FOOD CHEMISTRY
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2023
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IF 8.8
Changxing Wang,Feifei Qin,Siyuan Tang,Xiameng Li,Tingting Li,Guoqiang Guo,Chenjie Gu,Xu Wang,Da Chen
The design of intelligent and real-time sensing devices is significant in the medical drug monitoring field, but it is still highly challenging. Here, ratiometric fluorescent detections of ofloxacin (OFL) and its L-isomer levofloxacin (LEV) constructed from tri-doped graphene quantum dots (T-GQDs) are reported, and the detection limits reach as low as 46/67 nM toward OFL/LEV due to the intermolecular electron transfer (intermolecular ET) effect. After adding OFL/LEV, the generation of electrostatic bond provides a channel for the intermolecular ET from the edge of T-GQDs to OFL/LEV, resulting in the fluorescence quenching at 414 nm and the fluorescence promoting at 498 nm. Furthermore, a smartphone can be used for the visual and quantitative detection of OFL and LEV by identifying the RGB values of test paper and drink samples. This work not only reveals the physics mechanism of ratiometric detection, but also develops a convenient smartphone diagnostic for OFL and LEV .
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Xueqin Sun,Yan Fan,Jiacheng Liu
A novel of ratiometric fluorescence sensor Eu 3+ @UiO-67-TFSA with pre-concentration effect was fabricated by PSM. • The prepared Eu 3+ @UiO-67-TFSA exhibited high selectivity and sensitivity toward OFL. • The possible sensing mechanism of Eu 3+ @UiO-67-TFSA for OFL was systematically studied. • The Eu 3+ @UiO-67-TFSA paper sensor with smartphone allowed on-site visual rapid OFL detection. The excessive use of ofloxacin (OFL) has led to its persistent residues in water sources and animal-derived foods, posing a threat to human health. Therefore, it is urgent to develop fluorescent sensing materials capable of detecting ofloxacin in water environments and food matrices. Herein, a novel Eu 3+ @tetrafluorosuccinic acid-functionalized ratiometric fluorescent material Eu 3+ @UiO-67-TFSA was prepared by a two-step post-synthetic modification of UiO-67. In the concentration range of 1–15 μM, the Eu 3+ @UiO-67-TFSA had a limit of detection (LOD) of 0.42 μM for OFL, which was approximately 3.90 times lower than that of the non-fluorinated Eu 3+ @UiO-67-SA (LOD = 1.64 μM). The improved sensing performance could be attributed to the pre-concentration effect provided by the Eu 3+ @UiO-67-TFSA. The possible detection mechanism was systematically elucidated through relevant experiments and density functional theory (DFT) calculation. Moreover, the constructed smartphone-assisted visual sensing platform was successfully applied to detect OFL in actual food samples and real water environment samples. A novel ratiometric fluorescent sensor Eu 3+ @UiO-67-TFSA was synthesized through two-step PSM. The preparation of Eu 3+ @UiO-67-TFSA enabled effective detection of OFL via ratiometic fluorescence signals, with a detection limit as low as 0.42 μM, which was approximately 3.90 times lower than that of the non-fluorinated Eu 3+ @UiO-67-SA. The improved sensing performance could be attributed to the pre-concentration effect provided by the as-obtained Eu 3+ @UiO-67-TFSA. Furthermore, the fluorescent test strips based on Eu 3+ @UiO-67-SA was combined with smartphone to realized on-site, visual and rapid detection of OFL. Download: Download high-res image (286KB) Download: Download full-size image
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ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Bingbing Feng,Juan Chen,Chao Wang,Guoxiang You,Junkai Lin,Han Gao,Shanrui Han,Junchao Ma
Ofloxacin (OFL) is a typical fluoroquinolone antibiotic widely detected in rural domestic sewage, however, its effects on the performance of aerobic biofilm systems during sewage treatment process remain poorly understood. We carried out an aerobic biofilm experiment to explore how the OFL with different concentrations affects the pollutant removal efficiency of rural domestic sewage. Results demonstrated that the OFL negatively affected pollutant removal in aerobic biofilm systems. High OFL levels resulted in a decrease in removal efficiency: 9.33% for chemical oxygen demand (COD), 18.57% for ammonium (NH 4 + -N), and 8.49% for total phosphorus (TP) after 35 days. The findings related to the chemical and biological properties of the biofilm revealed that the OFL exposure triggered oxidative stress and SOS responses, decreased the live cell number and extracellular polymeric substance content of biofilm, and altered bacterial community composition. More specifically, the relative abundance of key genera linked to COD (e.g., Rhodobacter ), NH 4 + -N (e.g., Nitrosomonas ), and TP (e.g., Dechlorimonas ) removal was decreased. Such the OFL-induced decrease of these genera might result in the down-regulation of carbon degradation ( amyA ), ammonia oxidation ( hao ), and phosphorus adsorption ( ppx ) functional genes. The conventional pollutants (COD, NH 4 + -N, and TP) removal was directly affected by biofilm resistance, functional genes, and bacterial community under OFL exposure, and the bacterial community played a more dominant role based on partial least-squares path model analysis. These findings will provide valuable insights into understanding how antibiotics impact the performance of aerobic biofilm systems during rural domestic sewage treatment.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
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IF 7.963
Boqiang Gao,Qianqian Chang,Hu Yang
A series of actinia-shaped lignin-based adsorbents (LNAEs) featuring lignin (LN) as the core and grafted poly(acrylic acid) (PAA) as the tentacle were designed and fabricated. Two fluoroquinolones (FQs) with similar molecular structures, ofloxacin (OFL) and ciprofloxacin (CIP), were used as targets to study the selective adsorption performance of LNAEs associated with the structural effects of the LN-based adsorbents in FQs binary aqueous system. The adsorption of the two FQs by LNAEs complied with the competitive Langmuir isothermal model, and showed selective removal of CIP over OFL due to the additional negative charge-assisted hydrogen bond (CAHB) formed between the carboxyl group of LNAEs and the secondary amino group of CIP, in addition to the effects of electrostatic attraction and normal hydrogen bonds, according to quantitative studies and density functional theory analysis. A binary nonlinear model based on phenomenological theory was applied to study the effects of PAA branched-chain length and distribution on the selective adsorption performance of the LN-based adsorbents. Accordingly, the branched-chain distribution played a more important role and higher distribution density of branched PAA could expose more adsorption sites on LNAEs' surface and improve the adsorptive selectivity . This study offers a well understanding of the structure–activity relationship of the surface grafting-modified adsorbents in binary pollutant systems and fundamental guidance for the exploitation and design of novel and efficient adsorbents.
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RSC Advances
·
2019
·Vol. 9
·期 48
·27953-27960
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IF 3.049
Zhian Sun,Huachun Liu,Yanqiang Zhou,Shanwen Zhao,Jianmin Li,Xiaoxiao Wang,Bolin Gong
A restricted access molecularly imprinted polymer (RAMIP) crosslinked with bovine serum albumin (BSA) was prepared on the surface of the mesoporous UiO-66-NH2 metal–organic framework (MOF). The surface morphology, imprinting behavior, and protein exclusion properties of UiO-66-NH2@RAMIP@BSA were investigated. The maximum adsorption capacity was 50.55 mg g−1 for ofloxacin, with a 99.4% protein exclusion rate. Adsorption equilibrium was reached in 9 min. Combined with RP-HPLC, a solid-phase extraction column filled with UiO-66-NH2@RAMIP@BSA was used to selectively enrich and analyze ofloxacin and enrofloxacin antibiotics from bovine serum with recoveries of 93.7–104.2% with relative standard deviations of 2.0–4.5% (n = 3). The linear range and the limit of detection were 0.1–100 μg mL−1 and 15.6 ng mL−1, respectively. These results suggest that UiO-66-NH2@RAMIP@BSA is an efficient pretreatment adsorbent for biological sample analysis.
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Journal of Water Process Engineering
·
2025
·
IF 6.7
Wei Qian,Yi-Li Deng,Xiao-Long Liu,Hui Liu,Mao-You Ye,Ying-Ying Li,Yong-Zheng Zhang,Zeng-Hui Diao,Jia-Lin Liang
Recently, pollution caused by the extensive use of ofloxacin (OFX) antibiotics has had a profound impact on human health and environmental ecosystems. Herein, two types of biochar materials, namely cobalt‑nitrogen and iron‑nitrogen co-doped modified peanut shell biochar (Co-N-BC and Fe-N-BC, respectively), were synthesized using a hydrothermal pyrolysis method and then employed to activate persulfate (PS) for OFX degradation. The results showed that Co/Fe and N atoms were successfully loaded onto the surface and inside the biochar. Under optimal conditions, the degradation rate of OFX by Co-N-BC/PS was 93.99 %, whereas that of Fe-N-BC/PS reached 77.37 % within 120 min. After three cycles, the OFX degradation rate remained notably high, exceeding 60 % for both the Co-N-BC/PS and Fe-N-BC/PS samples. Hydroxyl radicals, sulfate radicals, and singlet oxygen were involved in both systems during OFX degradation. Four pathways for OFX degradation were proposed for the Co-N-BC/PS system, whereas the Fe-N-BC/PS system included three pathways. The Toxicity Evaluation Software Tool (T.E.S.T.) estimation showed that the toxicity of the OFX degradation intermediates decreased after treatment with Co-N-BC/PS and Fe-N-BC/PS. Overall, this study showed that these novel biochar catalysts can provide a new direction for the purification of wastewater laden with OFX antibiotics.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Nguyen Trung Dung,Vu Dinh Thao,Nguyen Phuong Thao,Cao Thi Minh Thuy,Nguyen Hong Nam,Le Viet Ngan,Kun-Yi Andrew Lin,Ta Cong Khiem,Nguyen Nhat Huy
Biochar is an environmentally friendly material with various potential applications in water treatment. Herein, nitrogen and sulfur co-doped biochars (N,S-BCD-X) were fabricated from durian peel as an agricultural waste by coupling with thiourea via thermal treatment to activate peroxymonosulfate (PMS) for degradation of ofloxacin (OFX) in water. The OFX removal using PMS activated by N,S-BCD-800 was over 85 % after 120 min of reaction, which was 17.78 times higher than that by pure BCD. The OFX degradation was not inhibited over a wide pH range of 3 to 9. Through radical quenching tests, electron paramagnetic resonance, and DFT calculations, 1 O 2 was revealed as the key reactive species in the N,S-BCD-800/PMS system because of PMS’s elongated O-O bond-induced promoted generation of • OH and SO 4 • - with an insignificant contribution and the generation of 1 O 2 via various reactions associated with • OH, SO 4 • - , and PMS. The boosted catalytic activity of N,S-BCD-800 mainly came from synergetic effect of N and S co-doping due to the enhanced electron-donating capability caused by decrease in the work function. Furthermore, the increase in electrostatic potential and the difference in electron density and atomic charge could also account for stronger adsorption and activation of PMS on N,S-BCD-800 to generate more 1 O 2 besides the N,S-BCD-800/PMS complex as a minor species responsible for the degradation of OFX via electron transfer. Finally, the attainment of high efficiency of N,S-BCD/PMS for OFX degradation in various water matrices as well as after 5 cycles proved that N,S-BCD had high stability and applicability.
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RSC Advances
·
2015
·Vol. 5
·期 111
·91716-91722
·
IF 3.84
Xiujuan Guan,Xinyue Zhu,Bianfei Yu,Tong Zhao,Haixia Zhang
Nickel foam was firstly used as a solid phase microextraction support to prepare temperature sensitive molecularly imprinted polymers using ofloxacin molecules as the template. The fluorescence intensity could be observed by the naked eye under ultraviolet light after ofloxacin adsorption onto the new materials, which was positively proportional to the adsorbance. After adsorption had occurred, the significantly different fluorescence intensities distinguished the molecularly imprinted polymers from the corresponding non-molecularly imprinted polymers. A detailed evaluation was made by different characterization methods and various adsorption experiments. Finally, the molecularly imprinted polymer on nickel foam was used as an adsorbent in solid phase microextraction, coupled with high performance liquid chromatography, to detect ofloxacin, norfloxacin and enrofloxacin in Yellow River water, obtaining recoveries of 93.2 to 108.3% and limits of quantification of 0.014 to 0.020 μg mL−1.
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Journal of Physical Chemistry C
·
2025
·
IF 3.2
Xuan Liu,Yujie Yan,Feifei Guo,Liangliang Chang,Zengzhe Xi,Chunsheng Zhou
This study demonstrates a tripartite strategy to significantly enhance the piezo-photocatalytic degradation of ofloxacin (OFL) using modified BTO@BGFZ9 composite nanoparticles. Gd/Zr codoping optimizes the band structure and ferroelectricity of BFO, while heterojunction construction with BTO promotes interfacial charge separation. Corona poling treatment further aligns ferroelectric domains to amplify the piezoelectric field. The optimized 0.4BTO@BGFZ9 composite achieved 88.96% OFL degradation within 120 min under ultrasonic and visible-light synergy with a first-order rate constant of 0.0175 min–1. Mechanistic studies reveal that VO and a type-II heterojunction facilitate the generation of dominant reactive species (•O2– and h+), enabling efficient OFL mineralization via piperazine ring cleavage and defluorination.
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JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Shi-Wen Lv,Jing-Min Liu,Ning Zhao,Chun-Yang Li,Zhi-Hao Wang,Shuo Wang
Nowadays, designing highly active photocatalysts for pollutant degradation under visible light still remains a challenging problem. Herein, a novel benzothiadiazole functionalized Co-doped MOF-based photocatalyst with electron deficient unit was first synthesized via a feasible step-by-step assembly strategy. Benzothiadiazole, as typical electron deficient group, could effectively promote the separation and transfer of photoinduced charge carriers. The implantation of Co ion could be served as an effective mediator to further facilitate the charge transfer through a Co 3+ /Co 2+ redox pathway. Interestingly, the as-synthesized Co-MIL-53-NH-BT exhibited significantly enhanced photocatalytic degradation capacity for BPA and OFX under visible light irradiation, with removal efficiency as high as 99.9 % and 99.8 % within 120 min. TOC analysis suggested that majority of contaminants had been degraded into CO 2 and H 2 O. The important parameters influencing the photocatalytic activity were investigated, and the kinetics study was also conducted. The possible degradation pathways and the possible photocatalytic mechanism were proposed. More importantly, the as-synthesized Co-MIL-53-NH-BT showed good reusability, stability as well as universal applicability. To sum up, current work not only developed an efficient and visible-light active photocatalyst for treating organic-contaminated wastewater, but also afforded some novel insight into the utilization of benzothiadiazole in MOF-based photocatalyst towards improving photocatalytic activity.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jin Liu,Zhirui Fan,Wenzhe Zhao,Peipei Song
Recently, escalating antibiotics contamination in aquatic environments has become a critical global threat to public health. In this study, a novel cathode catalyst (NH 2 -MIL-101(Fe)@Mel-MoPc/BC) was fabricated via hydrothermal method for efficient degradation of ofloxacin (OFX) through an electro-activated peroxymonosulfate (PMS) system. The incorporation of Mo-C and Fe/Mo-N substantially enhanced the electrocatalytic performance. The influence of various parameters, including the internal mass ratio of the catalyst, current, PMS concentration, OFX concentration, pH, as well as electrolyte concentration and type on OFX degradation were systematically evaluated. Under optimal conditions, OFX degradation reached 92.6 %, with 84.2 % total organic carbon removal, outperforming previous studies. The free radical quenching experiment and electron paramagnetic resonance analysis identified singlet oxygen ( 1 O 2 ) as the dominant active species. In situ Raman spectroscopy, high performance liquid chromatography-mass spectrometry and density functional theory calculation elucidated the degradation mechanism and pathways of OFX, including demethylation, decarboxylation, hydroxylation, and dehydrogenation, ultimately forming water, carbon dioxide, and inorganic ions. Furthermore, computational toxicology and seed germination tests confirmed significantly reduced wastewater toxicity after treatment by electro-activated PMS system based on NH 2 -MIL-101(Fe)@Mel-MoPc/BC cathode. Additionally, it also exhibited superior cyclic stability and excellent performance in various real water matrices and for other organic pollutants such as Rhodamine B, phenol, tetracycline, and dimethyl phthalate, demonstrating great application potential. This work provides valuable insights into cathode catalyst design and establishes a sustainable technology for antibiotic wastewater treatment.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Zhiming Jiang,Guangyu Li,Mingxiao Zhang
A novel electrochemical sensor based on SH-β-cyclodextrin functionalized gold nanoparticles/reduced-graphene oxide (SH-β-CD/AuNPs/rGO) nanohybrids for ultrasensitive electrochemical sensing of acetaminophen and ofloxacin was developed. A SH-β-CD/AuNPs/rGO nanohybrids modified glassy carbon electrode (GCE) was successfully fabricated by one-pot electrochemical synthesis. The morphology and structure of the SH-β-CD/AuNPs/rGO/GCE were investigated by scanning electron microscopy (SEM) and fourier transform infrared (FT-IR). The conditions for the SH-β-CD/AuNPs/rGO/GCE preparation and the determination of acetaminophen and ofloxacin were discussed in detail. Under the optimized conditions, the differential pulse voltammograms (DPV) exhibited that the oxidation peak currents were linearly proportional to their concentrations in the range of 0.05–100 μM for acetaminophen and 0.01–10 μM for ofloxacin with high sensitivities of 0.26 μA μM –1 for acetaminophen and 0.28 μA μM –1 for ofloxacin, respectively. The detection limits of acetaminophen and ofloxacin were 0.03 μM and 0.008 μM ( S / N =3), respectively. This sensor was successfully used to detect the concentrations of acetaminophen and ofloxacin in pharmaceutical formulations and human urine samples. The results suggest that the SH-β-CD/AuNPs/rGO nanohybrids has a potential application for electroanalytical sensor.
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