Future Medicinal Chemistry
·
2019
·Vol. 11
·期 20
·
IF 3.617
Hongmei Xu,Fangfang Teng,Feilong Zhou,Li Zhu,Yi Wen,Runliang Feng,Zhimei Song
Aim: To encapsulate amphotericin B (AmB) with reduced toxicity and comparable activity. Results & methodology: The α-linolenic acid (ALA)-modified monomethoxy polyethylene glycol-g-PEI-g-ALA conjugate was employed to prepare AmB-loaded micelles (AmB-M). In vitro activity and release behavior of AmB-M were investigated. AmB-M enhanced AmB's water-solubility to 1.2 mg/ml, showing good storage stability. AmB-M could achieve a sustained and slow release of AmB, low hemolysis activity and negligible kidney toxicity when compared with commercial AmB injection. Antifungal activity and biofilm inhibition experiments confirmed that the antifungal activity of AmB-M against Candida albicans was similar to that of AmB injection. Conclusion: Monomethoxy polyethylene glycol-g-PEI-g-ALA micelles could be a preferable choice to treat systemic fungal infections as an efficient drug delivery system.
研究领域:
药剂学
·
抗感染研究
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DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 36
·期 40
·2406987
·
IF 27.4
Hong Fan,Kefan Wang,Yangjian Ding,Yueyue Qiang,Zhuo Yang,Huan Xu,Min Li,Zewen Xu,Cheng Huang
Radiative cooling technology, which is renowned for its ability to dissipate heat without energy consumption, has garnered immense interest. However, achieving high performance, multifunctionality, and smart integration while addressing challenges such as film thickness and enhancing anisotropic light reflection remains challenging. In this study, a core–shell composite nanofiber, PVDF@PEI, is introduced and designed primarily from a symmetry-breaking perspective to develop highly efficient radiative cooling materials. Using a combination of solvent-induced phase separation (EIPS) inverse spinning and (aggregation) self-assembly methods (EISA or EIAA) and coaxial electrostatic spinning (ES), superconformal surface anisotropic porous nanofiber membranes are fabricated. These membranes exhibit exceptional thermal stability (up to 210 °C), high hydrophobicity (contact angle of 126°), robust UV protection (exceeding 99%), a fluorescence multiplication effect (with a 0.6% increase in fluorescence quantum efficiency), and good breathability. These properties enable the material to excel in a wide range of application scenarios. Moreover, this material achieved a remarkable daytime cooling temperature of 8 °C. The development of this fiber membrane offers significant advancements in the field of wearables and the multifunctionality of materials, paving new paths for future research and innovation.
研究领域:
材料科学
·
纺织工程
·
环境科学
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DOI
PubMed
高影响因子
Biosurface and Biotribology
·
2020
·Vol. 6
·期 3
·82-86
·
IF 0
Yixin Wang,Li Wan,Yulong Sun,Hongyu Zhang
The superlubrication property of articular cartilage is attributed to the hydration lubrication mechanism. This involves the complexation of biomacromolecules with phosphatidylcholine lipids to form a lubricating boundary layer on the surface. Based on this mechanism, a branched polyelectrolyte polymer – PEI-PMPC was synthesised in this study to enhance lubrication via tert-butyl hydroperoxide-initiated grafting polymerisation of 2-methacryloyloxyethyl phosphorylcholine (MPC) onto polyethyleneimine (PEI) with various molecular weights. Following the characterisation of the polymer using nuclear magnetic resonance, a series of tribological tests were performed under different normal loads and different scan rates. The results showed that the PEI-PMPC polyelectrolyte polymer in aqueous solution could effectively reduce the friction coefficient and wear generation between the polyethylene ball and the silica wafer. Additionally, an improvement in the lubrication performance was detected for the PEI-PMPC polyelectrolyte polymer when high molecular weight PEI was used during the reaction, which was attributed to the formation of the hydration shells surrounding the zwitterionic charges of PMPC and the viscosity of the polymer. In conclusion, the PEI-PMPC polyelectrolyte polymer developed herein was characterised by enhanced lubrication, and may be potentially used for biomedical applications such as intra-articular injection to restore joint lubrication.
研究领域:
生物材料学
·
摩擦学
·
高分子化学
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DOI
ACS Omega
·
2019
·
IF 2.584
Xueting Zhao,Ning Jia,Lijuan Cheng,Ruoxi Wang,Congjie Gao
The development of antifouling membranes plays a vital role in the widespread application of membrane technology, and the hybridization strategy has attracted a significant amount of attention for antifouling applications. In this work, TA/PEI@TiO2 hierarchical hybrid nanoparticles (TPTi HHNs) are first synthesized through a simple strategy combining the multiple catechol chemistries of phenolic tannic acid (TA) with the biomimetic mineralization chemistry of titania. The TPTi HHNs are used as nanofillers to prepare PVDF/TPTi hybrid membranes. The TPTi HHNs endow the membrane with higher porosity, hierarchical roughness, greater hydrophilicity, and underwater superoleophobicity. Upon TPTi HHN loading, the PVDF/TPTi hybrid membranes exhibit enhanced antifouling performance. The flux recovery ratio can reach 92% when utilized to separate oil-in-water emulsion. Even being applied to the three-cycle filtration of oil-in-water emulsion with much higher concentration, the PVDF/TPTi membrane can still maintain a high flux recovery ratio about 85%. This study will provide a facial polyphenol-based platform to fabricate antifouling hybrid nanofillers and antifouling hybrid membranes with promising applications in oil/water separation.
研究领域:
材料科学
·
环境工程
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Qin Meng,Shengdong Wu,Chong Shen
Currently, there is an increasing interest in adding value to corncob, since corncob is a low-cost, green, and reliable cellulose material that is often discarded as waste without utilization. To increase the value of corncob, we developed a multifunctional corncob-based material by grafting polyethylenimine on oxidized corncob (PEI-g-OC). The PEI-g-OC was then used to remove the heavy metal ions and kill bacteria from water. We found that PEI-g-OC presented high adsorptive capabilities to Cu2+, Cd2+, and Pb2+ at 159.5, 212.6, and 224.0 mg/g in water, more potent than the other corncob-based biosorbents. Moreover, the PEI-g-OC is able to kill the model bacteria of S. aureus, P. aeruginosa, and E. coli with minimal inhibitory concentrations (MIC) at 3.5, 12.0, and 8.5 mg/mL, indicating its effect on antibacteria. Hence, PEI-g-OC with multiple functions improved the recyclability of corncob and added its value for application in water treatment.
研究领域:
环境科学
·
材料科学
·
生物技术
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DOI
高影响因子
JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2013
·Vol. 46
·期 34
·345303
·
IF 2.528
Pan Wang,Han Zhu,Shiyong Bao,MingLiang Du,Ming Zhang
Two strategies are demonstrated to fabricate AgNPs/PVA and AgNPs/(PVA/PEI) nanofibre hybrids. In the first approach, we synthesized AgNPs in poly(vinylalcohol) (PVA) solution and then electrospun the AgNPs/PVA solution into the AgNPs/PVA nanofibres. In the other one, the polyethylenimine (PEI) was introduced to improve the water-stability of PVA and then the AgNPs were immobilized on electrospun PVA/PEI nanofibres to fabricate the AgNPs/(PVA/PEI) nanofibres. Field-emission scanning electron microscopy, transmission electron microscopy, ultraviolet–visible spectroscopy and x-ray photoelectron spectroscopy (XPS) were utilized to investigate the morphology and the growth mechanism of the hybrids. The investigations demonstrate that both of the obtained AgNPs/PVA hybrids and AgNPs/(PVA/PEI) hybrids exhibit good water-stability and good antibacterial activity against E. coli and S. aureus.
研究领域:
材料科学
·
微生物学
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DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 10
·1692
·
IF 5.719
Yixiang Cao,Shiyin Zhang,Ming Ma,Yu Zhang
CXC chemokine receptor 4 (CXCR4) is a promising therapeutic target. Previous studies have shown that intracellular delivery of siRNA to knockdown CXCR4 expression in cancer cells is an effective therapeutic strategy. To prepare efficient magnetic nucleic acid carriers, it is now necessary to improve the endocytosis efficiency of PEGylated magnetic nanoparticles. In our work, Heptafluorobutyryl-polyethylene glycol-polyethyleneimine (FPP) was first prepared and then used to coat magnetic nanoparticles (MNPs) to obtain magnetic nanocarriers[email protected]The materials were characterized by19F-Nuclear Magnetic Resonance (NMR), transmission electron microscope (TEM), energy dispersive spectroscopy (EDS), and dynamic light scattering (DLS). The biosecurity of[email protected]was confirmed by cell viability and apoptosis experiments. Cellular uptake of[email protected]and siRNA transfection enhanced by external magnetic fields were detected by fluorescence microscopy, confocal laser microscopy, and flow cytometry. The results show that the cellular uptake efficiency of[email protected]was significantly improved, and transfection efficiency reached more than 90%. The knockdown of CXCR4 on the 4 T1 cell membrane was confirmed by real-time polymerase chain reaction (RT-PCR) and flow cytometry. In conclusion, the fluorinated cationic polymer-coated magnetic nanoparticles[email protected]can be loaded with siRNA to reduce CXCR4 expression as well as be expected to be efficient universal siRNA carriers.Keywords:magnetic nanoparticles;fluorination;polyethyleneimine;polyethylene glycol;RNA interference;CXC chemokine receptor 4
研究领域:
纳米技术
·
分子生物学
·
药学
·
癌症研究
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DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2026
·
IF 3.1
Niu Xuejuan,Huo Weiping,Wang Xiao,Xu Yuancheng,Lin Zheng
Regulating the interlaminar structure is an effective approach to tailoring the viscoelastic response of carbon fiber-reinforced polymer (CFRP) laminates. PEI/GnP@PEI nanofiber membranes prepared by electrospinning are embedded into CFRP laminates to modify the interlaminar region. The influence of membrane addition on interlayer microstructure is investigated, and the viscoelastic behavior of the main transition zone (MTZ) of the laminates with hybrid layup configuration is parameterized. Two quantitative indicators, the loss-modulus integral area (LMIA) and the full width at half maximum (FWHM) of the loss factor, are proposed to characterize energy-dissipation behavior and damping-response broadening of the laminates, respectively. A Williams–Landel–Ferry (WLF)-based dual-element viscoelastic model is established to describe the dynamic viscoelastic response within the MTZ. The correlation between the membrane microstructure and the MTZ-based quantitative indicators is analyzed. The results show that moderate GnP addition refines the PEI fibers, improves membrane coverage, and promotes a more uniform interlaminar network. Compared with CF/EP, the LMIA values of PEI-G0 and PEI-G1.5 increase by 64.1% and 86.3%, respectively. PEI-G2 shows a lower LMIA than PEI-G1.5, but it remains 68.5% higher than that of CF/EP. This work provides a basis for designing CFRP interleaves with improved stiffness retention and energy-dissipation behavior under dynamic thermal–mechanical conditions. Graphical
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高影响因子
Polymers
·
2025
·Vol. 17
·期 12
·1702
·
IF 4.9
Ningxin Ma,Wenzheng Xu,Xiaolong Chang,Shuying Lan
The issue of interfacial inhomogeneity in energetic materials remains a significant challenge. In this study, fluoroelastomer F2602 was applied to HMX crystals using a water suspension granulation technique, followed by a bio-inspired coating formed via the crosslinking polymerization of polyethyleneimine (PEI) and pyrogallol (PG) on the HMX/F2602 composite. This process resulted in the formation of an HMX/F2602/PEI-PG microcapsule structure. Various characterization techniques confirmed that the chemical structure and polycrystalline morphology of the crystals were preserved throughout the coating process, maintaining the characteristic β-HMX morphology. The introduction of the PG–PEI shell significantly improved the coating coverage and minimized the exposure of crystal surfaces. Furthermore, compared to HMX/F2602, the HMX/F2602/PEI-PG composite exhibited notably enhanced thermal stability and reduced mechanical sensitivity. These improvements are attributed to the advantageous effects of the microcapsule structure formed by the bio-inspired coating on the material’s properties.
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yan Li,Hang Lei,Qingfeng He,Sisi Tang,Yuxia Zhong,Yue-Fei Zhang
The escalating global energy demand has intensified the reliance on nuclear power generation, necessitating advanced solutions for radioactive iodine sequestration from nuclear wastewater. Chitosan (CS) exhibits significant potential for radioactive iodine capture due to the ion-exchange capabilities of its amino and hydroxyl functional groups with iodide ions. Herein, a novel A/CS-PEI composite hydrogel was synthesized through crosslinking chitosan with acrolein and polyethyleneimine (PEI) for enhanced iodine adsorption. The effect of temperature, contact time, and initial concentration on the adsorption of iodine was studied. The results demonstrate that the adsorption capacity of the adsorbent for I 2 can achieve as high as 840.91 mg∙g −1 . Additionally, molecular dynamics simulations demonstrated that the maximum absolute adsorption energy of −214.50 kcal/mol was achieved at 318 K, an increase in temperature enhances the adsorption capacity to a certain extent. Also van der Waals interactions dominate the non-bonded energy components with a value of −197.99 kcal/mol. The adsorption mechanism can be explained by hydrogen bond, van der Waals force, electrostatic force and charge transfer interaction. This work establishes a fundamental framework for designing multifunctional hydrogels with tailored functionalities for nuclear waste remediation.
研究领域:
环境科学
·
材料科学
·
核工程
·
化学工程
·
高分子科学
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产品关联
DOI
高影响因子
Pharmaceutics
·
2019
·Vol. 11
·期 9
·430
·
IF 4.773
Xiaoxiao Sun,Nan Wang,Li-Ye Yang,Xiao-Kun Ouyang,Fangfang Huang
Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific surface areas, adjustable pore sizes, easily modifiable surfaces, and good biocompatibility. In this work, polyethyleneimine (PEI) grafted MSN were modified with folic acid (FA) as an active target molecule using chemical methods. The product was characterized by SEM, TEM, Zetasizer nano, FTIR, and an N2adsorption and desorption test. MSN-PEI-FA are porous nano particles with an average particle size of approximately 100 nm. In addition, the loading rate and release behavior of MSN-PEI-FA were studied with curcumin as a model drug. The results show that when loading curcumin to MSN-PEI-FA at 7 mg and 0.1 g, respectively, the encapsulation efficiency was 90% and the cumulative release rate reached more than 50% within 120 h at pH = 5. This drug delivery system is suitable for loading fat-soluble antineoplastic drugs for sustained release and pH sensitive delivery.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·
IF 4.229
Aisheng Huang,Bo Feng
Pristine graphene oxide (GO) sheets were pretreated with polyethyleneimine (PEI) to prepare PEI-modified GO (PEI-GO), which was further inserted with ZIF-8 crystals to form a novel PEI-GO@ZIF-8 nanocomposite for CO 2 capture. The good dispersion of PEI and interlayer growth of ZIF-8 within the GO sheets is helpful for high CO 2 adsorption. Therefore, the PEI-GO@ZIF-8 nanocomposite show high surface area and enhanced CO 2 adsorption capacity . The adsorption capacity of the PEI-GO@ZIF-8 nanocomposite was six times higher than that of the pristine GO and ZIF-8. The CO 2 /N 2 adsorption selectivity was significantly improved due to amine groups loading which provide more sites for CO 2 adsorption. The preferential adsorption of CO 2 over N 2 makes PEI-GO@ZIF-8 nanocomposite be a promising candidate in the field of CO 2 capture.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）