INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Sina Seifi,Azadeh Ghaee
In this study, a novel nanocomposite scaffold comprising pectin, gelatin, and amoxicillin trihydrate-loaded UiO-66-NH 2 metal-organic frameworks (UiO-66-NH 2 @AMX) was fabricated for skin tissue engineering applications. UiO-66-NH 2 nanoparticles were synthesized hydrothermally and subsequently loaded with amoxicillin trihydrate. Finally, UiO-66-NH 2 @AMX nanoparticles were incorporated into pectin-gelatin scaffolds using the freeze-drying method. FE-SEM imaging confirmed the octahedral morphology of the nanoparticles before and after drug loading. FTIR analysis demonstrated successful drug incorporation via non-covalent interactions. DLS and zeta potential measurements showed that UiO-66-NH 2 nanoparticles had a mean size of 218.5 ± 14 nm and a surface charge of +44.1 ± 2.7 mV. After drug loading, the size slightly increased to 248.8 ± 19 nm, and the surface charge decreased to +32.6 ± 2.5 mV, while maintaining colloidal stability. All of the scaffolds showed porous structures with interconnected pores in SEM imaging. The incorporation of UiO-66-NH 2 @AMX nanoparticles into the pectin-gelatin scaffolds up to 3 % (w/w) increased the tensile strength and Young's modulus of the scaffolds 37.6 % and 56.7 %, respectively. Antibacterial activity was evaluated by CFU assay, where UiO-66-NH 2 @AMX containing scaffolds revealed significant bacterial reduction against E. coli and S. aureus colonies. MTT, cell adhesion, and cell scratch assays conducted on L929 fibroblasts. All of the scaffolds demonstrated >85 % cell viability after 3 days of culture. Furthermore, scaffolds with 3 % (w/w) UiO-66-NH 2 @AMX enhanced cell adhesion and increased migration rate in scratch closure assay. Overall, the results indicate that the novel nanocomposite scaffolds are promising candidates for skin tissue engineering and wound healing applications.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuxin Li,Zhimin Wang,Yuanfeng Wei,Ting Wang,Maosong Zhao,Jie Luo,Jun Zhou,Zhaoshuang Li,Kai Yin,Chengbin Liu
Water decontamination from arsenic-contaminated groundwater is critical to the health of millions of households worldwide. However, efficiently removing the low-adsorbing As(III) remains challenging. Herein, a multifunctional biocomposite bead UiO-66-NH 2 -Cl@PCB integrating defects, oxidation and adsorption properties was prepared to effectively remove As(III). The N -chlorosulfonamide bound within the embedded UiO-66-NH 2 -Cl oxidizes the lower-adsorbing As(III) to As(V), which could be effectively adsorbed by the defect-rich MOF, while the porous chitosan bead (PCB) host ensures the utilisation of the reactive sites of UiO-66-NH 2 -Cl. Using 1 g/L of UiO-66-NH 2 -Cl@PCB, 1 mg/L of As(III) can be reduced to under 10 μg/L in 300 min. Furthermore, similar As(III) removal efficiencies were achieved across a wide pH spectrum (3–9) or in the presence of interfering substances (anions, cations, organic matter). High concentrations of phosphate will inhibit its performance. As(III) removal followed the Freundlich isotherm modal, and its maximum removal capacity reached 58.09 mg/g at pH 7. Furthermore, at equilibrium concentrations of 10 μg/L, its As(III) removal capacity exceeded 10 mg/g. UiO-66-NH 2 -Cl@PCB can purify the As(III)-spiked groundwater to meet the drinking standard level. Using NaOH solution for regeneration, the removal efficiency maintained above 70 % in the fifth cycle. Additional chlorination treatment can significantly improve reusability. 2.4 g of UiO-66-NH 2 -Cl@PCB packed fixed-bed column was capable of purifying 3820 BV of groundwater containing 100 μg/L of As(III). The proposed UiO-66-NH 2 -Cl@PCB has the potential to be an easy-to-use and reliable material for efficient As(III) removal.
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CRYSTENGCOMM
·
2025
·
IF 2.6
Huanxia Lin,Wensong Lin,Yeheng Zhang,Ran Gao,Yong He
BiOCl/UiO-66-NH2 photocatalysts were synthesized by a hydrothermal method. BUNH-8 (BiOCl/UiO-66-NH2 composite with 8% UiO-66-NH2) exhibits exceptional photocatalytic performance under visible-light illumination, degrading 92% of rhodamine B (RhB) within 60 minutes, which is 38.16% greater than that of pure BiOCl. The enhanced performance of the BiOCl/UiO-66-NH2 composite photocatalyst can be attributed to the distinct band structure difference between BiOCl and UiO-66-NH2, facilitating effective Z-scheme charge separation and transfer under light irradiation. Superoxide radicals were determined to be the crucial active species in the photocatalytic degradation process via electron paramagnetic resonance (EPR) analysis and a simulated photocatalytic degradation experiment of the dye RhB with scavengers added. Apart from its high efficiency, BUNH-8 demonstrates excellent stability as well. Even after being reused four times, it maintains its excellent photocatalytic performance, suggesting its high potential for application.
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ANALYTICAL SCIENCES
·
2024
·Vol. 40
·期 6
·1081-1087
·
IF 1.8
Mei Xuqiao,Zeng Zhenhua,Xu Wenxin,Yang Huicong,Zheng Yuanhai,Gao Haimin,Wu Chuncai,Zheng Yanping,Xu Qiaoli,Wang Guowei,Xu Yuhuang,Wu Ayang
CA125 (carbohydrate antigen 125) is an important biomarker of ovarian cancer, so developing effective method for its detection is of great significance. In the present work, a novel sandwich-like electrochemical immunosensor (STEM) of CA125 was constructed by preparing nanoribbon-like Ti 3 C 2 T x MXenes (Ti 3 C 2 T x NR) to immobilize primary antibody (PAb) of CA125 and UIO-66-NH 2 MOFs structure to immobilize second antibody (SAb) and electroactive toluidine blue (Tb) probe. In this designed STEM assay, the as-prepared Ti 3 C 2 T x NR nanohybrid offers the advantages in large surface area and conductivity as carrier, and UIO-66-NH 2 provided an ideal platform to accommodate SAb and a large number of Tb molecules as signal amplifier. In the presence of CA125, the peak currents of Tb from the formed STEM structure increase with the increase of CA125 level. After optimizing the related control conditions, a wide linear range (0.2–150.0 U mL −1 ) and a very low detection limit (0.05 U mL −1 ) of CA125 were achieved. It’s thus expected the developed STEM strategy has important applications for the detection of CA125. Graphical abstract
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2020
·
IF 4.551
Hao Guo,Jiaqin Liu,Yanhong Li,Jürgen Caro,Aisheng Huang
Due to their rationally controlled pore size and easy functionalization, metal-organic frameworks (MOFs) are a promising candidate for membrane separation . As one of the most stable MOFs, UiO-66 has attracted intense attention for the preparation of molecular sieving membranes. A new post-synthesis modification (PSM) strategy was developed to enhance the separation selectivity of supported UiO-66-NH 2 membranes on porous ceramic tubes called UiO-66-NH 2 @SA by using salicylaldehyde (SA) modification. The mixed gas separation factors of H 2 /CO 2 and H 2 /CH 4 can be improved due to constrictions of the pore size through reaction of –NH 2 with SA giving iminophenol moieties. Notably, SA-modified UiO-66-NH 2 membranes are rather stable, at a high operation temperature of 200 °C and 1 bar, mixture separation factors of 11.3 for H 2 /CO 2 and 22 for H 2 /CH 4 can be obtained. Further, no obvious performance degradation has been observed after 3 months storing in air. This high stability of UiO-66-NH 2 @SA membrane could provide possibility for the industrial applications of hydrogen separation and purification.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 5
·1-9
·
IF 5.3
Li Rui,Que Wenzhong,Han Haiyan,Shi Honghui,Wang Rongfeng,Qiu Bin
IL-17 (interleukin-17) is a common proinflammatory cytokine and can be adopted as an important biomarker for several diseases; it is thus very necessary to design an effective method for monitoring IL-17. Herein, by preparing silver nanoparticles/graphdiyne (Ag/GDY) with simple electroless deposition as the sensing platform and methylene blue/UiO-66-NH 2 MOFs (MB/MOFs) as the signaling-amplifier, a highly efficient sandwich-like electrochemical immunosensing (SLEI) platform was designed for IL-17 detection. The superior electrical property, easy preparation, large surface area, and high stability of Ag/GDY make it a desirable substrate to immobilize primary antibody of IL-17. Meanwhile, the unique structure of UiO-66-NH 2 is beneficial to immobilize MB probe and secondary antibody. By optimizing experimental conditions, the MB current obtained at the as-designed SLEI platform increases along with IL-17 increase, and the related linearity is 1.0 pg mL −1 –1.0 ng mL −1 coupled with a low detection limit of 0.3 pg mL −1 . It is expected that the SLEI platform based on Ag/GDY and MB/MOFs shows some potential application for IL-17 detection. Graphical abstract
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JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Pei Jia,Kairong Yang,Jinjie Hou,Yuanyuan Cao,Xin Wang,Li Wang
The increasing deterioration of ecosystem derived from heavy metals residues brings about the environmental and food contamination , which presses the exploration of facile platform for monitoring heavy metals. Herein, a ratiometric fluorescence sensor was designed for Hg 2+ detection based on the compound of UiO-66-NH 2 and Ru(bpy) 3 2+ (Ru@UiO-66-NH 2 ) which was synthesized by situ encapsulation. The innovative composite displayed two emission peaks at 437 and 604 nm, and the addition of Hg 2+ could only quench the blue fluorescence due to static quenching and photo-induced electron transfer mechanism, providing an internal standard to promote the precision. Under optimal conditions, the ratiometric Ru@UiO-66-NH 2 probe revealed outstanding anti-interference capability and performed with a great limit of detection (LOD) of 0.053 μM for Hg 2+ , which was 2-fold lower than that of single-color UiO-66-NH 2 . By merit of Ru@UiO-66-NH 2 , test hydrogels were fabricated to provide a tactics for visual, rapid and on-site detection of Hg 2+ . Additionally, the dual-emitting sensing platform presented satisfactory recoveries and reliabilities in lake water, tap water , and drink water, demonstrating the application potential of this proposed ratiometric fluorescence sensor for monitoring Hg 2+ .
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ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Jiali Liu,Xianbiao Wang,Yangyang Zhao,Yongfei Xu,Yang Pan,Shaojie Feng,Jin Liu,Xianhuai Huang,Huanting Wang
Radioactive U(VI) in nuclear wastewater is a global environmental pollutant that poses a great threat to human health. Therefore, it is of great significance to develop a U(VI) sensor with desirable sensitivity and selectivity. Inspired by electron-donating group modification for enhancement of binding affinity toward U(VI), we report an amine group functionalization of UiO-66-NH2, using a low-cost, environmentally friendly, and low-temperature NH3 plasma technique as a fluorescence switching nanoprobe for highly sensitive and selective detection of U(VI). The resulting amine-functionalized UiO-66-NH2 (LTP@UiO-66-NH2) shows dramatically enhanced fluorescence emission and selective sensitivity for U(VI) on the basis of the quenching effect. The quenching efficiency increases from 58 to 80% with the same U(VI) concentration (17.63 μM) after NH3 plasma functionalization. As a result, the LTP@UiO-66-NH2 has the best Ksv (1.81 × 105 M–1, 298 K) and among the lowest LODs (0.08 μM, 19.04 ppb) compared with those reported in the literature. Intraday and interday precision and application in real environment experiments indicate stable and accurate U(VI) detection performance. Fluorescence lifetime and temperature-dependent detection experiments reveal that the quenching mechanism belongs to the static quenching interaction. The highly selective fluorescence detection is attributed to the selective binding of U(VI) by the rich functionalized amine groups of LTP@UiO-66-NH2. This work provides an efficient fluorescence probe for highly sensitive U(VI) detection in water, and a new strategy of tailored plasma functionalization for developing a practical MOF sensor platform for enhanced fluorescence emission, sensitivity, and selectivity for detecting trace amounts of radioactive species in the environment.
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Journal of Water Process Engineering
·
2024
·
IF 6.3
Nan Zhao,Kangjie Zhang,Yuexiang Lu,Shuang Liu,Zhe Wang,Xiangke Wang
The photocatalytic method has been proven as one of the effective methods for uranium removal from radioactive wastewater. Herein, a photocatalyst UiO-66-NH 2 -Pt was prepared using the adsorption-photoinduction method. Pt was first adsorbed on the substrate and then photo-reduced under light irradiation to be doped into the structure of UiO-66-NH 2 . The characterization results implied the formation and atomic dispersion of Pt with a loading content of 1.90 wt%. The loading of Pt has promoted the effective separation and transfer of photogenerated electron-hole pairs, broadened the visible light adsorption range and narrowed down the bandgap, thus to enhance the photocatalytic activity. Then they were applied for the photo-removal of uranium under air atmosphere. The reaction rate of UiO-66-NH 2 -Pt was about 7 times that of pure UiO-66, confirming the higher photocatalytic activity after the loading of Pt. It showed good reusability and was also universal for different water matrix. The detection of hydroxyl radicals with EPR method indicated the formation of H 2 O 2 , which could react with uranyl ions to form metastudtite under air. This work further verified the feasibility of photoinduced synthesis of Pt single atom and provided a novel material for photocatalytic removal of uranyl ion under air.
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ACS Applied Polymer Materials
·
2024
·
IF 4.4
Zhaojie Wang,Qinglong Liu,Xinle Sun,Caifeng Xia,Qikang Yin,Maohuai Wang,Xiaodong Chen,Huili Zhang,Shuxian Wei,Xiaoqing Lu,Siyuan Liu
MOFs-filled mixed matrix membranes (MMMs) have great potential to break the trade-off effects of traditional gas separation membranes. However, achieving good interfacial compatibility and adequate dispersion of the MOF is not straightforward. In this study, a continuous postmodification was developed for advanced CO2/N2 MMMs. UiO-66-NH2 was easily modified with trimesoyl chloride (UiO-66-TMC) and polyethylene glycol (UiO-66-PEG) sequentially, which was utilized as fillers to construct polyimide (PI) mixed matrix membranes (MMMs). Rich interactions between modified UiO-66-NH2 and the PI polymer contribute to efficient CO2 and N2 separation. At 25 °C and 0.1 MPa, UiO-66-TMC/PI MMMs showed a CO2/N2 selectivity of 55.3, and a CO2 permeability of 616.17 Barrer, and those are 56.7 and 686 Barrer for UiO-66-PEG200/PI MMMs. Both of their CO2/N2 separation performances exceed the 2008 Robeson upper bound. The ether bonds in PEG exhibit strong interactions with the CO2 molecules and improve the CO2 dissolution selectivity. Meanwhile, the introduction of organic ingredients realized good dispersion and interfacial compatibility within the PI matrix. This work lays the groundwork for the further fabrication of highly selective CO2 separation materials with specific microscopic interface structures and properties.
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DESALINATION
·
2025
·
IF 9.8
Xinyue Zhang,Shichen Xiao,Zerong Miao,Xudong Wang,Jin Wang,Jiajin Hao,Junwei Xin,Huihui Zhang,Lei Wang
The selective recovery of lithium from salt-lake brines using functionalized polyamide nanofiltration (NF) membranes offers a promising strategy to alleviate the global lithium resource shortage. However, the structural controllability of functional fillers and their interfacial compatibility remain critical challenges in constructing high-performance NF membranes. In this study, a polyamide NF membrane was modified with defect-engineered and gel-state UiO-66-NH 2 nanoparticles, combined with an external electric field, to achieve efficient Li + /Mg 2+ separation. By tuning the HCl/HAc ratio, the nucleation and growth of UiO-66-NH 2 were regulated, yielding gel-state nanoparticles with abundant defects (defect coordination number ~ 0.73), excellent dispersibility, and high protonation, facilitating interfacial integration with the polyamide matrix. In situ characterization revealed that defect-engineered and gel-state UiO-66-NH 2 enhanced the membrane's positive surface charge and formed a “spinal-like” microstructure. Under the optimal acid ratio, the nanoparticles promoted higher polyamide cross-linking, reducing the average effective pore size from 0.54 to 0.46 nm, enabling synergistic control of both physical and chemical membrane properties. With an applied electric field, monovalent ion dehydration and migration were accelerated, enhancing ion decoupling and achieving a separation factor of 83.87 for Li + /Mg 2+ at an applied current of 6 mA. This work demonstrates a triple synergistic mechanism involving interface regulation, structural optimization, and electric-field coupling, highlighting the pivotal role of gel-state defect-engineered MOFs in tuning membrane microstructure and surface charge. This finding provides new theoretical guidance and design strategies for efficient lithium recovery using electric-field assisted functional nanofiber membranes.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Chengli Xie,Longcheng Gong,Tong Xu,Lianzhe Hu,Zhining Xia,Min Wang
To overcome the limitation of low catalytic activity in nanozyme labels for immunoassay, this study proposed a heterovalent Co-doping strategy to construct the bimetallic Zr/Co-UiO-66-NH2 nanozyme. Compared to the undoped UiO-66-NH2, the resulting nanozyme exhibited a 14-fold enhancement in phosphatase-like catalytic efficiency (kcat/Km). Mechanistic investigations revealed that the activity enhancement was not only dependent on the high specific surface area and increased defects introduced by heterovalent Co doping, but also was attributed to the electronic synergy between Zr and Co. Furthermore, a fluorescent immunoassay method utilizing highly efficient Zr/Co-UiO-66-NH2 as the nanozyme label was developed for the ultrasensitive detection of carcinoembryonic antigen (CEA). This method achieved a broad linear detection range spanning 6 orders of magnitude (1 × 10–12 g/mL to 1 × 10–6 g/mL) and a detection limit as low as 0.74 × 10–12 g/mL. The high recovery rates (95.89%–99.31%) in serum samples demonstrate great potential for the detection of CEA in complex biological matrices.
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