OPTICS AND LASER TECHNOLOGY
·
2025
·
IF 5
Jun Dong,Yixuan Hou,Wei Gao,Chengyun Zhang,Lipeng Zhu,Yongkai Wang,Qingyan Han,Jianxia Qi
Surface-Enhanced Raman Scattering (SERS), with the exceptional single-molecule detection capability and high sensitivity, has become an advanced spectroscopic analysis method in fields such as chemical analysis and biosensing. Three-dimensional (3D) sandwich substrates, due to their unique structural characteristics, have attracted considerable attention for their ability to enhance SERS detection sensitivity. However, the controlled assembly of 3D sandwich substrates with bimetallic nanoparticles remains a challenge. In this paper, a fabrication method for constructing 3D sandwich substrates via a bottom-up approach is proposed. Using a liquid–liquid phase self-assembly method, Au@Ag nanocubes (Au@Ag NCs) were assembled on a polystyrene (PS) microsphere array with monolayer MXene (Ti 3 C 2 T X ) adsorption, successfully constructed an Au@Ag NCs/MXene/PS microsphere substrate. Furthermore, the SERS sensitivity of the substrate was evaluated using Rhodamine 6G (R6G), Crystal Violet (CV), and Aspartame (APM) molecules, and experimental results show that the detection limits are 10 −12 M, 10 −11 M, and 0.0313 g/L (1.06 × 10 −4 M), respectively, with excellent uniformity and stability of the substrate. These findings demonstrate that the constructed 3D substrate exhibits outstanding SERS performance and holds significant potential for applications in environmental pollutant detection and food safety.
研究领域:
分析化学
·
纳米生物技术
·
环境监测
·
食品安全
·
光谱学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Wenjing Xie,Jiajiu Liang,Guangtao Chang,Ruoxin Li
Driven by increasing global energy consumption, smart textiles for personal thermal management, offering energy saving and dynamic temperature regulation, have garnered significant attention. This study introduces an all-weather personal thermal management textile engineered with three-dimensional structured MXene nanosheets, achieving bidirectional temperature control through passive thermal insulation and active photothermal conversion. Fabricated by electrostatically adsorbing MXene nanosheets onto hollow, thermally expandable microspheres (TEMs) and incorporating these MXene/TEMs composites as fillers in polyurethane coatings on cotton fabrics, the resulting textile exhibited exceptional thermal management capabilities. Experimentally, the coating exhibited a low thermal conductivity of 0.031 W m −1 K −1 and demonstrated remarkable photothermal performance, with 93.5 % solar absorption and 28.5 % conversion efficiency. In passive mode, the 0.8 mm coating can increase simulated skin temperature by 4.2 °C, while in active mode, rapid warming of 15.8 °C within 30 s under solar irradiation was achieved with minimized heat loss. In addition to the low-density characteristics, the coatings also exhibit excellent mechanical strength, flexibility, breathability, and water vapor transmission. This smart textile, based on the synergy of thermal conductivity inhibition and efficient photothermal conversion, presents a novel strategy for lightweight and versatile all-weather personal thermal management textiles with broad application potential.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Yiyu Wang,Wenlong Yu,Chunqing Niu,Guiting Yu,Xin Huang,Jian Shi,Da Ma,Xuezheng Lin,Kai Zhao
Microspheres produced from biodegradable poly (D, L-lactic-co-glycolic acid) (PLGA) have been studied widely as drug delivery carriers for therapeutics. This study aimed to develop a near-infrared (NIR) light-activated PLGA microsphere loaded with two kinds of drugs with different molecular weights respectively or simultaneously by the double emulsion method (bovine serum albumin (BSA) and tetracycline hydrochloride (TH) as the drug model agents, indocyanine green (ICG) as the NIR responsive component). To optimize the incorporation of drugs and particle size for PLGA microspheres loaded single drug, the effect of three processing parameters, including the amount of polymer, initial ICG content, and initial BSA or TH content on the drug entrapment efficiency (EE), drug loading and the particle size were investigated. The PLGA microspheres were spherical and ranged from 5 to 10 μm in diameter. The EE of ICG and BSA in PLGA@ICG-BSA was 78.41 ± 0.71% and 69.88 ± 5.14%, respectively. The EE of ICG and TH in PLGA@ICG-TH was 71.52 ± 5.07% and 28.39 ± 3.39%. The PLGA microspheres exhibited desirable biodegradability and low cytotoxicity. Based on the optimized processing of single drug-loaded microspheres, dual-drug-loaded microspheres containing both large and small molecule drugs were further prepared. The EE of ICG, BSA, and TH was 83.37 ± 0.59%, 52.65 ± 3.48%, and 12.88 ± 2.53%; the particle size was ∼7.21 μm. All the NIR-responsive PLGA microspheres exhibited an efficient photothermal property and enhanced photothermal stability under multiple NIR irradiation cycles. The drugs from the different PLGA microspheres were released continuously over 18 days, mainly determined by Fick's diffusion. Furthermore, the drugs can be controlled released through a NIR light trigger, resulting in a dosage increase at a specific time point.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
Journal of Energy Chemistry
·
2019
·
IF 5.162
Chongrong Zhang,Hui Li,Shixuan Wang,Yuliang Cao,Hanxi Yang,Xinping Ai,Faping Zhong
Thermal runaway is the main factor contributing to the unsafe behaviors of lithium-ion batteries (LIBs) in practical applications. The application of separators for the thermal shutdown has been proven as an effective approach to protecting LIBs from thermal runaway. In this work, we developed a thermal shutdown separator by coating a thin layer of low-density polyethylene microspheres (PM) onto a commercial porous polypropylene (PP) membrane and investigated the thermal response behaviors of the as-prepared PM/PP separator in LIBs. The structural and thermal analysis results revealed that the coated PM layer had a porous structure , which facilitated the occurrence of normal charge-discharge reactions at ambient temperature, although it could melt completely and fuse together within very short time periods: 3 s at 110 °C and 1 s at 120 °C, to block off the pores of the PP substrate, thereby cutting off the ion transportation between the electrodes and interrupting the battery reaction. Consequently, the PM/PP separator exhibits very similar electrochemical performance to that of a conventional separator at ambient temperature. However, it performs a rapid thermal shutdown at an elevated temperature of ∼110 °C, thus controlling the temperature rise and maintaining the cell in a safe status. Due to its synthetic simplicity and low cost, this separator shows promise for possible application in building safe LIBs.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
Catalysts
·
2024
·Vol. 14
·期 6
·345
·
IF 3.8
Xiufang Chen,Qingguang Xiao,Yiguo Yang,Bo Dong,Zhengping Zhao
The efficient hydrogenation of N-heterocycles with H2under mild conditions remains a significant challenge. In this work, polyphosphazene (PZs) microspheres, novel organic–inorganic hybrid materials possessing unique –P=N– structural units and a diverse range of side groups, were used to serve as support for the design of a stable and efficient Pd nanocatalyst (Pd/PZs). The PZs microspheres were prepared by self-assembly induced by precipitation polymerization, and Pd nanoparticles were grown and loaded on the support by a chemical reduction process. Several characterization techniques, including XRD, FTIR, SEM, TEM, XPS, BET and TGA, were used to study the structural features of the nanocomposites. The results revealed that Pd nanoparticles were uniformly distributed on the PZs microspheres, with primary sizes ranging from 4 to 9 nm based on the abundance of functional P/N/O groups in PZs. Remarkably high catalytic activity and stability were observed for the hydrogenation of quinoline compounds using the Pd/PZs nanocatalyst under mild conditions. Rates of 98.9% quinoline conversion and 98.5% 1,2,3,4-tetrahydroquinoline selectivity could be achieved at a low H2pressure (1.5 bar) and temperature (40 °C). A possible reaction mechanism for quinoline hydrogenation over Pd/PZs was proposed. This work presents an innovative approach utilizing a Pd-based nanocatalyst for highly efficient multifunctional hydrogenation.
研究领域:
化学
·
材料科学
·
催化反应
✓ 已验证
DOI
高影响因子
MOLECULES
·
2021
·Vol. 26
·期 24
·7449
·
IF 4.412
Xiali Zheng,Wei Luo,Yun Yu,Zebin Xue,Yifan Zheng,Zongjian Liu
A comparative study of the metal emulsion-based synthesis of Sn-based materials in two different types of molten salts (namely LiCl–KCl–CsCl and LiNO3-NaNO3-KNO3eutectics) is presented, and the properties of Sn, Sn-Cu and Sn-Cu-Zn microsphere phase change materials prepared in chloride salts are evaluated by differential scanning calorimetry (DSC) to understand the effect of element doping. Despite a high ultrasonic power (e.g., 600 W or above) being required for dispersing liquid Sn in the chloride system, well-shaped Sn microspheres with a relatively narrow size range, e.g., about 1 to 15 µm or several micrometers to around 30 µm, can be prepared by adjusting the ultrasonic power (840–1080 W), sonication time (5–10 min) and the volume ratio of salts to metal (25:1–200:1). Such a method can be extended to the synthesis of Sn-based alloy microspheres, e.g., Sn-Cu and Sn-Cu-Zn microspheres. In the nitrate system, however, a very low ultrasonic power (e.g., 12 W) can be used to disperse liquid Sn, and the particles obtained are much smaller. At low ultrasonic power (e.g., 12 W), the particle size is generally less than 10 or 4 µm when the sonication time reaches 2 or 5 min, and at high ultrasonic power, it is typically in the range of hundreds of nanometers to 2 µm, regardless of the change in ultrasonic power (480–1080 W), irradiation time (5–10 min), or volume ratio of salts to metal (25:1–1000:1). In addition, the appearance of a SnO phase in the products prepared under different conditions hints at the occurrence of a reaction between Sn droplets and O2in situ generated by the ultrasound-induced decomposition of nitrates, and such an interfacial reaction is believed to be responsible for these differences observed in two different molten salt systems. A DSC study of Sn, Sn-Cu, and Sn-Cu-Zn microspheres encapsulated in SiO2reveals that Cu (0.3–0.9 wt.%) or Cu-Zn (0.9 wt.% Cu and 0.6% Zn) doping can raise the onset freezing temperature and thus suppress the undercooling of Sn, but a broad freezing peak observed in these doped microspheres, along with a still much higher undercooling compared to those of reported Sn-Cu or Sn-Cu-Zn solders, suggests the existence of a size effect, and that a low temperature is still needed for totally releasing latent heat. Since the chloride salts can be recycled by means of the evaporation of water and are stable at high temperature, our results indicate that the LiCl–KCl–CsCl salt-based metal emulsion method might also serve as an environmentally friendly method for the synthesis of other metals and their alloy microspheres.Keywords:molten salts;metal emulsion;microspheres;interfacial reaction;ultrasound
研究领域:
材料科学
·
热能工程
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Liu Kunliang,Jin Zhicheng,Hu Xiaolong,Yan Dan,Zhang Yu,Zhu Haidong,Teng Gaojun,Xiong Fei
Trans-arterial chemoembolization (TACE) has been a mainstream treatment for hepatocellular carcinoma (HCC), accordingly there are more requirements for embolic agents’ properties, mainly concentrated on biodegradability and imaging function. A new kind of biodegradable multifunctional porous microspheres (BMPMs) with internal coarse plications are ingeniously designed and manufactured, consisting of carrageenan, inhexol and superparamagnetic iron oxide nanoparticle (SPIO). BMPMs’ sound roundness and excellent swelling behavior guarantee them to be smoothly transported into appointed arteries’ ends and achieve satisfactory embolization effect. Porous structure together with sulphate groups on BMPMs’ skeleton weaved by cross-linked carrageenan contributes to a marvelous doxorubicin hydrochloride (Dox) loading capacity over 45 mg Dox per mL of swollen microspheres, as well as a controllable degradation rate by allowing enzymes to infiltrate into BMPMs through holes, degrading 20–35% after two months in vitro . Inner coarse plications enable BMPMs to effectively combine with iohexol via hydrophilic effect and SPIO by blocking, which can further exhibit a decent imaging performance under digital subtraction system (DSA) and magnetic resonance imaging (MRI) for optimization of current TACE and development of a more advanced imageable TACE (iTACE). Safety evaluation and animal experiment manifest that BMPMs are reliable enough and hold great potential and competitiveness of being used in curing HCC.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
·
医学影像
✓ 已验证
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Xingyu Wu,Jingyi Wang,Yuantong Lei,Haoyang He,Zhibo Lei,Xinjuan Huang,Hong Xiao,Ganxue Wu,Zhenxing Zeng,Yingjun Wang,Liping Huang,Fei Shen,Shihuai Deng,Xiaoping Gao,Zhuoyao Fang,Dexin Fang
Over the past decades, considerable efforts have been made to find useful solutions for phosphate pollution control . The state transition of nanomaterials from freely dispersed to encapsulated provides a realizable route for their application in phosphate elimination. The separation convenience offered by encapsulation has been widely recognized, however, the unique binding mode of nanostructures and phosphate in the confined space remains unclear, limiting its further development. Here, carboxymethyl cellulose (CMC) microspheres were used as hosts to deploy layered double hydroxide (LDH) nanoparticles . On this basis, we described an attempt to explore the adsorption behavior of LDH and phosphate in the microsphere space. Compared to their freely dispersed analogues, LDH particles exhibited higher structural stability, wider pH adaptability, and better phosphate selectivity when spatially confined in the CMC microsphere. Nevertheless, the kinetic process was severely inhibited by three orders of magnitude. Besides, the saturated phosphate adsorption capacity was also reduced to 74.6 % of the freely dispersed system. A combinative characterization revealed that the highly electronegative CMC host not only causes electrostatic repulsion to phosphate, but also extracts the electron density of the metal center of LDH, weakening its ability to act as a Lewis acid site for phosphate binding. Meanwhile, the microsphere encapsulation also hinders the ion exchange function of interlayer anions and phosphate. This study offers an objective insight into the reaction of LDH and phosphate in the confined microsphere space, which may contribute to the advanced design of encapsulation strategies for nanoparticles.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Theranostics
·
2025
·Vol. 15
·期 9
·4135
·
IF 13.3
Ye Yuan,Longsheng Xu,Yu Zhao,Tizhen Yan,Baobiao Zhuo,Fan Bu,Qian Cai,Youjia Xu,Qing Bi,Yu Tong,Dan Xing,Di Sun,Jianhao Lin
Rationale: Osteoarthritis (OA) is a chronic joint disorder with limited treatment efficacy, necessitating innovative therapeutic strategies. This study explores one-pot-synthesized gelatin microspheres devoid of glutaraldehyde as a novel biomaterial for OA management. Focusing on the Ext1 gene, critical for cartilage development and downregulated in OA, we investigated its restoration and immune regulation using gelatin microspheres cultured with mesenchymal stem cells (MSCs). Methods: OA patients undergoing knee replacement surgery have their lateral compartment (remote zone) and medial compartment (lesion zone) cartilage collected for transcriptomic testing. The differential gene Ext1 is identified, and the expression of immune regulatory genes is examined. MSCs were cultured with gelatin microspheres to evaluate their compatibility and ability to promote cell attachment. The effects of the gelatin microspheres on Ext1 gene overexpression, immune regulation, and OA symptom mitigation were investigated through in vitro and in vivo experiments. Results: OA patients exhibit decreased expression of the Ext1 gene in the medial compartment (lesion zone) cartilage area, accompanied by abnormal expression of immune regulatory genes. The study demonstrated that the gelatin microspheres exhibited excellent compatibility with MSCs and facilitated their attachment. Culturing MSCs with the microspheres led to enhanced overexpression of the Ext1 gene, which is crucial for cartilage growth and development. Additionally, the microspheres regulated immune responses, contributing to a reduction in OA symptoms. Conclusion: This study introduces an innovative therapeutic strategy for osteoarthritis using gelatin microspheres cultured with MSCs. By promoting Ext1 gene overexpression and regulating immune responses, these microspheres effectively mitigate OA symptoms. The findings highlight the potential of this biomaterial as a promising treatment option for OA.
研究领域:
医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Zhaopeng Liu,Dianlun Wu,Shouhao Wei,Kangqian Xing,Meilin Li,Yue Jiang,Rongfeng Yuan,Guangming Chen,Zhe Hu,Yang Huang,Zhuoxin Liu
Thermal energy, constantly being produced in natural and industrial processes, constitutes a significant portion of energy lost through various inefficiencies. Employing the thermogalvanic effect, thermocells (TECs) can directly convert thermal energy into electricity, representing a promising energy-conversion technology for efficient, low-grade heat harvesting. However, the use of high-cost platinum electrodes in TECs has severely limited their widespread adoption, highlighting the need for more cost-effective alternatives that maintain comparable thermoelectrochemical performance. In this study, a nanocomposite electrode featuring Ti3C2Tx with hollow microsphere structures is rationally designed. This design addresses the restacking issue inherent in MXene nanosheets, increases the electrochemically active surface area, and modifies the original MXene surfaces with oxygen terminations, leading to improved redox kinetics at the electrode–electrolyte interface, particularly in n-type TECs employing Fe2+/3+ redox ions. The optimized n-type TEC achieved an output power of 84.55 μW cm–2 and a normalized power density of 0.53 mW m–2 K–2 under a ΔT of 40 K, outperforming noble platinum-based TECs by a factor of 5.5. An integrated device consisting of 32 TEC units with a p–n connection is also fabricated, which can be successfully utilized to power various small electronics. These results demonstrate the potential of MXene-based composite electrodes to revolutionize TEC technology by offering a cost-effective, high-performance alternative to traditional noble metal electrodes and contributing to efficient low-grade heat harvesting.
研究领域:
材料科学
·
能源技术
·
纳米科技
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AMB Express
·
2025
·Vol. 15
·期 1
·1-12
·
IF 3.7
Hu Yanli,Xia Yingjun,Mo Huiwen,Zhang Li,Cao Wenjian,Fang Rui,Zhao Junlong
African swine fever (ASF) is a contagious viral disease in pigs, caused by the African swine fever virus (ASFV). Currently, there are no effective vaccines and drugs for ASFV, making diagnostic methods crucial for the prevention and control of ASF. In this study, the ASFV p30 protein was successfully expressed using a prokaryotic expression system and used as an immunogen to prepare monoclonal antibody (mAb) 2A5. The antigenic epitope recognized by the mAb 2A5 was identified as 58 VKYDIVKSARIYAGQGY 74 . Then, a blue latex microsphere immunochromatographic strip method for detecting ASFV antigens was established. Wherein a rabbit polyclonal antibody (pAb) against p30 stored in our laboratory was coupled with blue latex microspheres to prepare an immune probe, with mAb 2A5 as the test line and goat anti-rabbit IgG as the control line. The immunochromatographic strip exhibited excellent sensitivity, with a minimum detection limit of 10 ng/mL for the p30 protein. It demonstrated good specificity, showing no cross-reactivity with PRRSV, PCV2, PPV, and PEDV. Moreover, it maintained good stability and could be stored for at least 100 days at 37 °C. The concordance rate between the immunochromatographic strip and qPCR test kit was 92.2%. The immunochromatographic strip method can meet the requirements of clinical testing and provide technical support for ASFV diagnosis.
研究领域:
兽医学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2015
·Vol. 11
·期 18
·2200-2208
·
IF 8.368
Dian Li,Yuting Zhang,Ruimin Li,Jia Guo,Changchun Wang,Chuanbing Tang
Circulating tumor cells (CTCs) captured from blood fluid represent recurrent cancers and metastatic lesions to monitor the situation of cancers. We develop surface-enhanced Raman scattering (SERS)-coding microsphere suspension chip as a new strategy for fast and efficient capture, recovery, and detection of targeting cancer cells. Using HeLa cells as model CTCs, we first utilize folate as a recognition molecule to be immobilized in magnetic composite microspheres for capturing HeLa cells and attaining high capturing efficacy (up to 95%). After capturing cells, the composite microsphere, which utilizes a disulfide bond as crosslinker in the polymer shell and as a spacer for linking folate, can recycle 90% cells within 20 min eluted by glutathion solution. Taking advantage of the SERS with fingerprint features, we characterize captured/recovered cells with the unique signal of report-molecule 4-aminothiophenol through introducing the SERS-coding microsphere suspension chip to CTCs. Finally, the exploratory experiment of sieving cells shows that the magnetic composite microspheres can selectively capture the HeLa cells from samples of mixed cells, indicating that these magnetic composite microspheres have potential in real blood samples for capturing CTCs.
研究领域:
生物医学工程
·
癌症诊断
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）