Theranostics
·
2020
·
IF 8.579
Chao Fang,Dong Cen,Yifan Wang,Yongjun Wu,Xiujun Cai,Xiang Li,Gaorong Han
Abnormal tumor microenvironment, such as hypoxia, interstitial hypertension and low pH, leads to unexpected resistance for current tumor treatment. The development of versatile drug delivery systems which present responsive characteristics to tumor microenvironment (TME) has been extensively carried out, but remains challenging. In this study, zeolitic imidazolate framework-8 (ZIF-8) coated ZnS nanoparticles have been designed and prepared for co-delivery of ICG/TPZ molecules, denoted as ZSZIT, for H 2 S-amplified synergistic therapy. Methods: The ZSZ nanoparticles were characterized using SEM, TEM and XRD. The in vitro viabilities of cancer cells cultured with ZSZIT under normoxia/hypoxia conditions were evaluated by cell counting kit-8 (CCK-8) assay. In addition, in vivo anti-tumor effect was also performed using male Balb/c nude mice as animal model. Results: ZSZIT shows cascade PDT and hypoxia-activated chemotherapeutic effect under an 808nm NIR irradiation. Meanwhile, ZSZIT degrades under tumor acidic environment, and H 2 S produced by ZnS cores could inhibit the expression of catalase, which subsequently favors the hypoxia and antitumor effect of TPZ drug. Both in vitro and in vivo studies demonstrate the H 2 S-sensitized synergistic antitumor effect based on cascade PDT/chemotherapy. Conclusion: This cascade H 2 S-sensitized synergistic nanoplatform has enabled more effective and lasting anticancer treatment.
研究领域:
纳米医学
·
肿瘤学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 111
·91206-91212
·
IF 3.84
Wen Long Li,Hong Yan Zou,Jing Lan,Qiang Wang,Yuan Fang Li,Cheng Zhi Huang
Hollow nanostructures have been diversely applied in many fields and efforts have been made to develop their various synthesis methodologies. Herein, homogeneous hollow Cu2−xSeyS1−y/reduced graphene oxide (rGO) nanocomposites were prepared for the first time via a facile and green aqueous chemical approach using H2S gas bubble templates as soft templates at room temperature. It is found that 2D hexagonal Cu2−xSeyS1−y nanosheets assemble around the gas–liquid interface of H2S bubbles to form hollow nanospheres on the rGO sheets, wherein rGO sheets as molecular templates play a critical role in maintaining the structural integrity of single-crystal hollow Cu2−xSeyS1−y nanospheres. Increasing the S content in the precursors, i.e., increasing the amount of H2S bubbles, both the diameter and chalcogen composition (S/Se molar ratio) of hollow Cu2−xSeyS1−y/rGO nanocomposites gradually increase. The near-infrared (NIR) localized surface plasmon resonance (LSPR) in Cu2−xSeyS1−y/rGO nanocomposites, arising from the free carriers (holes) in Cu2−xSeyS1−y, gets red shifts with increasing the S content, due to the higher carrier mass and assembly degree of Cu2−xSeyS1−y.
研究领域:
材料科学
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Lijia Huang,Jiao Shen,Yi Yuan,Yaoqi Huang,Ying Liang,Shaojun Yuan
The development of efficient photocatalysts for hydrogen sulfide (H 2 S) degradation under visible light remains a critical challenge due to constraints in light absorption efficiency and rapid electron-hole recombination. In this study, a novel dual S-scheme ternary heterojunction photocatalyst, In-TiO 2 @BiOBr@In-TCPP (IBP), was synthesized via a hydrothermal method for high-performance H 2 S desulfurization. Comprehensive characterization confirmed the successful formation of the heterostructure, where In-TiO 2 facilitated spontaneous H 2 S dissociation, BiOBr served as an efficient electron transport medium, and In-TCPP extended the light absorption spectrum to 1200 nm. The optimized IBP-3 demonstrated exceptional performance, achieving complete H 2 S degradation (100 %) within 120 min under visible light irradiation and retaining over 70 % efficiency even after 8 h of continuous operation. Mechanistic investigations revealed that the synergistic integration of In-TiO 2 , BiOBr, and In-TCPP enhanced visible light utilization, suppressed charge carrier recombination, and promoted reactive oxygen species (ROS) generation via internal electric fields (IEF) and S-scheme charge transfer pathways. This study not only presents the rational engineering of multi-component systems for designing advanced heterojunction photocatalysts to address industrial desulfurization challenges, but also emphasizes the potential of tailored heterostructures in advancing sustainable environmental remediation technologies.
研究领域:
环境科学
·
材料科学
·
化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yan Huang,Qiang Zuo,Mengyang Yin,Jingzhen Wang,Boqiang Gao,Jia Song,Xiaodang Tang,Yali Zhang,Shuanglong Ma,Dangling Hua,Rui Wang
The efficient removal of H 2 S is necessary for clean production and energy safety. However, industrial gases are usually accompanied by CO 2 significantly affecting desulfurization effects. Hence, novel imprinted adsorbents (PMo 12 @UiO-66@H 2 S-MIP-CDs) were synthesized through surface imprinting technology using cyclodextrins (CDs) as molecular scaffolds and UiO-66 modified by phosphomolybdic acid (PMo 12 @UiO-66) as a support. Wherein, PMo 12 @UiO-66@H 2 S-MIP-β-CD was determined as the optimal adsorbent since β-CD with low solubility is prone to keep its inherent cavity to promote dispersion of imprinted polymers and enrich internal pore channels. H 2 S capacity of PMo 12 @UiO-66@H 2 S-MIP-β-CD (31.67 mg/g) was about 2.4 and 1.7 times that of PMo 12 @UiO-66 and PMo 12 @UiO-66@H 2 S-MIPs, respectively, revealing the remarkable contribution of β-CD as a molecular scaffold to improve desulfurization. The results showed that PMo 12 @UiO-66@H 2 S-MIP-β-CD can maintain stable desulfurization efficiency regardless of the presence of CO 2 or moisture, and O 2 can strengthen the redox reaction between H 2 S and PMo 12 accompanied by the increased reduction degree of Mo 6+ in PMo 12 . After five adsorption-regeneration cycles, PMo 12 @UiO-66@H 2 S-MIP-β-CD still exhibited ideal removal efficiency. The excellent desulfurization performance is mainly ascribed to the selective adsorption role of H 2 S-MIP-β-CD and oxidative removal ability of PMo 12 . This work provides a valuable reference for the directional design of high-capacity functional adsorbents for room-temperature desulfurization.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2019
·
IF 10.273
Jiang Wu,Anqi Chen,Yajiao Zhou,Sen Zheng,Yao Yang,Ying An,Ke Xu,Huacheng He,Jianming Kang,Jittima Amie Luckanagul,Ming Xian,Jian Xiao,Qian Wang
Hydrogen sulfide (H 2 S), as a gaseous messenger, exhibits potential therapeutic effects in biological and clinical applications. Herein, an in situ forming biomimetic hyaluronic acid (HA) hydrogel was used as a matrix to dope a pH-controllable H 2 S donor, JK1, to form a novel HA-JK1 hybrid system. This HA-JK1 hydrogel was designed as an ideal delivery scaffold for JK1 with pH-dependent prolonged H 2 S releasing profile. In vitro study suggested that JK1 could induce the polarization of M2 phenotype indicating a higher pro-healing efficiency of macrophages. The in vivo studies on dermal wounds showed that the HA-JK1 hybrid hydrogel significantly accelerated the wound regeneration process through enhanced re-epithelialization, collagen deposition, angiogenesis and cell proliferation . Furthermore, the in vivo results also demonstrated a higher level of M2 polarization in HA-JK1 treated group with reduced inflammation and improved wound remodeling effects, which was consistent with the in vitro results. These observations could be considered as a key to the efficient wound treatment. Therefore, we suggest that HA-JK1 can be used as a novel wound dressing material toward cutaneous wound model in vivo . This system should significantly enhance wound regeneration through the release of H 2 S that induces the expression of M2 macrophage phenotype.
研究领域:
生物医学工程
·
药学
·
组织工程
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Xue-Yan Wu,Li-Yuan Zhu,Jie Sun,Kai-Yue Zhu,Xiao-Yong Miao,Meng-Yang Liu,Xue-Feng Zhao,Hong-Liang Lu
Pt nanoparticle (NP)-modified SnO2–ZnO (SnO2–ZnO–Pt) core–shell nanosheets (NSs) for hydrogen sulfide (H2S) gas sensing were successfully synthesized via atomic layer deposition, hydrothermal method, and magnetron sputtering. More importantly, the SnO2–ZnO–Pt NS sensing materials were synthesized in situ on microelectromechanical system (MEMS) devices, which are expected to be high-performance gas sensors with superior sensitivity, great selectivity, good reproducibility, and low power consumption. To be specific, the SnO2–ZnO–Pt NSs displayed a high sensitivity (Ra/Rg) of 30.43 and an excellent selectivity when detecting 5 ppm H2S at an operating temperature of 375 °C. Their rate of resistance change was 29.43, which was about 24 and 9 times those of the pristine SnO2 NS (∼1.25) and SnO2–ZnO core–shell NS (∼3.43) sensors, respectively. These substantially improved sensing properties could be mainly attributed to the formation of heterojunctions, catalytic sensitization effect, and increased specific surface area of Pt NP modification. Thus, the proposed SnO2–ZnO–Pt NS gas sensors demonstrate great potential as a high-performance sensing material for application in H2S gas sensors.
研究领域:
材料科学
·
纳米技术
·
气体传感
·
微机电系统
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Hui Zhang,Lizhen Xu,Wenqiang Chen,Jun Huang,Chusheng Huang,Jiarong Sheng,Xiangzhi Song
Biothiols are essential reactive sulfur species (RSS), which play crucial roles in various critical physiological activities. To clarify their complex correlations in signal transduction and metabolism pathways, methods to distinguish H2S, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) at the same time are highly needed. Herein, we deliberately integrate 7-diethylcoumarin and resorufin through an ether bond to develop RC for simultaneous differentiation of Cys, Hcy, GSH, and H2S for the first time. RC displays distinct fluorescence colors in response to H2S, Cys, Hcy, and GSH as red, blue-red, blue-green-red, and green-red, respectively, both in aqueous media and living cells. This work not only reported a robust molecule, RC, to disentangle the intricate interplay networks among different biothiols in biosystems but also demonstrated a strategy for the design of multisignal fluorescent probes for the simultaneous sensing of diverse RSS species as well as other biological species.
研究领域:
化学
·
生物化学
·
细胞生物学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Jingjiao Xie,Huiyuan Gong,Zhihan Du,Chen Hong,Wen Luo
Hydrogen sulfide (H 2 S) plays an important role in various pathophysiological processes, and its concentration is associated with various diseases. As such, the development of new H 2 S probes for the early detection of these diseases is of great significance. To date, a variety of probes have been developed for H 2 S detection, however, most probes exhibit response to other sulfur-containing compounds, resulting in a lack of specificity and weaker anti-interference performance. In this paper, a new flavone-based near-infrared (NIR) fluorophore was synthesized by introducing a 5-[4-(dimethylamino) phenyl] thiophene group at the 2-position of the chromone structure. Moreover, using nitrobenzoate as recognition group, two novel probes (TF-3NO 2 and TF-4NO 2 ) were synthesized to detection of H 2 S in biological systems. Among them, TF-3NO 2 exhibited a more specific fluorescent response to H 2 S compared to TF-4NO 2 . Upon treatment with H 2 S, the fluorescence intensity showed a significant increase, showcasing the high specificity, strong anti-interference capability, near-infrared emission (690 nm), and large Stokes shift (∆λ = 223 nm) of the probe. Moreover, the probe was successfully applied for imaging both exogenous and endogenous H 2 S in cells and mice, and enabled to distinguish changes in the H 2 S concentration in the brains of APP/PS1 transgenic and wild-type mice. The above results indicate that TF-3NO 2 can penetrate the mouse blood brain barrier, and is expected to be a powerful molecular tool for detecting H 2 S in living systems within basic and biomedical research fields.
研究领域:
生物化学
·
分子生物学
·
生物医学工程
·
神经科学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Bo Zhou,Ben-Xu Jia,Ming-Jin Zhang,Yan-Jun Tan,Wei-Yuan Liang,Xiang Gan,Hong-Tao Li,Xiaoli Yang,Xing-Can Shen
Zn 2+ and H 2 S are essential to maintain normal prostate function, and sometimes can evolve into weapons to attack and destroy prostate cancer (PCa) cells. Nevertheless, how to achieve the targeted and effective release of Zn 2+ and H 2 S, and reverse the concentration distribution within PCa tumor cells still highly challenging. Herein, combined with these pathological characteristics of prostate, we proposed a tumor microenvironment (TME) responsive Zn 2+ -interference and H 2 S-mediated gas synergistic therapy strategy based on a nanoplatform of tannic acid (TA) modified zinc sulfide nanoparticles ( [email protected] ) for the specific treatment of PCa. Once the constructed pH-responsive [email protected] internalized by cancer cells, it would instantaneously decomposed in acidic TME, and explosively release excess Zn 2+ and H 2 S exceeding the cell self-regulation threshold. Meanwhile, the in situ produced Zn 2+ and H 2 S synergistic enhancement of cell apoptosis, which is evidenced to increase levels of Bax and Bax/Bcl-2 ratio, release of Cytochrome c in cancer cells, contributing to inhibit the growth of tumor. Moreover, the TA in cooperation with Zn 2+ specifically limits the migration and invasion of PCa cells. Both in vitro and in vivo results demonstrate that the Zn 2+ -interference in combination with H 2 S-mediated gas therapy achieves an excellent anti-tumor performance. Overall, this nanotheranostic synergistic therapy provides a promising direction for exploring new strategies for cancer treatment based on specific tumor pathological characteristics, and provides a new vision for promoting practical cancer therapy.
研究领域:
癌症生物学
·
纳米医学
·
诊疗学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Yuanqi Chen,Kezheng Lei,Yinxi Li,Zhixiang Mu,Tengda Chu,Jiajun Hu,Bairui Zeng,Yi Wang,Jianliang Shen,Xiaojun Cai,Tianpeng Shi,Hui Deng
Oral mucosal wounds are more prone to inflammation due to direct exposure to various microorganisms. This can result in pain, delayed healing, and other complications, affecting patients' daily activities such as eating and speaking. Consequently, the overall quality of life for patients is significantly reduced. To address these challenges, we developed a multifunctional therapeutic nanoplatform, DATS@Arg-EA-SA, through the self-assembly of guanidinated dendritic peptides (Arg-EA-SA) that encapsulate diallyl trisulfide (DATS), a hydrogen sulfide (H 2 S) donor. The guanidine-rich surface of DATS@Arg-EA-SA efficiently neutralizes reactive oxygen species (ROS) in the ulcer microenvironment, generating nitric oxide (NO), which acts as the primary antimicrobial agent by disrupting bacterial membranes. Concurrently, the presence of glutathione triggers the release of H 2 S from DATS, providing supplementary antibacterial support. DATS@Arg-EA-SA effectively kills all bacteria, achieving results comparable to those of penicillin, a classical antibiotic. Moreover, it demonstrates superior sterilization efficacy against drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), significantly outperforming penicillin. Following the initial antimicrobial phase, the nanoplatform transitions into an anti-inflammatory stage. H 2 S, in synergy with NO, facilitates the conversion of M1 macrophages to M2 macrophages, thereby reducing the expression of inflammatory factors. Importantly, the combination of H 2 S and NO provides effective analgesia by downregulating the expression of TRPV1 and TRPV4, thus restoring normal dietary behaviors and improving the overall quality of life. This system ultimately promotes collagen fiber deposition and accelerates the re-epithelialization of the ulcer wound, positioning DATS@Arg-EA-SA as a promising gas-delivery nanoplatform for rapid wound repair in the clinical treatment. Statement of Significance Oral mucosal wounds are highly susceptible to microbial infections, leading to inflammation, pain, delayed healing, and a significant decline in quality of life. We developed a multifunctional therapeutic nanoplatform (DATS@Arg-EA-SA) via the self-assembly of guanidinated dendritic peptides encapsulating the H 2 S donor DATS, which exhibited antibacterial, anti-inflammatory, and analgesic properties. In the oral ulcer microenvironment, DATS@Arg-EA-SA generates substantial NO under elevated ROS levels, while glutathione triggers the controlled release of H 2 S. NO disrupts bacterial membranes as the primary antibacterial agent, with H 2 S providing synergistic antibacterial effects. Furthermore, H 2 S and NO synergistically promote the transformation of M1 to M2 macrophages, attenuating inflammation. Importantly, the combined action of H 2 S and NO alleviates pain by downregulating TRPV1 and TRPV4, supporting the restoration of normal dietary behavior and improving quality of life.
研究领域:
药学
·
纳米技术
·
生物材料
·
医学
·
牙科
·
炎症研究
·
伤口愈合
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Zhixin Jia,Jingbin Zhang,Zengtao Ji,Jiaran Zhang,Xinting Yang,Ce Shi,Xia Sun,Yemin Guo
Hydrogen sulfide (H 2 S) contamination of food has raised widespread public health concerns, leading to substantial medical and economic burdens. Herein, a 2D/0D heterojunction fluorescent probe (TCTG) with Schottky barriers (SB) is designed and synthesized, utilizing Ti 3 C 2 T x MXene-loaded graphene quantum dots (GQDs), for the detection of H 2 S during food spoilage. The microstructures observed through SEM and TEM reveal that uniformly sized GQDs are evenly attached to the surface of a monolayer Ti 3 C 2 T x . The chemisorption between GQDs and Ti 3 C 2 T x facilitates charge transfer and the formation of SB, resulting in intramolecular charge transfer (ICT) effects. With the introduction of H 2 S, TCTG (50%) exhibits the highest sensitivity, selectivity, and anti-interference properties, with ultra-fast fluorescence transient reaction (3s) and remarkably low detection limit of 41.82 ppb as well as noticeable color change. When TCTG (50%) reacted with H 2 S, the ICT effects are inhibited, leading to the recovery of photoinduced electron transfer (PET) and fluorescence quenching. Notably, probe TCTG is effectively utilized to detect changes in H 2 S levels in raw foods to assess their quality. Overall, the significance of this study is its potential to revolutionize food spoilage detection, offering a fast, reliable, and sensitive method to ensure food safety and reduce associated health and economic burdens.
研究领域:
材料科学
·
分析化学
·
食品科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Xuetao Zhang,Yunxue Sun,Xinru Zhao,Yimei Bai,Hui Wang,Jing Zhang,Xiaoping Jiang,Meng Gao
As the significant role of hydrogen sulfide (H 2 S) in the fields of health, safety and environmental protection, the exploitation of portable sensing platforms for real-time H 2 S monitoring with versatile antibacterial function is highly anticipated. Herein, a multifunctional fluorescence film sensor (Zr-MOF&RB-P@F) with self-antibacterial performance was constructed by electrospinning method for convenient and accurate detection of H 2 S. Ratiometric sensing process with color changes could be achieved in this system by utilizing the Zr centered metal-organic framework (Zr-MOF) as fluorescent responder and rose bengal modifed polymer (RB-P) as reference unit. As anticipated, the flexible film exhibited low detection limit of 22.4 μM, superior selectivity, visual recognition ability and improved photostability, demonstrating the availability of the design strategy. In addition, excellent antibacterial ability of the film was endowed by the photosensitive RB-P, realizing an antibacterial efficiency of 87.5%. Moreover, the obtained flexible sensing film was able to evaluated the food freshness in real-time and simultaneously decrease their bacterial deterioration, which revealed great potential as intelligent packaging in food safety field. This research provided a valuable reference for the design of flexible multifunctional sensing material, and gave a promising platform for the comprehensive security protection applications.
研究领域:
化学传感
·
材料科学
·
环境监测
·
食品安全
·
抗菌技术
·
荧光材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）