Nano Research
·
2020
·Vol. 14
·期 1
·222-231
·
IF 8.183
Zhu Huimin,Cao Guodong,Fu Yike,Fang Chao,Chu Qiang,Li Xiang,Wu Yulian,Han Gaorong
Multidrug resistance (MDR) restricts chemotherapy efficacy due to P-glycoprotein (P-gp) mediated drug efflux, whereas current approaches to suppressing P-gp expression suffer from intrinsic challenges, such as low transfection, high toxicity and poor specificity. Here, hollow ferric-tannic acid complex nanocapsules (HFe-TA), which can be effectively degraded by the reaction with adenosine triphosphate (ATP), are synthesized for the delivery of glucose oxidase (GOx) and doxorubicin (DOX) for tumor treatment. The findings indicate that the intracellular ATP is significantly decreased due to the combined effect of HFe-TA degradation and GOx-mediated glucose consumption. Along with this ATP down-regulation, P-gp expression of tumor cells is suppressed remarkably, which in turn promotes the intracellular accumulation and anticancer efficacy of DOX. In addition, the production of OH by Fe ions released from HFe-TA is promoted by the by-products of the oxidation of glucose process by GOx. In consequence, HFe-TA nanocapsules loaded with DOX and GOx enable significant inhibition effect to tumors both in vitro and in vivo due to the synergistic effect of cascade reactions. This study has therefore provided an alternative therapeutic platform for effective tumor inhibition with the potential in overcoming intrinsic MDR.
研究领域:
纳米技术
·
药学
·
癌症研究
·
生物医学工程
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Shi-Wen Lv,Jialu Pan,Xiaoran Wang,Yifan Shao,Yanqing Cong,Lin Che
It is of great significance to establish an effective method for removing Cr(VI) from wastewater. Herein, Fe-doped g-C 3 N 4 (namely Fe-g–C 3 N 4 –2) was synthesized and then employed as photocatalyst to conduct the test of Cr(VI) reduction. Notably, the embedding of Fe ion in g-C 3 N 4 can offer the Fe 2+ /Fe 3+ redox couples, so reducing the interfacial resistance of charge transfer and suppressing the recombination of photogenerated electrons and holes. The impurity energy levels will form in g-C 3 N 4 after the introduction of Fe ion , thereby boosting the light absorption capacity of catalyst. Thus, Fe-g–C 3 N 4 –2 showed good performance in photocatalytic Cr(VI) reduction, and the reduction efficiency of Cr(VI) can reach 39.9% within 40 min. Different with many previous studies, current work unexpectedly found that the addition of p -benzoquinone (BQ) can promote the Cr(VI) reduction, and the reduction efficiency of Cr(VI) over Fe-g–C 3 N 4 –2 was as high as 93.2% in the presence of BQ (1.5 mM). Further analyses showed that BQ can be reduced to hydroquinone (HQ) by photogenerated electrons, and UV light can also directly induce BQ to generate HQ by using H 2 O as the hydrogen donor . The HQ with reducing ability can accelerate the Cr(VI) reduction. In short, current work shared some novel insights into photocatalytic Cr(VI) reduction in the presence of BQ. Future research should consider possible reactions between photogenerated electrons and BQ. For the UV-induced photocatalysis , the suitability of BQ as the scavenger of O 2 •‒ must be given carefully consideration.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Energy Advances
·
2024
·Vol. 3
·期 3
·654-663
·
IF 3.2
Xi Guo,Li Li,Shuo Wang,Huan Zhang,Yuzhen Kuang,Guangbin Duan,Bingqiang Cao
In situ growth of nano-arrays on substrate materials is a neoteric and efficacious catalyst design strategy, but it is still a difficulty to prepare unique nano-structured electrocatalysts with excellent activity for the oxygen evolution reaction (OER). In this study, phosphidizating ternary nickel/iron/cobalt hybrid nano-arrays (NiFeCo-P) with vertically staggered growth were successfully synthesized on the surface of nickel foam (NF) through three steps: impregnation, hydrothermal reaction and phosphidizating calcination. The initial ZIF-67/NF and the derived NiFeCo-layered double hydroxide (LDH)/NF nano-array (NiFeCo-LDH/NF) template promote the charge transfer and ion diffusion between electrolyte surfaces, which is attributed to the enhancement of the interface contact area of electrolyte ions. Phosphidizated NiFeCo-LDH/NF nano-arrays (NiFeCo-P/NF) showed lower overpotential of 251 and 278 mV at 50 mA cm−2 and 100 mA cm−2, respectively. The Tafel slope was 25.24 mV dec−1, which was better than the performance of some transition metal-based OER catalysts reported before. Electrochemical impedance spectroscopy further revealed the good kinetics in the electrolysis process. Furthermore, the high structural stability of the nanosheet array promotes the generation of the active phase in the OER process, so it has good stability after continuous operation for 20 h at a current density of 50 mA cm−2.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2024
·
IF 11.3
Zaixiang Xu,Fengcang Zhou,Hanchi Chen,Jianguo Wang
The regeneration of NAD(P)H and its analogues is crucial for biocatalytic processes. However, despite the efficiency of enzymatic catalysis in regenerating NAD(P)H, the sustainability of enzymes is often compromised, particularly under extreme catalytic conditions. Moreover, artificial cofactors may present advantages in certain reactions due to their stability and versatility, yet the substrate specificity of enzymes poses significant challenges to their regeneration through the enzymatic method. Therefore, it is imperative to develop a highly stable regeneration method that can be adapted to both natural and artificial cofactors. In this work, employing potassium-ion-doped carbon nitride (ionCN-0.2) as a catalyst not only achieves high-efficiency photocatalytic regeneration of NAD(P)H, comparable to that of glucose dehydrogenase (GDH), but also a remarkable ability to regenerate nicotinamide analogues. This enhanced performance stems from the tunable negative ζ-potential, which effectively adsorbs the positively charged [Cp*Rh(bpy)H2O]2+ mediator, resulting in enhanced regeneration kinetics of the nicotinamide moiety. The catalyst demonstrates superior performance compared to the reported systems; the optimal regeneration rate reaches 0.55 mmol L–1 gcat–1 min–1 and approaches enzymatic regeneration efficiency. Expanding the reaction conditions to a wider temperature and pH range also confirms the effectiveness and sufficient stability of this photocatalytic system, offering a promising strategy for stable cofactor regeneration in biocatalytic processes.
研究领域:
生物化学
·
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS & DESIGN
·
2020
·
IF 6.289
Yuxin Wang,Linlin Guan,Zhen He,Shengping Zhang,Harshpreet Singh,Muhammad Dilawer Hayat,Caizhen Yao
Aluminum often requires protective coatings to prevent corrosion. The aluminum alloy substrate usually needs pretreatment to minimize, stabilize or convert the surface oxide in order to achieve adequate coating adhesion. The electrodeposited Ni-P coating is a promising candidate as a protective coating due to its easy fabrication and excellent performance. This study comprehensively investigates the pretreatment of zincating and anodizing on 6061 aluminum alloy, and systematically discusses their influence on the electrodeposited Ni-P coatings. The crystal structure and elemental composition were investigated for interlayers and Ni-P coatings subsequently, while morphologies of the coating surface and cross-section were also determined. The results revealed similar phase composition for differently pretreated Ni-P coatings, while distinct nodule featured morphology was observed for anodized Ni-P coating. It was found that anodized Ni-P coatings had the best performance due to its superior coating adhesion, wear-resistance, and corrosion resistance. In contrast, severe wear damage was occurred to zincated Ni-P coatings due to its inferior microstructure and weak zinc interlayer. Lastly, the influence of anodizing pretreatment on the coating microstructure is discussed, and a model is proposed for Ni-P electrodeposition employing anodizing pretreatment.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Ming Li,Caiping Ding,Pengde Jia,Longhua Guo,Sui Wang,Zhiyong Guo,Fengmei Su,Youju Huang
p -Aminophenol (p-AP) is one of the common environmental pollutants with teratogenic effects, nephrotoxicity and genotoxicity. In this study, a novel colorimetric method for quickly, sensitive and on-site detection of p-AP was developed based on target induced etching of AuNRs, which will generate colorful color changes. Our investigation reveals that potassium iodate (KIO 3 ) can be reduced by p-AP to generate iodine (I 2 ), and I 2 can etch CTAB stabilized AuNRs along the longitudinal direction. As an emerging fascinating colorimetric material, LSPR extinction peak of AuNRs will shift to short wave direction with a color change from the initial tea red to brown, gray, dark green, cyan, blue, indigo, purple, purplish red and final pink. Under the optimal conditions, our strategy is analytically specific and sensitive for the detection of p-AP from 0.5 μM to 20 μM by the naked eye, and a detection limit of 0.27 μM was achieved. Meanwhile, this colorimetric method is used to detect p-AP in environmental water, paracetamol tablets and human urine. Hence, this proposed strategy has the advantages of rapid semi-quantitative analysis of p-AP with naked eyes, simple operation and good application prospect.
研究领域:
环境科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Liting Zheng,Shaoshuai Ma,Zihua Wang,Yunhui Shi,Qian Zhang,Xinhua Xu,Qiang Chen
This study accounts the controllable design over the structure and morphology of Ni-P nanomaterials directly growing on cellulose paper, and its excellent non-enzymatic electrocatalytic performance to urea. The Ni-P papers were prepared by simple solution soaking and electroless bathing. And the simple experimental steps and mild experimental conditions make it possible for large-scale industrial production, and potential for practical applications. In addition, tuning the pH and concentration of the electroless bath, the Ni-P nanomaterials with different morphologies of nanoflower , nanosheet , nanowire microsphere and microsphere were obtained. The Ni-P nanomaterials impart conductivity to cellulose paper while being potently sensitive to urea owing to its high catalytic activity. Cellulose paper has a large specific area and open macroporous framework which hadn't been damaged during the process of electroless bathing, providing much more activated sites for Ni-P deposition. And the prepared Ni-P papers, as composite materials of cellulose papers loading Ni-P nanomaterials, have high electrocatalytic properties to urea. Comparing the electrochemical behaviors of the four Ni-P paper electrodes with different morphologies, the Ni-P nanoflower paper electrode showed the best electrochemical performance with highest sensitivity of 683.46 μA mM −1 cm −2 in the low concentration range (0–1 mM) and 1140 μA mM −1 cm −2 in the high concentration range (1–11 mM), lowest detection limit of 12 μM, shortest response time of 3 s, which may owes to the highest surface area of the Ni-P nanoflower structure. It also has a good stability in room environment remaining 97% after 35 days of storage. Moreover, the electrocatalytic activities of the four Ni-P paper electrodes are ranked as follows: nanoflower > nanosheet > nanowire microsphere > microsphere. What's more, the long-term stability and repeatability, good selectivity of the flexible Ni-P paper make it successfully applied to swimming pool water quality monitoring.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS TODAY
·
2020
·
IF 5.825
Yang Yong,Gu Huajun,Zhang Qingxiao,Zhang Fang,Li Hui
In this paper, hollow Ni − P nanospheres (NSs) are prepared through Ni electroless plating on the Au-activated silica NSs externally covered by aminopropyl moieties, followed by removing the silica template with sodium hydroxide. With various characterizations, the resulting hollow Ni − P NSs are identified to be amorphous alloy. During liquid-phase hydrogenation of sugars to sugar alcohols, the hollow Ni − P amorphous alloy NSs delivered much superior catalytic performances to the commercial Raney Ni catalyst, showing a good potential in practical applications. Of particular interest is the unique hollow chamber structure of the hollow Ni − P amorphous alloy NSs, which allows for improving catalytic activity and durability relative to those associated with the dense Ni − P amorphous alloy NSs. This work demonstrated that such hollow Ni materials with nanoporous chamber structure displayed advantages such as easy experimental handling and high accessibility for the reactants in liquid-phase reaction, more Ni active sites, as well as the existence of more electron-enriched inner surface, which is essential to provide highly efficient catalysts for some reactions.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Materials Research Express
·
2022
·Vol. 9
·期 9
·095001
·
IF 2.025
Wanshu Yan,Pingping Hu,Yiguo Jiang,Xiuquan Xu,Xianfeng Ma,Mengru Wang,Xinyue Bao
Photocatalytic inactivation has been proved to be an effective strategy to eliminate pathogenic bacteria in water. Herein, a novel 0D/2D p-n heterojunction of Ag2S-anchored P-doped g-C3N4 (Ag2S/PCN) were constructed by a simple two-step process coupling one-pot calcination and ultrasonic-assisted synthesis. The photocatalytic performance of as-prepared Ag2S/PCN composites was investigated by inactivating multidrug-resistant E. coli under visible light irradiation. The results indicated that Ag2S/PCN-5 possessed outstanding photocatalytic inactivation activity and superior stability, which could completely inactivate 7.0 log E. coli cells within 60 min. The enhanced photocatalytic activity of Ag2S/PCN-5 was mainly attributed to the elevated visible-light response and improved production and transfer of photoexcited charges. In addition, the free radicals trapping experiments results revealed that h+ and •O2− were predominantly responsible for the efficient inactivation activity. Finally, according to the 0D/2D structure and energy band configuration analysis, the enhanced p-n type heterojunction photocatalytic inactivation mechanism of Ag2S/PCN was discussed in detail.
研究领域:
环境科学
·
微生物学
·
材料科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Qian Liu,Changdi Wang,Hao Wang,Lu Li,Xingrong Zhang,Ruiyang Zhao,Jishu Han,Lei Wang
Hydrogen energy produced through photocatalytic water splitting is widely recognized as a viable solution to the depletion of non-renewable energy resources and ecological contamination concerns. This work designed and synthesized the MOF-derived hollow octahedral Co x P/MOF-801 p-n heterojunction photocatalyst . According to the result of hydrogen production test, the hydrogen production amount of Co x P/MOF-801-2 could reach 25.31 mmol g −1 under light irradiation for 5 h. The hollow octahedral structure and p-n heterojunction of the photocatalyst helped to enhance the light trapping ability and promote carrier transfer, resulting in improved performance of photocatalytic hydrogen production. To sum up, the design of hollow octahedral Co x P/MOF-801 photocatalyst effectively improved the photocatalytic hydrogen production performance.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
·
2020
·Vol. 97
·期 3
·289-300
·
IF 1.659
Hardy Z. Castada,Zhaoyu Sun,Sheryl A. Barringer,Xuesong Huang
p -Hydroxybenzoic acid (PHBA) plays a significant role in sustaining the oxidative stability of macadamia nut oil (MNO). However, PHBA undergoes thermal decarboxylation and loses its bioactive antioxidant properties. In this study, we determine PHBA degradation kinetics in oils at various heating temperatures, which provides fundamental understanding of PHBA thermal degradation in oils and oil quality changes during high-temperature processing. PHBA degradation kinetics in MNO, olive oil, and corn oil were evaluated at temperatures typical for cooking and frying. PBHA headspace concentration was measured using selected ion flow tube mass spectrometry. PHBA decarboxylation followed a zero-order reaction, where degradation could be affected by factors such as the type of oil matrix having different FA compositions, antioxidants, and component interactions. PHBA degradation activation energies ( E a ) showed that PHBA was more stable against thermal decarboxylation in MNO (85 kJ mol –1 ) than in olive oil (40 kJ mol −1 ) or corn oil (22 kJ mol −1 ). The higher enthalpy ( ) of decarboxylation in MNO (82 kJ mol −1 ) indicates that PHBA is more inhibited from decomposition than olive oil (37 kJ mol −1 ) or corn oil (19 kJ mol −1 ). Moreover, the negative entropy values ( ) of PHBA degradation from MNO (−192 J mol −1 K −1 ), olive oil (−277 J mol −1 K −1 ), and corn oil (−325 J mol −1 K −1 ) indicates that these oils impart some inhibitory properties against PHBA thermal decarboxylation.
研究领域:
食品科学
·
化学动力学
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2021
·
IF 13.084
Binbin Zhou,Weihui Ou,Junda Shen,Chenghao Zhao,Jing Zhong,Peng Du,Haidong Bian,Pan Li,Liangbao Yang,Jian Lu,Yang Yang Li
Plasmon-mediated chemical reactions (PMCRs) possess desirable opportunities for manipulating the reaction outcomes due to the unique impact from surface plasmons. However, achieving PMCR product selectivity by tuning the light wavelength has rarely been demonstrated and the underlying mechanism of product selectivity remains elusive. This work studies the reaction mechanism of one classical type of PMCR, plasmon-aided reduction of p-nitrothiophenol (PNTP), and discovers that the reduction product of PNTP can be easily manipulated by adjusting the excitation light wavelength due to the different thermal and hot-electron effects induced by the different wavelengths. Specifically, the sole product of p,p′-dimercaptoazobenzene is obtained under 514 nm light due to the dominant thermal effect thus created, whereas p-aminothiophenol is more favorably produced under 785 nm light, which enables more efficient generation of hot electrons.
研究领域:
物理化学
·
纳米光学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）