RSC Advances
·
2019
·Vol. 9
·期 57
·33302-33309
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IF 3.049
Yanhua Zhang,Hui Huang,Hao Fu,Meng Zhao,Zhihua Wu,Yang Dong,He Li,Yourong Duan,Ying Sun
As known to all, ovarian cancer ranks the most lethal of the gynecological malignancies. The antitumor drugs based on platinum are first-line chemotherapy drugs for ovarian cancer. However, their therapeutic efficiency is severely limited owing to dose-limiting toxicities of platinum. New theranostic strategies to overcome chemotherapy toxicity is highly desirable. Meanwhile, the real-time treating effect is not visible for doctors. Herein, we constructed PFH/siRNA/Fe3O4@Pt(IV) NPs-cRGD (NPs-cRGD) for precise theranostics against ovarian tumors with real-time imaging. The NPs-cRGD had a good storage stability and resisted the serum-induced aggregation, which was beneficial for drug delivery. Additionally, gel-retardation assay demonstrated that the NPs-cRGD exhibited great protection to siRNA to resist nuclease degradation. In vitro, the NPs-cRGD showed good dual-mode US/MRI imaging and the relative imaging research was also discussed. Moreover, the in vitro experiments indicated that the NPs-cRGD with US exhibited excellent antitumor therapeutic efficiency, resulting from the cRGD ligands and US exposure enhanced the cellular uptake efficiency. Thus, the dual-mode nanoparticles in this work may provide precious insight into the development of various multi-mode nanoplatforms delivering drugs or genes for precise theranostics against various cancer.
研究领域:
癌症治疗
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纳米医学
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医学影像
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
Nanomedicine
·
2019
·
IF 4.717
Yiming Yu,Li Zhang,Miao Wang,Zhe Yang,Leping Lin,Yuxuan Xiong,Zushun Xu,Jing Wang
Aim: To develop a H2O2/near-infrared (NIR) laser light-responsive nanoplatform (manganese-doped Prussian blue@polypyrrole [MnPB@PPy]) for synergistic chemo/photothermal cancer theranostics. Materials & methods: Doxorubicin (DOX) was loaded onto the surface of polypyrrole shells. The in vitro and in vivo MRI performance and anticancer effects of these nanoparticles (NPs) were evaluated. Results: The MnPB@PPy NPs could not only generate heat under NIR laser irradiation for cancer photothermal therapy but also act as an excellent MRI contrast agent. The loaded DOX could be triggered to release by both NIR light and H2O2 to enhance synergistic therapeutic efficacy. The antitumor effects were confirmed by in vitro cellular cytotoxicity assays and in vivo treatment in a xenograft tumor model. Conclusion: The designed H2O2/NIR light-responsive MnPB@PPy-DOX NPs hold great potential for future biomedical applications.
研究领域:
生物医学工程
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癌症研究
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纳米技术
·
医学影像
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 11
·期 3
·648-656
·
IF 7.571
Xiaoxuan Zhou,Xiaodan Xu,Qiuhui Hu,Yan Wu,Feidan Yu,Chengbin He,Yue Qian,Yuxin Han,Jianbin Tang,Hongjie Hu
Therapeutic nanoplatforms are widely used in the diagnosis and treatment of breast cancer due to the merits of enabling high soft-tissue resolution and the availability of numerous therapeutic nanoparticles. It is thus vital to develop multifunctional theranostic nanoparticles for the visualization and dynamic monitoring of tumor therapy. In this study, we designed a manganese-based and hypericin-loaded polyester dendrimer nanoparticle (MHD) for magnetic resonance imaging (MRI) and hypericin-based photodynamic therapy (PDT) enhancement. We found that MHD could greatly enhance MRI contrast with a longitudinal relaxivity of 5.8 mM−1 s−1 due to the Mn-based paramagnetic dendrimer carrier. Meanwhile, the MRI-guided PDT inhibition of breast tumors could be achieved by the hypericin-carrying MHD and further improved by Mn2+-mediated alleviation of the hypoxic microenvironment and the enhancement of cellular ROS. Besides, MHD showed excellent biocompatibility and biosafety with liver and kidney clearance mechanisms. Thus, the high efficiency in MRI contrast enhancement and excellent tumor-inhibiting effects indicate MHD's potential as a novel, stable, and multifunctional nanotheranostic agent for breast cancer.
研究领域:
医学影像学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 75
·47715-47725
·
IF 3.108
Le Shang,Qiu-yue Wang,Kang-long Chen,Jing Qu,Qing-han Zhou,Jian-bin Luo,Juan Lin
In this research, reducible polydopamine coated magnetic nanoparticles (SPIONs@PDA) were prepared and doxorubicin (DOX) was encapsulated for both magnetic resonance imaging (MRI) detection and cell targeting drug delivery. The SPIONs@PDA exhibited excellent water-solubility and colloidal stability, because the coating of the magnetic nanoparticle was a crosslinked reducible polydopamine synthesized with N,N-bis(acrylate) cystamine (BACy) as a crosslinker, dopamine methacrylamide (DMA) as an anchor to immobilize SPIONs, and polyethylene glycol (PEG) to provide colloidal stability. The SPIONs@PDA showed reduction-sensitivity due to the reducible disulfide bond in the polymer network. Subsequently, a sustained and high cumulative drug release in glutathione (GSH) was observed, rather than the low drug release in PBS (pH 7.4). Fluorescent imaging studies by confocal laser scanning microscopy indicated that the prepared SPIONs@PDA could specifically target tumor cells. The results of the cytotoxicity assays further demonstrated that the DOX-loaded SPIONs@PDA presented efficient antitumor activity to HeLa cells. These favorable properties suggested SPIONs@PDA as promising targeted magnetic nanoparticles for MRI detection and stimuli-triggered drug delivery in cancer theranostics.
研究领域:
生物材料学
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医学影像学
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肿瘤学
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产品关联
DOI
高影响因子
RSC Advances
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2022
·Vol. 12
·期 7
·3871-3882
·
IF 4.036
Mingming Zhao,Xiaoxi Song,Jiahui Lu,Siwen Liu,Xuan Sha,Qi Wang,Xu Cao,Kai Xu,Jingjing Li
Accurate drug delivery is a common topic, and it has always been an aim that scientists strive to achieve. To address this need, multifunctional and stimulus-sensitive nanoplatforms have attracted significant attention. Here we fabricated a glutathione (GSH) and adenosine-5′-triphosphate (ATP) dual-sensitive nanoplatform for controlled drug release and activatable MRI of tumors based on DNA aptamer and manganese dioxide (MnO2) nanosheets. Cleverly utilizing the DNA tunability, AS1411 aptamer which binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, was designed with ATP aptamer and its cDNA to load the anticancer drug, doxorubicin (Dox). The formed DNA-Dox complex was delivered to the tumor region with the help of MnO2 nanosheets and AS1411 aptamer. Then, the on-demand drug release in tumor cells was realized with the co-effect of the ATP aptamer and GSH reduction. It was found that without the structure of the MnO2 nanosheets being broken by GSH, Dox almost could not be released even in the presence of ATP. Similarly, without ATP, Dox was still maintained in the duplex even with GSH. Further combining the MRI ability and chemodynamic therapy of the produced Mn2+, an improved effect of the inhibition of tumor growth and imaging was achieved. Our designed DNA aptamer-based dual-responsive nanoplatform can realize the targeted drug delivery and MRI of breast tumor cells both in vitro and in vivo.
研究领域:
生物医学工程
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
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2021
·
IF 0.284
Hao Guo,Songjie Fan,Jianhua Liu,Yumei Wang
With co-precipitation method we successfully synthesized an aqueous dispersible, superparamagnetic manganese ferrite nanoparticles at relatively low temperature (190 °C). This material shows potential application as T 2 MRI contrast agent. Cost-effective and less toxic manganese (II) chloride (MnCl 2 ·4H 2 O) and iron (III) chloride hexahydrate (FeCl 3 ·6H 2 O) were used as precursors and 2-[2-(2-Hydroxyethoxy)ethoxy] ethanol (TEG) were utilized as solvent which served as stabilizer and provided a reduction system. The mean diameter of these nanoparticles is about 7 nm. Its saturation magnetization (Ms) and relaxivity value (r 2 ) are as high as 46 emu/g and 593.9 mM −1 s −1 respectively. In vitro cell study demonstrated pancreatic cancer cells could keep viable when the manganese ferrite nanoparticles concentration reached up to 50 μg/mL.
研究领域:
材料科学
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医学影像学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Fei Wang,Li Li,Chaohui Yang,Zhongxing Cai,Ziyi Guo,Siyu Hou,Xiaoya Xie,Yinghao Chen,Jing Huang,Long Zhang
A series of GdPO 4 :5%Eu 3+ micro/nanomaterials with different morphologies and crystal structures were successfully prepared by the one-step solvothermal method using only the gadolinium source, the phosphoric acid source and ethanol as solvents, without any surfactants or templates, without further calcination and by adjusting only the ratio of phosphoric acid and gadolinium sources. They all have good dispersion and homogeneity. The morphology of the products was mainly regulated by the ratio of H 3 PO 4 to Gd(NO 3 ) 3 · 6H 2 O, with ratios of 2:1, 8:1, 16:1, 24:1, 32:1, 40:1 and 48:1 mL/g resulting in the formation of square, pillow, star, carambola, hollow cylinder, drum and jujube shaped GdPO 4 :5%Eu 3+ micro/nanomaterials, respectively. Ratios of 2:1–24:1 and 32:1–48:1 allow for the direct solvothermal synthesis of monoclinic and hexagonal phase gadolinium phosphate, simultaneously. In addition to their crystal structure and morphology, chemical bonding, thermal stability and specific surface area, their luminescence properties and magnetic resonance imaging (MRI) tracing properties have also been studied in comparison. Interestingly, the GdPO 4 :5%Eu 3+ micro/nanoparticles in the carambola shape had a higher photoluminescence intensity and relaxation rate of 0.7709 mM −1 s −1 (r 1 ) among all the morphologies. The possible mechanisms by which various morphologies of GdPO 4 :5%Eu 3+ were prepared in different ratios were analyzed, and the reasons for their effects on the fluorescence and MRI tracer properties were further investigated. This study is of reference significance for the simple-regulated synthesis of rare earth inorganic gadolinium-containing micro/nanomaterials and provides a reliable guarantee for the expansion of their multifunctional applications in UV–Vis luminescence and MRI tracing for implants.
研究领域:
材料科学
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医学影像学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2023
·
IF 10.9
Lili Hao,Haoyang Ding,Xiangchuan Xu,Hongli Mao,Zhongwei Gu
Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various fields. Currently, there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex diseases. In this study, iron oxide-gadolinium nanoparticles (IO-Gd NPs) bridged by hydrophilic ligand ethylenediamine tetramethylenephosphonic acid (EDTMP) are designed inspired by Solomon-Bloembergen–Morgan (SBM) theory, where T 1 and T 2 relaxivity increase with a reduction in Gd content. In particular, the NPs with minimum Gd content exhibit excellent dual-mode contrast performance ( r 1 = 94.42 mM −1 s −1 , r 2 = 343.62 mM −1 s −1 ). The underlying mechanism is that the bridged EDTMP coordinate limits Gd tumbling and forces Gd 3+ to expose itself to the surface of the NPs. This provides more opportunities for water molecules to coordinate with Gd 3+ and significantly enhances proton relaxivity. Moreover, the hydrophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs, further enhancing the dual-mode contrast effect. Finally, the biocompatibility and in vitro / vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated, and the results demonstrate their potential as dual-mode contrast agents. This study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.
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DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 40
·6413-6423
·
IF 4.776
Juanjuan Li,Ruitao Cha,Yulong Zhang,Hongbo Guo,Keying Long,Pangye Gao,Xiaohui Wang,Fengshan Zhou,Xingyu Jiang
Even though iron oxide (Fe3O4) nanoparticles are promising materials for magnetic resonance imaging (MRI) contrast agents, their biocompatibility and targeting efficacy still need to be improved. Herein, we modified glycyrrhetinic acid (GA) groups on Fe3O4 nanoparticles (Fe3O4@cGlu-GA) for liver tumor-targeted imaging. To evaluate the biocompatibility of these nanoparticles, we studied their cytotoxicity, hemolysis, and hepatotoxicity. We measured the uptake of Fe3O4@cGlu-GA nanoparticles in normal and liver tumor cells, then we investigated the specificity of Fe3O4@cGlu-GA nanoparticles in mouse models bearing subcutaneous and orthotopic liver tumors. With good biocompatibility and targeting efficacy both in vitro and in vivo, the Fe3O4@cGlu-GA nanoparticles are promising MRI contrast agents with ultralow hepatotoxicity and show great improvement on existing Fe3O4-based nanoparticles.
研究领域:
纳米技术
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医学成像
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药学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yang Zhang,Sijie Cheng,Yu He,Chaojie Tang,Feng Liu,Yun Sun,Shuo Zhao,Greta S. P. Mok,Hong Yang,Zhiguo Zhou,Wu Wang
Thrombosis is closely related to the instability of intracranial aneurysm (IA), whose rupture is associated with high morbidity and mortality. It is difficult to detect an IA-related thrombus because traditional magnetic resonance imaging (MRI) and even contrast-enhanced MRI cannot clearly distinguish a thrombus from the surrounding tissues. Herein, a nanoplatform [(MFe2O4–ZnDPA nanoparticles (NPs)], consisting of Zn0.4Co0.6Fe2O4@Zn0.4Mn0.6Fe2O4 NPs for imaging and Zn(II)-bis(dipicolylamine) (ZnDPA) for thrombus targeting, is constructed to target an experimental aneurysm-related thrombus in rabbits via MRI. In vitro experiments including platelet safety evaluation primarily prove that MFe2O4–ZnDPA NPs with a high MRI transverse relaxation time (T2) have good biocompatibility. MFe2O4–ZnDPA NPs could target a thrombus via the special interaction between ZnDPA and phosphatidylserine of activated platelets in the thrombus through MRI and Fe quantification assays. Moreover, after MFe2O4–ZnDPA NPs are injected into the ear vein of common carotid artery aneurysm model rabbits, MRI shows that MFe2O4–ZnDPA NPs could accumulate in the aneurysm-related thrombus from 0 to 15 min after injection and decrease in the next 45 min. Meanwhile, MFe2O4–ZnDPA NPs could decrease the MRI T2 signal of the aneurysm-related thrombus to enhance the outline of the aneurysm. This study demonstrates that a nanoplatform can enhance the detection of an aneurysm-related thrombus as well as aneurysm itself to assist further treatment of IA.
研究领域:
医学成像
·
纳米技术
·
神经病学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
Theranostics
·
2019
·
IF 8.063
Yuqing Miao,Qian Xie,Huan Zhang,Jing Cai,Xiaoli Liu,Ju Jiao,Shanshuang Hu,Anujit Ghosal,Yu Yang,Haiming Fan
The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T 1 contrast agent for high-resolution magnetic resonance imaging (MRI) is highly desirable. However, the correlations between the chemical compositions, in vitro T 1 relaxivities, in vivo nano-bio interactions and toxicities remain unclear, which has been a challenge in optimizing the in vivo T 1 contrast efficacy. Methods : Ultrasmall (3 nm) manganese ferrite nanoparticles (Mn x Fe 3-x O 4 ) with different doping concentrations of the manganese ions (x = 0.32, 0.37, 0.75, 1, 1.23 and 1.57) were used as a model system to investigate the composition-dependence of the in vivo T 1 contrast efficacy. The efficacy of liver-specific contrast-enhanced MRI was assessed through systematic multiple factor analysis, which included the in vitro T 1 relaxivity, in vivo MRI contrast enhancement, pharmacokinetic profiles (blood half-life time, biodistribution) and biosafety evaluations ( in vitro cytotoxicity testing, in vivo blood routine examination, in vivo blood biochemistry testing and H&E staining to examine the liver). Results : With increasing Mn doping, the T 1 relaxivities initially increased to their highest value of 10.35 mM -1 s -1 , which was obtained for Mn 0.75 Fe 2.25 O 4 , and then the values decreased to 7.64 m M -1 s -1 , which was obtained for the Mn 1.57 Fe 1.43 O 4 nanoparticles. Nearly linear increases in the in vivo MRI signals (ΔSNR) and biodistributions (accumulation in the liver) of the Mn x Fe 3-x O 4 nanoparticles were observed for increasing levels of Mn doping. However, both the in vitro and in vivo biosafety evaluations suggested that Mn x Fe 3-x O 4 nanoparticles with high Mn-doping levels (x > 1) can induce significant toxicity. Conclusion : The systematic multiple factor assessment indicated that the Mn x Fe 3-x O 4 (x = 0.75-1) nanoparticles were the optimal T 1 contrast agents with higher in vivo efficacies for liver-specific MRI than those of the other compositions of the Mn x Fe 3-x O 4 nanoparticles. Our work provides insight into the optimization of ultrasmall ferrite nanoparticle-based T 1 contrast agents by tuning their compositions and promotes the translation of these ultrasmall ferrite nanoparticles for clinical use of high-performance contrast-enhanced MRI.
研究领域:
医学影像学
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纳米医学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Jingjing Liu,Jing Huang,Meng Lv,Shuguo Wang,Gaoqi chen,Zhihao Zhang,Jiajun Tao,Xu Hou,Xudong Yang,Yu Wang,Shuo Wang,Fei Li,Tong Xu,Yunru Wan,Jiaying Zhao,Xiangyu Gong
RE 3+ -activated BaGdF 5 phosphors have broad applications in LED-based fluorescence displays and biological tracing. In this research, various types (GdF 3 :5%Eu 3+ , BaGdF 5 :5%Eu 3+ ) and different morphologies (peanut, octahedron, microsphere) of gadolinium-based fluoride micro/nano-materials with down-shifting luminescence were synthesized via the hydrothermal method. The coordination environments of Gd 3+ , Eu 3+ , Ba 2+ , and F - ions were tuned by systematically varying the reaction time (6–36 h), the initial pH (3–11), and surfactants/chelating agents (CTAB, EDTA-2Na, Na 3 Cit and PVP). The optimal synthesis conditions (36 h, pH=3) were identified through X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. The samples were comprehensively characterized using thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) surface area measurements, Fourier-transform infrared (FT-IR) spectroscopy, and photoluminescence (PL) spectroscopy. The octahedral BaGdF 5 :5%Eu 3+ particles synthesized with CTAB demonstrated good thermal stability and the strongest fluorescence emission intensity at 595 nm, producing an orange-red light with CIE chromaticity coordinates of (0.5141, 0.4845). The luminescence intensity was 2.23 times greater than that of samples prepared with PVP. Moreover, the signal intensity in MRI T 1 -weighted imaging exhibits a positive correlation with Gd 3+ concentration. The composite material containing 2% wt% BaGdF 5 :5% Eu 3+ within the chitin matrix demonstrated optimal performance in CT imaging. Research indicates that the synthesised octahedral BaGdF 5 :5% Eu 3+ compound holds potential applications for down-shifting luminescence and multimodal MRI/CT imaging.
研究领域:
材料科学
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纳米技术
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生物医学成像
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发光材料
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无机化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）