JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Jiangping Song,Mengjun Wu,Tian Tian,Sixiu Zeng,Dan Liu,Hao Li,Shengqiu Zhao,Haolin Tang
The vaporization-condensation-conversion method is the prominent technique used for synthesizing red phosphorus/carbon (P/C) composites. However, its practical application is limited by the inevitable formation of toxic white phosphorus (WP) residues, posing severe safety concerns. Theoretical calculations of the WP polymerization process performed in this study revealed that the introduction of iodine can considerably accelerate the polymerization of WP molecules, yielding P/C composites free of WP residues. Furthermore, in the resulting iodine-doped P/C (I-P/C) composites, iodine forms I-P bonds, considerably enhancing electronic conductivity and promoting faster Na-P redox kinetics compared to those in the original P/C composites. Consequently, an I-P/C electrode exhibited a capacity of 1193 mA h g⁻ 1 , retaining 100 % of its capacity after 100 cycles at 0.2 A g⁻ 1 . Furthermore, an assembled I-P/C||Na 3 V 2 (PO 4 ) 2 F 3 full cell retained 91.9 % of its capacity after 200 cycles at 0.5 A g⁻ 1 . Additionally, the full cell exhibited a high energy density of 132.2 W h kg⁻ 1 at a power density of 9942.1 W kg⁻ 1 , demonstrating potential to complete charging or discharging within ∼57 s. Finally, an I-P/C||Na 3 V 2 (PO 4 ) 2 F 3 pouch cell, with a capacity of 0.36 A h, demonstrated excellent cycling performance even after 150 cycles at 0.05 A g⁻ 1 .
研究领域:
材料科学
·
能源化学
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Sen Xu,Mengyu Fan,Qimeng Ding,Yibin Wang,Muhammad Ismail,Weimin Ruan,Yan Zou,Dongya Zhang,Meng Zheng
RNA interference (RNAi) has emerged as a highly promising therapeutic strategy for glioblastoma (GBM), yet its clinical efficacy heavily relies on the success of delivery systems. Traditional vehicles, including cationic polymers, lipids, and inorganic nanoparticles, frequently encounter critical challenges such as cationic toxicity, poor blood-brain barrier (BBB) penetration, or poorly-defined structures that hinder their clinical translation. To overcome these challenges, we developed a novel, structurally-defined non-cationic siRNA-micelle system based on siRNA-docosahexaenoic acid (DHA) conjugates. These conjugates self-assemble into stable siRNA-micelles that exhibit prolonged blood circulation, enhanced cellular uptake, and efficient BBB penetration. Due to their non-cationic nature and the inherent safety profile of DHA, these siRNA-DHA micelles exhibit exceptional biocompatibility, potentially minimizing carrier-based toxicity. By simultaneously targeting epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGFA), the siRNA-micelles potently inhibited tumor progression and substantially extended survival in orthotopic GBM mouse models via dual-target modulation. This structurally-defined, non-cationic siRNA delivery platform represents a robust and clinically translatable strategy for GBM treatment, and holds considerable promise for the RNAi-based therapy of other neurological disorders.
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Kunyan Lu,Dongxu Jia,Haixin Zhang,Jingjing Cheng,Yuheng Zhang,Yanxia Zhang,Qian Yu,Hong Chen
Gene transfection, defined by the delivery of nucleic acids into cellular compartments, stands as a crucial procedure in gene therapy. While branched polyethylenimine (PEI) is widely regarded as the “gold standard” for nonviral vectors, its cationic nature presents several issues, including nonspecific protein adsorption and notable cytotoxicity. Additionally, it often fails to achieve high transfection efficiency, particularly with hard-to-transfect cell types. To overcome these challenges associated with PEI as a vector for plasmid DNA (pDNA), the photothermal agent indocyanine green (ICG) is integrated with PEI and pDNA to form the PEI/ICG/pDNA (PI/pDNA) complex for more efficient and safer gene transfection. The negatively charged ICG serves a dual purpose: neutralizing PEI’s excessive positive charges to reduce cytotoxicity and, under near-infrared irradiation, inducing local heating that enhances cell membrane permeability, thus facilitating the uptake of PI/pDNA complexes to boost transfection efficiency. Using pDNA encoding vascular endothelial growth factor as a model, our system shows enhanced transfection efficiency in vitro for hard-to-transfect endothelial cells, leading to improved cell proliferation and migration. Furthermore, in vivo studies reveal the therapeutic potential of this system in accelerating the healing of infected wounds by promoting angiogenesis and reducing inflammation. This approach offers a straightforward and effective method for gene transfection, showing potentials for tissue engineering and cell-based therapies.
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Guan-Qi Zheng,Jia-Ning Wu,Lin Zhang,Qin Zhang,Lin Chen,Xiu-Li Wang,Hai-Bo Zhao,Bo-Wen Liu,Yu-Zhong Wang
Constructing thermally cross-linkable structures into thermoplastic polymers has emerged as a compelling strategy to enhance flame retardancy. However, the cross-linking reactions are hard to control, leading unexpected deterioration of processability and mechanical properties. Here, we report a novel strategy to modulate cross-linking reactions utilizing intramolecular hydrogen bonding and steric hindrance effects. Taking aromatic Schiff base (SA) as an example, novel monomers SAP and SAPN were designed and synthesized by incorporating phenolic and naphthalene units. As expected, the resultant copolymer PET- co -SAPN n exhibited a 120 °C higher cross-linking temperature compared with that of PET- co -SA n , powering them with great processability. Robust mechanical properties were obtained owing to the enhanced polymerization stability and intramolecular hydrogen bonding of SAPN, as evidenced by the tensile strength of 86.0 MPa for PET- co -SAPN 15 , 1.6 times to that of pure PET. Additionally, PET- co -SAPN n exhibits the highest fire safety, whose peak heat release rate (pHRR) and maximum smoke density ( D m ) decreased by 49% and 53%, attributing to enhanced char-forming ability from the cross-linking and the phenolic and naphthalene units in SAPN. Considering these adequate improvements, this study provides a novel strategy for designing “self-cross-linking” flame-retardant polymers with improved processability and fire-safety.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Mohammed Kamal Hadi,Xiangya Wang,Meimei Yu,Manasa Pantrangi,Zhijiang Sun,Fen Ran
Blood biocompatibility and permeability are major challenges that limit the wide implementation of polyethersulfone membranes for hemodialysis and bio-related applications. In this regard, polyethersulfone's surface modification is a commonly used strategy to improve permeability/selectivity, prevent protein-based fouling, and suppress the inflammation of the immune response. As a new approach to enhancing blood biocompatibility, this paper reports a feasible and effective method for the synthesis of heparin-like structures by modifying the polysaccharide guar gum macromolecule with magnetic nanoparticles and metanilic acid. The prepared magnetic, sulphated polysaccharide was blended with polyethersulfone to obtain a hydrophilic and biocompatible membrane surface. The modified membranes show an improved permeability of 144 L m −2 h −1 bar −1 . A comprehensive and in-depth analysis of the protein adsorption on the membrane surface is also conducted. Blood compatibility tests reveal that the polyethersulfone-modified membrane demonstrates a low hemolysis rate, prolonged activated partial thromboplastin time, and low platelet adhesion. It is also performed simulation studies based on molecular docking between different guar gum-modified structures and each of human serum albumin and immunoglobulin. Accordingly, the docking results are in line with the practically obtained biocompatibility analyses. Through the obtained results, this study uniquely affirms that the modification of polyethersulfone membranes with magnetic and negatively charged guar gum has promising potential for effective usage in bio-related applications.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Yaning Wang,Ruimin Xie,Jielin Xu,Zhenguang Li,Mingfa Guo,Fenghuan Yang,Jing Wu,Huaping Wang
Bisphenol-A polycarbonate (BPA-PC) has been widely used, but it has been restricted from use in several food-contact products due to the estrogen-like and antiandrogen effects of BPA. With the aim of developing novel, biobased, and ecologically safe high-performance polycarbonates with the potential to replace BPA-PC, in this work, a series of novel biobased copolycarbonates, viz., poly(isosorbide carbonate-co-isoidide-2,5-dimethylene carbonate) (PIsIeC), were designed and successfully synthesized via melt polymerization. The combination of two isohexide building blocks, the highly rigid isosorbide (IS) and the semirigid isoidide-2,5-dimethanol (IIDML), afforded an optimal candidate (PIsIeC-39) with a nice balance of high Tg (120.5 °C), high tensile strength (72.6 MPa), and also a high elongation at break (75.2%), which are comparable or even surpass the properties of BPA-PC and a few oil-based commercial benchmarks. The SEC/viscosity results and also a DFT simulation jointly revealed that the molecular weights of these copolycarbonates were significantly enhanced when using the two isohexide building blocks together due to a possible autocatalytic effect induced by the hydrogen bonding between IIDML and IS. These polymers were obtained with number-average molecular weights of 27,300–113,200 g/mol and intrinsic viscosities of 54–83 mL/g, which are also comparable to those of BPA-PC. Meanwhile, all copolycarbonates have good transparency similar to BPA-PC and also exhibit similar γ-relaxation and higher biobased content (72–84%). These biobased copolycarbonates with superior thermal and mechanical properties have high potential to be an ecologically safe alternative for BPA-PC.
研究领域:
材料科学
·
环境科学
·
化学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Penghui Wang,Ruixue Li,Juping Ma,Wenjie Zhang,Haifeng Shen,Yanhan Ren,Xun Zhang,Shuang Li,Bo Chi
Traditional submucosal filling materials frequently show insufficient lifting height and duration during clinical procedures. Here, the anionic polysaccharide polymer sodium carboxymethyl starch and cationic Laponite to prepare a hydrogel with excellent shear-thinning ability through physical cross-linking, so that it can achieve continuous improvement of the mucosal cushion through endoscopic injection. The results showed that the hydrogel (56.54 kPa) had a lower injection pressure compared to MucoUp (68.56 kPa). The height of submucosal lifting height produced by hydrogel was higher than MucoUp, and the height maintenance ability after 2 h was 3.20 times that of MucoUp. At the same time, the hydrogel also showed satisfactory degradability and biosafety, completely degrading within 200 h. The hemolysis rate is as low as 0.76 %, and the cell survival rate > 80 %. Subcutaneous implantation experiments confirmed that the hydrogel showed no obvious systemic toxicity. Animal experiments clearly demonstrated the in vivo feasibility of using hydrogels for submucosal uplift. Furthermore, successful endoscopic submucosal dissection was executed on a live pig stomach, affirming the capacity of hydrogel to safely and effectively facilitate submucosal dissection and mitigate adverse events, such as bleeding. These results indicate that shear-thinning hydrogels have a wide range applications as submucosal injection materials.
研究领域:
生物医学工程
·
材料科学
·
胃肠病学
·
生物相容性
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产品关联
DOI
PubMed
高影响因子
FOOD SCIENCE AND BIOTECHNOLOGY
·
2016
·Vol. 25
·期 2
·631-636
·
IF 0.699
Huang Xiaojun,Nie Shaoping,Yang Meiyan,Xie Jianhua,Li Chang,Xie Mingyong
Nine different edible oil types from 7 cities in China were analyzed. Trans fatty acid (TFA) contents in edible oils were determined, TFA distribution characteristics were analyzed, and a risk assessment was performed. Total TFA contents varied from 0.075±0.011 to 2.243±0.770 g/100 g of oil, with a mean content of 0.66 g/100 g of oil. TFA contents differed among different oil types and among different cities. Generally speaking, oil samples from northern areas of China contained more TFA, and lard usually had higher levels of TFA than other oils. An exposure assessment showed that the estimated daily intake of TFA from Chinese edible oils was low, and a risk assessment indicated that there was a low risk for TFA consumption in Chinese edible oils.
研究领域:
营养学
·
食品安全
·
公共卫生
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Xiaojun Cai,Haofang Zhu,Yanmei Zhang,Zhongwei Gu
RNA interference (RNAi) has a great promise in treating various acquired and hereditary diseases. However, it remains highly desirable to develop new delivery system to circumvent complex extra- and intracellular barriers for successful clinical translation. Here, we report on a versatile polymeric vector, bioreducible fluorinated peptide dendrimers (BFPD), for efficient and safe small interfering RNA (siRNA) delivery. In virtue of skillfully integrating all of the unique advantages of reversible cross-linking, fluorination, and peptide dendrimers, this novel vector can surmount almost all extra- and intracellular barriers associated with local siRNA delivery through highly improved physiological stability and serum resistance, significantly increased intratumoral enrichment, cellular internalization, successful facilitation of endosomal escape, and cytosolic siRNA release. BFPD polyplexes, carrying small interfering vascular endothelial growth factor (siVEGF), demonstrated excellent VEGF silencing efficacy (∼65%) and a strong capability for inhibiting HeLa cell proliferation. More importantly, these polyplexes showed superior performance in long-term enrichment in the tumor sites and had a high level of tumor growth inhibition. Furthermore, these polyplexes not only exhibited excellent in vivo antitumor efficacy but also demonstrated superior biocompatibility, compared with LPF2000, both in vivo and in vitro. These findings indicate that BFPD is an efficient and safe siRNA delivery system and has remarkable potential for RNAi-based cancer treatment.
研究领域:
药剂学
·
分子生物学
·
癌症研究
·
纳米医学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Yilin Wang,Xuelian Huang,Chao He,Yupei Li,Weifeng Zhao,Changsheng Zhao
Safe and efficient carboxymethyl chitosan (CMC)-based heparin-mimicking cross-linked beads (CMC/PAMPS) as adsorbents for the clearance of low-density lipoprotein-cholesterol (LDL-c) in blood purification were prepared through hydrogen bonding interactions followed with in situ cross-linking with 2-acrylamido-2-methyl-1-propanesulfonicacid (AMPS). Fourier transform infrared spectra (FTIR), two-dimensional correlation FTIR spectroscopy (2D IR), thermal gravimetric analysis (TGA) and energy dispersive X-ray spectrometer (EDS) demonstrated the successful synthesis of CMC/PAMPS beads. The porous structures of the beads may contribute to the adsorption of toxins. Owing to their favorable hydrophilicity, when contacted with blood, the beads showed excellent hemocompatibility. The hemolysis ratios for all the beads were less than 5%, the thromboplastin time of CMC/PAMPS 10 beads exceed 600 s, and they can suppress contact activation and complement activation effectively. Additionally, the beads have no obvious cytotoxicity with endothelial cells, thus could be used as a safe adsorbent for blood purification. Moreover, the CMC/PAMPS 10 beads possessed a LDL-c adsorption capacity of 24.8 mg/g under static adsorption and a LDL-c adsorption capacity of 8.2 mg/g in the simulation of hemoperfusion for whole blood, due to the large surface areas and high density of functional groups. Meanwhile, the concentration of high-density lipoprotein-cholesterol (HDL-c) was almost unaffected. In general, the safe adsorbent with high LDL-c adsorption capacity has great potentials for hemoperfusion and other clinical applications.
研究领域:
生物材料学
·
医学工程
·
分子生物学
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DOI
PubMed
高影响因子
Energy Storage Materials
·
2020
·
IF 16.28
Zhu Liao,Jun Huang,Wenting Chen,Nagahiro Saito,Zhengxi Zhang,Li Yang,Shin-ichi Hirano
Solid polymer electrolytes (SPEs) garner tremendous attention for both enabling higher energy density battery chemistry and alleviating the safety concerns of liquid electrolytes, but the practical utilizations of SPEs are severely hindered by the limited room temperature ionic conductivity , low transference number and huge interface impedance. Unlike the polymer chain movement in traditional SPEs, in the present work, we develop novel “polymer-in-plastic salts” electrolytes (PIPSEs) via a high weight ratio of plastic salts to polymer in which polymer just function as framework so that non-flammable, superionic conductive and flexible SPEs can be obtained. Also, the high content of plastic salts in PIPSEs can wet electrodes and form compatible solid electrolyte interface (SEI) with lithium metal. As a consequence, solid-state dendrite-free symmetric Li cells with PIPSEs show ultralong cycle life over 1000 h under up to 2.0 mA cm −2 and Li/LiFePO 4 and high-voltage Li/LiNi 0.6 Co 0.2 Mn 0.2 O 2 cells utilizing above PIPSEs exhibit excellent cycle performance and appealing rate performance. It is anticipated that our work provides a new strategy for the next-generation solid-state batteries.
研究领域:
材料科学
·
能源存储与转换
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产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2021
·
IF 6.475
Tingting Cui,Yaowen Wu,Fanghui Fan
β -Carotene ( β - Car ) is insoluble compounds in water and liable to degradation, which has health benefits for human beings. Although layer-by-layer ( LBL ) emulsions provide a better protection for β - Car towards environmental stresses, the handling and transportation of LBL emulsions still faces restrictions. In this paper, therefore, the LBL emulsions including β-Car were carefully prepared and encapsulated to obtain vitreous encapsulated solids ( VES ) using trehalose and maltodextrins ( MD ) as wall materials. Morphological results indicated that the LBL emulsions were formed a spheric shape, in where the polyelectrolyte shell was 30 nm. The MD exhibited the characteristics of not easy to absorb moisture, suitable carrier, and good stabilizer, which could improve the stability of VES systems at studied environmental stresses. Despite compositional effects from MD and environmental stresses, LBL emulsions changed the water sorption behavior of VES as oil dispersion in storage. Strength analysis indicated that LBL emulsions lubricated systems and increased the molecular mobility of wall materials. Structural collapse, rapid color changes, and β-Car loss were confirmed in VES systems at 0.56 a w from 25 to 45 °C after 30 days of storage. Besides, a relationship between S and β-Car loss kinetics was established, where the β-Car degraded more rapidly in a sample with quicker molecular mobility of wall materials Therefore, the controlling of molecular mobility in wall materials can slow down the β -Car degradation and improve the quality and stability of lipophilic nutrients delivery systems with high total solids.
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）