Small
·
2024
·
IF 13
Xinqing Duan,Lei Li,Zehui Peng,Mingqiang Wang,Yanxin Liu,Dar-Jen Hsieh,Kuan-Chang Chang
The burgeoning implantable biodevices have unlocked new frontiers in healthcare, promising personalized monitoring strategies tailored to specific needs. Herein, hyaluronic acid (HA) is harnessed to create fully biocompatible, acidity-sensitivity and cleft-adjustable neuromorphic devices. These HA-biodevices exhibit remarkable sensitivity to pH variations, effectively mimicking biological acid-sensing ion channels (ASICs) through protonation reactions between electronegative atoms and hydrogen ions, even at ultralow driving voltage (5 mV). They can monitor joint cartilage acidity by tracking changes in proton concentration and successfully diagnose the onset of arthritis. Furthermore, by adjusting the synaptic device's cleft distance, which determines responsiveness, power efficiency and plasticity, HA-based neuromorphic devices can be tailored to meet the unique demands of various implantation sites, providing both high-sensitivity and low-heat dissipation, thus broadening their application scopes. Moreover, the HA-biodevices maintain stable performance across various bending degrees, up to a curvature radius of 7.5 mm, with flexibility and deformation resilience enabling installation on joints of varying curvatures. The combination of all-biocompatibility, high sensitivity, low heat dissipation, ultralow low power (2 pW), and extraordinary deformation tolerance paves the way for the development of versatile, multipurpose medical monitoring devices with immense potential in the field of healthcare.
研究领域:
生物医学工程
·
材料科学
·
医疗设备开发
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Hang Gao,Hang Li,Shuaiqiang Shao,Lintongqing Tan,Yudie Wang,Dawei Li,Wen Zhang,Tao Zhu,Guangchun Liu,Xin Meng
Breast cancer is a malignant tumor that poses a significant threat to women's health and single therapy fails to play a good oncological therapeutic effect. Synergistic treatment with multiple strategies may make up for the deficiencies and has gained widespread attention. In this study, sulfhydryl-modified hyaluronic acid (HA-SH) was covalently crosslinked with polydopamine (PDA) via a Michael addition reaction to develop an injectable hydrogel, in which PDA can be used not only as a matrix but also as a photothermal agent. After HSA and paclitaxel were spontaneously organized into nanoparticles via hydrophobic interaction, hyaluronic acid with low molecular weight was covalently linked to HSA, thus conferring effectively delivery. This photothermal injectable hydrogel incorporates PTX@HSA-HA nanoparticles, thereby initiating a thermochemotherapeutic response to target malignancy. Our results demonstrated that this injectable hydrogel possesses consistent drug delivery capability in a murine breast cancer model, collaborating with photothermal therapy to effectively suppress tumor growth, represented by low expression of Ki-67 and increasing apoptosis. Photothermal therapy (PTT) can effectively stimulate immune response by increasing IL-6 and TNF-α. Notably, the treatment did not elicit any indications of toxicity. This injectable hydrogel holds significant promise as a multifaceted therapeutic agent that integrates photothermal and chemotherapeutic modalities.
研究领域:
肿瘤学
·
药学
·
生物医学工程
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DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Cheng Gu,Shu Fang,Lin Liu,Benjin Chen,Lingling Xu,Min Shao,Jianan Sun,Haisheng Qian,Wanni Wang
The production of bacterial toxins and excessive accumulation of reactive oxygen species (ROS) can induce localized oxidative stress, triggering an exaggerated immune response that impedes wound healing and culminates in chronic wounds. To address this issue, a microneedle (MN) system loaded with copper-manganese oxide (CMO) is developed to modulate the hyperimmune response in wounds. CMO@MN exhibits excellent antimicrobial and anti-inflammatory properties by effectively killing bacteria, scavenging ROS, and modulating macrophage polarization through their multiple enzymatic activities and photothermal properties. RNA sequencing revealed that CMO@MN improved the therapeutic effect on the infected skin of mice by balancing the ratio of M1/M2 macrophages and promoting cell migration and angiogenesis through the regulation of relevant pathways. Overall, this CMO@MN patch skillfully balances the complex issues between the immune response and wound healing and has potential applications in the treatment of other serious bacterial infections.
研究领域:
生物医学工程
·
免疫学
·
药理学
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DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2026
·
IF 2.6
Fei Sheng,Xiaomei Liu,Yi Liu,Botao Zhang,Hua Li
Titanium alloy implants face persistent risks of bacterial infection and insufficient early osseointegration. In this work, a hierarchical micro/nano-structured hydroxyapatite (HA)-ε-polylysine (PL)-tannic acid (TA) composite coating was fabricated on sandblasted titanium alloy via a controlled drop-casting strategy. Surface roughness increased with deposition cycles and was tuned from 1.91 to 5.01 μm after eight cycles. The HA-PL/TA 8 coating exhibited excellent antibacterial activity (> 99.99%) against both Staphylococcus aureus and Escherichia coli , mainly attributed to the intrinsic antibacterial properties of PL and TA. The coating maintained structural integrity and antibacterial performance after 7-day PBS immersion. Meanwhile, the bioactivity of HA and hierarchical structure promoted MC3T3-E1 osteoblast adhesion and proliferation. This multifunctional coating provides a simple strategy for constructing antibacterial and cytocompatible interfaces on titanium implants.
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DOI
高影响因子
Journal of Magnesium and Alloys
·
2026
·
IF 15.8
Chao Zhang,Jiaying Wang,Xuhui Liu,Hongshuai Cao,Huijuan Wang,Kaiwei Tang,Feng Peng,Yilong Dai,Liwei Lu,Fugang Qi
Hydroxyapatite (HA) is widely used in bone implants due to its inherent biocompatibility, however, conventional single-layer HA coating still faces limitations when applied to biodegradable magnesium alloys. In this study, a Zn-ZnO@HA nanocomposite coating was fabricated on AZ31B magnesium alloy through in situ ZnO doping assisted by ion plating combined with hydrothermal treatment. The results demonstrated that in situ generated ZnO on the ion-plated Zn layer effectively promoted HA nucleation and growth, resulting in a stable and well-adhered nanostructured coating. The composite coating exhibited superior mechanical performance, with a bonding strength (12.88 N) and plasticity index (0.76), significantly higher than those of the single-layer HA. Electrochemical analyses revealed that the Zn-ZnO@HA coating increased the polarization resistance by approximately seven orders of magnitude, while decreasing the corrosion rate and carrier concentration by approximately two and three orders of magnitude, respectively. Compared with the bare AZ31B substrate, and exhibited long-term degradation stability in simulated body fluid (SBF), attributed to the synergistic effects of barrier protection, cathodic protection, and self-healing behavior of the Zn/ZnO/HA interface. Moreover, owing to the broad-spectrum antibacterial properties of Zn and ZnO, the composite coating effectively inhibits bacterial adhesion and proliferation, thereby offering potential protection for maintaining an aseptic implant interface. In vitro studies further confirm that the Zn-ZnO@HA coating creates a favorable microenvironment for osteogenic differentiation, significantly enhancing early alkaline phosphatase activity and promoting late-stage mineralized nodule formation. Overall, the Zn-ZnO@HA nanocomposite coating integrates outstanding corrosion resistance with high bioactivity, offering an effective strategy for surface functionalization of biodegradable magnesium alloy bone implants.
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DOI
高影响因子
Polish Journal of Chemical Technology
·
2020
·Vol. 22
·期 4
·61-68
·
IF 1.193
Xiaonan Deng,Sihong Ye,Kun Liu,Changfeng Li,Fangzhi Liu,Xiaoming Yan
To collect permeability data and establish its database of fertilizer nutrients and water vapor through different polymer membranes for the development of polymer-coated fertilizer, the permeabilities of N-, P-, and K-nutrient from saturated aqueous of urea, NaH2PO4 and KCl solution and the permeability of water vapor through the membranes of poly lactic acid (PLA), its blends with polystyrene (PS), and its composites with humic acid (HA) particles were determined experimentally at the temperatures of 288, 298, and 308 K, respectively. The effects of the addition of PS and HA particles, temperature, and coating thickness on the permeability of fertilizer nutrient and water vapor were investigated. It was found that the addition of PS and HA increased the permeability for both the fertilizer nutrients and water vapor. The increase in temperature raised the permeability of N-, P-, and K-nutrient while decrease the permeability of water vapor in the range studied.
研究领域:
农业科学
·
材料科学
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 298
·期 1
·103-111
·
IF 1.906
Lv Haitao,Tang Dongyan,Sun Zhaojie,Gao Jingru,Yang Xu,Jia Shuyue,Peng Jing
Shape memory polymers (SMP) with better biodegradability and better stability have great potential applications in biomedical fields, such as the drug carriers or the tissue engineering scaffolds. In this study, poly(ε-caprolactone)(PCL)-based polyurethane(PU) microfibers were fabricated with the containing of hydroxyapatite(HA) to enhance the biodegradability and to exhibit excellent shape memory performance. The composition, the morphology, the thermal stability, and the mechanical properties of the microfibers were characterized and detected using Fourier transform infrared spectroscopy (FTIR), 1 H nuclear magnetic resonance ( 1 HNMR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC). and dynamic mechanical analysis (DMA), etc. And dexamethasone was selected as drug model to investigate the delivery and release behaviors of the carrier of the microfibers. It was revealed that HA enhanced the degradation rate of the shape memory polyurethane (SMPU) fibers, and the fibers could guarantee a sustained long time drug release. The detection on the shape memory performance found that, with the different addition amounts of HA, the composite microfibers of (SMPU) and HA exhibited the different shape memory transition temperature ( T trans ) values. And with the addition of 3 wt% of HA, the excellent shape recovery ratios of R r (> 97%) and the shortest recovery time of ~ 6 s could be obtained. With further increase of the amounts of HA, the recovery force and the recovery time were reduced and prolonged, respectively. The obtained results proved that the biodegradable SMPU/HA composite microfibers have more valuable application prospects in biomedical fields.
研究领域:
生物材料
·
药物递送
·
组织工程
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Mingxiang Ji,Han Li,Hailin Guo,Anjian Xie,Shaohua Wang,Fangzhi Huang,Shikuo Li,Yuhua Shen,Jiacai He
A novel porous graphene oxide (GO)/chitosan (CTS)-hydroxyapatite (HA) nanocomposite film was successfully prepared for the first time by combining layer-by-layer (LBL) assembly technology with biomimetic mineralization method. The LBL technology was used to control the thickness of film as well as induce the biomimetic mineralization of biocompatible HA. The obtained (GO/CTS-HA) n film provided ideal platform for the proliferation of mouse mesenchymal stem cells (mMSCs). The pore size in the film is about 300 nm, and the porous architecture made the film have high aspirin loading efficiency. Also the accumulated loading dosage could be adjusted by the film thickness, and the sustained release of aspirin could ensure well anti-inflammatory effect. The above advantages may alleviate the pain of patients and give the better environment for bone regeneration. This multifunctional aspirin-loaded (GO/CTS-HA) n film provided an inspiration for the synthesis of novel porous inorganic/biomacromolecule nanocomposite films as the biocoatings applied in bone tissue engineering.
研究领域:
生物材料学
·
医学工程
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Xiaojing Sun,Hang Li,Liujie Qi,Fei Wang,Yachen Hou,Jingan Li,Shaokang Guan
In recent years, functional molecules such as metal-organic frameworks (MOFs), hyaluronic acid (HA) and heparin have been widely studied in the field of surface modification of cardiovascular and cerebrovascular implant materials . However, magnesium (Mg) alloy scaffolds, which are used as implanted materials, have difficulties such as poor cell compatibility, insufficient endothelialization, and remodeling of the blood–brain barrier. In this study, MOF-Cu formed after chelating organic ligand catechol (HPT) and Cu(II) was coated by Sulfonated hyaluronic acid (S-HA) on the surface of ZE21B Mg alloy to form a composite coating , which not only inherited the excellent anticoagulant and anti-inflammatory properties of S-HA, but also significantly improved the bio-compatibility of the coating by reasonably regulating the concentration of Nitric oxide (NO) catalytic release, promoted the proliferation, migration and expression of specific factors in endothelial cells (ECs), regulated the transformation of smooth muscle cells (SMCs) to contractile phenotypes. And it has important and remarkable performance in promoting the transformation of macrophage (MA) into anti-inflammatory M2 phenotype. These results provide important research strategies for Mg alloy vascular stents materials in remodeling blood–brain barrier, relaxing cerebrovascular vessels, inhibiting inflammatory responses, and maintaining cardiovascular and cerebrovascular elasticity.
研究领域:
材料科学
·
生物医学工程
·
心血管疾病研究
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yuxin Zheng,Wentao Zhang,Runzhi Chen,Linhong Wang,Danni Wu,Zhuoheng Xia,Feng Chen,Fan Yang,Yude Ding
In guided bone regeneration (GBR) surgery, a barrier membrane, commonly collagen material, is broadly used to prevent epithelial and fibroblast tissue from interfering with osteogenesis. However, collagen membranes usually fail to withstand the pressure from soft tissue collapse, leading to the severe collapse and displacement of bone graft materials, which ultimately results in inadequate bone augmentation. Besides, the collagen material cannot well prevent soft tissue adhesion. In this study, a novel light-cured, bioabsorbable hydrogel has been developed by co-assembling silk fibroin and hyaluronic acid without any small molecular crosslinkers, which can be directly injected into the bone-augmented region and quickly cured under UV light curing. The as-prepared hydrogel can be adhesive onto various irregular bone defect surfaces and provide a complete and continuous tissue barrier for bone graft materials. Among the hydrogels with different ratios of silk fibroin to hyaluronic acid, the one with a ratio of 1:3 (SF-HA-3) demonstrated the best mechanical performance, the lowest expansion rate, and a moderate degradation rate. In the animal models, the SF-HA-3 showed an excellent barrier effect and a stable space maintenance ability, accelerating obvious new bone formation, which was observed in the bone defect area.
研究领域:
生物医学工程
·
组织工程
·
牙科材料
·
再生医学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Jie Liu,Qin Zou,Bin Cai,Jiawei Wei,Chen Yuan,Yubao Li
A novel bilayer fibrous membrane for guided tissue regeneration (GTR) was prepared via two-step electrospinning process, subsequent crosslinking and surface conjugation with heparin. The bilayer membrane consists of upper layer polycaprolactone/gelatin (PCL/Gel) membrane for soft tissue regeneration and lower layer PCL/Gel/nano-hydroxyapatite (PCL/Gel/n-HA) membrane for hard tissue regeneration. The results indicated that the physicochemical and biological properties of the membrane were strongly influenced by the crosslinking time and by the heparin conjugation. Crosslinking effectively prolonged the degradation time while maintaining the membrane barrier function, and the surface heparin conjugation obviously improved the biological performance of the membrane. An enhanced cell adhesion and proliferation were observed on the heparin-conjugated fibrous membranes, which also showed good histocompatibility and favorable in vivo degradability. The electrospun bilayer fibrous membrane may have promising prospect for modulation of cell response and simultaneous regeneration of soft and hard tissues.
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DOI
PubMed
高影响因子
Small Structures
·
2025
·
IF 11.3
Lixuan Zang,Haomiao Zhu,Bohan Chen,Feng Sun,Jinhua Zhang,Huarong Shao,Yishu Wang,Fei Liu,Haining Tan,Peixue Ling
Activating the mitochondrial apoptosis pathway cancer therapy holds significant theoretical and clinical implications in cancer therapy. However, the complex regulation of tumorigenesis limits the efficacy of single-target therapeutic approaches. This article introduces a novel antitumor nanoparticle (ICG-HA-ADH-CBA-TATKLA, IHTK), which combines glycosaminoglycan (hyaluronic acid, HA), proapoptotic fusion peptide (TAT-KLA), and photothermal/photodynamic agent (indocyanine green, ICG). The nanoparticle enables precise tumor targeting and enhance ICG accumulation, generating substantial reactive oxygen species under near-infrared irradiation. This process upregulates damage-associated molecular patterns, including ATP, calreticulin (CRT), and HMGB1, to induce immunogenic cell death. Consequently, immune cell infiltration is promoted, and the tumor microenvironment (TME) is remodeled. Furthermore, the acidic TME triggers the release of TAT-KLA (TK) through the nanoparticle's pH-responsiveness, facilitating the rapid mitochondrial localization of TK. This mechanism disrupts mitochondrial membrane potential, enhances permeability, promotes Cytochrome C release, and activates caspase cascades to directly induce tumor cell apoptosis. In tumor-bearing mice, IHTK effectively suppressed tumor progression and prolonged survival. In summary, IHTK, based on a multitarget regulation strategy, achieves TME-responsive precision delivery, multipathway coordinated apoptosis induction, and immunomodulatory TME remodeling for synergistic therapeutic efficacy. This approach offers both a theoretical foundation and innovative insights for antitumor drug development.
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高影响因子
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