TALANTA
·
2025
·
IF 6.1
Luyang Zhao,Yang Song,Guoyang Xie,Hengyi Xu
A colorimetric assay based on the Fe/Al bimetallic organic framework NH 2 -MIL-53(Fe, Al) was developed for the sensitive detection of Escherichia coli O157:H7 ( E. coli O157:H7), a critical pathogen threatening food safety. The framework’s high specific surface area facilitated efficient antibody immobilization, whereas the incorporation of Al 3+ enhanced electron transfer between Fe 2+ /Fe 3+ , thereby significantly boosting peroxidase activity. The optimized NH 2 -MIL-53(Fe, Al) exhibited 1.4-fold and 4.9-fold higher relative absorbance than NH 2 -MIL-53(Fe) and NH 2 -MIL-53(Al), respectively. And it demonstrated 40-fold and 2-fold greater affinity for TMB and H 2 O 2 , respectively, compared to the natural enzyme. By integrating a dual-recognition system based on antibody and aptamer, the method enabled rapid detection with a limit of detection of 10 1 CFU/mL in colorimetric mode. Its successful application in complex matrices, including lettuce, juice, pool water, and chocolate milk, had yielded satisfactory recovery and precision, confirming its promising potential for food safety monitoring.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xiaohan Guo,Yanfang Liu,Hongxiang Zhu,Xiaohui Yu,Feng Shi,Qinqin Liu,Qiang Liu,Ying Xu
Asp donates electrons to reprogram Fe O clusters of MIL-53(Fe). • This electronic switch redirects dominant ROS from •OH to •O 2 − . • The mechanism enables neutral-pH POD-like activity of MIL-53(Fe)@Asp. • The Asp-modified nanozyme integrates with GOX for cascade glucose sensing. MIL-53(Fe) exhibits peroxidase-like activity only under acidic conditions, limiting its biosensing applications. We overcome this by using aspartic acid (Asp) as a structure-directing agent to modify MIL-53(Fe) (MIL-53(Fe)@Asp) via hydrothermal synthesis followed by Asp coordination. Unlike conventional pH-reduction strategies, Asp modification does not alter bulk pH but induces intrinsic electronic restructuring of Fe O clusters, as confirmed by increased Fe 3+ /Fe 2+ ratio and introduction of N → Fe coordination (XPS). At pH 6.9, the TMB-based activity of MIL-53(Fe)@Asp is 27-fold higher than that of pristine MIL-53(Fe). Steady-state kinetics show favorable Km values (TMB 0.27 mM, H 2 O 2 1.38 mM) at neutral pH. Mechanistic studies (ROS identification, EPR, band structure, DFT) reveal that Asp exerts an electron-donating effect that reprograms the electron distribution of Fe O clusters, activating the otherwise inactive MIL-53(Fe) framework at neutral pH and diversifying the catalytic pathways to include a less pH-dependent •O 2 − route alongside the partially maintained •OH pathway. This pathway diversification enables efficient neutral-pH peroxidase-like catalysis, with •O 2 − as the dominant pathway. Leveraging this, we construct a cascade nanoplatform (MIL-53(Fe)@Asp@GOX) integrating glucose oxidase, which exhibits excellent cascade activity at neutral pH. The method is applied to glucose detection in blood and saliva, demonstrating good linearity, precision, selectivity, and recovery. The glucose concentrations determined by our sensor correlated well with those obtained using a commercial assay kit. Notably, the limit of detection for glucose in saliva reaches 2.08 μM, offering a promising route toward non-invasive glucose sensing. This work establishes a design principle for creating pH-adaptive catalytic microenvironments in Fe-MOFs through electronic restructuring and pathway diversification, overcoming a long-standing limitation of MIL-53(Fe) for biomedical applications. Download: Download high-res image (111KB) Download: Download full-size image
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高影响因子
ANALYTICAL BIOCHEMISTRY
·
2019
·
IF 2.507
Ying Jiang,Qi-Meng Yang,Qiu-Ju Xu,Shi-Yu Lu,Lin-Yu Hu,Mao-Wen Xu,Ying-Shuai Liu
Biothiols play critical roles in many biological processes and their aberrant is related to a variety of syndromes. A simple and reliable colorimetric method is developed in this work for biothiols detection based on an oxidase mimic, a metal organic framework (MOF) MIL-53(Fe), and a peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB). In this design, MIL-53(Fe) is utilized to catalyze the conversion of TMB to a blue colored 3,3′,5,5′-tetramethylbenzidine diimine, which can be read on a spectrophotometer at 652 nm. The oxidation-induced blue color generation can be efficiently inhibited by biothiols, thus a colorimetric analytical method is proposed for biothiols detection based on the above system. Under optimal conditions, a linear relationship in a range from 1 to 100 μM and a limit of detection (LOD) at 120 nM are achieved with Cys as a model target. The developed platform is further applied to evaluate cellular biothiols in normal (RWPE-1) and cancer (LNCap) cell lines, revealing that the overall biothiols level in LNCap is much higher than that in RWPE-1. This work renders a powerful tool for identifying cancer cells in a simple manner for biomedical diagnosis associated with biothiols.
研究领域:
材料科学
·
分析化学
·
纳米技术
·
生物医学诊断
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生物无机化学
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高影响因子
ChemCatChem
·
2026
·Vol. 18
·期 5
·e70662
·
IF 4.1
Mengjiao Yu,Xiong-Fei Zhang,DongEn Zhang,Jianhao Qiu,Jianfeng Yao
The development of stable, efficient catalysts for fructose conversion to 5-hydroxymethylfurfural (5-HMF) remains a challenge. While sulfonation enhances Brønsted acidity in metal–organic frameworks (MOFs), it often compromises their structural integrity. This work addresses the critical challenge by demonstrating that amino (–NH 2 ) functionalization in MIL-53(Al) acts as a stabilizer, enabling the framework to withstand direct modification with chlorosulfonic acid and facilitating the introduction of sulfonic acid groups. The resulting sulfonated catalyst, MIL-53-N/S(1), achieves an outstanding 5-HMF yield of 84.3% in a biphasic system (170°C, 6 h). This work underscores the dual role of amino functionalization in stabilizing MOFs and enabling efficient acid catalysis for biomass conversion. Graphical A strategy using amino-functionalized MIL-53(Al) was proposed, where pre-grafted –NH 2 groups facilitate effective sulfonation to create abundant –SO 3 H sites without compromising framework stability. This approach addresses the challenge between acidity and structural degradation of MOFs. Under optimized conditions, MIL-53-N/S(1) achieves an HMF yield of 84.3%, demonstrating its potential for practical biomass valorization.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·123915
·
IF 7.5
Jumeng Di,Xiaohua Li,Songyu Guan,Wenwen Ma,Wen Li,Jie Gao,Yuzhi Xu,Bing Yu,Hailin Cong
Nanoplastics (NPs) pose severe risks to aquatic environments, and adsorption technology provides a promising strategy for their removal. Metal-organic frameworks (MOFs) are promising adsorbents, but their practical application is limited by insufficient water stability and restricted pore accessibility. To bridge this gap, defect-engineered Al/Mn bimetallic MOFs were synthesized via mild post-synthetic ion exchange. n-Octanoic acid (OA) was employed to modulate the crystallization process of MIL-53(Al), inducing missing linker defects, suppressing excessive crystal growth, and generating mesoporous structure. Subsequently, the partial substitution of terephthalic acid linkers with manganese clusters could introduce additional active sites, alter the surface properties while maintain the overall crystallinity of MOFs. The optimized Mn-0.2-OA maintained high PS removal efficiency under acidic to neutral conditions, with removal efficiencies above 92% over pH 1–7. It also showed good tolerance to representative interference factors, retaining removal efficiencies above 97.5% in the presence of common cations and 89.37% at 40 mg/L humic acid. The adsorption of 500 nm polystyrene microspheres was mainly driven by the synergistic effects of electrostatic attraction, π-π interactions, enhanced hydrophobic affinity, and hierarchical pore structure. Meanwhile, Mn-0.2-OA achieved a Langmuir-fitted maximum adsorption capacity of 849.17 mg/g and exhibited rapid adsorption kinetics, removing 96.4% of PS within 10 min at an initial concentration of 25 mg/L. Regeneration tests further confirmed its acceptable reusability for repeated PS adsorption. This strategy provides a feasible approach for designing efficient and reusable adsorbents for nanoplastic removal from aquatic environments.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yao Zhang,Ruixue Bai,Fanyong Yan,Yidi Wang,Yu Wang,Juanru Huang
Metal-organic frameworks (MOFs) have attracted wide attention owing to unique structural advantages and excellent catalytic properties, yet the inherent poor conductivity and limited visible-light responsiveness constrain their practical applications. Herein, a dual modification strategy based on the thermal decomposition of ligands to construct nitrogen-doped carbon dots (NCDs) decorated MIL-53(Fe) with oxygen vacancies (Ov) is reported in this work. By selectively removing thermally unstable ligands from the dual-ligand MIL-53(Fe) at elevated temperatures, oxygen vacancies were successfully introduced into the MOF framework while maintaining structural integrity. The subsequently integrated amino-rich NCDs facilitated interfacial charge transfer and contributed to improved light utilization. The optimized NCDs@Ov-MIL-53 composites exhibited excellent photocatalytic performance for the degradation of tetracycline. Under visible light irradiation, a removal rate of 93.72 % was achieved within 60 min, which was 2.8 times higher than that of the original MIL-53 (Fe). Systematic characterization showed that oxygen vacancies promoted carrier separation and created active sites, while NCDs acted as electron acceptors. A new insight into defect engineering through ligand-selective pyrolysis is provided by this work and offers a viable strategy for the design of MOF-based photocatalysts for environmental applications.
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高影响因子
Inorganics
·
2022
·Vol. 10
·期 5
·59
·
IF 3.149
Sander Dekyvere,Mohamed Elhousseini Hilal,Somboon Chaemchuen,Serge Zhuiykov,Francis Verpoort
MOF-derived carbon-based materials have attracted widespread attention due to their relatively large surface area, morphology, and their stability in water. Considering these advantages, these materials present themselves as excellent adsorbents. In this work, a novel method was designed for the fabrication of a nano zero-valent-iron (nZVI) carbon composite. The utilization of zinc oxide nanorods (ZnONRs) in the role of sacrificial consumable nuclei for the synthesis of MIL-53 sacrificial zinc oxide nanorods (MIL-53-SNR) and the subsequent pyrolysis at 700 °C in the inert atmosphere led to a graphitic-supported nZVI material (Fe-C-SNR). Fe-C-SNR was compared with a commercial zinc oxide bulk (MIL-53-SB) and with a pristine MIL-53. By virtue of the ZnONRs, Fe-C-SNR exhibited a greatly improved mesoporous structure. Consequently, the pyrolyzed materials were applied as adsorbents for methylene blue. Fe-C-SNR’s performance increased to more than double of the pyrolyzed MIL-53 (Fe-C), with a remarkably fast adsorption time (10 min) for a concentration of 10 mg L−1with only 200 mg L−1adsorbent required. This functional composite also displayed exceptional recyclability; after ten complete cycles, Fe-C-SNR was still capable of completely adsorbing the methylene blue. The utilization of ZnONRs proves itself advantageous and could further be extended to other MOFs for a wide range of applications.Keywords:mesoporous material;zero-valent-iron nanoparticles;methylene blue adsorption;metal–organic framework
研究领域:
材料科学
·
环境科学
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2022
·
IF 3.656
Chunfu Liu,Chenyu Zhu,Han Wang,Shenao Xie,Junyang Zhou,Hongjun Fang
Co-doped metal organic frameworks (MOFs) were fabricated by a facile route and applied to remove (tetracycline, congo red, methylene blue and rhodamine B) through integrated adsorption and photocatalysis . The assembled MOFs composite exhibited larger S BET (889 m 2 /g), broad light adsorption, and accelerated carrier kinetics, which helped to enhance adsorption and photocatalysis performance. Specifically, nearly 100% TC (40 mg/L) could be removed by the Co-MIL-10 within 12 min solar-light irradiation, significantly faster than that of solo MIL-53(Al) (82%) and CoAl-LDH (54%), separately. Furthermore the obtained rate constant (0.2064 min −1 ) was 4.8 times and 9.7 times greater than that of MIL-53(Al) and CoAl-LDH, respectively. The quenching/EPR characterization suggested that photo-generated h + / • O 2 − / • OH species were responsible for TC oxidation , of which h + showed the great impact. Cycling experiments verified the robust stability of the MOFs catalyst. As well, an underlying photocatalytic mechanism of the current system was investigated in detail.
研究领域:
环境科学
·
材料科学
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Shiyu Zhang,Mengru Li,Jingwen Wang,Ruonan Zhang,Xiaoyu Ma,Haisheng Tao
Metal-organic frameworks with high porosity have received much attention in environmental pollutant treatment. This study presented a simple single-pot solvent thermal method for the preparation of a bimetal-organic framework MIL-53(Fe,Ni), further used for activated peroxydisulfate to degrade rhodamine B (RhB). The morphology and structure of the sample were characterized by scanning electron microscopy, transmission electron microscopy , x-ray diffraction, photoelectron spectroscopy , fourier transform infrared spectroscopy , and thermogravimetric analysis . The results showed that MIL-53(Fe,Ni) was successfully synthesized by the simple reaction, with high thermal stability and high specific surface area. The effects of pH value, co-existing ions, temperature, humic acid and different real water samples on RhB degradation were systematically investigated. Under optimized conditions, 93.9% of RhB was degraded within 180 min, together with excellent reusability. Quenching experiments and electron paramagnetic resonance showed that both free radicals (∙OH, SO 4 ∙- and O 2 ∙- ) and non-free radicals ( 1 O 2 and direct charge transfer) were responsible for the RhB degradation. In addition, the identification of intermediates by high-resolution mass spectrometer and reaction site prediction calculations (electrostatic potential, Fukui function and molecular orbit analysis), proposing a possible degradation pathway of RhB. The work highlights the broad applications of bimetal-organic frameworks in advanced oxidation processes .
研究领域:
环境科学
·
材料科学
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2017
·
IF 3.981
Sha Chen,Xiao-Xin Li,Lun Shu,P. Somsundaran,Jian-Rong Li
The baseline separation of divinylbenzene (DVB) and ethylvinylbenzene (EVB) isomers was achieved using HPLC with MIL-53(Fe) and MIL-100(Fe) packed columns respectively when hexane/dichloromethane (100:0) used as mobile phase, at flow rate of 0.5 mL min −1 , room temperature, and monitored with a UV detector at 254 nm. The two Fe-based MILs packed columns showed different separated performances, analytes had short retention time on MIL-100(Fe) compared to MIL-53(Fe), but selectivity of DVB isomers (m-DVB and p-DVB) was lower, which was mainly due to the differences of the pore size and structure of MILs. Moreover, the results of calculated thermodynamic parameters showed that the separation of DVB and EVB isomers was not only controlled by enthalpy change (ΔH), but also controlled by entropy change (ΔS). The head-to-tail stacking was the main reason for the separation according to the mechanism of the DVB and EVB isomers on Fe-based MILs packed columns.
研究领域:
分析化学
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材料科学
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PubMed
高影响因子
NANOTECHNOLOGY
·
2025
·Vol. 36
·期 39
·395401
·
IF 2.8
Wang Zhang,Tianci Feng,Shiqi Li,Xin Zhang,Tang Wang,Yu Zhou,Long Lin,Lin Qiao,Xiao Han,Rui Li
Electrocatalytic nitrate reduction has emerged as a promising strategy for sustainable ammonia synthesis, providing the dual advantage of mitigating nitrate pollution and producing value-added green ammonia. However, enhancing intrinsic catalytic activity and catalytic site accessibility remains a challenge for further improving the performance of nitrate electroreduction to ammonia. Herein, a series of gradient Cu2+-doped MIL-53(Fe) electrocatalysts were synthesized via an all-solid-state mechanochemical synthesis method for electrocatalytic nitrate-to-ammonia conversion. MIL-53(Fe)–CuB exhibits a large NH3 production rate of 2391 ± 327 μg h−1 mgcat−1 at −0.6 V vs RHE and a high Faradaic efficiency of 82.1% ± 1.2% at −0.3 V vs RHE in 1 M KOH with 100 ppm NO3−, demonstrating an excellent electrocatalytic performance for nitrate reduction. This work reveals that Cu2+-doping in mechanochemically synthesized Fe-metal-organic frameworks (MOFs) boosts nitrate reduction efficiency and selectivity, while broadening research on foreign metal ion anchoring in MOF electrocatalysis.
研究领域:
电催化
·
材料化学
·
环境修复
·
可持续能源
·
纳米材料
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·Vol. 14
·期 1
·120546
·
IF 7.2
JinCheng Dai,Shuyue He,Xiyu Song,Hongjuan Zhang,Ruyi Xie
The construction of heterojunction photo-Fenton catalysts to activate hydrogen peroxide for the efficient degradation of organic pollutants in water has attracted considerable attention. Herein, a CuBi 2 O 4 @MIL-53(Fe) Z-scheme heterojunction catalyst was successfully prepared by solvothermal method for tetracycline (TC) degradation. In this catalytic system, the heterogeneous photocatalytic reaction and the Fenton reaction form a strong synergistic effect in the degradation of organic pollutants through the transfer of photogenerated electrons. The results indicate that in the presence of trace concentrations of H 2 O 2 (2.60 mM), 0.20 g/L of MC-15 (with CuBi 2 O 4 accounting for 15 % of the mass of MIL-53(Fe)) exhibited the highest catalytic activity, with a TC (150 mg/L) removal rate of 94.0 % after 50 min of visible light irradiation. Interestingly, the MC-15 catalyst can still achieve a removal rate of 62.1 % of TC even under dark conditions. Furthermore, in degradation experiments, MC-15 exhibited high environmental stability and applicability in different natural water system. The excellent catalytic performance of the light/MC-15/H 2 O 2 system is attributed to the quick separation of photogenerated electron-hole pairs from Z-scheme heterojunction CuBi 2 O 4 @MIL-53(Fe) and the accelerated bimetallic ions cycle. A possible photo-Fenton catalytic mechanism of MC-15 catalyst is proposed based photoelectrochemical tests, free radical capture experiment and electron paramagnetic resonance (EPR) analysis. This study provides a reference for the development of iron-based metal-organic framework composite photo-Fenton catalysts.
研究领域:
环境催化
·
材料科学
·
水处理技术
·
高级氧化过程
·
多相催化
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高影响因子
危险品化学品经营许可证（带存储）