BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2018
·Vol. 42
·期 2
·279-290
·
IF 2.139
Bin Zou,Yanhong Chu,Jiaojiao Xia
A novel and highly stable biomimetic oxidase sensor system was designed for catehol detection. FePP used as biomimetic horseradish peroxidase (HRP) was immobilized onto modified multi-walled carbon nanotubes (MWCNTs). Functional groups such as –OH, –NH 2 and –COOH were introduced onto the surface of MWCNTs to provide biomimetic microenvironment for iron porphyrins (FePP). Stable biomimetic enzyme electrode has been developed to detect catechol as a simple, economical and efficient method. At optimal condition, the detection limit of OH-MWCNTs/FePP/Nafion was 3.754 × 10 − 6 M. After stored at − 4 °C for 35 days, the oxidation current value still maintained 98.3% of initial activity. In repetitive nature test, relative standard deviation (RSD) of oxidation current remained within 1.0% after ten consecutive measurements in the same concentration of catechol solution, while most of reported oxidase sensor was within 2.0% under the same condition.
研究领域:
分析化学
·
生物传感技术
·
环境监测
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Guihua Yan,Shuaiming He,Sen Ma,Anqi Zeng,Gaofeng Chen,Xing Tang,Yong Sun,Feng Xu,Xianhai Zeng,Lu Lin
In recent years, research on multifunctional conductive hydrogels has focused on improving their mechanical properties. However, challenges remain in achieving all these properties by natural polymers and inorganic molecules. Here, we assembled all-wood tough hydrogels with anisotropic mechanical properties through the formation of dynamic bonding between cellulose fibers, natural wood lignin, Polyacrylamide (PAM) chains, and iron ions. Inspired by the catechol-based chemistry, the Fe 3+ ions and catechol groups of lignin can trigger the rapid self-gelation of the hydrogels under the effect of Ammonium peroxydisulfate (APS), and serve as the reversible hydrogen bonds and metal-coordination bonds to endow the hydrogel with the flexible property. The highly aligned delignified wood acts as a frame structure endows the hydrogel with strong mechanical strength. Meanwhile, the PAM chains flooding the cellulose fibers further enhance the mechanical properties of hydrogels by hydrogen bonds. The all-wood hydrogel displays much higher stretchability (up to 0–50% strain) than natural wood (0–5% strain). The all-wood hydrogels hold great potential for compressive sensing due to their wide range of strain, high sensitivity, and good flexibility.
研究领域:
材料科学
·
生物工程
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Yongrong Zhang,Feifei Xing,Shourong Zhu
A lariat anthraquinone macrocycle functionalized with catechol (H2L) was synthesized via the Mannich reaction. The Mannich base H2L can be partially decomposed into L1·3H2O and HL1·NO3·2H2O in the presence of tetrabutylammonium hydroxide/Al(NO3)3·9H2O in dimethyl sulfoxide (DMSO). Free L1·3H2O is essentially coplanar, while protonated HL1·NO3·2H2O is highly distorted. Dark-green FeCl3·H2L·2H2O powder and Fe2(HL)2Cl4 crystal can be isolated from ethanol (C2H5OH) in high/low H2L concentration. Anthraquinone in H2L is essentially coplanar but distorted in Fe2(HL)2Cl4. The Fe(III) ion in Fe2(HL)2Cl4 adopts a less common five-coordination with three catecholate O and two Cl atoms in the dimer. The distortion of inbound C═O is much higher than that of outbound C═O in anthraquinone in all of these compounds. H2L responds to chlorides of Li+, Na+, K+, Cs+, Mg2+, Ca2+, Sr2+, Ba2+, Fe3+, Cu2+, Zn2+, and Al3+ in a DMSO solution, which can be observed by differential pulse voltammetry, UV–vis, and 1H NMR. All of these metal ions shift Ep of anthraquinone to positive, especially the second reduction peak of anthraquinone. Fe3+, Zn2+, and Al3+ change the reduction of catechol fundamentally. H2L (0.50 mM) shows a chromogenic response to FeCl3 and Fe(NO3)3 to form uncommon 2:1 and 3:2 (H2L/Fe) complexes, both peaking at 748 nm in DMSO. In the presence of 2 equiv of sodium hydroxide (NaOH), the 748 nm absorbance shifts to 777 nm, identical with Fe2(HL)2Cl4 in DMSO. Different from the fast reaction between H2L and FeCl3, Fe(NO3)3 reacts with H2L rather slowly in DMSO. Catechol can coordinate to FeCl3 without any deprotonation in C2H5OH and DMSO. H2L also shows a chromogenic response to fluorides and hydroxides, which peak at 670 and 684 nm, respectively, in DMSO. The binding ratio between H2L and F–/OH– is 1:2. In a higher concentration of hydroxides, a 684 nm greenish-blue 1:2 complex forms immediately, which gradually transforms to a red complex and peaks at ∼530 nm in minutes at room temperature. No color change can be observed in an C2H5OH solution in the presence of OH–.
研究领域:
超分子化学
·
无机化学
·
传感器与传感材料
·
配位化学
·
有机合成
·
电化学
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2023
·Vol. 170
·期 7
·077509
·
IF 3.9
Qi Wang,Wenjing Liu,Jinjin Zhang,Jianying Qu
In this work, Cu/N-C derived from MOF composites were synthesized and characterized by SEM, XRD, FTIR, XPS and EIS, which was modified on the glassy carbon electrode (GCE) to construct a novel electrochemical sensor (Cu/N-C/GCE). Due to the good electrical conductivity and abundant catalytic active sites of Cu/N-C, Cu/N-C/GCE exhibited excellent electrocatalytic performance for catechol (CC) and hydroquinone (HQ) with the oxidation peak potential difference of 112 mV. The proposed sensor could realize the simultaneous detection of CC and HQ successfully. Under optimal conditions, the redox peak currents of both CC and HQ have good linear relationship with their concentrations in the ranges of 0.50–100.00 μM and 0.50–150.00 μM with the detection limits for CC and HQ of 0.12 μM and 0.09 μM, respectively. At the same time, the sensor exhibits good stability, reproducibility and selectivity in the analysis of practical samples.
研究领域:
分析化学
·
材料科学
·
环境科学
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DOI
高影响因子
Biomaterials Advances
·
2026
·
IF 6.7
Yuzhou Chen,Zidi Yan,Meng Zhu,Yu Liu,Kejia Li,Le Yue,Ye Tian,Hongyan Xiao,Liping Wen,Zhongwei Niu
2,3-Catechol shows superior antioxidant property and oxidation resistance than 3,4-isomer. • An innovative fabrication strategy for a chitosan hydrogel is established. • A new therapeutic option for granulation regeneration in diabetic wounds is provided. Diabetic wound healing remains a major clinical challenge due to a pathological microenvironment characterized by excessive reactive oxygen species (ROS) and chronic inflammation. Excessive ROS through multiple distinct pathways hinders the regeneration of granulation tissue, which is the essential scaffold for wound repair. Although catechol attracted considerable interest for antioxidant applications in biomaterials, its inherent chemical instability under physiological conditions severely limits its therapeutic potential and clinical applications. To address these critical challenges, an antioxidant 2,3-HCat-CS/STPP hydrogel has been developed via the freeze-thaw method, composed of 2,3-dihydroxybenzoic acid modification of chitosan (2,3-HCat-CS) and sodium tripolyphosphate (STPP). As an antioxidant, 2,3-HCat-CS was demonstrated both theoretically and experimentally to possess superior oxidative stability and ROS-scavenging property compared to the conventional 3,4-isomer. Exploration of the gelation mechanism revealed that 2,3-HCat-CS/STPP hydrogel is formed from electrostatic interactions, crystalline regions and hydrogen bonds. Hydrogel exhibited excellent antioxidant property and biocompatibility in vitro . In a full-thickness wound model in db/db mice, treatment with 2,3-HCat-CS/STPP hydrogel effectively reduced local ROS levels, mitigated inflammation and increased the levels of key anti-inflammatory cytokines (TGF-β1 and IL-10). This intervention effectively disrupted the detrimental inflammatory cycle characteristic of diabetic wounds, thereby fostering the process of angiogenesis and granulation regeneration. This work combines the molecular design of catechol and the fabrication process of chitosan gelation to create 2,3-HCat-CS/STPP hydrogel that promotes granulation regeneration in diabetic wounds, which presents a potential therapeutic platform for chronic wounds management. Download: Download high-res image (294KB) Download: Download full-size image
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2019
·Vol. 49
·期 6
·563-574
·
IF 2.366
Zheng Sining,Wu Dan,Huang Limei,Zhang Mengxin,Ma Xiuling,Zhang Zhangjing,Xiang Shengchang
Abstract It is needed to speed up the development of a sensitive detection platform for simultaneous determination of dihydroxybenzene isomers with harmful properties. Here, two isomorphic Metal–organic frameworks (MOFs) [Zn(Trz)(R-BDC) 1/2 ] (FJU-40-R, R = H or NH 2 ; Trz = 1,2,4-Triazole; H-BDC = terephthalic acid) were selected to derive two N-doping porous carbon (NPC) materials. Further, a strategy for constructing electrochemical sensors for simultaneous determination of hydroquinone (HQ) and catechol (CT) was proposed by the MOF-derived NPC modifying glass carbon electrode (GCE). It was found that HQ and CT had good responses on NPC-FJU-40-H/GCE, but had no obvious responses on NPC-FJU-40-NH 2 /GCE. NPC-FJU-40-H/GCE displayed excellent reproducibility, stability, and anti-interference. Under the optimal conditions, the linear ranges of HQ and CT on NPC-FJU-40-H/GCE were 1 ~ 70 µmol L −1 and 1 ~ 100 µmol L −1 with the detection limits of 0.18 µmol L −1 for HQ and 0.31 µmol L −1 for CT, respectively. Although the porous carbon (PC) derived from MOFs has been applied in electrochemical sensing, the effect of the ligand functional groups of isomorphic MOFs on the electrochemical properties of the derived PC materials is still lack of relevant research. Our research provided an idea that the electrocatalysis properties of MOF-derived porous carbon materials could be tuned by changing the functional groups in ligands of isomorphic MOFs in electrochemical sensing field. Graphical abstract A feasible strategy was proposed by changing the ligands of the two isomorphic MOFs (FJU-40-H and FJU-40-NH 2 ) to tune the electrocatalysis properties of MOF-derived N-doped porous carbon materials for the simultaneous determination of dihydroxybenzene isomer.
研究领域:
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Delai Jiao,Hengji Zhao,Haofei Sima,Chunzu Cheng,Bo Liu,Chunling Zhang
In this work, we synthesized a 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative flame retardant dopamine modified DOPO (DOPO-DA) for flame retardant thermosetting epoxy resins (EP). The effects of different amounts of flame retardants on the flame retardancy, thermal properties, and mechanical properties of EP composites were studied. Compared with the control EP, the peak heat release rate (PHRR) of EP/5 wt% DOPO-DA decreased by 26.1%. In addition, EP/5 wt% DOPO-DA reached V-0 level. It can be attributed to the quenching effect of P element and catechol groups in DOPO-DA, reducing the active free radicals. N element can release non-combustible gases to dilute the concentration of oxygen. Meanwhile, P element can promote the formation of a dense carbon protective layer and slow down the heat and oxygen transfer on the surface. In addition, DOPO-DA can also participate in the crosslinking reaction of EP as a curing promoter, reducing crosslinking density and improving tensile properties.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Liuxin Yang,Pengfei Ren,Dandan Wei,Min Liang,Li Xu,Yinghua Tao,Guanhua Jiao,Tianzhu Zhang,Qianli Zhang
Temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) polymers have been studied in many fields due to their “on–off” adjustable properties under temperature stimulation. In this work, the “on–off” mechanism for poly(N-isopropylacrylamide-co-dopamine methacrylamide) (PNIPAM-co-DMA) microgels for cell culture and nonenzymatic cell harvest was explored. Thermoresponsive surfaces were developed on silica wafers using microgels with different DMA contents using a simple spin-coating method. Experiments showed that the microgels showed an “on” state above the lower critical solution temperature (LCST), and PNIPAM-co-DMA (PND) microgels shrank to expose catechol groups for enhanced cell adhesion and proliferation. Conversely, the microgels showed an “off” state below LCST, and the hydrophobic and cell-repellent properties of DMA contributed to the rapid hydration of microgels for accelerated cell disassociation. The developed microgels presented DMA content and distribution-related cell detachment efficiency, with PND (100:0.5) and PND (100:2) showing better results. The failure of cell harvest caused by too much DMA restricted the shrinkage and swelling of microgels due to the strong hydrogen-bonding adhesion of catechol moieties for PND (100:10). Overall, the presented strategy exhibits a wide-ranging utility to construct thermoresponsive surfaces with “on–off” functionalization by introducing catechol chemical monomers.
研究领域:
材料科学
·
生物医学工程
·
细胞生物学
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Xiaoyong An,Yida Wang,Zhenghao Chen,Jiafei Zhang,Shuangbao Zhang
This study explores a cost-effective and environmentally friendly surface modification of bamboo fibers to improve their interfacial compatibility with poly (β-hydroxybutyric acid). Laccase catalyzed the oxidation of bamboo fibers, increasing their active reaction sites and surface roughness so that the deposition of catechol and tetraethylenepentamine (TEPA) reactions on the bamboo fiber surface was promoted. The FTIR , XPS , and XRD results of bamboo fibers indicate that laccase can effectively oxidize lignin, generating oxygen radicals and promoting the reactive deposition of catechol and TEPA on the surface of the bamboo fibers, without destroying the structure of bamboo fibers. The TGA results of bamboo fibers indicate that when the concentrations of both catechol and TEPA are 15 mM, a laccase concentration of 150 U/L is more effective in enhancing the thermal stability of bamboo fibers. Furthermore, the mechanical properties of BFs/PHB composites showed that the addition of 200 U/L of laccase led to relatively good interfacial compatibility between bamboo fibers and PHB, tensile strength , flexural strength , flexural modulus and impact strength of the composite material respectively increased by 18.4%, 14.1%, 13.4% and 10.4%, while the tensile modulus decreased by 9.4%, compared to the composite material prepared with unmodified bamboo fibers.
研究领域:
材料科学
·
生物技术
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuanying Li,Han Shao,Yunxiu Zhang,Qiang Liu,Changhan Yan,Xiyin Liu,Yaolan Tao,Renhao Nie,Jianhong Zhang,Qingyan Jia,Peng Li
Due to the heightened nutritional consumption resulting from aberrant metabolism of tumor cells, starvation therapy, which involves blocking or depleting key nutrients in tumors, has gained popularity as an attractive approach to treating cancer. Herein, the catechol-containing polymer, P(DMA-co-MAA)-BTZ, was successfully synthesized via the copolymerizing dopamine methacrylamide (DMA) with polymethacrylic acid (MAA), followed by grafted with chemotherapy drug bortezomib (BTZ). The P(DMA-co-MAA)-BTZ exhibited pH-responsive behavior in the acidic tumor microenvironment, facilitating controlled release of BTZ for chemotherapy. Additionally, the liberated phenolic groups could form a membranal coating on the surface of tumor cells in response to overexpressed H 2 O 2 , thereby impeding the uptake of external nutrients and enabling starvation therapy. The efficacy of P(DMA-co-MAA)-BTZ in inhibiting glucose uptake by tumor cells has been demonstrated through both in vitro and in vivo experiments, resulting in a reduction of intracellular lactate, GSH, and ATP synthesis as well as the accumulation of reactive oxygen species as metabolic waste. This synergistic strategy of combining starvation therapy with chemotherapy yielded efficient anti-tumor effects while suppressing tumor metastasis and invasion, presenting a promising alternative approach for clinical tumor treatment.
研究领域:
肿瘤学
·
生物化学
·
药物化学
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产品关联
DOI
高影响因子
Minerals
·
2024
·Vol. 14
·期 12
·1255
·
IF 2.2
Chenglong Du,Jiang Yu,Guangyi Liu
Iron ore is the main raw material of the iron and steel metallurgy industry, but quartz in iron ore reduces metallurgical efficiency and increases metallurgical costs. Therefore, iron ore desiliconization by flotation plays an important role in the iron and steel metallurgy industry. In this study, 4-tert-butyl-catechol (TBC) was designed as a collector to directly float out hematite from quartz. The micro-flotation tests demonstrated that under pH ~9.0, 1 × 10−5mol·L−1TBC recovered 98% hematite from its mixture with quartz, while the recovery of quartz was only about 17%. Zeta potential and contact angle results inferred that the adsorption affinity of TBC toward hematite was greater than that to quartz. The results of FTIR and XPS inferred that TBC adsorbed on the Fe3+sites of hematite interfaced via the O atom of its two adjacent hydroxyl groups to form a stable five-membered chelating ring at pH 9.0. This study offered new research insight on the development of novel collectors for hematite flotation through bionics technology.
研究领域:
矿物加工工程
·
材料科学与工程
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2017
·Vol. 8
·期 19
·2997-3005
·
IF 5.375
Meng Shan,Chu Gong,Bingqiang Li,Guolin Wu
An injectable polyethylene glycol (PEG) hydrogel was successfully prepared via borate–catechol complexation using dopamine functionalized 4-armed PEG (4-arm-PEG-DA) and phenylboronic acid modified 4-armed PEG (4-arm-PEG-PBA). The hydrogel was formed within 10 s by mixing 15 wt% 4-arm-PEG-DA with 15 wt% 4-arm-PEG-PBA buffer solutions at pH 9.0. The hydrogel was characterized by Fourier transform infrared (FT-IR) spectroscopy, rheological measurements, scanning electron microscopy (SEM) and lap shear strength tests. Furthermore, pH, glucose and dopamine responsiveness of the hydrogel based on phenylborate–catechol complexation was demonstrated by degradation experiments and drug release tests. The lap shear strength tests indicated that the hydrogel possessed the ability of self-healing which was bestowed by the phenylborate–catechol dynamic covalent bond. Moreover, the hydrogel could serve as a decent bio-adhesive due to its adhesion properties on different substrates especially the porcine skin. In vitro cytotoxicity tests demonstrated the excellent cytocompatibility of the hydrogel. The results of all the experiments indicate that our newly developed multi-functionalized hydrogel can have potential applications in biomedical fields such as drug delivery, tissue engineering, and bio-adhesives.
研究领域:
生物材料
·
药物递送
·
组织工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）