CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Jiwei Cui,Jiayin Gao,Yuan Zhuang,Longben Huo,Zhiheng Meng,Hui Feng,Pei Sun,Xinyuan Zhu,Xin Jin
All-polymer PVDF/PVA sea-island hydrogels are engineered by LLPS and NIPS. • Uniform PVDF islands improve stress transfer and promote electroactive phase formation. • Electroactive PVDF phase exceeds 95% with an effective piezoelectric response of 40.9 ± 1.6 pC N −1 . • Stable electromechanical sensing is maintained over 1600 loading cycles. • LSTM-assisted sensors enable personalized recognition of exercise patterns. Flexible piezoelectric materials are promising for wearable electronics and biosensing applications, yet achieving high electromechanical sensitivity while maintaining mechanical softness remains challenging for hydrogel-based systems. Herein, we report an all-polymer piezoelectric hydrogel with a controlled sea-island structure, engineered via coupled liquid-liquid phase separation and non-solvent-induced phase separation. The resulting architecture consists of uniformly dispersed PVDF islands embedded in a continuous PVA matrix. PVDF islands provide electroactive crystalline domains and contribute to stress transfer within the hydrated network, while the sea–island architecture and interfacial interactions synergistically enhance the effective piezoelectric response ( d 33,eff = 40.9 ± 1.6 pC N −1 ). The hydrogel sensors exhibit stable and sensitive responses to subtle biomechanical signals, including finger, face, throat and pulse monitoring. For exercise-related limb movements, the sensor signals were analyzed using a Long Short-Term Memory (LSTM) neural network under subject-independent validation, demonstrating the feasibility of signal-based discrimination between standard and non-standard movements. This work establishes a microstructure-engineering strategy for improving the mechanical and piezoelectric performance of PVDF/PVA hydrogels, enabling their application in wearable motion monitoring. Download: Download high-res image (214KB) Download: Download full-size image
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Meng Xia,Shuyang Hu,Wenqi Luo,Yang Guo,Peng Zhao,Jiakai Li,Guiqiu Li,Lulu Yan,Wei Huang,Meng Li,Juanxiu Xiao,Yijun Shen,Qi Chen,Dong Wang
Solar-driven steam generation (SSG) is regarded as a feasible solution to the problem of fresh water scarcity. Although several attempts have been devoted to increase the efficiency of solar-to-steam conversion, it remains difficult to fabricate cost-effective, steady, and multi-angle sunlight-absorbing evaporators from readily available biomass materials. Herein, a novel hierarchical structured SSG evaporator (PDA@Shell-NaClO) is developed through a simple, low-cost, and scalable etching treatment on discarded sea urchin (SU) shells. Attributing to the dedicatedly designed microneedles array structure and porous skeleton structure of the SU shell, this PDA@Shell-NaClO evaporator shows an outstanding average light absorption performance (>90%) in a broad range of angles from 0° to 60° and exceedingly high evaporation rate of 2.81 kg m -2 h −1 under one sun condition. Furthermore, the prepared evaporator also maintains an overall stable evaporation performance and exhibits an excellent durability for a long time of up to two weeks in actual seawater. This full-ocean biomass-based SSG evaporator with plentiful raw material availability offers innovative opportunities for large-scale fresh water production.
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Food Science and Technology
·
2023
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IF 2.602
LI Ying,LEE Xiangjun,GUO Jianfeng,FENG Jingjing,XU Chenshuai,BAI Yujie,GUO Shiwei,WANG Fang
Palmitoleic acid (C16:1n7, POA), a 16-carbon ω-7 monounsaturated functional fatty acid, has been demonstrated a variety of beneficial properties to human health and a wide range of applications in nutrition, medical and chemical industries. Lipozyme® RM IM (Rhizomucor Miehei lipase), a Sn-1,3 specific lipase, was used to catalyze the hydrolysis of seabuckthorn fruit oil and produce monoglycates rich in palmitoleic acid. The fruit oil of seabuckthorn was used as the research object, the dosage of enzyme taking 10% wt.% oil, the influence of water/oil ratio, pH value and reaction temperature to hydrolysis rate were investigated, and then the response surface methodology was applied for optimizing the process conditions. Further, the relationship between the hydrolysis rate and the content of monoacylglycerol was studied under the optimal hydrolysis conditions. The result indicated that the optimal combined condition is as follows: the reaction temperature is 55°C, the pH is 7, the water-oil quality ratio is 1:1. The hydrolysis rate achieved 79.59% within 12 h in the condition above. Under the optimal conditions, the hydrolysis rate was positively correlated with the content of monoester, and the correlation coefficient was 0.999 within the first 10 h of the reaction. The hydrolysis rate was 66.76% at 10 h, and the content of monoglyceride reached the highest of 61.11%. Hereafter, the hydrolysis of monoglyceride began if the reaction continued. The content of palmitoleic acid increased from 27.11% to 40.84%, and that of linoleic acid increased from 4.51% to 33.34%, so the total amount of the two functional fatty acids reached 74.18%. Enzymatic hydrolysis can be an effective way to improve the function of seabuckthorn fruit oil.
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Frontiers in Oncology
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2023
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IF 4.7
Guangchun Liu,Shenglin Zhang,Ruoyan Lin,Xudong Cao,Lihong Yuan
Cancer remains the leading cause of death worldwide. In spite of significant advances in targeted and immunotherapeutic approaches, clinical outcomes for cancer remain poor. The aim of the present study was to investigate the potential mechanisms and therapeutic targets of Frondoside A for the treatment of liver, pancreatic, and bladder cancers. The data presented in our study demonstrated that Frondoside A reduced the viability and migration of HepG2, Panc02, and UM-UC-3 cancer cell in vitro . Moreover, we utilized the GEO database to screen and identify for differentially expressed genes (DEGs) in liver, pancreatic, and bladder cancers, which resulted in the identification of 714, 357, and 101 DEGs, respectively. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were performed using the Metascape database for DEGs that were significantly associated with cancer development. The protein-protein interaction (PPI) networks of the identified DEGs in liver, pancreatic, and bladder cancers were analyzed using Cytoscape 3.9.0 software, and subsequently identified potential key genes that were associated with these networks. Subsequently, their prognostic values were assessed by gene expression level analysis and Kaplan-Meier survival analysis (GEPIA). Furthermore, we utilized TIMER 2.0 to investigate the correlation between the expression of the identified key gene and cancer immune infiltration. Finally, molecular docking simulations were performed to assess the affinity of Frondoside A and key genes. Our results showed a significant correlation between these DEGs and cancer progression. Combined, these analyses revealed that Frondoside A involves in the regulation of multiple pathways, such as drug metabolism, cell cycle in liver cancer by inhibiting the expression of CDK1, TOP2A, CDC20, and KIF20A, and regulates protein digestion and absorption, receptor interaction in pancreatic cancer by down-regulation of ASPM, TOP2A, DLGAP5, TPX2, KIF23, MELK, LAMA3, and ANLN. While in bladder cancer, Frondoside A regulates muscle contraction, complement and coagulation cascade by increase FLNC expression. In conclusion, the present study offers valuable insights into the molecular mechanism underlying the anticancer effects of Frondoside A, and suggests that Frondoside A can be used as a functional food supplement or further developed as a natural anti-cancer drug.
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Chemosensors
·
2022
·Vol. 10
·期 5
·170
·
IF 4.229
Henggan Li,Feiming Li,Yipeng Huang,Linchun Zhang,Min Ye,Jingwen Jin,Xi Chen
In this study, CsPbBr3@SiO2perovskite nanocrystal composites (CsPbBr3@SiO2PNCCs) were synthesized by a benzyl bromide nucleophilic substitution strategy. Homogeneous halide exchange between CsPbBr3@SiO2PNCCs and Cl−solution (aqueous phase) was applied to the determination of Cl−in sea sand samples. Fast halide exchange with Cl−in the aqueous phase without any magnetic stirring or pH regulation resulted in the blue shift of the photoluminescence (PL) wavelength and vivid PL color changes from green to blue. The results show that the PL sensing of Cl−in aqueous samples could be implemented by using the halide exchange of CsPbBr3@SiO2PNCCs. A linear relationship between the PL wavelength shift and the Cl−concentration in the range of 0 to 3.0% was found, which was applied to the determination of Cl−concentration in sea sand samples. This method greatly simplifies the detection process and provides a new idea for further broadening PL sensing using the CsPbBr3PNC halide.Keywords:CsPbBr3perovskite nanocrystal composites;colorimetric sensing;photoluminescence wavelength shift;sea sand;Cl−
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LANGMUIR
·
2021
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IF 3.882
Peng Wang,Fengtao Zhang,Cailing Wu,Jianji Wang,Buxing Han,Zhimin Liu
Herein, we report CoCO3-coated nitrogen-doped carbon nanotubes (NCNTs) with a sea cucumber-like morphology for water splitting. The sample with a CoCO3 content of 26.8 wt % (CoCO3/NCNT-1) exhibits excellent performance for the hydrogen evolution reaction in 1.0 M KOH electrolyte with an overpotential of 58 mV to reach 10 mA cm–2, better than the most non-noble metal catalysts reported; meanwhile, it exhibits superior electrocatalytic activity for the oxygen evolution reaction. The excellent performance of the catalyst is attributed to the nanotip effect caused by the sea-cucumber-like morphology. Notably, CoCO3/NCNT-1 can attain turnover frequencies of 2.7 s–1 at an overpotential of 50 mV, higher than that of Pt/C (1.5 s–1). A cell constructed using CoCO3/NCNT-1 as the catalyst of the electrode pair needs a low cell voltage of 1.54 V at 10 mA cm–2, superior to most reported cells. In addition, CoCO3/NCNT-1 can maintain 10 mA cm–2 for overall water splitting for 100 h without activity loss.
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Frontiers in Nutrition
·
2021
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IF 6.576
Wei Wei,Fan Xiao-Man,Jia Shao-Hui,Zhang Xi-Ping,Zhang Zhao,Zhang Xue-Jun,Zhang Jiu-Xun,Zhang Ye-Wang
Sea cucumbers are one of many marine echinoderm animals that contain valuable nutrients and medicinal compounds. The bioactive substances in sea cucumbers make them have promising biological and pharmacological properties, including antioxidant, anti-bacterial, and anti-tumor effects. In this study, sea cucumber intestinal peptide (SCIP) is a small molecular oligopeptide (<1,000 Da) extracted from sea cucumber intestines hydrolyzed by alkaline protease. The analysis of amino acid composition showed that hydrophobic amino acids and branched-chain amino acids were rich in SCIP. Nowadays, although increasing studies have revealed the biological functions of the sea cucumber active substances, there are few studies on the function of SCIP. Furthermore, due to the anti-cancer activity being an essential characteristic of sea cucumber active substances, we also investigated the anti-cancer potential and the underlying mechanism of SCIP in vivo and in vitro. The results indicate that SCIP inhibits the growth of MCF-7 tumor cells in zebrafish and increases the apoptosis of human breast cancer MCF-7 cells. Further mechanism studies confirm that SCIP promotes the expression of apoptosis-related proteins and thus promotes the breast cancer cells (MCF-7) apoptosis via inhibition of PI3K/AKT signal transduction pathway.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Weijie Wei,Jingjing He,Lan He,Xinyu Qi,Xiaqing Zhang,Wubo Wan,Zhuwei Gao
The use of solar desalination is expected to solve the problem of water scarcity. Based on this, MWCNTs were loaded on filter paper and assembled into a MWCNTs disc evaporator using cotton threads as water channels in this paper. MCED with different loadings were prepared, and the photothermal conversion performance of MCED was evaluated through experiments. The results showed that the evaporation rate of 0.7-MCED at one solar intensity could reach 1.3134 kg/m 2 h; the efficiency of solar separation of vapor and salt was 77.63 %. Meanwhile, after a 7-day evaporation cycle of 0.3-MCED, salt crystallizes at the edge of MCED under light and is recovered by gravity shedding during darkness, and the freshwater collection rate and salt recovery rate are 0.82 kg m −2 h −1 and 38.24 g m −2 h −1 , realizing efficient and continuous water collection and salt recovery. In addition, MCED can generate voltage through water evaporation. This work demonstrates a solar evaporator that can be used for continuous seawater desalination as well as salt recovery and power generation, and provides a new direction for the design of photothermal modulation of MWCNTs and solving the salt crystallization problem for solar desalination.
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MATERIALS & DESIGN
·
2019
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IF 5.77
Hui Yu,Jianlin Li,Jianbao Li,Yongjun Chen,Xue Hou,Shuaifeng Chen,Haotian Yang
Multibiological multiscale biomimetic design is a novel bionic idea that involves multi-mechanisms. Porous ceramics with a sea urchin stereom structure on a micrometre scale and a nacre mineral bridge structure on a submicron scale have been fabricated via organic foam impregnation and controlled crystallisation. The microstructure and mechanical properties of biomimetic ceramics are, respectively, characterised using scanning electron microscopy and universal testing machine. Moreover, the porosity, reliability and grain boundary stress of biomimetic ceramics are calculated via Archimedes method, Weibull theory and finite element method, respectively. Results show that the ceramic produced in this work has a porosity of 88.16% and an average pore size of 284.65 μm. Mineral bridges of Al 2 TiO 5 with a thickness of 30–230 nm are widely and randomly distributed in the grain boundary glass phase of Al 2 O 3 and improved the compressive strength (2.32 MPa) and Weibull modulus (7.85) of ceramics by the multi-mechanisms of crack deflection, reducing maximum stress and homogenising stress on the grain boundary. These investigations would be of great value to the design and synthesis of novel biomimetic materials.
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Advanced Science
·
2025
·
IF 14.1
Si Meng,Nihuan Wu,Jie Fang,Yidan Yu,Xin Tang,Yihan Wang,Xiaokang Deng,Cheng Qi,Tiantian Kong,Tengda Ding,Zhou Liu
Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic hollow fibers with spiral surface microstructures is developed. Using oxidized bacterial cellulose, bacterial cellulose, and polydopamine, a “brick-and-mortar” scaffold is created through precise shear control during microfluidic coaxial spinning. The scaffold mimics natural extracellular matrices, providing mechanical stability and supporting cell growth. In vitro studies show successful co-culture of endothelial cells (ECs) and smooth muscle cells (SMCs), with SMCs aligning along spiral surface microstructures and ECs forming a confluent inner layer. In vivo implantation confirms biocompatibility, biodegradability, and low immunogenicity. This Euplectella -inspired scaffold presents a promising approach for vascular tissue engineering and regenerative medicine.
研究领域:
生物材料学
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再生医学
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组织工程学
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JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
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2024
·Vol. 129
·期 10
·e2024JC021373
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IF 3.3
Kan Chen,Rui Yang,Min Li,Yanan Chen,Xiurong Han,Jing Zhao,Keqiang Li,Xiulin Wang
Human-induced dissolved organic nitrogen (DON) input is impacting coastal ecosystems globally, and the shift from diatoms to dinoflagellates may be associated with increasing DON concentrations and changing DON compositions. Based on field microcosm experiments, changes in three-dimensional fluorescence component and extracellular leucine aminopeptidase activity were used to reveal the effects of DON on diatom and dinoflagellate growth. Additionally, a Nutrients–bi-Phytoplankton–Detritus biogeochemical model was employed to elucidate the kinetic mechanism of DON on the shift from diatoms to dinoflagellates in the Bohai Sea (BS). Our results revealed that shifting diatom–dinoflagellate dominance was associated with the hydrophobic component of terrestrial DON. Dinoflagellates (i.e., Karenia mikimotoi ) efficiently assimilated humic-like substances in hydrophobic DON; whereas, diatoms (i.e., Chaetoceros spp.) efficiently utilized the protein-like components in hydrophilic DON. The reason for this was the higher extracellular leucine aminopeptidase activity of dinoflagellates compared to that of diatoms, which enabled them to degrade humic-like substances and protein-like components more effectively. The modeling study clarified that the DON composition, particularly the proportion of hydrophobic DON, regulated the shift from diatoms to dinoflagellates. Our study provides insight into the mechanisms underlying phytoplankton regime shifts in the BS and valuable guidance for decreasing eutrophication by controlling terrestrial DON inputs and compositions. Key Points Karenia mikimotoi can efficiently assimilate humic-like substances Chaetoceros spp. can efficiently utilize protein-like components Karenia mikimotoi has higher extracellular leucine aminopeptidase activity than Chaetoceros spp. Plain Language Summary Human-induced nitrogen input is causing major changes in coastal ecosystems worldwide and posing a threat to human well-being. In the Bohai Sea (BS), the increase in DON concentrations and changes in its composition have been linked to harmful algal blooms and a shift from diatom to dinoflagellate dominance. This study investigated the mechanism behind the shift from diatoms to dinoflagellates using field experiments, a biogeochemical model, and techniques for analyzing organic chemicals. Our findings indicated that dinoflagellates (represented by Karenia mikimotoi ) can efficiently assimilate humic-like substances in hydrophobic DON, and that diatoms (represented by Chaetoceros spp.) can effectively utilize protein-like components in hydrophilic DON. This difference arose because of higher extracellular leucine aminopeptidase activity in dinoflagellates compared to diatoms, enabling them to degrade humic-like substances and protein-like components more effectively. Our modeling study further revealed that the DON composition, particularly the proportion of hydrophobic DON, regulated the shift from diatoms to dinoflagellates. These insights into the mechanisms driving phytoplankton regime shifts in the BS provide valuable guidance for mitigating eutrophication by controlling terrestrial DON inputs and compositions.
研究领域:
海洋生态学
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环境科学
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Weiqing Lan,Mingxing Zhou,Bingjie Zhang,Shucheng Liu,Jing Xie
Phenolic acid-chitosan derivatives have received extensive attention due to their greatly enhanced mechanical, antibacterial and antioxidant properties, especially in food preservation. The chitosan-gentianic acid (CS-g-GA) was prepared and its impact on myofibrillar proteins (MPs) in sea bass ( Lateolabrax maculatus ) during refrigerated storage was investigated in this study. Fish fillets were immersed in distilled water, CS, GA and CS-g-GA solutions, respectively, followed by an 18-day refrigerated storage. MPs were extracted from fish fillets every 3 days, and then the degree of oxidation and conformational changes of MPs were evaluated. The results of myofibril fragmentation index (MFI) and surface hydrophobicity confirmed that CS-g-GA can retard the fragmentation and degradation of myofibrils. Additionally, the total sulfhydryl content of CS-g-GA-treated samples in the later storage was significantly higher than those of other groups, confirming that CS-g-GA treatment protected the structure and function of protein. Results of Fourier transform infrared spectroscopy (FT-IR) and inner fluorescence intensity (IFI) showed that CS-g-GA maintained the secondary and tertiary structure of MPs. The results from scanning electron microscope (SEM) further clarified that CS-g-GA can maintain the tight arrangement of muscle fibers and protect the microstructure of myofibrils. Furthermore, the observation of confocal laser scanning microscopy (CLSM) demonstrated that CS-g-GA can prevent protein cross-linking and aggregation. Therefore, CS-g-GA treatment can effectively protect the structure and delay the oxidation of MPs.
研究领域:
食品科学
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蛋白质化学
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高影响因子
危险品化学品经营许可证（带存储）