JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Ping He,Qian Zheng,Matin Naghizadeh,Guiqi Huang,Sheying Dong
The removal of personal care products (PCPs) in aqueous environments is a huge challenge. Traditional powder and magnetic materials are not conducive to complete solid–liquid separation, which hinders their practical application. In this study, the convenient recyclable magnetic self-stirring system combining with n-octanol hollow fiber-liquid phase micro-extraction (HF-LPME), wormhole-like mesoporous carbon (WMC) solid phase and magnetic stirring was constructed to improve the extraction and removal efficiency of the trace PCPs (triclosan, triclocarban, 2, 2′-Dihydroxy-4-methoxybenzophenone, and 2, 4-dihydroxydiphenylketone) in wastewater. The adsorption process of triclosan and 2,2′-dihydroxy-4-methoxybenzophenone on the WMC surface followed the pseudo-first-order kinetics as well as Freundlich isotherm model. Because WMC had oxygen-containing groups and the multiple mesoporous distribution forming the n-octanol microextraction unit and the shearing strength generated by the stir bar in the water sample accelerated the mass transfer efficiency of PCPs, this system had the advantage of simultaneous removal and extraction of four PCPs from wastewater samples. The extraction mechanism involved the hydrophobic force and size effect between the WMC and PCPs. In addition, the factors affecting extraction efficiencies (EEs) were discussed, such as the concentrate of WMC (1 mg/L), rotation rate (400 rpm), extraction time (15 min), and salt concentration (30%). The results indicated that the method possessed a wide linear range (0.05–200 μg L -1 ), and lower limits of detection (LODs) (S/N = 3, 0.005–0.05 μg L −1 ), at the optimal conditions. This method also showed excellent reusability and stability, with higher recovery (88–98%) and fewer relative standard deviations (2.4–6.3%). This work not only minimized secondary pollution from powder adsorbents, but provided an economic and green magnetic self-stirring system and absorbent for the extraction, removal, and determination of typical PCPs pollutants from actual wastewater samples.
研究领域:
环境科学
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化学工程
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分析化学
·
水处理
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产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·Vol. 35
·期 38
·2503713
·
IF 19
Caiyan Shen,Dichang Guan,Wenchao Liu,Yanbing Cao,Zhongdong Peng,Yu Ren,Litao Kang,Jinhao Meng,Zhichen Xue,Ke Du
The development of fluorine-free electrolytes offers a promising route for more environmentally sustainable lithium-ion batteries (LIBs). However, the low solubility of fluorine-free lithium salts in conventional carbonate solvents limits this progress. Additionally, while strongly coordinating solvents enhance salt dissolution, their use can lead to co-intercalation in graphite, complicating electrolyte design. Herein, lithium bis(oxalate)borate (LiBOB) is chosen as lithium salt, and a synergistic electrolyte design strategy is employed, combining a strongly coordinating solvent (tris(2-methylpropyl) phosphine oxide, TMP) and weakly coordinating solvent (dimethyl carbonate, DMC). This approach enables the use of fluorine-free lithium salts while ensuring compatibility with graphite by modulating the primary coordination shell. Furthermore, this solvation structure enables the formation of an inorganic-dominated cathode electrolyte interphase (CEI) on the LiMn 2 O 4 (LMO) and a solid electrolyte interphase (SEI) on the graphite, improving lithium-ion conductivity and overall electrochemical performance. Additionally, compared to lithium hexafluorophosphate (LiPF 6 ), fluorine-free lithium salt minimized the formation of HF by-products, suppressing transition metals (TMs) dissolution. As a result, 1 Ah LMO||graphite pouch cell with fluorine-free electrolyte retains 92.8% of its capacity after 200 cycles, demonstrating excellent cycling stability and delivering high-rate capacity of 0.8486 Ah at 2 C, compared to 84.8% retention and 0.652 Ah with the conventional electrolyte.
研究领域:
电化学
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能源材料
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电池技术
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可持续化学
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材料科学
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xin Fang,Yanan Liu,Jingyi Xiao,Cunqiang Ma,Youyi Huang
High-performance liquid chromatography (HPLC), headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC–MS) and ultra-high performance liquid chromatography–Q-Exactive HF-X mass spectrometer (UHPLC–Q-Exactive HF/MS) were carried out to reveal dynamic changes of volatile and non-volatile compounds during the withering process of black tea. A total of 118 volatile organic compounds (VOCs) and 648 metabolites were identified in fresh and withered tea-leaves, respectively. Among them, 47 VOCs (OAV > 1.0) for the aroma formation, and 46 characteristic metabolites (VIP > 1.50, p < 0.01) selected through orthonormal partial least squares-discriminant analysis, indicated the withering contribution during black tea processing. Overall, the withering promoted alcohols, aldehydes, phenols, heterocyclic oxygen, hydrocarbons and halogenated hydrocarbons through relevant hydrolyzation, decomposition, terpene synthesis, and O -methylation. The hydrolyzation, O -methylation, condensation and N -acylation of kaempferol glycosides, quercetin glycosides, ester catechins, and gallic acid generated the accumulation of methoxyl flavonoids and flavonoid glucosides, dihydrokaempferol, syringic acid, theaflavins, and N -acylated amino acids, respectively.
研究领域:
食品科学
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农学
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化学
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代谢组学
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茶叶加工
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产品关联
DOI
PubMed
高影响因子
Signal Transduction and Targeted Therapy
·
2024
·Vol. 9
·期 1
·1-17
·
IF 40.8
Peng Fu,Liao Minru,Jin Wenke,Liu Wei,Li Zixiang,Fan Zhichao,Zou Ling,Chen Siwei,Zhu Lingjuan,Zhao Qian,Zhan Gu,Ouyang Liang,Peng Cheng,Han Bo,Zhang Jin,Fu Leilei
Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide + (NAD + )-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis, myocardial fibrosis and even heart failure (HF), through its deacetylation modifications. Accordingly, discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently needed. Herein, we identified a new small-molecule activator of SIRT3 (named 2-APQC) by the structure-based drug designing strategy. 2-APQC was shown to alleviate isoproterenol (ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat models. Importantly, in SIRT3 knockout mice, 2-APQC could not relieve HF, suggesting that 2-APQC is dependent on SIRT3 for its protective role. Mechanically, 2-APQC was found to inhibit the mammalian target of rapamycin (mTOR)-p70 ribosomal protein S6 kinase (p70S6K), c-jun N-terminal kinase (JNK) and transforming growth factor-β (TGF-β)/ small mother against decapentaplegic 3 (Smad3) pathways to improve ISO-induced cardiac hypertrophy and myocardial fibrosis. Based upon RNA-seq analyses, we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1 (PYCR1) axis was closely assoiated with HF. By activating PYCR1, 2-APQC was shown to enhance mitochondrial proline metabolism, inhibited reactive oxygen species (ROS)-p38 mitogen activated protein kinase (p38MAPK) pathway and thereby protecting against ISO-induced mitochondrialoxidative damage. Moreover, activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase (AMPK)-Parkin axis to inhibit ISO-induced necrosis. Together, our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis, which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.
研究领域:
心血管药理学
·
分子生物学
·
细胞生理学
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DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Pan-Pan Jia,Rohana Chandrajith,Muhammad Junaid,Tian-Yun Li,Yong-Zhi Li,Xing-Yi Wei,Li Liu,De-Sheng Pei
Chronic kidney disease with uncertain etiology (CKDu) in Sri Lanka has attracted much attention as a global health issue. However, how environmental factors in local drinking water induce kidney damage in organisms is still elusive. We investigated multiple environmental factors including water hardness and fluoride (HF), heavy metals (HM), microcystin-LR (MC-LR), and their combined exposure (HFMM) to elucidate their toxic effects on CKDu risk in zebrafish. Acute exposure affected renal development and inhibited the fluorescence of Na, K-ATPase alpha1A4:GFP zebrafish kidney. Chronic exposure influenced the body weight of both genders of adult fish and induced kidney damage by histopathological analyses. Furthermore, the exposure significantly disturbed differential expression genes (DEGs), diversity and richness of gut microbiota, and critical metabolites related to renal functions. The transcriptomic analysis revealed that kidney-related DEGs were linked with renal cell carcinoma, proximal tubule bicarbonate reclamation, calcium signaling pathway, and HIF-1 signaling pathway. The significantly disrupted intestinal microbiota was closely related to the environmental factors and H&E score, which demonstrated the mechanisms of kidney risks. Notably, the Spearman correlation analysis indicated that the changed bacteria such as Pseudomonas , Paracoccus , and ZOR0006 , etc were significantly connected to the DEGs and metabolites. Therefore, the assessment of multiple environmental factors provided new insights on “bio-markers” as potential therapies of the target signaling pathways, metabolites, and gut bacteria to monitor or protect residents from CKDu.
研究领域:
环境科学
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毒理学
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分子生物学
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基因组学
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微生物学
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公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）