Journal of Coatings Technology and Research
·
2025
·
IF 2.8
Ran Ke,Kang Fenghua,Zhou Wentao,Zhang Ziyuan,Li Yintao,He Zhiyu
The widely used indicator, 2-(5-bromo-2-pyridylazo)− 5-diethylaminophenol (Br-PADAP), can enable color tracing of radioactive contaminants when incorporated into strippable decontamination materials. However, its practical application is hindered by poor dispersion in aqueous substrates. To address this issue, this study prepared an amphiphilic diblock copolymer, PEA-b-PAA, using a one-pot synthesis method. Ethyl acrylate (EA) and acrylic acid (AA) were used as monomers, with S,S,S-trisulfanyl dibenzyl carbonate (DBTTC) serving as the initiator for reversible addition-fragmentation chain transfer (RAFT) polymerization. Test results demonstrated that block copolymers with EA:AA monomer ratios of 2:1, 1.5:1, and 1:1 effectively dispersed and stabilized the Br-PADAP indicator. Among these, the copolymer with a 1.5:1 monomer ratio, added at a concentration of 4%, improved the mechanical properties of the peelable decontamination material without compromising the color tracing function of Br-PADAP. This enhancement facilitates practical applications by enabling incorporation into aqueous peelable substrates, while maintaining the indicator’s color development mechanism. The resulting materials exhibit both effective decontamination and reliable color tracing capabilities.
研究领域:
高分子化学
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材料科学
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环境科学
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核技术
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DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2024
·
IF 8.1
Xiaolu Chen,Mingen Ding,Chuan Yang,Wei Zhang,Hao Deng,Dawei Yan,Haohao Ren,Yonggang Yan
Developing biomaterials with high osteogenic activity and mechanical properties comparable to cortical bone is critical for repairing load-bearing bone defects. Poly(amino acid) (PAA), with its excellent biocompatibility and collagen-like structure, shows great potential as a biomaterial. In this study, PAA was synthesized via melt copolymerization, and bioactive glass (BG) with high osteogenic activity was uniformly dispersed in the PAA matrix using solution co-deposition. High-strength quartz fibers (QF) were added to form PAA/BG/QF composites. Amongst, the P/20BG-20QF composite exhibited bending strength (174.7 MPa), bending modulus (8.8 GPa), compressive strength (135.1 MPa) and compressive modulus (3.7 GPa) comparable to the lower range of cortical bone. In vitro analysis showed low degradation (1.1 %), optimal pH (7.2) and no surface cracks, indicating lasting stability. Cell compatibility tests and osteogenic gene expression further confirmed the potential of P/20BG-20QF composites as implants for low-load-bearing bone defect repair.
研究领域:
生物材料
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组织工程
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材料科学
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生物医学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Zhenglin Chen,Jiaqi Yang,Zhicheng Du,Jiansong Ji,Likun Zhang,Haifei Guan,Zhengyang Lei,Xiaopeng Zhang,Canhui Yang,Ying Zhu,Qianhui Sun,Lulu Xu,Ke Lin,Yuchen Wang,Chuhui Wang,Chong Zhang,Dongmei Yu,Peiwu Qin,Can Yang Zhang
In the realm of flexible wearable electronics and interactive technologies, the adhesive and touch-sensing properties of materials play a crucial role, especially soft ionic conductors. However, these materials face several challenges in practical application, including structural damage, loss of functionality, and device stratification, particularly in extreme environments. To address this, a novel multifunctional organic hydrogel, termed PC-OH, was designed and prepared to enhance its performance. The hydrogel exhibits self-adhesion, self-healing, anti-freezing, anti-drying, and conductive capabilities. It demonstrates outstanding self-adhesive properties on skin surfaces under air (approximately 967 J/m2) or underwater (approximately 428 J/m 2 ) conditions, with high transparency (visible light transmittance of 87 %), anti-freezing capability (−60 °C), anti-drying capability (60 °C), rapid self-healing in air or water (within 4 s), long-term stability over a wide temperature range (−20 °C to 60 °C for up to 7 days), high extensibility (up to ∼1700 % at 60 °C and ∼1200 % at −20 °C), and conductivity over a broad temperature range (ionic conductivity of 1.93 S m −1 at 60 °C and 3.13 × 10 -3 S m −1 at −30 °C). Based on these properties of PC-OH hydrogel, we constructed a capacitive touch system to demonstrate its practical application. The touch panel features high stretchability, transparency, anti-freezing, anti-dehydration, self-healing, and self-adhesive human–machine interface capabilities, enabling integration with the skin under abnormal temperature and humidity conditions. Tasks such as writing text, drawing graphics, and playing electronic games validated the significant potential of the hydrogel in touch panels, providing a solution to long-standing issues of adhesion and tactile sensing.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 91
·88306-88314
·
IF 3.289
Ping Yong,Yuejiao Yang,Zhiyong Wang,Liming Yang,Jie Chen
A thermo- and dual-pH-sensitive ABC triblock copolymer composed of poly(N-isopropylacrylamide)-block-poly(acrylic acid)-block-poly(4-vinyl pyridine) (PNIPAM-b-PAA-b-P4VP, NAV) was synthesized via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization and subsequent hydrolysis. NAV, which had the property of multi-stimuli, containing thermo-sensitive PNIPAM block and opposite pH-sensitive PAA and P4VP blocks, formed diverse nanostructures in an aqueous solution by varying the temperature and pH. Nanostructures including large compound micelles (LCMs), vesicles, spherical micelles and 3D topologies were observed using dynamic light scattering (DLS) and transmission electron microscopy (TEM). More significantly, the solation–gelation behaviour and morphology of the NAV system induced by temperature and pH were investigated by rheology and scanning electron microscopy (SEM), respectively. TEM and SEM revealed that the gelation behaviour of NAV resulted from the bridge effect of the ionized PAA chains between the hydrophobic P4VP cores (V-core) and PNIPAM cores (N-core) over the LCST of PNIPAM. The results obtained from the rheology measurements showed that the gelation temperature was independent of alkaline pH, but slightly tuned by the copolymer concentration or pH (only 6 to 7). Repeated sol–gel transition via temperature changes under alkaline conditions showed the good hydrogel recyclability of NAV.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2020
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IF 4.389
Fan Gao,Hongjun Zhou,Zhichuan Shen,Guowei Zhu,Li Hao,Huayao Chen,Hua Xu,Xinhua Zhou
Tea tree oil (TTO) is an efficient natural antibacterial agent. However, the bacteriostatic effect of TTO does not prevail for a long period because of the volatile nature of the oil. Therefore, a novel sustained-release formulation of TTO should be developed for improving the applicability of TTO. Herein, the mesoporous silica was selected for constructing a carrier for TTO. Mesoporous silica is non-toxic, easy to modify and exhibited an adjustable pore size. First, the mesoporous silica was modified by an aminated silane coupling agent (NH 2 -MCM-41). Then, the polyacrylic acid (PAA) was bonded by electrostatic bonds (PAA-NH 2 -MCM-41), which imparted the sustained-release effect in the TTO, supported in the mesoporous silica channel (TTO/PAA-NH 2 -MCM-41). The prepared bacteriostatic agent can achieve long-term sustained-release properties. At room temperature (26 ℃), the release rate of TTO after 11 h release reached 50 %. However, the release rate of TTO from TTO/PAA-NH 2 -MCM-8 reached only 42 % after 24 h. Furthermore, the sustained release behavior of TTO/PAA-NH 2 -MCM-41 was consistent with the Korsmeyer-Peppas kinetic model. Compared to TTO, TTO/PAA-NH 2 -MCM-41 exhibited a stable and sustained bacteriostatic effect even after 50 days in a natural environment. The minimum inhibitory concentration (MIC) value of the TTO/PAA-NH 2 -MCM-41 against Escherichia coli ( E. coli ) was 0.37∼0.44 mg/mL. TTO altered the cell morphology of E. coli and broke the integrity of the cell membrane, leading to cell death.
研究领域:
材料科学
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微生物学
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药物递送
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DOI
PubMed
高影响因子
STARCH-STARKE
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2020
·
IF 2.226
Yadi Huang,Juan Wu,Shengsong Deng,Fenghe Li,Xialing Bian,Xiaowen Li,Risheng Yao
Polymer nanoparticles have made progress in pharmaceutical nanotechnologies due to their efficient drug delivery. However, considerable amounts of surfactant are required during polymerization, which inevitably brings some potential problems. Herein, template polymerization is utilized to synthesize polyacrylic acid/soluble starch (PAA/SS) complex nanoparticles by surfactant-free polymerization. As a template, soluble starch (S-starch, SS) nanoparticles are obtained by nanoprecipitation due to their polyhydroxy structure. The resultant complex nanoparticles with pH sensitivity have core–shell structures, which facilitates their use as nanoparticles in preparation of gelatin-like materials. Another interesting property of PAA/SS complex nanoparticles is that the SS template can be removed by α-amylase, then PAA nanocapsules are obtained. A hypothesis for the mechanisms of PAA/SS complex nanoparticles formation and PAA nanocapsules preparation with α-amylase is also proposed.
研究领域:
药物纳米技术
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高分子化学
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材料科学
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DOI
高影响因子
PROCESS BIOCHEMISTRY
·
2024
·
IF 3.7
Pengpeng Cheng,Zhenyu He,Bo Liu,Jinmei Wang,Chuyue Zhang,Lan Tang,Lihua Du,Yuan Lu,Zhimin Ou
Nano-bienzyme conjugates (nano-BECs) for catalysing one-pot reactions can simplify the reaction process and improve the efficiency of biocatalytic reactions. In this work glucose dehydrogenase (GDH) and Candida parapsilosis secondary alcohol dehydrogenase (CpSADH) were immobilised with polyacrylic acid (PAA) to form two types of PAA-based nano-BECs (2-S, 2-P), which achieved in situ regeneration of NADH for the production of chiral alcohols in oil-water biphasic systems, such as the key chiral pharmaceutical intermediate of ( S )-1-(3-trifluoromethylphenyl)ethanol (( S )-TMPE). At a substrate concentration of 100 mM 3-trifluoromethylacetophenone (TMAP), the conversion catalyzed by nano BEC was 98.2 % in dipentyl phthalate-phosphate buffer biphasic system. In contrast, the conversion was only 39.5 % and 38.9 % in the PB buffer and 8.4 % and 7.7 % in dipentyl phthalate system. The experiments on kinetic constants demonstrated that the catalytic efficiencies (K cat /K m ) of nano-BECs (2-S, 2-P) were enhanced by 6.7-fold and 7-fold, respectively, compared to free CpSADH. Additionally, nano-BECs showed stronger coenzyme regeneration ability. Under optimal reaction conditions, nano-BECs achieved 96.2 % conversion of TMAP to ( S )-TMPE in an organic-buffer system with e.e. > 99.6 % at 300 mM substrate concentration. This research expands the potential applications of polymers and proteins, and offers valuable insights into the synergistic effects of PAA on bienzyme catalytic systems in biocatalysis.
研究领域:
生物催化
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药物化学
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材料科学
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酶学
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DOI
高影响因子
Materials
·
2018
·Vol. 11
·期 2
·247
·
IF 2.467
Quanguo He,Jun Liu,Jing Liang,Xiaopeng Liu,Du Tuo,Wen Li
Solubility parameter-dependent drug releasing property is essential in practical drug delivery systems (DDS), and how to combine magnetic nanoparticles(NPs) and suitable polymer coating towards DDS is always a crucial and valuable challenge in biomedical application. Herein, a controllable drug delivery model with a surface having a chemically tunable solubility parameter is presented using hollow magnetite/polyacrylic acid (Fe3O4/PAA) nanocomposites as nanocarrier towards DDS. This composite is prepared by simply coating the modified hollow Fe3O4with PAA. The coating amount of PAA onto the surface of Fe3O4(measured by TGA) is about 40% (w/w). Then, Rhodamine 6G (R6G) is selected as model drug in drug delivery experiment. The efficiency of drug loading and drug release of these Fe3O4/PAA nanocarriers are evaluated under various temperature, solvent and pH values. As a result, the best drug releasing rate was achieved as 93.0% in pH = 7.4 PBS solution after 14 h. The releasing efficiency is 86.5% in acidic condition, while a lower releasing rate (30.0%) is obtained in aqueous solution, as different forms (polyacrylic acid and polyacrylate) of PAA present different solubility parameters, causing different salt and acid effects in various solvents, swelling property of PAA, and binding force between PAA and R6G. Therefore, by changing the solubility parameter of coating polymers, the drug delivery properties could be effectively tuned. These findings prove that the DDS based on magnetic particle cores and polymer encapsulation could efficiently regulate the drug delivery properties by tuning surface solubility parameter in potential cancer targeting and therapy.Keywords:hollow Fe3O4NPs;Fe3O4/PAA composite NPs;solubility parameter;controlled release;drug delivery systems
研究领域:
材料科学
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生物医学工程
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药学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Gaocan Qi,Kaiyue Guo,Jie Yang,Yuhang Wang,Ziyu Wang,Zhihao Yuan
The practical application of filter membranes for oil–water separation requires high efficient, large flux and excellent stability. Hydrogel membrane with superhydrophilicity and underwater superoleophobicity has been considered as an ideal material for efficient separation of oil–water mixture. However, hydrogel materials are generally fragile and easy to dehydrate. In this work, inorganic CuO oriented-rods framework was used to support water-adsorbent polyacrylic acid (PAA) resin for constructing superhydrophilic-superoleophobic composite hydrogel membrane. The as-prepared composite membrane displayed stable underwater superoleophobicity during swelling-drying cycles and abrasion test. In “bottom-injection” filter apparatus, the CuO@PAA membrane exhibited high separation efficiencies, above 99.90%, for kerosene-water, hexadecane-water, soybean oil–water and rapeseed oil–water mixtures with water penetration fluxes larger than 5700 L•m −2 •h −1 . The excellent separation efficiency and flux were capable of maintaining for 200 separation processes. This work paved the way for designing and constructing economical and practical oil–water separation equipment for industrial application.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
GIANT
·
2023
·
IF 7
Caihong Zhang,Weijie Wang,Pengfei Zhang,Shuguang Yang
Complexation between polymers of different species in a common solvent is a fundamental process in various applications such as functional polymeric membrane and drug delivery, yet the understanding of energetics, phase behaviors, and kinetics of polymer complexation is rather challenging partially due to the multi-component nature of the system. In this work, we investigate the hydrogen-bonding complexation of poly(acrylic acid) (PAA) and poly(vinylpyrrolidone) (PVPON) in different solvents, and identify a variety of phase states, including homogenous solution, solid precipitate, liquid–liquid separation, gelation, and kinetically trapped structures. Among different solvents, N -methyl-2-pyrrolidone (NMP) has a similar structure to the repeating unit of PVPON and the complexation in NMP almost has no heat, suggesting the process is driven by entropy. The PAA/PVPON-NMP system exhibits an upper critical solution temperature; specifically, as the temperature decreases, a homogeneous solution first becomes opalescent, then undergoes a liquid–liquid separation, and finally undergoes a liquid–gel separation. On the other hand, when the polymer concentration is above a threshold, a homogenous solution turns into a gel directly without involving liquid–liquid separation with decreasing temperature. Accordingly, we construct a temperature–concentration phase diagram that shows how the gelation interplays with coacervation. This work provides a broad vision on phase behaviors of polymer complexation.
研究领域:
高分子科学
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材料科学
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物理化学
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产品关联
DOI
高影响因子
TRIBOLOGY INTERNATIONAL
·
2020
·
IF 4.271
Yuntong Liu,Dangsheng Xiong,Xiaoduo Zhao
To improve the contact mode of artificial joints and their tribological performance , inspired by the ‘soft-on-hard’ structure of ‘cartilage-subchondral bone’ as well as negatively charged characteristic of the cartilage surface with brush-like molecules, a polyetheretherketone (PEEK)-hydrogel composite structure with negatively charged surface adsorbing cationic molecules through electrostatic interaction was designed and fabricated. Characterization results demonstrated that polyacrylic acid (PAA) hydrogel strengthened by polyvinyl alcohol (PVA) microcrystals was successfully fabricated on the PEEK substrate through ultra-violet (UV) radiation. Adsorption of cationic monomers was also confirmed. The PEEK-hydrogel composite structure had significantly reduced friction coefficient , ~80% lower than that of PEEK, owing to the synergistic effect of biphasic and boundary lubrication . This work proposes a novel route to develop the friction surface of artificial joints with advanced performance and contributes to the understanding of lubrication mechanism of artificial joints.
研究领域:
生物材料
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摩擦学
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生物医学工程
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材料科学
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产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2026
·Vol. 26
·期 8
·e70242
·
IF 4.2
Linhan Hu,Zheng Yang,Xinwei Tao,Bowen Ren,Tianle Zhou,Jianliang Li,Huaping Tan,Xiaohong Hu
Hydrogel-based dressings are widely used in wound healing. Herein, we report a polyacrylic acid (PAA)/polyvinyl alcohol (PVA) composite hydrogel fabricated via self-catalyzed free radical polymerization, with borax serving as the reinforcing phase. Meanwhile, metal-ligand coordination bonding between tannic acid (TA) and Fe 3 + further elevates the crosslinking density of the hydrogel network. Magnetic chitosan microspheres (MCMs) were synthesized by emulsion cross-linking and loaded with two antibacterial agents, namely tetracycline hydrochloride (TH) and berberine hydrochloride (Bbh). The incorporation of MCMs into the hydrogel matrix resulted in the development of a multifunctional composite hydrogel suitable for wound dressing applications. Results demonstrated that the composite hydrogel containing a specific concentration of 4‰ (w/v) borax and 20 mg/mL MCMs exhibited superior performance, including enhanced mechanical strength, improved responsiveness, sustained drug release, and potent antibacterial efficacy. The core novelty of this work lies in the synergistic integration of borax-based mechanical reinforcement, MCM-mediated dual drug loading and sustained release, and the self-catalyzed polymerization system. This innovative structural and functional collaboration effectively optimizes the mechanical stability of the hydrogel dressing and achieves synergistic antibacterial and intelligent responsive therapeutic performances, providing a reliable and high-efficiency candidate for advanced wound care and next-generation wound dressing applications.
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DOI
高影响因子
危险品化学品经营许可证（带存储）