Catalysts
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2026
·Vol. 16
·期 4
·354
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IF 4.5
Weiwei Cai,Min Zheng
Flue gas denitrification represents an environmentally friendly and economically viable strategy for alleviating energy crises and advancing carbon neutrality goals. Although traditional selective catalytic reduction (SCR) catalysts demonstrate excellent denitrification efficiency and catalytic stability, they still face significant challenges, including high cost and ammonia slip. In this study, the high-entropy oxide (HEO) NiCoZnVCrOxwas synthesized via the sol–gel method and evaluated for the reduction of NO to N2. The effects of varying reaction conditions on the NO reduction performance of this material were systematically investigated alongside the underlying reaction mechanism. The results reveal that the reduced oxygen carrier (OC) achieves optimal performance at an oxidation temperature of 800 °C, oxidizing gas flow rate of 200 mL/min and reduction time of 60 min, yielding the highest NO conversion and N2selectivity while simultaneously minimizing NO2selectivity. The reaction mechanism was further elucidated through a series of characterization techniques, including DRIFTS. Overall, this HEO demonstrates significant potential as a candidate OC for flue gas denitrification.
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Cyborg and Bionic Systems
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2026
·
IF 20.9
Ming Yang,Jian Hu,Zerui Li,Hanhan Xie,Hongri Gu,Chengzhi Hu
Multimodal nanotherapeutic systems capable of integrating photothermal, catalytic,and gas-mediated strategies offer powerful opportunities to overcome the limitations ofsingle-mode cancer therapies. Here, we develop a near-infrared (NIR) light-activatedbiomimetic nanomotor for targeted NO delivery and synergistic cancer therapy. Thenanomotor is constructed from bowl-shaped mesoporous polydopamine (PDA)nanoparticles loaded with Fe(II) as a Fenton catalyst and BNN6 as a thermallyresponsive NO donor (Denoted as PFB). To endow tumor specificity, the nanomotor isfurther camouflaged with MCF-7 cancer cell membrane (PFB@CM), enablinghomologous recognition and enhanced intratumoral accumulation. Upon NIRirradiation, PFB@CM exhibits strong photothermal conversion efficiency that initiatesthree synergistic processes: (i) self-thermophoretic propulsion that promotes cellularinternalization; (ii) heat-triggered decomposition of BNN6 for precise NO release; and(iii) heat-accelerated Fe(II) release from the PDA matrix. The liberated Fe(II) catalyzesendogenous H2O2 via a Fenton-like reaction to generate reactive oxygen species (ROS),which subsequently react with NO to yield highly cytotoxic reactive nitrogen species(RNS). This cascade amplifies oxidative and nitrosative stress within tumor cells,enabling photothermal, chemodynamic, and NO-mediated synergistic therapy. Thedesign of PFB@CM integrates homologous targeting, autonomous motility, and NIR-responsive multi-mechanism activation, demonstrating a versatile strategy for precisionnanomedicine and highlighting the potential of light-activated nanomotors for safe andeffective multimodal cancer therapy.
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Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 45
·24644-24650
·
IF 11.9
Dongrun Xu,Weiye Qu,Junhong Liu,Junxiao Chen,Xue Fang,Liwei Chen,Zhen Ma,Xi Liu,Xingfu Tang,Yaxin Chen
Selective catalytic reduction (SCR) is the most effective technology to control NO emission using commercial V2O5–WO3/TiO2 catalysts, but the nature of active catalytic sites remains under debate. Here we provide evidence demonstrating that dinuclear vanadium–tungsten sites are the most active catalytic sites of conventional V2O5–WO3/TiO2 catalysts, inconsistent with a prevailing view that dimeric vanadium sites are the active sites. The dinuclear vanadium–tungsten sites have inherently stronger acidity than the dimeric vanadium sites, favoring NH3 adsorption. Meanwhile, the vanadium 3d electrons of the dinuclear vanadium–tungsten sites are richer than those of the dimeric vanadium sites, facilitating O2 activation in SCR. Hence, the dinuclear vanadium–tungsten sites have higher SCR activity than the dimeric vanadium sites under identical reaction conditions. This work settles a long dispute on the identification of active sites of conventional V2O5–WO3/TiO2 SCR catalysts, thus having implications for a unified explanation of disparate SCR reaction mechanisms and rational design of improved SCR catalysts.
研究领域:
催化化学
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环境化学
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材料科学
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化学工程
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
·
IF 6.6
Xiaofei Qian,Qingyan Wang,Feiyu Chen,Dongyun Ye,Dizhi Wu,Kai Ouyang,Dzmitry Hrynsphan,Tatsiana Savitskaya,Zeyu Wang,Marakkale Manage Pathmalal,Jun Chen
Nitrogenous wastewater is a major environmental problem. Denitrification refers to the sequential reduction of nitrate (NO 3 - ) and nitrite (NO 2 - ) to nitric oxide (NO) and nitrous oxide (N 2 O) to form N 2 . Oxygenic denitrification could transform NO into N 2 and O 2 via NO dismutase (Nod), an unusual O 2 -forming process to reduce N 2 O emission during nitrogen removal. After confirming the presence of the nod gene in three samples including anaerobically-activated sludge, farmland soil, and paddy soil, the targeted enrichment experiment was conducted. The abundance of key denitrification genes rose by 4.6–13 fold, including NO 2 - reductase ( nir ), N 2 O reductase ( nos ), NO reductase ( nor ), and nod . Principal coordinate and α -diversity analyses revealed the progressive enrichment of oxygenic denitrifiers by eliminating irrelevant microorganisms. Focusing on paddy soil with optimal O 2 -generating capacity, novel nod genes were identified. Specifically, recombinant-engineered bacteria containing the nod genes were constructed to assess their NO dismutation activity. Results demonstrated that these recombinant strains exhibited excellent NO degradation efficiency at 72.6–85.4%, indicating superior dismutation performance. Apparent enzymatic activity assays using the crude Nod enzyme extract from the representative recombinant strain SD52149 showed Michaelis-Menten-type saturation behavior. These findings provide critical insights into the application of oxygenic denitrification for reducing N 2 O emissions in nitrogenous wastewater treatment and enhancing microbial remediation strategies.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haifeng Ji,Peihuan Lv,Liming Zhang,Lanyue Shen,Zhenqiu Gao,Zhen Wen,Xuhui Sun
Tactile sensors with multifunctional sensing characteristics enhance people’s perception of external stimuli and have become an indispensable part of human–computer interaction. However, constructing a multi-functional tactile sensor that is able to respond to multiple stimuli without signal crosstalk still remains challenging. Here, we proposed a temperature–pressure integrated multi-functional tactile sensor (TP-MTS) by coupling thermoresistive and contact-electrification effects, which can simultaneously detect human body temperature and physiological motion. A sensing electrode model was validated by using a PVDF/PEG/Gr (polyvinylidene difluoride/Polyethylene terephthalate/graphene) composite thermoresistive film instead of the traditional metal as the electrode of the pressure sensing unit. The multi-functional tactile sensor converts temperature and pressure stimuli into two independent output signals from different paths, realizing simultaneous detection of temperature and pressure without signal crosstalk. The TP-MTS can achieve real-time temperature monitoring with a minimum resolution of 0.1℃ and a sensitivity of 1.51 % ℃ -1 and it could also detect pressure in a wide pressure range (0.25 kPa ∼ 253.87 kPa) with the sensitivity of 3.73 kPa −1 . Through the structure design and the huge impedance difference between the thermosensitive film and the triboelectric unit, the real-time monitoring of temperature and pulse is realized simultaneously in a single device without crosstalk.
研究领域:
生物医学工程
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材料科学
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传感技术
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MATERIALS LETTERS
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2016
·
IF 2.437
Xingxing Jin,Yanfang Wang,Jiang Yuan,Jian Shen
Keratin-based biomaterials have emerged as potential candidates for various biomedical and biotechnological applications due to their intrinsic biocompatibility, biodegradability, mechanical durability, and natural abundance. The objective of our study is to explore the feasibility and potential applications of keratin for promoting nitric oxide (NO) release. Herein, keratin was first extracted from human hair and then modified with iodoacetic acid to afford S-carboxymethyl keratin. The amino acid residues, isoelectric point, and molecular weight of keratin were quantified with amino acid analyzer, zeta potential measurement, and SDS-PAGE method. Interestingly, human hair keratin was proved to be capable of promoting NO release from endogenous donor of S-nitrosoglutathione (GSNO) in the presence of glutathione.
研究领域:
生物医学
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生物技术
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Catalysis Science & Technology
·
2023
·Vol. 13
·期 20
·5989-5997
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IF 5
Canyang Qu,Ping Wang,Miao He,Cheng Yang,Jing Xiong,Xiaohua Sun,Yuechang Wei,Zhenxing Li
NOx is one of the main sources of air pollution, which primarily comes from automobile exhausts. Rare earth-based catalysts for NO oxidation have excellent oxygen storage and release performance and good structural stability. Herein, a series of three-dimensional ordered microporous (3DOM) cerium–manganese composite oxide catalysts with different cerium–manganese ratios for NO oxidation were prepared by the sol–gel method. The 3DOM structure improves the contact efficiency of the NO, soot and the catalyst. By incorporating Mn3+ ions into the cerium oxide lattice, a Ce–Mn solid solution forms with an ordered macroporous structure, and the interaction between cerium and manganese significantly increases the amount of reactive oxygen species. The catalyst with the optimal cerium–manganese ratio (1 : 2) was able to achieve a conversion rate of 62% at 250 °C, and the highest conversion rate reached 98%, which is far higher than pure cerium oxide and pure manganese oxide catalysts. This work provides a promising catalyst for NO oxidation and soot combustion applications.
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Science Advances
·
2020
·Vol. 6
·期 39
·
IF 13.117
Yaqin Jiang,Pengfei Fu,Yanyan Liu,Chaochao Wang,Peiran Zhao,Xu Chu,Xingwu Jiang,Wei Yang,Yelin Wu,Ya Wang,Guohua Xu,Jin Hu,Wenbo Bu
Traumatic spinal cord injury (SCI) is caused by external physical impacts and can induce complex cascade events, sometimes converging to paralysis. Existing clinical drugs to traumatic SCI have limited therapeutic efficacy because of either the poor blood–spinal cord barrier (BSCB) permeability or a single function. Here, we suggest a “pleiotropic messenger” strategy based on near-infrared (NIR)–triggered on-demand NO release at the lesion area for traumatic SCI recovery via the concurrent neuroregeneration and neuroprotection processing. This NO delivery system was constructed as upconversion nanoparticle (UCNP) core coated by zeolitic imidazolate framework–8 (ZIF-8) with NO donor (CysNO). This combined strategy substantial promotes the repair of SCI in vertebrates, ascribable to the pleiotropic effects of NO including the suppression of gliosis and inflammation, the promotion of neuroregeneration, and the protection of neurons from apoptosis, which opens intriguing perspectives not only in nerve repair but also in neurological research and tissue engineering.
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PLoS One
·
2018
·Vol. 13
·期 4
·e0192324
·
IF 2.766
Hai-qian Zhao,Zhong-hua Wang,Xing-cun Gao,Cheng-hao Liu,Han-bing Qi
H 2 O 2 was adopted to oxidize NO in simulated flue gas at 100–500°C. The effects of the H 2 O 2 evaporation conditions, gas temperature, initial NO concentration, H 2 O 2 concentration, and H 2 O 2 :NO molar ratio on the oxidation efficiency of NO were investigated. The reason for the narrow NO oxidation temperature range near 500°C was determined. The NO oxidation products were analyzed. The removal of NO x using NaOH solution at a moderate oxidation ratio was studied. It was proven that rapid evaporation of the H 2 O 2 solution was critical to increase the NO oxidation efficiency and broaden the oxidation temperature range. the NO oxidation efficiency was above 50% at 300–500°C by contacting the outlet of the syringe needle and the stainless-steel gas pipe together to spread H 2 O 2 solution into a thin film on the surface of the stainless-steel gas pipe, which greatly accelerated the evaporation of H 2 O 2 . The NO oxidation efficiency and the NO oxidation rate increased with increasing initial NO concentration. This method was more effective for the oxidation of NO at high concentrations. H 2 O 2 solution with a concentration higher than 15% was more efficient in oxidizing NO. High temperatures decreased the influence of the H 2 O 2 concentration on the NO oxidation efficiency. The oxidation efficiency of NO increased with an increase in the H 2 O 2 :NO molar ratio, but the ratio of H 2 O 2 to oxidized NO decreased. Over 80% of the NO oxidation product was NO 2 , which indicated that the oxidation ratio of NO did not need to be very high. An 86.7% NO removal efficiency was obtained at an oxidation ratio of only 53.8% when combined with alkali absorption.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2018
·
IF 4.841
Yongheng Xiong,Yiqing Zeng,Wei Cai,Shule Zhang,Jie Ding,Qin Zhong
The effects of various factors on the NO removal activity in the (NH 4 ) 2 SO 3 solution were investigated to explore more details and characteristics of the related reactions using full infrared sensor flue gas analyzer (FISFGA). It was found that the conversion yield of NO (9.0%–29.0%) was obviously improved with the increase of gas–liquid contact area, NO residence time and (NH 4 ) 2 SO 3 concentration as well as the adding of CuSO 4 . However, it was mainly limited by gas–liquid mass transfer rate and slightly inhibited by the gas velocity. Moreover, the FISFGA analysis revealed that two nitric oxide (NO) conversion route with different reduction product of N 2 O and N 2 existed simultaneously upon the existence form of SO 3 2− . It was confirmed by the calculations and the experiments of pH factor that the NO reduction steps were based on the following equation: (1) NO + HSO 3 − ⇋ N 2 O + SO 4 2− + H + ; (2) NO + SO 3 2− ⇋ N 2 + SO 4 2− . In this system, Eq. (1) with N 2 O product was the major pathway, but the ratio of Eqs. (2) to (1) was intensified in the presence of CuSO 4 . It is believed that the suitable additives could promote the NO reduction to N 2 furtherly.
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Journal of Cardiovascular Translational Research
·
2024
·
IF 2.4
Zhang Ning,Liu Liangju,Lv Xiaowang,Wang Yixuan,Zhang Wei,Wen Xin,Yu Fan,Zhou Tingting
Trimethylamine oxide (TMAO) is an intestinal flora metabolite associated with risk of cardiovascular diseases. Transient receptor potential vanilloid 4 (TRPV4) is a Ca 2+ -permeable ion channel that is essential for vasodilation and endothelial function. Currently, there are few studies on the effect of TMAO on TRPV4 channels. In the present study, Ca 2+ imaging of vascular tissue showed that TMAO inhibited TRPV4-mediated Ca 2+ influx into aortic endothelial cells in a dose-dependent manner. Furthermore, a whole-cell patch clamp assay showed that TMAO blocked TRPV4-mediated cation currents. Notably, results of aortic vascular tension measurement showed that TMAO impaired endothelium-dependent vasodilation in mouse aortic vessels through the TRPV4-NO pathway. Our results indicated that TMAO inhibited Ca 2+ entry in endothelial cells and impaired vasodilation through the TRPV4-NO pathway in mice. These results provide scientific evidence for novel pathogenic mechanisms underlying the role of TMAO in cardiovascular disease. Graphical Abstract TMAO impairs mouse aortic vasodilation by inhibiting TRPV4-NO pathway in endothelial cells.
研究领域:
药理学
·
心血管生理学
·
分子生物学
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JOURNAL OF CONTROLLED RELEASE
·
2022
·
IF 11.467
Qing Xu,Gui Chen,Guimei Chen,Hualan Wu,Yuanyuan Yang,Ziyi Mai,Rui Sun,Ping Luan,Chaowan Guo,Meng Yu,Zhenwei Peng,Zhiqiang Yu
Nonspecific biodistribution and poor permeability of conventional therapeutic agents in solid tumors severely compromised the antitumor efficacy. Herein, we report a cascade tumor therapeutic nanoplatform consisting of docosahexaenoic acid (DHA) and nicorandil (NI), namely DNP, to specifically produce cytotoxic agents in tumor cells as well as dilating blood vessels to increase the intratumoral oxidative stress levels. The DHA embedded in the membrane could generate reactive oxygen species (ROS) meanwhile NI produced nitric oxide (NO) in response to intracellular glutathione (GSH) in tumors. Notably, the two functional species could further react in situ to form a more tumoricidal reactive nitrogen species (RNS), causing selectively cascade amplification of antitumor performance. In addition, NO-induced vasodilation could consequently result in a series of functions, including hypoxia relief and deep tumor transportation. In general, we anticipate that the DNP could show great potential for tumor-specific treatment by selectively producing RNS precursors in response to the interior environment of tumor cells for hypoxia normalization and tumor inhibition.
研究领域:
药理学
·
肿瘤学
·
生物医学工程
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