COLLOIDS AND SURFACES B-BIOINTERFACES
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2014
·
IF 4.287
Fang Yuan,Shasha Wang,Gaojian Chen,Kehua Tu,Hongliang Jiang,Li-Qun Wang
A novel approach to design pH-sensitive and disintegrable polyelectrolyte nanogels composed of citraconic-based N -(carboxyacyl) chitosan (polyanion) and quaternary chitosan (polycation) was reported. Firstly, the hydrolysis of citraconic-modified chitosan was monitored using fluorescamine assay and it could selectively dissociate in acidic media (e.g., pH ∼5.0) due to the isomerization during the addition of citraconic anhydride to chitosan. Secondly, the self-assembly behaviors of different polyelectrolyte pairs between citraconic-based chitosan and quaternary chitosan were investigated via colloidal titration assay. It was indicated that the difference in molecular weight (MW) of opposite charged polyelectrolytes played an important role on the formation of polyelectrolyte nanogels. Results showed that polyelectrolyte nanogels (ca. 300 nm in size) only formed when polyanion and polycation had a very large difference in MW. The pH-sensitive behavior of polyelectrolyte nanogels was comprehensively investigated by dynamic light scattering (DLS) and transmission electron microscope (TEM). The incorporation of charge-conversional citraconic-based chitosan into polyelectrolyte complexes has provided an effective approach to prepare polyelectrolyte nanogels which were very stable at neutral pH but disintegrated quickly in acidic media.
研究领域:
材料科学
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生物医学工程
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DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
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2014
·
IF 5.039
Changlong Dong,Wei Chen,Cheng Liu
A kind of amphoteric chitosan-based flocculant (quaternized carboxymethyl chitosan, denoted as QCMC) has been prepared. QCMC presented significant improvement of water solubility in the whole pH range. The effects of pH, dosage, temperature and original turbidity of algal water on the flocculation performance were investigated. The optimal dosages of QCMC at pH 5, 9 and 12 with original turbidity of 20 NTU at 20 °C were 0.1, 0.6 and 2.0 mg/L, respectively, which were much less than that of chitosan, PAM, Al 2 (SO 4 ) 3 and FeCl 3 . The floc properties during grow, breakage and regrow period were also evaluated at different pH values in terms of floc size, strength and density. It was demonstrated that QCMC produced larger, stronger and denser flocs than Al 2 (SO 4 ) 3 . There is every indication that QCMC is more suitable for algal harvesting than other traditional coagulants or flocculants.
研究领域:
环境科学
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水处理
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化学工程
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DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2017
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IF 2.329
Suwei Jiang,Zhenyu Yu,Hailiang Hu,Jian Lv,Hualin Wang,Shaotong Jiang
Polyphenolic bioflavonoids are easily oxidized when exposed to oxygen during the processing or storage. This research developed a porous chitosan-modified starch for the adsorption of procyanidins . The modified starch was fabricated by a facile surface modification of chitosan on porous rice starch. Besides the investigation of the morphologies and structures of starches, the adsorption kinetics of procyanidins onto starches was evaluated. The modified starch was mesoporous with a relative moderate specific surface area at 1.13 ± 0.05 m 2 /g, and the interactions between starch and chitosan were intermolecular hydrogen bonds. The modification of chitosan resulted in the positive zeta potential of starch at pH 2-10. The enzymolysis reduced starch size slightly and induced a decrease in the apparent viscosity of starch suspension, while the modification of chitosan increased starch size and induced an increase in the apparent viscosity of the suspension. The adsorption capacity of the modified starch towards procyanidins was significantly improved and reached 96 ± 3% of the total amount of procyanidins, and the adsorption was chemisorption or strong surface complexation rather than mass transport. The results suggested that the porous chitosan-modified starch might be used as an efficient adsorbent for polyphenols.
研究领域:
食品科学
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生物化学
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DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2017
·Vol. 17
·期 6
·3873-3879
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IF 1.483
Hu Gaoli,Song Botao,Zhu Jie
The aim of this study was to implement a novel bioinspired process based on the superhydrophobic surface to produce organic solvent-free spheres for drug controlled release. Firstly, superhydrophobic substrate with large area was successfully constructed in one step by the electrospray
approach. Then, by utilizing the as-synthesized superhydrophobic substrate the chitosan (CS) spheres with controllable sizes and drug loading contents were fabricated. The drug encapsulation efficiency was further carefully studied, and it was found that the encapsulation efficiencies were
very high and could reach up to 92% and above. Finally, the drug release behaviors of the drug-loaded CS spheres were systematically investigated, and the results demonstrated that both the diameter of the CS spheres and the drug loading content influenced the drug release characteristics.
This present approach opened up a new possibility for the development of novel drug delivery systems with controllable drug delivery property for a broad range of pharmaceutical and biomedical applications.
研究领域:
生物材料学
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药剂学
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DOI
高影响因子
Micro & Nano Letters
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2017
·Vol. 12
·期 6
·386-390
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IF 0.723
Lv Ming-zhe,Wang Li-feng,Fang Lei,Li Pu-wang,Li Si-dong
Chitosan microspheres were prepared by ion induction and chemical cross-linking using water as the medium. Natural rubber/chitosan microsphere blends were then prepared by blending the chitosan microsphere suspension with natural rubber latex. An infrared spectrometer, particle size analyser, scanning electron microscope, surface contact angle analyser, thermogravimetric analyser, and differential scanning calorimeter were employed for structure and property characterisation. The results showed that the average particle diameter and the polydispersity index of chitosan microspheres were 323.8 nm and 0.283, respectively. The thermal stability and mechanical properties of natural rubber/chitosan blends were enhanced by introducing chitosan microspheres into natural rubber latex. The water contact angle was significantly decreased, from 94.64° to 55.47°, indicating improved hydrophilic properties for the natural rubber/chitosan film. The natural rubber/chitosan blends showed excellent antibacterial properties when the chitosan microsphere content was >4.00% w/w.
研究领域:
材料科学
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生物医学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
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2017
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IF 4.811
Lin Yue,Jingru Li,Wanwen Chen,Xiaoli Liu,Qixing Jiang,Wenshui Xia
The novel derivatives of geraniol grafted chitosan oligosaccharide were synthesized via substitution and deprotection reaction, respectively. The products were identified by Fourier transform infrared (FT-IR), 1 H nuclear magnetic resonance (NMR), X-ray diffraction analysis (XRD), Thermogravimetric analysis (TGA) and UV–vis absorption spectroscopy. It is revealed that the derivatives exhibited a good solubility, thermal stability and antibacterial properties.
研究领域:
生物材料学
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微生物学
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2017
·
IF 4.811
Xun Sun,Zonghao Tang,Meng Pan,Zhengchao Wang,Hongqin Yang,Haiqing Liu
The hemostatic performance of chitosan was greatly improved by blending it with kaolin to fabricate porous composite microspheres (CSMS-K) through inverse emulsion method combining with thermally induced phase separation. The CSMS-K had high amount of interior and surface pores. The synergetic hemostatic competence of chitosan and kaolin components made the hemostatic efficacy of CSMS-K superior to chitosan porous microspheres (CSMS). The hemostatic time of CSMS-K3 in the rat tail amputation and liver laceration models was down to respective 120 and 99 s from 183 and 134 s of CSMS, and the blood loss of CSMS-K3 was respectively 65% and 36% of that of CSMS in the rat tail amputation and liver laceration models. The whole blood clotting kinetics proved that CSMS-K3 formed larger blood clots than CSMS and Celox within a same time period. Our results suggested that the CSMS-K is a potential quick pro-coagulant agent for traumatic hemorrhaging control.
研究领域:
材料科学
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生物医学工程
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止血
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DOI
PubMed
高影响因子
Polymers
·
2017
·Vol. 9
·期 4
·116
·
IF 3.364
Rengui Weng,Lihui Chen,Shan Lin,Hui Zhang,Hui Wu,Kai Liu,Shilin Cao,Liulian Huang
Presently, most nanofiltration membranes are prepared with non-biodegradable petrochemical materials. This process is harmful to the ecosystem and consumes a large amount of non-renewable energy. In this study, biodegradable and biocompatible antibacterial cellulose/chitosan nanofiltration membranes (BC/CS-NFMs) were fabricated and characterized for their mechanical strength, antimicrobial activity, salt and dye filtration performance, and polyethylene glycol (PEG) retention using Thermal gravimetric analysis (TGA), Field emission scanning electron microscopy(FE-SEM), Fourier transform infrared spectroscopy(FT-IR), and X-ray diffraction (XRD). The BC/CS-NFMs were obtained by the hydrolysis and carboxymethylation of dense cellulose/chitosan membranes (BC/CSMs). The tensile strength of the BC/CS-NFMs decreased as the chitosan content increased. In addition, the thermal stability and antibacterial ability of the BC/CS-NFMs improved. The pore size is less than 1 nm, and a spongy, layered structure is observed in the cross-sectional FE-SEM images. FT-IR analysis shows that a part of the hydroxyl in cellulose transforms to carboxymethyl during the hydrolysis and carboxymethylation of the BC/CSMs. No obvious changes can be observed in the cellulose and chitosan after the blend membrane formation from the XRD measurements. Based on the experimental results on the permeation and rejection of BC/CS-NFMs, different proportions of cellulose and chitosan nanofiltration membranes almost did not affect the water flux and rejection rate. The BC/CS-NFMs showed better water flux and a higher rejection rate in aqueous dye-salt solutions.Keywords:cellulose;chitosan;antibacterial activity;nanofiltration membranes
研究领域:
材料科学
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环境科学
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生物医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2016
·
IF 3.138
Hongli Liu,Xiaoli Liu,Lin Yue,Qixing Jiang,Wenshui Xia
N , O -Carbonylated chitosan derivative (NTCS) was synthesized via oxidation and substitution reaction, respectively. The carboxyethylation of the polysaccharide was identified by Fourier transform infrared (FTIR), 1 H nuclear magnetic resonance (NMR), X-ray diffraction analysis (XRD), Zeta potential measurement and Thermogravimetric analysis (TGA). It is revealed that compared with chitosan (CS), NTCS exhibited an excellent solubility in distilled water, high in vitro bile acid binding capacity, as well as a low viscosity. The in vitro bile acid binding capacity reached 17.21 mg/g, which was 4.5-fold higher than that of CS. The results suggest that NTCS may be useful as a potential functional food supplement in food industry or a key ingredient in the pharmaceutical industry. These findings provide important supports for developing new food additive, and expand the scope of application of CS in the food industry.
研究领域:
食品科学
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生物化学
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药学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Muthuchamy Maruthupandy,Govindan Rajivgandhi,Thillaichidambaram Muneeswaran,Thirumalaiswamy Vennila,Franck Quero,Ji-Ming Song
This study was about the simple method for the rapid colorimetric and visual detection of glucose molecules in water medium. Silver nanoparticles were spread on the chitosan surface (CS/Ag NCs) and it was characterized by UV–visible spectroscopy, fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy (XRD), scanning electron microscope (SEM) and transmission electron microscope (TEM). The CS/Ag NCs displayed a strong surface plasmon resonance band at 429 nm which disappears in the addition of accelerative concentrations of glucose molecules and it was attended by color alteration from yellow to colorless. The interaction of glucose molecules on the CS/Ag NCs was displayed through TEM technique. Glucose molecules was detected not only by naked eyes (from yellow to purple grey) but also by UV–vis spectrophotometer in the concentration range between 0 and 100 μM, with limit detection of 5 μM and a good linear relationship of R 2 value = 0.99. The proposed paper was used for the application of the detection of glucose molecules in water sample with adequate outcome. This CS/Ag NCs was very simple and low cost system without using any other enzymatic catalyst and organic chromogenic agents for glucose molecules detection.
研究领域:
生物化学
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纳米材料科学
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分析化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Wentao Shi,Xuan Zhang,Lu Bian,Yao Dai,Zhe Wang,Yanjun Zhou,Shuang Yu,Zhijian Zhang,Peng Zhao,Hong Tang,Qing Wang,Xiaojie Lu
Here, we evaluated osteogenic differentiation in vitro and new bone formation in vivo using an alendronate-loaded chitosan/polycaprolactone scaffold (CS/PCL) in rats with a critical-sized calvarial defect. Through the action of genipin, which has a crosslinking function, alendronate (AL) was anchored throughout the CS/PCL composite scaffold (CS/ [email protected] ) to form an AL sustained release system. We demonstrated that CS/ [email protected] scaffolds significantly enhanced the osteogenic differentiation of ectomesenchymal stem cells (EMSCs) in vitro. Additionally, we explored the possible molecular mechanism of CS/ [email protected] scaffolds in the osteogenic differentiation of EMSCs. This composite scaffold exerted two positive effects on EMSC osteogenic differentiation: 1) the CS/ [email protected] scaffold enhanced EMSC osteogenic differentiation by upregulating bone morphogenetic protein 2, interleukin 10 and laminin expression; and 2) the CS/ [email protected] scaffold promoted the osteogenic differentiation of EMSCs by activating the yes-associated protein (YAP) signaling pathway. YAP and its downstream target transglutaminase are crucial mediators in the osteogenic differentiation of EMSCs. Finally, micro-computed tomography analyses and histology results suggested that the CS/ [email protected] scaffold exhibited a superior capacity to accelerate new and mature bone formation in skull bone defects in Sprague–Dawley rats. This simple and low-cost technology may represent a promising strategy to construct an efficient delivery system to repair bone defects.
研究领域:
生物材料
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组织工程
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骨科
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干细胞研究
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骨再生
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DOI
PubMed
高影响因子
Science China-Technological Sciences
·
2022
·Vol. 65
·期 5
·1029-1042
·
IF 3.903
Shi MingYue,Jiang LiJie,Yu ChaoJie,Dong XiaoRu,Yu QingYu,Yao MengMeng,He ShaoShuai,Yue ZhiWei,Yao FangLian,Zhang Hong,Sun Hong,Li JunJie
Currently, it is a challenge to develop hemostatic materials with high water absorption capacity and anti-fatigue properties for quickly preventing massive hemorrhage from arteries and visceral organs. A series of polyacrylic acid/chitosan (PAA/CS) cryogels were prepared by a cryostructurization technique to improve mechanical performance and hemostatic efficiency of chitosan (CS). In this system, the chemically cross-linked PAA network was used as a framework to improve water absorption behaviors and mechanical strength. The CS network was co-blended by hydrogen bonding and electrostatic interactions, both of which synergistically promoted hemostasis. These cryogels had high porosity (>94%), rapid water absorption rate (<3 s), high blood absorption capacity (>2000%), outstanding mechanical strength, and fatigue resistance. Moreover, the results of cytotoxicity and hemolysis demonstrated that the cryogels had good biocompatibility. Notably, the PAA/CS cryogels exhibited superior whole blood coagulation ability and red blood cell and platelet adhesion ability compared to those of commercial hemostatic dressing (gauze, gelatin sponges, and CS sponges). Based on these results, mouse femoral artery hemorrhage models and liver hemorrhage models were prepared to investigate the hemostatic ability of the prepared PAA/CS cryogels. Results suggested that the hemostatic ability of PAA 5 /CS cryogels was superior to that of commercial hemostatic materials. Therefore, the PAA/CS cryogels showed potential application in preventing massive hemorrhage from arteries and visceral organs.
研究领域:
生物医学工程
·
材料科学
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产品关联
DOI
高影响因子
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