ENERGY
·
2023
·
IF 9
Lin Qiu,Kening Yan,Yanhui Feng,Xianglei Liu
The low thermal conductivity and easy leakage of phase change materials are the shortcomings that hinder their further application for thermal energy storage . It is crucial how to properly match skeleton materials and phases to improve heat transfer in order to solve the above problem. Here, we systematically investigate the effects of nano additives on the phase change and thermal properties of bionic hierarchical porous aluminum nitride-polyethylene glycol (PEG/AlN) composites. Alumina (Al 2 O 3 ) nanoparticles were found to have the largest enhancement effect for the thermal conductivity of PEG (84% for 4 wt% addition) compared to silica , titanium dioxide, and boron nitride . For these additives, the thermal conductivity and stability of the nano additives-enhanced PEG increase with the increase of their mass fraction. After 100 heating/cooling cycles, the thermal response curve shows that the Al 2 O 3 -enhanced PEG can maintain the phase transition behavior, and the measured phase transition temperature agrees well with the differential scanning calorimeter results. The thermal conductivity of the PEG/AlN enhanced with 4 wt% Al 2 O 3 is 20.41 W/m·K, and the melting point and phase change enthalpy are 55.93 °C and 81.05 J/g. In addition to the great improvement in thermal response, the heat storage rate also increases by 36.10%.
研究领域:
材料科学
·
热能工程
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 37
·e04026
·
IF 2
Hongwei Li,Zhibin Liu,Pengju Lei,Jichong Xia,Shoudeng Wang,Guixian Li,Xinhong Zhao,Dong ji
A PEG-400-assisted impregnation-precipitation method synthesized 50 wt% Ni/AC catalysts for dinitrotoluene (DNT) hydrogenation. Optimal PEG-400 dosage (0.4 g) suppressed Ni agglomeration via steric hindrance, yielding uniform 10.9-nm Ni nanoparticles and mesopores (12.24 nm). This enhanced dispersion and mass transfer, achieving complete DNT conversion in 5 min under mild conditions (120 °C, 2.1 MPa H 2 ) with 99.99% TDA selectivity and zero tar. The catalyst retained > 95.5% conversion and > 97.3% selectivity over 10 cycles, demonstrating exceptional stability. PEG's dual role in structural control and pore engineering effectively addresses the dispersion challenges inherent to high-loading catalysts. Graphical PEG-400 directs the synthesis of a 50 wt% Ni/AC catalyst via impregnation-precipitation. Optimal PEG dosage (0.4 g) enables steric hindrance control, yielding uniform 10.9-nm Ni nanoparticles and mesopores. This catalyst achieves complete DNT hydrogenation to TDA in 5 min (120 °C; 2.1 MPa H 2 ) with > 99.99% selectivity and zero tar, retaining high performance over 10 cycles.
研究领域:
催化化学
·
材料化学
·
化学工程
·
纳米催化
·
有机合成
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2022
·
IF 7.033
Yanan Shi,Wan Huang,Rongcai Liang,Kaoxiang Sun,Fangxi Zhang,Wanhui Liu,Youxin Li
To improve the pharmacokinetics and stability of recombinant human erythropoietin (rhEPO), rhEPO was successfully formulated into poly(ethylene glycol)–poly(d,l-lactide) (PEG–PLA) di-block copolymeric micelles at diameters ranging from 60 to 200 nm with narrow polydispersity indices (PDIs; PDI < 0.3) and trace amount of protein aggregation. The zeta potential of the spherical micelles was in the range of −3.78 to 4.65 mV and the highest encapsulation efficiency of rhEPO in the PEG–PLA micelles was about 80%. In vitro release profiles indicated that the stability of rhEPO in the micelles was improved significantly and only a trace amount of aggregate was found. Pharmacokinetic studies in rats showed highly enhanced plasma retention time of the rhEPO-loaded PEG-PLA micelles in comparison with the native rhEPO group. Increased hemoglobin concentrations were also found in the rat study. Native polyacrylamide gel electrophoresis results demonstrated that rhEPO was successfully encapsulated into the micelles, which was stable in phosphate buffered saline with different pHs and concentrations of NaCl. Therefore, PEG–PLA micelles can be a potential protein drug delivery system.
研究领域:
药学
·
生物技术
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Fangqian Sui,Zengjun Fang,Lingjun Li,Xinhuan Wan,Yongqing Zhang,Xiaoqing Cai
Multifunctional nanoparticles have attracted significant attentions for oncology and cancer treatment. In fact, they could address critical point for tumour treatment by creating a stimuli-responsive targeted drug delivery system that can exist stably in the systemic circulation, efficiently penetrate the tumour tissue, and then accumulate in tumour cells in large quantities. A novel stepwise pH-responsive multifunctional nanoparticles (FPDPCNPs/DTX) for targeted delivery of the antitumour drug docetaxel (DTX) is prepared by coating a tumour acidity-sensitive “sheddable” FA modified β-carboxylic amide functionalized PEG layer (folic acid-polyethylene glycol-2,3-dimethylmaleic anhydride, FA-PEG-DA) on the cationic drug-loaded core (poly(β-amino ester-cholesterol, PAE-Chol) through electrostatic interaction in this study. The charge shielding behaviour of the FPDPCNPs/DTX was confirmed by zeta potential assay. The surface charges of the nanoparticles can change from positive to negative after PEG coating. The IC 50 values of FPDPCNPs/DTX was 3.04 times higher than that of PEG “unsheddable” nanoparticles in cytotoxicity experiments. The results of in vivo experiment further showed that FPDPCNPs/DTX had enhanced tumour targeting effect, the tumour inhibition rate of FPDPCNPs/DTX was as high as 81.99%, which was 1.51 times that of free DTX. Under a micro acidic environment and folate receptor (FR)-mediated targeting, FPDPCNPs/DTX contributed to more uptake of DTX by MCF-7 cells. In summary, FPDPCNPs/DTX as a multifunctional nano-drug delivery system provides a promising strategy for efficiently delivering antitumour drugs.
研究领域:
肿瘤学
·
癌症治疗
·
药物递送系统
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xin-zheng Jin,Zhen-yu Yang,Chen-hui Huang,Jing-hui Yang,Yong Wang
Recently, the miniaturization of microelectronics has proposed a more urgent demand for the multi-functionalization of packaging materials. Here, a PEDOT:PSS/MXene/PEG composite, which is prepared by vertical directional freezing and vacuum infiltrating, integrates the function of heat management & EMI shielding into single packaging material. The melting & cooling enthalpy (237.6 & 236.1 J g −1 ) and the phase transition temperature of composite are enhanced synchronously for the first time. The zigzag modification of polyethylene glycol (PEG) crystal is induced by poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). The rest of crystal with (7/2) helix conformation packs preferentially along the (1 2 0) plane. The stability of the melting composite is enhanced. The PEG leakage is less than 0.66 %, and over 80 % dimension is maintained under the pressure of 1.88 kPa. The composite shows excellent photo-thermal (η = 94.9 %) and electro-thermal (t η = 7.86) conversion performances. The EMI shielding mechanism is reflection-dominated and the total EMI shielding effectiveness (SE T ) of composite is 29.8 dB at the framework content as low as 1.22 wt%, which is the relatively low filler content and the highest enthalpy efficiency among the reported composites with the equivalent SE T . The HF-band shielding capability of composite is verified by the Tesla kit. The assembled heterogeneous asynchrony photo-thermal-electric conversion system identifies its potential application on photo-thermal converters and heat buff. The HF-band & X-band (Sub-6G) EM waves shielding and heat management in microelectronics can be achieved simultaneously by applying this composite.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Weiqian Wu,Ruilai Liu,Jiahao Guo,Zhihuan Hu,Chenjing An,Yan Zhang,Tengyuan Liu,Lian Cen,Yukun Pan
The high hydrophobicity and low oral availability of immunosuppressive drug, rapamycin, seriously limit its application. It was thus aimed to develop a PEG-PLGA based nano-loading system for rapamycin delivery to achieve improved bioavailability with sustained effects via a novel microfluidic chip and manipulation of the hydrophobic PLGA chain length. PDMS based microfluidic chip with Y shape was designed and PEG-PLGA polymers with different PLGA chain length were used to prepare rapamycin nano-delivery systems. Dendritic cells were selected to evaluate the immunosuppressive effect of the nanoparticles including cytotoxicity assay, dendritic cell activation, and cytokine levels. The effects of different PEG-PLGA nanoparticles on the immunomodulatory properties were finally compared. It was shown that PEG-PLGA could be successfully used for rapamycin encapsulation via microfluidics to obtain nano-delivery systems (Rapa&P-20 k, Rapa&P-50 k and Rapa&P-95 k) ranging from 100 nm to 116 nm. The encapsulation efficiency was ranged from 69.70% to 84.55% and drug loading from 10.45% to 12.68%. The Rapa&P-50 k (PLGA chain length: 50 k) could achieve the highest drug loading (DL) and encapsulation efficiency (EE) as 12.68% and 84.55%. The encapsulated rapamycin could be gradually released from three nanoparticles for more than 1 month without any noticeable burst release. The Rapa & P nanoparticles exhibited enhanced immunosuppressive effects over those of free rapamycin as shown by the expression of CD40 and CD80, and the secretion of IL-1β, IL-12 and TGF-β1. Rapa&P-50 k nanoparticles could be the optimal choice for rapamycin delivery as it also achieved the most effective immunosuppressive property. Hence, this study could provide an efficient technology with superior manipulation to offer a solution for rapamycin delivery and clinical application.
研究领域:
药学
·
纳米技术
·
免疫学
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
Therapeutic Delivery
·
2018
·Vol. 9
·期 4
·
IF 0
Ya Xiao,Jiajia Huang,Jiajia Xu,Liuwei Zeng,Jiaran Tian,Yunru Lou,Yuxue Liu,Bo Hu,Fei Tong,Ruilin Shen
Aim: To synthesize a puerarin nanoparticle based on glycyrrhetinic acid (GA)-PEG-PBLA and evaluate it in vivo. Materials & methods: In this study, drug nanoparticle was synthesized, characterized and assessed as puerarin delivery system. Nanoparticle GA-PEG-PBLA could combine with puerarin via hydrophobic interaction to form the compound. Puerarin could be quickly and efficiently loaded via the nanoparticle GA-PEG-PBLA at pH 7.4. Further, GA-PEG-PBLA-mediated puerarin delivery system could target for the liver that had GA receptor binding. The antiliver ischemia/reperfusion injury role of puerarin/GA-PEG-PBLA was measured in rats using free puerarin and puerarin/PEG-PBLA as the controls. Results: GA-PEG-PBLA displayed efficient loading and sustained release. Puerarin/GA-PEG-PBLA showed strengthened antiliver ischemia/reperfusion injury characteristics. Conclusion: Overall, the results show that GA-PEG-PBLA could be regarded as an underlying puerarin nanoparticle.
研究领域:
药理学
·
肝脏病学
✓ 已验证
产品关联
DOI
PubMed
Nature Communications
·
2019
·Vol. 10
·期 1
·1-8
·
IF 11.878
Liu Kairui,Hou Guangjin,Mao Jingbo,Xu Zhanwei,Yan Peifang,Li Huixiang,Guo Xinwen,Bai Shi,Zhang Z. Conrad
While numerous single atoms stabilized by support surfaces have been reported, the synthesis of in-situ reduced discrete metal atoms weakly coordinated and stabilized in liquid media is a more challenging goal. We report the genesis of mononuclear electron deficient Pt 1 (0) by reducing H 2 PtCl 6 in liquid polydimethylsiloxane-polyethylene glycol (PDMS-PEG) (Pt 1 @PDMS-PEG). UV–Vis, far-IR, and X-ray photoelectron spectroscopies evidence the reduction of H 2 PtCl 6 . CO infrared, and 195 Pt and 13 C NMR spectroscopies provide strong evidence of Pt 1 (0), existing as a pseudo-octahedral structure of (R 1 OR 2 ) 2 Pt(0)Cl 2 H 2 (R 1 and R 2 are H, C, or Si groups accordingly). The weakly coordinated (R 1 OR 2 ) 2 Pt(0)Cl 2 H 2 structure and electron deficient Pt 1 (0) have been validated by comparing experimental and DFT calculated 195 Pt NMR spectra. The H + in protic state and the Cl − together resemble HCl as the weak coordination. Neutralization by a base causes the formation of Pt nanoparticles. The Pt 1 @PDMS-PEG shows ultrahigh activity in olefin hydrosilylation with excellent terminal adducts selectivity.
研究领域:
材料科学
·
化学工程
·
光谱学
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Biomaterials and Tissue Engineering
·
2014
·Vol. 4
·期 12
·1047-1053
·
IF 1.167
Wu Gang,Huang Chao,Li Hong,Ke Yu,Fang Guan-Yu,He Jia-Zhi,Wang Si-Han,Chunlin Deng
In this study, PEG–CaO–SiO2–P2O5 hybrid materials were synthesized by the triethosysilane-propyl end caped polyethylene glycol (PEG), teraethylorthosilicate (TEOS), triethyl phosphate and calcium nitrate tetrahydrate using a two-step
method. The telechelic PEG was first synthesized by the reaction of PEG with isocyanatopropyl triethoxysilane (IPTS). Then, PEG–CaO–SiO2–P2O5 hybrid materials were synthesized by using sol–gel method. Transmission electron microscopy
(TEM) revealed that the phase structure of the hybrid material changed from organic dominated to inorganic dominated when the PEG content decreased. The size of the dispersed phase is about several microns observed by TEM. Bioactivity tests employed by soaking the specimen in simulated body
fluid (SBF) indicated that hydrophilic polymer contents have no adverse effect on the hydroxyapatite formation. After soaking the hybrid samples in SBF for 2 days, the deposition with the characteristic diffraction peaks of hydroxyapatite was presented on the hybrid material. It's also noticed
the deposition amounts increased with the inorganic contents increasing in the hybrid materials. Mechanical tests displayed no brittle cracks were developed in all the hybrid material samples. The compressive strength of the hybrid materials increased while the elastic deformation decreased
with the polymer contents reduction in the hybrid materials.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Nano Research
·
2018
·Vol. 11
·期 12
·6244-6251
·
IF 7.994
Zhang Xuejing,Wang Xingchao,Liu Shuang,Tao Zhanliang,Chen Jun
In recent years, development of all-solid-state batteries has become a promising approach to improve the safety of batteries. Herein, we report the preparation of a new composite polymer electrolyte (CPE) for use in all-solid-state sodium ion batteries. The CPE comprising of poly(methacrylate) (PMA), poly(ethylene glycol) (PEG), α -Al 2 O 3 with acidic surface sites, and NaClO 4 exhibited high ionic conductivity (1.46 × 10 -4 S·cm -1 at 70 °C), wide electrochemical stability window (4.5 V vs. Na + /Na), and good mechanical strength. With the introduction of the prepared CPE and Na 3 V 2 (PO 4 ) 3 , the final all-solid-state sodium ion batteries showed good rate and cycle performance, with a high reversible capacity of 85 mAh·g -1 when operated at 0.5 C (1 C = 118 mA·g –1 ) and 94.1% capacity retention rate after 350 cycles at 70 °C. Our work provides a novel solid electrolyte for the development of all-solid-state sodium ion batteries.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
SAUDI PHARMACEUTICAL JOURNAL
·
2020
·
IF 2.879
Yuandou Wang,Laishun Xi,Baogang Zhang,Qingzhen Zhu,Feng Su,Katarzyna Jelonek,Arkadiusz Orchel,Janusz Kasperczyk,Suming Li
PTMC-PEG-PTMC triblock copolymers were prepared by ring-opening polymerization of trimethylene carbonate (TMC) in the presence of dihydroxylated poly(ethylene glycol) (PEG) with Mn of 6000 and 10,000 as macro-initiator. The copolymers with different PTMC block Lengths and the two PEGs were end functionalized with acryloyl chloride. The resulting diacrylated PEG-PTMC-DA and PEG-DA were characterized by using NMR, GPC and DSC. The degree of substitution of end groups varied from 50.0 to 65.1%. Hydrogels were prepared by photo-crosslinking PEG-PTMC-DA and PEG-DA in aqueous solution using a water soluble photo-initiator under visible light irradiation. The effects of PTMC and PEG block lengths and degree of substitution on the swelling and weight loss of hydrogels were determined. Higher degree of substitution leads to higher crosslinking density, and thus to lower degree of swelling and weight loss. Similarly, higher PTMC block length also leads to lower degree of swelling and weight loss. Freeze dried hydrogels exhibit a highly porous structure with pore sizes from 20 to 100 µm. The biocompatibility of hydrogels was evaluated by MTT assay, hemolysis test, and dynamic clotting time measurements. Results show that the various hydrogels present outstanding cyto- and hemo-compatibility. Doxorubicin was taken as a model drug to evaluate the potential of PEG-PTMC-DA and PEG-DA hydrogels as drug carrier. An initial burst release was observed in all cases, followed by slower release up to more than 90%. The release rate is strongly dependent on the degree of swelling. The higher the degree of swelling, the faster the release rate. Finally, the effect of drug loaded hydrogels on SKBR-3 tumor cells was evaluated in comparison with free drug. Similar cyto-toxicity was obtained for drug loaded hydrogels and free drug at comparable drug concentrations. Therefore, injectable PEG-PTMC-DA hydrogels with outstanding biocompatibility and drug release properties could be most promising as bioresorbable carrier of hydrophilic drugs.
研究领域:
生物材料
·
药物递送
·
肿瘤治疗
✓ 已验证
DOI
PubMed
高影响因子
Green Processing and Synthesis
·
2023
·Vol. 12
·期 1
·
IF 4.3
Xin Zhang,Xutong Zhu,Lifa Huang,Zupeng Chen,Yuchen Wang,Yajun Liu,Ruihan Pan,Ling Lv
Tanshinone IIA has a potential therapeutic effect on cerebral ischemia/reperfusion injury (CIRI). In this study, tanshinone IIA was encapsulated in poly(lactic- co -glycolic acid)-block-poly (ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) nanoparticles, and its therapeutic efficacy on CIRI was investigated. Morphology and dynamic light scattering analyses were performed to identify and optimize nano-formulations. A drug release test was conducted using the dialysis method. The cytotoxic effect of tanshinone IIA on human neuroblastoma cells (SH-SY5Y) and brain endothelial capillary cells (hCMEC/D3) was measured using the MTT assay. The protective effect of PLGA-PEG-COOH-encapsulated tanshinone IIA against CIRI was evaluated in oxygen and glucose deprivation/reoxygenation-induced SH-SY5Y/IR cells and middle cerebral artery occlusion (MCAO) rats. Results showed that PLGA-PEG-COOH-encapsulated tanshinone IIA promoted viability and inhibited apoptosis of SH-SY5Y/IR cells ( P < 0.01). Moreover, PLGA-PEG-COOH-encapsulated tanshinone IIA facilitated the invasion of SH-SY5Y/IR cells and repressed inflammation in MCAO rats ( P < 0.01). Noteworthy, PLGA-PEG-COOH-encapsulated tanshinone IIA combined with angiopep-2 peptide presented a better inhibitory effect on CIRI than tanshinone IIA alone ( P < 0.01). Angiopep-2 peptide contributes to traversing blood–brain barrier by recognizing lipoprotein-related protein expressed in the brain capillary endothelial cells. In conclusion, PLGA-PEG-COOH-encapsulated tanshinone IIA plus angiopep-2 peptide holds promising therapeutic potential toward CIRI.
研究领域:
药学
·
神经科学
·
纳米技术
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）