS QDs to achieve great MR enhancement without compromising the fluorescence properties of the initial ZCIS/ZnS QDs. The as-prepared GZCIS/ZnS QDs show high T
1 MR contrast as well as “color-tunable” photoluminescence (PL) in the range of 550–725 nm by adjusting the Zn/Cu feeding ratio with high PL quantum yield (QY). The GZCIS/ZnS QDs were transferred into water via a bovine serum albumin (BSA) coating strategy. The resulting Cd-free GZCIS/ZnS QDs reveal negligible cytotoxicity on both HeLa and A549 cells. Both fluorescence and MR imaging studies were successfully performed in vitro and in vivo . The results demonstrated that GZCIS/ZnS QDs could be a dual-modal contrast agent to simultaneously produce strong MR contrast enhancement as well as fluorescence emission for in vivo imaging.
研究领域:
生物医学工程
·
纳米医学
·
影像学
✓ 已验证
DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2026
·
IF 6.9
Xuejiao Li,Xiaoyu Tan,Xiaofei Gao,Yuxiao Wang,Lianwei Shan,Xin Liu,Limin Dong,Piaoping Yang
Background: Near-infrared-II (NIR-II, 1000-1350 nm) energy conversion systems offers enhanced spatial resolution, deeper tissue penetration, and reduced autofluorescence compared to NIR-I (780-1000 nm). However, treatment precision is limited by complex nanosystems and the lack of real-time imaging. Method: Herein, we develop Gd-doped W 18 O 49 (xGd-W 18 O 49 ) nanoprobes via an engineered solvothermal process (200°C, 24 h), systematically modulating Gd concentrations (2-5 at%) to achieve crystallographic phase stability, uniform morphology, and optimized NIR absorption kinetics. Significant findings: The 3%Gd-W 18 O 49 exhibits prominent photothermal conversion efficiency, photodynamic performance, and in vitro inhibition of MCF-7 cancer cells. Capitalizing on tungsten’s high atomic number (Z=74) and gadolinium’s paramagnetism, this nanoplatform enables synergistic CT/MR dual-modal imaging with contrast enhancement for real-time guidance. This “all-in-one” system demonstrates a scalable strategy for transition metal oxide doping, integrating reactor-synthesized nanomaterials with NIR-induced photothermal/photodynamic therapy for precision theranostics.
✓ 已验证
DOI
高影响因子
Kidney International Reports
·
2026
·
IF 6.2
Shangbin Kao,Yuemiao Zhang,Shaoqing Dang,Shichao Hu,Mengwei Li,Tianyu Zheng,Yuan Qin,Biao Huang,Qiang He,Jicheng Lv
Introduction IgA nephropathy (IgAN) diagnosis remains dependent on invasive renal biopsy because currently available serologic biomarkers, including galactose-deficient IgA1 (Gd-IgA1), have limited diagnostic performance. This study aimed to develop and evaluate a high-sensitivity time-resolved fluorescence immunoassay (TRFIA) based on a novel anti-Gd-IgA1 monoclonal antibody (MH33) for Gd-IgA1 detection in IgAN. Methods MH33 glycoepitope specificity was characterized by surface plasmon resonance (SPR). A MH33-based TRFIA was developed and evaluated for analytical and diagnostic performance in healthy controls, non-IgAN renal disease controls, and IgAN patients, with comparison to a KM55-based assay. Results SPR analysis showed that MH33 recognized a GalNAc-modified IgA1 hinge-region glycopeptide distinct from the KM55 epitope. The MH33-based TRFIA achieved a detection limit of 0.20 Ru/mL, a quantification range of 0.20–600 Ru/mL, and acceptable analytical performance (intra-/inter-assay CVs: 2.32%–5.49% and 3.97%–5.23%; recoveries: 89.80%–103.76%). Correlation with KM55 was moderate (IgAN, r = 0.23, p =0.09). For distinguishing IgAN from combined controls (healthy controls and non-IgAN renal diseases), the MH33-based TRFIA yielded an AUC of 0.90 (95% CI: 0.86–0.93), compared with 0.78 (95% CI: 0.71–0.86) for KM55 . At the optimal cutoff value (22.0 Ru/mL), the assay achieved a specificity of 93.82% and sensitivity of 64.44%. Conclusion MH33-based TRFIA provides a sensitive approach for Gd-IgA1 detection and demonstrates favorable diagnostic performance for IgAN.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Shuo Yan,Yuhong Chen,Ziqiang Yin,Binwei Huang,Quanxing Ren,Tihao Cao,Xuxin Ping,Ruibin Liu,Zhengren Huang,Qing Huang,Yinsheng Li
SiC ceramics were fabricated by spark plasma sintering of β-SiC powder with various rare-earth (RE = La, Gd, Yb, Sc) oxides and magnesia additives. The phase compositions, microstructures, lattice oxygen contents, and thermal conductivities were systematically investigated. A decrease in the cationic radius of rare-earth element resulted in an increased cationic field strength. This enhanced attraction to oxygen anion led to higher viscosity and improved high-temperature stability of the intergranular RE-Mg-Si-O liquid phase. After sintering at 1850°C, influenced by liquid-phase viscosity, the degree of β→α phase transformation in SiC and the grain size decreased with decreasing cationic radius of rare-earth element. After sintering at 2050°C, the liquid-phase viscosity significantly decreased, but volatilization became pronounced. The extent of β→α phase transformation and the grain size were affected by both liquid-phase viscosity and volatility. Larger grain size and higher affinity of rare-earth cations for oxygen anions contributed to reduce lattice oxygen content. The thermal conductivities of the SiC ceramics ranged from 192 to 229 W/mK. Notably, the SiC ceramic with Yb 2 O 3 -MgO additives exhibited the largest grain size, the lowest lattice oxygen content, and the elimination of β/α heterophase boundaries, thereby achieving the highest thermal conductivity of 229 W/mK.
研究领域:
材料科学
·
热传导工程
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHARACTERIZATION
·
2025
·
IF 5.5
Qian Wen,Xiaopeng Hu,Junyao Wu,Qing Liu,Sai Liu,Duzhong Zhu,Jinwei Guo,Wang Zhu
Medium-high entropy RETaO 4 (RE = Y, Gd, Yb, Dy, Sm) ceramics are prepared by high-temperature solid-state reaction. Results show that doping rare earth ions into the A site improves the hardness, elastic modulus, fracture toughness, and fracture strength of the ceramics. As the solid solution components increase, hardness rises from 5.19 GPa to 7.43 GPa, elastic modulus from 55.2 GPa to 88.8 GPa, fracture toughness from 1.10 MPa·m 1/2 to 2.05 MPa·m 1/2 , and fracture strength from 31.8 MPa to 58.6 MPa. This enhancement is attributed to higher lattice distortion, increased internal energy, and stronger bonding. The proportion of transgranular fracture increases with solid solution content. Ferroelastic domain structures cause crack tip deflection, leading to greater fracture energy absorption. Furthermore, high-entropy and lattice distortion effects in (5RE 1/5 )TaO 4 ceramics promote high-density dislocation regions under stress, enhancing dislocation toughening.
研究领域:
材料科学
·
力学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 34
·2170
·
IF 2.8
Wang Yan,Su Congxue,Tao Wenlong,Chen Zelong,Fan Jun,Cheng Min,Chen Beiyi,Zhou Huanfu,Sun Yuan
In light of advancements in 5G/6G technologies, current research on microwave dielectric ceramics is focused on the development of materials characterized by low sintering temperatures and low permittivity, in order to satisfy the requirements of high-frequency low-temperature co-fired ceramic (LTCC) applications. Novel monoclinic structure GdBaK(MoO 4 ) 3 and YBaK(MoO 4 ) 3 ceramics, with C2 / c space group, were synthesized using a conventional solid-state method. GdBaK(MoO 4 ) 3 and YBaK(MoO 4 ) 3 ceramics were sintered at 830 °C and 850 °C, exhibited ε r ~ 8.54 and 8.77, τ f ~ − 51.1 ppm/°C and − 45.8 ppm/°C, Q × f ~ 23, 240 GHz and 59, 277 GHz, respectively. The compression from Ba 2+ and K + cations was identified as the main reason for the higher theoretical ε theo compared to the corrected ε corr . The dielectric loss of both ceramics is mainly affected by the density and packing fraction. The full width at half maximum (FWHM) values of the vibrational peak at 932 cm −1 , corresponding to the symmetric stretching modes of MoO 4 2− , exhibits a negative correlation with the Q × f values. Based on the P–V–L theory, the lattice energy and bond energy associated with the Mo–O bond played a substantial role in influencing the Q × f and τ f . Moreover, YBaK(MoO 4 ) 3 showed good chemical compatibility with Ag, indicating its potential for LTCC applications.
研究领域:
材料科学
·
陶瓷与复合材料
·
微波技术
·
介电材料
·
电子材料
·
固态化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2023
·
IF 3.6
Lin Xiang,Xianju Zhou,Li Li,Faling Ling,Yanhong Li,Jingfang Li,Hongmei Yang
Eu 3+ ions are extensively employed as spectroscopic probes because of the particular emissions due to the unique 4f 6 electronic configuration. Herein, we have developed a series of interesting fluorescent powders of Eu 3+ activated Sr 2 MNbO 6 (M = Ga, In, Gd). When Sr 2 GaNbO 6 :Eu 3+ is excited by the photons in the range of charge transfer band (CTB), the dark red 5 D 0 → 7 F 4 transition predominates the emission, exhibiting an anomalous intensity even higher than that of 5 D 0 → 7 F 1 or 5 D 0 → 7 F 2 . Whilst, if the sample is pumped by f-f characteristic transitions, the hypersensitive 5 D 0 → 7 F 2 transition emerges as the strongest. However, Eu 3+ doped Sr 2 InNbO 6 and Sr 2 GdNbO 6 never demonstrate such results, 5 D 0 → 7 F 1 acts as the most intense one regardless of the excitation wavelength. It is found that Eu 3+ substitutes Sr 2+ site, and cuboctaherdron [SrO 12 ] with O h symmetry is likely to deform to triangular orthobicupola D 3h symmetry, leading to two non-equivalent crystal sites in Sr 2 GaNbO 6 host. But Eu 3+ replaces In 3+ and Gd 3+ position with O h symmetry and has only one site in Sr 2 InNbO 6 and Sr 2 GdNbO 6 . Based on the comparative study on the intensity of 5 D 0 → 7 F 0 transition, as well as the influence factors of temperature, the doping concentration on the relative intensity among 5 D 0 → 7 F J transitions, and the band gaps of these three hosts, the origin of the abnormal intense 5 D 0 → 7 F 4 is ascribed to the mixing of CTB and low-lying 4f 6 configuration as well as two non-equivalent Eu 3+ sites.
研究领域:
材料科学
·
光物理学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Yun Wang,Zhiyuan Pan,Sihan Feng,Lijie Gao,Xuejiao Wang,Qi Zhu,Ji-Guang Li
Near-infrared (NIR)-emitting phosphors with high quantum efficiency and thermal stability are crucial to NIR pc-LEDs. Garnet-structured (GdLuCa)(Al4–zSiCrz)O12 (z = 0.01–0.2) and (Gd2–xLuCax)(Al4.95–xSixCr0.05)O12 (x = 0.2–1.0) new phosphors with promising NIR luminescence under blue light excitation were designed and fabricated by a solid-state reaction in this work. It was analyzed that the Ca2+, Cr3+, and Si4+ ions would replace Gd3+ in [GdO8], Al1 in [Al1O6], and Al2 in [Al2O4], respectively, and the optimal Cr3+ content is z = 0.05, above which concentration quenching would occur via an electric dipole–dipole interaction. Increasing Ca2+/Si4+ substitution up to x = 1.0 led to luminescence enhancement by a factor of up to 1.85 and internal/external quantum efficiency (%) increment from ∼25.9/10.7 to 63.4/27.5, and all of the phosphors showed excellent thermal stability (I423 K/I298 K ≥ 87.6%). The luminescence properties of Cr3+ were discussed in detail through systematic investigation of the effects of Cr3+ and Ca2+/Si4+ contents on the crystal structure, local coordination, and crystal field. With the NIR pc-LED device integrated from the optimal phosphor (x = 1.0) and a blue LED chip, electroluminescence manifested potential applications in night vision and medical diagnosis.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
PubMed
高影响因子
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