INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Yanping Liu,Ying Zou,Hong Hu,Hongxia Gao,Yuan Yuan,Mianhong Chen,Ruyi Li,Yaping Dai,Xiaobing Huang,Chenghui Zhang,Jihua Li,Wei Zhou
Natural essential oils, such as d -limonene, are frequently used as flavoring agents and fragrances in the food industry. However, their susceptibility to volatilization and chemical degradation poses challenges for widespread application. In this study, cellulose nanocrystals (CNCs) and cellulose nanofibers (CNFs) were used to stabilize palm oils (POs) with different melting points to prepare Pickering emulsions (PEs) for the encapsulation of d -limonene. The physicochemical properties, environmental stability, 3D printing performance, and retention of d -limonene were explored. It results indicated that CNFs stabilized PO emulsions exhibit a stronger gel network structure, particularly pronounced in high melting point PO. CNF-stabilized emulsions enhanced stability to pH changes, salt ion, and storage conditions, due to a greater gel structure. Notably, it should be noted that CNCs and CNFs slowed down the release of d -limonene in both fresh and heat-treated emulsions. Furthermore, CNCs and CNFs emulsions as 3D printing inks, ensure accurate and stable formation of target shapes. The volatilization of d -limonene during the process was effectively suppressed (<9 %). The lower release of d -limonene in CNF emulsions (<2.8 %) could be linked to the tight distribution of CNF particles between the oil/water interface and the droplets, which makes the emulsion more resistant to extrusion. This study provides valuable insights into the use of PEs for encapsulating flavor components in 3D printing applications.
研究领域:
食品科学
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材料科学
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化学工程
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DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2013
·Vol. 51
·期 15
·3213-3226
·
IF 3.543
Li Zhang,Yakai Feng,Hong Tian,Miao Zhao,Musammir Khan,Jintang Guo
Well-defined amphiphilic multiblock copolymers PDMAEMA-b-P(IBMD- co -PDO)-b-PEG-b-P(IBMD- co -PDO)-b-PDMAEMA [PDMAEMA-PIBMD-PPDO-PEG], based on poly(2-(dimethylamino)ethyl methacrylate) block (PDMAEMA), poly(3( S )-isobutyl-morpholine-2,5-dione- co-p -dioxanone) block (P(IBMD- co -PDO)), and poly(ethylene glycol) block (PEG) were successfully synthesized by combination of ring-opening polymerization (using 3( S )-isobutyl-morpholine-2,5-dione and p -dioxanone initiated by hydroxyl end of PEG) and atom transfer radical polymerization (ATRP). Furthermore, all these copolymers were characterized by 1 H NMR, 13 C NMR, Fourier transformed-infrared, gel permeation chromatography, differential scanning calorimetry, and thermogravimetric analysis measurements. The degradation experiments showed that the molecular weight of PDMAEMA-PIBMD-PPDO-PEG decreased along with degradation time. In addition, these copolymers could readily self-assemble into nanosized microspheres in phosphate buffered solution. Ibuprofen (IBU) and doxorubicin (DOX) as a kind of combined model drugs were loaded into these microspheres by the combination of ionic interaction and hydrophobic effect. These copolymer microspheres exhibited high loading capacity (LC, up to 26.88%), encapsulation efficiency (EE, up to 61.29%), and sustained release behavior of IBU–DOX in phosphate buffered solution. The results of transmission electron microscopy and dynamic light scattering showed that the microspheres were well-defined uniform spherical particles with average diameter less than 120 nm. Therefore, it can be envisaged that these copolymer systems are promising candidates for controlled release application. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3213–3226
研究领域:
材料科学
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药学
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高分子化学
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产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
·
2019
·Vol. 45
·期 1
·113-121
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IF 1.497
Yu Jiaojiao,Wang Qiongyan,Liu Haofan,Shan Xiaosong,Pang Ziyan,Song Pengjin,Niu Feng,Hu Liandong
Background and Objectives Diabetes mellitus, a disease of glucose regulation, has become one of the most common medical problems in the world. At present, alternative therapy for diabetes has, to a large extent, been widely concerned with the improvement of treatment efficacy. The aims of this study were to characterize and evaluate the surface morphology of the novel glucose-responsive injectable microspheres containing insulin, along with their in vitro release and in vivo efficacy. Methods In this study, glucose-responsive microspheres as an emerging smart drug delivery system for controlled release of insulin were developed by an improved water-in-oil-in-water (W/O/W) double emulsion preparation method. Here, methoxypolyethylene glycol-hydrazone-4-methoxypolyethylene glycol benzoate (mPEG-Hz-mPEG4AB) was synthesized as a pH-responsive carrier. Results The microspheres had a good spherical structure with a particle size of 5 ~ 10 μm. Approximately 61% of insulin was released in 15 h under a high glucose environment but was barely released within the normal glucose range in in vitro studies. After a subcutaneous injection of insulin microspheres in rats, blood glucose levels rapidly decreased within 2 h and could be maintained for 2 days in the normal range. Histopathological evaluation indicated that the microspheres were almost non-irritating. Conclusions The pH-responsive mPEG-Hz-mPEG4AB could be used as an efficient insulin microsphere carrier, and the optimized microspheres had good morphology and sustained hypoglycemic effect.
研究领域:
药剂学
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生物医学工程
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糖尿病治疗
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Haofu Liu,Zhiqing Huang,Yingyu Shi,Tingyao Cai,Qi Miao,Zideng Gao,Zhenling Cui
Ensuring efficient iron absorption by crops is crucial in terms of high crop yields and food security . Bio-based materials effectively transport nutrients with minimal environmental impacts. Here, highly efficient lightweight iron fertilizers , CSG@Fe was prepared using chitosan hydrogels (CSG) as the adsorption carrier. Iron release from the various CSG@Fe preparations was slow under neutral conditions but rapid under acidic conditions. The effects of various cross-linking agents were investigated; 1.0 wt% genipin chitosan hydrogels iron fertilizer (GE-CSG@Fe) evidenced an excellent iron adsorption rate and a higher iron loading (326.15 mg/g) than the other two iron fertilizers. Iron release from CSG@Fe materials followed the Korsmeyer-Peppas model. Notably, wheat seed germination and tomato pot experiments revealed that GE-CSG@Fe significantly enhanced germination and growth. GE-CSG@Fe appropriately reduced the soil pH, protected ferrous ions from soil oxidation and rapid fixation, activated the soil microenvironment, and improved nutrient absorption by the roots of crops growing. This work provides a simple and effective strategy for overcoming constraints in the development and application of iron fertilizers and provides insights into the development of green and efficient iron fertilizers with intelligent response properties.
研究领域:
农业科学
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材料科学
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植物营养学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Lei Chen,Die Zhang,Ling-Feng Wei,Wei-Jia Zhu,Xiao-Qin Yan,Rui Zhou,Zia-ud Din,Wen-Ping Ding,Tie-Zheng Ma,Jie Cai
We report a self-assembly method for the fabrication of multilayer-starch-based microgels used for anthocyanin encapsulation. Alcohol-heating treatment and ionization reactions were employed to reduce the crystallinity of starch and introduce ionic groups on the molecule to further cross-link it with sodium trimetaphosphate and produce a starch microgel. The molecular interactions between the starch and the anthocyanins facilitated the anthocyanin encapsulation and the starch-microgel/anthocyanin complexes with one, two, and three self-assembled layers were obtained. The Lay-1 microgel exhibited an encapsulation efficiency of 50.1% when the anthocyanin concentration, cross-linking starch concentration, contact time, and temperature were 0.25 mg/mL, 1.5 mg/mL, 3 h, and 40 °C, respectively. An increase in the number of layers resulted in a more compact microgel structure with the zeta potential presenting variations upon structural changes. Furthermore, the encapsulated anthocyanins presented a slow release from Lay-1, while the multilayered microgels (Lay-2 and Lay-3) displayed outstanding encapsulation stability. This study gives an insight on the encapsulation and release of anthocyanins by starch microgels, and provides a novel strategy for the design of starch-based encapsulation materials presenting great stability.
研究领域:
材料科学
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食品科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 8
·1667-1676
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IF 4.726
Jiadi Sun,Ye Zhu,Long Meng,Wei Wei,Yang Li,Xiaoya Liu,Yufeng Zheng
We report a potential example of using surface functionalization to provide magnesium alloys (Mg–Ca) with controlled release and corrosion resistance properties. A key feature of this approach is to treat the Mg–Ca surfaces with nanoparticles via electrodeposition that can stably load and controllably release bioactive agents or drugs. These photo-cross-linkable and nano-scale particles were prepared by the self-assembly of an amphiphilic poly(γ-glutamic acid)-g-7-amino-4-methylcoumarin (γ-PGA-g-AMC) with encapsulation of a vitamin; moreover, the size and morphology of the resulting particles were studied. Fluorescence microscopy analysis indicated that Vm was effectively incorporated into the γ-PGA-g-AMC particles. Scanning electron microscopy (SEM) images showed that the colloidal particles could be uniformly electrodeposited on the Mg–Ca alloys. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirmed the successful anchoring of the particles. After the surface electrodeposition of self-assembled colloidal particles, the in vitro degradation results show that deposition of the particles was found to reduce the degradation rate of the magnesium alloys; moreover, the vitamin was controllably released for up to 20 days. Furthermore, the Mg–Ca substrate functionalized with colloidal particles containing a vitamin significantly promoted the attachment, proliferation and spread of NIH-3T3 normal cells. The entire strategy may be used in various medical devices to create coatings for improved biomedical performance.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Jianwei Bai,Yunan Zhang,Longqi Chen,Huijun Yan,Chunhong Zhang,Lijia Liu,Xiaodong Xu
In this study, novel molecularly imprinted polymer (MIP) microparticles containing methacryl polyhedral oligomeric silsesquioxane (M-POSS) were synthesized through the RAFT precipitation polymerization (RAFTPP) method using paclitaxel (PTX) as the templates. During the course of this investigation, methacrylic acid (MAA) was used as the functional monomer, while ethylene glycol dimethacrylate (EGDMA) was utilized as a cross-linker. The effects of different molar ratios of M-POSS on the microparticles were characterized. The obtained MIP microparticles were confirmed by FT-IR and TGA-DSC. The results of SEM showed regular spherical-shaped MIP microparticles with diameters around 170–490 nm. The PTX loading quantity was closely correlated with the content of M-POSS, and the MIP microparticles showed a satisfactory affinity to PTX with high drug loading (17.1%) and encapsulation efficiency (85.5%). Moreover, these MIP microparticles were sensitive to pH, and consequently the release rates of PTX at pH 5 were much faster than those at pH 7 due to the acid cleavage of the hydrogen bonds. In addition, the results from release experiments of the MIP microparticles showed a very slow and controlled release of PTX, which heralded promising potential as a carrier for PTX delivery in cancer therapy.
研究领域:
药学
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材料科学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2015
·
IF 1.098
Zujin Yang,Yanxiong Fang,Hongbing Ji
Microcapsules of salicylic acid (SA) with chitosan were prepared by spray drying method. Various analytical methods were used to characterize the nature of microcapsules. Fourier-transform infrared spectroscopy (FTIR) confirmed the presence of intermolecular interactions between chitosan and SA. Particle size analysis showed that the average size of microcapsules ranged from 2 to 20 μm. Scanning electron microscopy (SEM) studies indicated that the microspheres were spherical and had a relatively smooth surface. Microbiological assay of antibacterial activity for SA and its microcapsules was measured using different bacterial strains. It was found that the antibacterial activity of SA was improved after the formation of microcapsules. The in vitro release profile showed that the microcapsules could control SA release from 1 h to 4 h. Kinetic studies revealed that the release pattern follows Korsmeyer–Peppas mechanism. Enhanced antibacterial activity of the SA microcapsules was attributed to the synergistic effects of intermolecular hydrogen-bonding interactions N–H⋯O and O–H⋯O C between SA and chitosan. It was also confirmed by quantum chemical calculation.
研究领域:
药剂学
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微生物学
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产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 56
·32193-32199
·
IF 2.936
Yiyuan Tang,Kai Chen,Jiacheng Li,Yuhong Feng,Gaobo Yu,Longzheng Wang,Xinyu Zhao,Yang Peng,Quan Zhang
In this study, a pH-responsive amphiphilic alginate (Ugi-Alg) was synthesized via Ugi reaction without using a catalyst. The structure of Ugi-Alg was confirmed by FT-IR and 1H NMR spectroscopy. Amphiphilic alginate can form micelles in an aqueous medium due to it's amphiphilic nature.. The impacts of Na+ concentration and pH on the micelle size were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The dynamic light scattering observations showed that micelle size increases with the decrease in Na+ concentration in aqueous solution. However, the micelle size decreases first and then increases as the pH value decreases from 5.3 to 2.0. Transmission electron microscopy confirmed that the mean size of micelles is 30–200 nm. In addition, a model hydrophobic pesticide (acetamiprid) was loaded in the micelles. The encapsulation efficiency and release behavior of micelles were studied, which could be controlled by Na+ concentration and pH. The results indicated that encapsulation efficiency of acetamiprid increases from 55% to 96% due to the increase in Na+ concentration from 0.01 M to 0.3 M. Moreover, with the decrease in pH from 5.3 to 2.0, encapsulation efficiency increases from 55% to 80%. Furthermore, the data of acetamiprid release kinetics could be well-fitted by the Weibull model.
研究领域:
材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2017
·
IF 4.529
Lingli Deng,Xuefan Kang,Yuyu Liu,Fengqin Feng,Hui Zhang
This work studied the effects of non-ionic Tween 80, anionic sodium dodecyl sulfonate (SDS) and cationic cetyltrimethyl ammonium bromide (CTAB) surfactants on the morphology of electrospun gelatin nanofibres, and on the release behaviour, antioxidant activity and antimicrobial activity of encapsulated curcumin. Scanning electron micrographs showed that addition of SDS significantly increased the nanofibre diameter. Fourier transform infrared and differential scanning calorimetry analysis indicated that gelatin and SDS intimately interacted via electrostatic and hydrophobic interactions. However, these interactions inhibited the release of curcumin from the nanofibres with SDS, while CTAB and Tween 80 both facilitated the release. SDS and Tween 80 showed protective effects on curcumin from the attack of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radicals, and the increased release of curcumin from nanofibres with CTAB or Tween 80 resulted in a higher reducing power. The antimicrobial activity results suggested that the curcumin encapsulated gelatin nanofibres with CTAB exhibited effective inhibition against Staphylococcus aureus .
研究领域:
材料科学
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药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Ziman Hu,Miao Shao,Bin Zhang,Xiong Fu,Qiang Huang
Menthol inclusion complexes (ICs) have addressed a range of opportunities in food applications due to their volatile resistance. However, previous protocols used for their synthesis give low yields and high industrial application costs. In the present investigation, metal–organic frameworks based on β-cyclodextrin (β-CD-MOF) have been prepared for the molecular encapsulation of menthol. Menthol/β-CD-MOF-IC was synthesized under the optimized parameters, after which release behavior was studied. In this optimized manner, a higher menthol capacity was obtained in which the menthol content and encapsulation efficiency were 27.1 and 30.6%, respectively. Compared with menthol/β-CD-IC, menthol/β-CD-MOF-IC is resistant to high temperature, but sensitive to moisture. In a simulated oral release experiment, the rate of menthol release from different samples followed the order of: pure menthol > β-CD > β-CD-MOF, which can be attributed to two mechanisms: non-specific binding and site preference. We propose that β-CD-MOF can be used as a promising delivery system for aroma compounds.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Bionic Engineering
·
2021
·Vol. 19
·期 1
·188-196
·
IF 2.682
Wang Qiaoying,Cai Jiali,Xu Zihan,Huang Shihui,Zhou Ruiping,Wang Zhiyong
Chemotherapy is still a kind of important strategy for cancer treatment, but lacking effective delivery system limits the therapeutic outcome. Owing to the excellent biocompatibility, albumin has been employed as drug vehicle; however, it has to face complicated synthesis procedures and still needs an effective technology for the drug delivery evaluation. In this study, a facile method was utilized to prepare a protein-based theranostic system through the self-assembly of albumins with small molecules and drugs; furthermore, the paramagnetic divalent manganese ions were conjugated on the surface of the nanocomposite through a coordination bond and carried out the magnetic resonance imaging. This nanosystem with a stable structure exhibited about 80 nanometer size and 7.7 [Mn] mM -1 S -1 T 1 relaxivity; moreover, the pH-sensitive drug releasing property and the imaging function empower it with theranostic cancer therapy. Moreover, the nanocomposites effectively entered into the cancer cells and showed superior antitumor ability; and these treated cells exhibited significant T 1 signal. These results suggested that the albumin-based nanosystem is a novel chemotherapy drug delivery vehicle and a promising candidate for magnetic resonance imaging.
研究领域:
纳米医学
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癌症研究
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生物医学工程
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药学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）