CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Huijuan Zhao,Nanping Deng,Jing Yan,Weimin Kang,Jingge Ju,Liyuan Wang,Zongjie Li,Bowen Cheng
In this study, a hybrid Poly-m-phenyleneisophthalamide/Octaphenyl-Polyhedral oligomeric silsesquioxane (PMIA/Octaphenyl-POSS) membrane (HPPS) was fabricated by electrospinning technique and its application performance as lithium-ion battery separators was discussed. The organic-inorganic feature of Octaphenyl-POSS (OPS) endowed admirable compatibility of membrane matrix for the HPPS membranes. The nanofiber membranes with OPS nanoparticles were provided with commendable thermal stability, robust mechanical strength (21.79 MPa), high porosity and electrolyte uptake, which laid a good foundation for improving the safety and cycle performance of the cells with the separator. The lithium-ion battery with the HPPS separator displayed a high ionic conductivity of 1.93 × 10 −3 S·cm −1 and a stable electrochemical window of 4.98 V. More significantly, the HPPS nanofiber membrane based Li/LiCoO 2 cell exhibited excellent cycling stability with high first discharge capacity up to 157.9 mAh·g −1 and superior capacity retention of 89.04% after 100 cycles. Therefore, the HPPS separator has extraordinary potential to be used in high-performance lithium-ion battery.
研究领域:
材料科学
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能源技术
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化学工程
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DOI
高影响因子
Frontiers in Immunology
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2022
·
IF 8.786
Zhang Nan,Gao Xiaochen,Zhang Weijia,Xiong Junyao,Cao Xiaojian,Fu Zhen F.,Cui Min
Japanese encephalitis virus (JEV) is one of the most important members of the flavivirus family. It is a typical zoonotic pathogen that has caused substantial social and economic losses worldwide. The relation between JEV-induced immunosuppression and inflammatory responses has not been thoroughly investigated. In this study, cells infiltrating the brain tissue of JEV-infected mice were mainly identified as monocytic myeloid-derived suppressor cells (M-MDSCs), which subsequently differentiated into CD3+ macrophages. Co-culture with T cells showed that both splenic M-MDSCs and brain infiltrated M-MDSCs isolated from JEV-infected mice inhibited T cell proliferation through ARG1 and iNOS. The splenectomy model revealed that JEV-induced M-MDSCs were mainly derived from bone marrow and migrated to the spleen and central nervous system (CNS). The results of the transcriptome analysis and IRF7-deficient mice indicated that the ZBP1-IRF7 signaling pathway stimulated by JEV RNA played a central role in the induction of M-MDSCs. M-MDSCs migrated into the CNS through the chemokine CCL2/N-CCL2 derived from astrocytes and brain infiltrated M-MDSCs differentiated into CD3+ macrophages through a mechanism mediated by M-CSF, IL-6 and IFN-γ in the brain microenvironment. These findings provide evidence for the mechanism that JEV regulates the differentiation of M-MDSCs and thereby exacerbates pathogenicity, which represents a potential therapeutic target for Japanese encephalitis (JE).
研究领域:
免疫学
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神经病毒学
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病毒学
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致病机制
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Tao Peng,Zhiwei Sui,Zhenghui Huang,Jie Xie,Kai Wen,Yongzhuo Zhang,Wenfeng Huang,Wei Mi,Ke Peng,Xinhua Dai,Xiang Fang
The coronavirus disease 2019 (COVID-19) epidemic continues to ravage the world. In epidemic control, dealing with a large number of samples is a huge challenge. In this study, a point-of-care test (POCT) system was successfully developed and applied for rapid and accurate detection of immunoglobulin-G and -M against nucleocapsid protein (anti-N IgG/IgM) and receptor-binding domain in spike glycoprotein (anti-S-RBD IgG/IgM) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Any one of the IgG/IgM found in a sample was identified as positive. The POCT system contains colloidal gold-based lateral flow immunoassay test strips, homemade portable reader, and certified reference materials, which detected anti-N and anti-S-RBD IgG/IgM objectively in serum within 15 min. Receiver operating characteristic curve analysis was used to determine the optimal cutoff values, sensitivity, and specificity. It exhibited equal to or better performances than four approved commercial kits. Results of the system and chemiluminescence immunoassay kit detecting 108 suspicious samples had high consistency with kappa coefficient at 0.804 (P < 0.001). Besides, the levels and alterations of the IgG/IgM in an inpatient were primarily investigated by the POCT system. Those results suggested the POCT system possess the potential to contribute to rapid and accurate serological diagnosis and epidemiological survey of COVID-19.
研究领域:
医学诊断
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流行病学
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免疫学
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产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
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2022
·
IF 7.34
Chengdong Guan,Lijuan Yang,Lijun Zhu,Daohong Xia
The fabrication of membranes with the advantages of simple operation and high separation efficiency is considered of great importance to meet the separation challenge of the oil-in-water emulsions produced in various types of industries. Along these lines, in this work, a membrane with a biomimetic gracilaria surface was ingenious designed and manufactured by using poly-pseudorotaxane structured poly ( m -phenylene isophthalamide) (PMIA) for attaining high efficiency of the oil-in-water separation. m-Phenylenediamine (MPD) included by γ-cyclodextrin (γ-CD) was also used to participate in the synthesis of PMIA and introduce more hydroxyl groups into the polymer chains. By the implementation of a non-solvent induced phase-inversion (NIPS) method, the superhydrophilic and the underwater superoleophobic γ-CD@PMIA membrane was successfully fabricated. Under the 0.05 MPa cross-flow filtration test, in addition to the high pure water flux (1366.69 L·m −2 ·h −1 ·bar −1 ) of the γ-CD@PMIA membrane, its separation efficiency for soybean oil-in-water emulsion was higher than 98.20 %. Moreover, during the application of the continuous separation process of up to 4 h, the membrane maintained a stable separation capacity for different oily wastewaters, which proved its good anti-pollution performance. Furthermore, the membrane exhibits good stability in harsh environments, which is of great significance for the future development of membranes with excellent chemical stability. Our work paves the way for the design of a novel biomimetic surface-based membrane with efficient oil-in-water emulsion separation properties.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Weipeng Zhang,Zhe Zhang,Wenwu Li,Xiaodong Huang,Le Ruan,Ling Wu
The synergistic corrosion inhibition effect of phytic acid (PA) and benzyltrimethyl ammonium bromide (BAB) on 1045 carbon steel (CS) in 0.5 M HCl is reported. Electrochemical measurements showed that PA and BAB can reduce the corrosion rate of 1045 CS in HCl solution and act as excellent corrosion inhibitors. The best inhibition efficiency n i of the combination inhibitor of PA with BAB is 90.6%. SEM images of the corroded steel surfaces suggest that the PA and BAB are simultaneously adsorbed on the CS surface to inhibit the corrosion of iron. The synergistic inhibition mechanism is investigated by dynamic simulations and quantum chemistry.
研究领域:
材料科学
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腐蚀工程
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电化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Yong Fu,Jinwen Jiang,Zhangpei Chen,Shaoming Ying,Jiwei Wang,Jianshe Hu
The toxic Hg(II) being released excessively into the water body from various sources has threatened the environment and human health. The aim of this study is to design a rapid and selective adsorbent, and propose an alternative way to dispose the spent adsorbent. To this end, a new material ( MAP ) was designed by inducing the polymerization of m -aminothiophenol onto MCM-41 (Mobil Composition of Matter) surface obtained using cheap diatomite as a silica source and modified by APTES ((3-aminopropyl) triethoxysilane), and the spent adsorbent was further converted into an active catalyst for acetophenone synthesis. The adsorption properties of the MAP were systematically explored under different parameters, and the corresponding results were analyzed based on different adsorption kinetic and isotherm models. The study found the removal rate and adsorption capacity of the MAP could reach 96.56% and 242.42 mg/g within 15 min. The coexisting cations showed little competition effect on the removal of Hg(II), and the adsorption capacities after five cycles did not obviously decrease. Kinetic study indicated that the adsorption data were well fitted to the pseudo-second-order model, and the adsorption equilibrium data followed the Langmuir model. After adsorption studies, the Hg(II)- MAP was used as a catalyst in the reaction of phenylacetylene to acetophenone with high yield of 97.01%. This work not only provides a rapid and selective adsorbent for removal of Hg(II) ions, but also opens a novel avenue for reusing the toxic spent adsorbent for catalytic application.
研究领域:
环境科学
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材料科学
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催化化学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
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IF 9
Haoruo Xu,Chenxi Huang,Weili Yu,Ningjie Fang,Yinghao Chu,Jinhui Li
The combined pollution toxicity of hexavalent chromium heavy metal (Cr(VI)) and antibiotics (such as ofloxacin, OFL) is much higher than that of a single pollutant, posing a serious challenge to the ecological environment. Photocatalytic technology can achieve the removal of both single pollutants and composite pollutants. It is urgent to develop catalysts with high carrier separation efficiency and photocatalytic degradation performance. In this work, we successfully prepared m-PDI/BiOI heterojunction catalysts (mPB-3) with tight contact interfaces using the continuous ion layer adsorption and reaction method, and applied them to the synergistic removal of OFL and Cr(VI). The results showed that mPB-3 exhibited a bidirectional enhancement effect. The degradation rate of OFL reached more than 99.5 % within 40 min, the corresponding reduction efficiency of Cr(Ⅵ) reached 63.7 % at pH = 9. Furthermore, the influence of different environmental factors on the degradation process have also been clarified, indicating that mPB-3 has good stability and adaptability. The system characterization results confirmed that a S-scheme heterojunction has been formed. This can accelerate the rapid migration of electrons from m-PDI to BiOI, achieving efficient charge separation, and ultimately enhancing the photocatalytic activity. Finally, the degradation intermediate products and degradation mechanism were analyzed. This study provides a feasible solution for the design of efficient photocatalytic materials and their application in the combined pollution treatment of OFL and Cr(VI). Environmental implication Cr(VI) and OFL coexisting in water bodies pose significant ecological risks due to their enhanced combined toxicity. Traditional treatment techniques often struggle to effectively address such complex pollution systems. This study demonstrates that the m-PDI/BiOI heterojunction photocatalyst can efficiently synergistically remove both contaminants under environmentally relevant conditions (e.g., pH = 9), providing a practical strategy to mitigate composite pollution challenges. The S-scheme charge separation mechanism offers insights for designing advanced catalysts to tackle emerging multi-pollutant threats in aquatic ecosystems, supporting sustainable water treatment solutions.
研究领域:
环境科学
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催化
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材料科学
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水处理技术
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污染控制
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产品关联
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 109
·64354-64363
·
IF 3.708
Liangliang Qu,Lijing Wang,Ximing Xie,Guozhu Yu,Shaohua Bu
A series of modified solution-polymerized styrene butadiene rubbers (M-S-SBRs) with different molar contents of polar groups were prepared through grafting 3-mercaptopropionic acid into solution-polymerized styrene butadiene rubber (S-SBR) chains. The molar contents of the polar groups in M-S-SBR were calculated using 1H nuclear magnetic resonance (1H NMR) spectroscopy. Thermodynamic analytical methods, including the surface energy of M-S-SBR and filler flocculation, show that the introduction of polar groups increases the work of adhesion of filler–rubber (Wrf), which is an indicator for the compatibility of the filler with rubber. The thermodynamic results can be further proved by TEM micrographs. Strain sweep experiments were carried out to investigate the temperature dependent nonlinear strain-dependence of elastic moduli, referred to as the Payne effect. The filler–filler network and interfacial strength were studied in terms of critical strain γc and activation energy Ea. Dynamic mechanical measurements show that a combination of higher energy dissipation in the low temperature range and higher elasticity in the high temperature region were achieved for M-S-SBR/Silica when compared with their non-modified counterpart.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
BIOPROCESS AND BIOSYSTEMS ENGINEERING
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2023
·Vol. 46
·期 12
·1801-1815
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IF 3.8
Zhou Zhaoxin,Liu Xinmin,Chen Ranran,Hu Xiude,Guo Qingjie
Anaerobic fluidized bed microbial fuel cell (AFB-MFC) is a technology that combines fluidized bed reactor and microbial fuel cell to treat organic wastewater and generate electricity. The performance and the mechanism of treating m- cresol wastewater in AFB-MFC using carbon brush as biofilm anode were studied. After 48 h of operation, the m- cresol removal efficiency of AFB-MFC, MAR-AFB (fluidized bed bioreactor with acclimated anaerobic sludge), MAR-FB (ordinary fluidized bed reactor with only macroporous adsorptive resin) and AST (traditional anaerobic sludge treatment) were 95.29 ± 0.67%, 85.78 ± 1.81%, 71.24 ± 1.86% and 70.41 ± 0.32% respectively. The maximum output voltage and the maximum power density of AFB-MFC using carbon brush as biofilm anode were 679.7 mV and 166.6 mW/m 2 respectively. The results of high-throughput sequencing analysis indicated the relative abundance of dominant electroactive bacteria, such as Trichococcus , Geobacter , and Pseudomonas , on the anode carbon brushes was higher than that of AST, and also identified such superior m- cresol-degrading bacteria as Bdellovibrio , Thermomonas , Hydrogenophaga , etc. Based on the determination of m- cresol metabolites detected by Gas Chromatography–Mass Spectrometry (GC–MS), the possible biodegradation pathway of m- cresol under anaerobic and aerobic conditions in AFB-MFC was speculated. The results showed that m- cresol was decomposed into formic acid–acetic anhydride and 3-methylpropionic acid under the action of electrochemistry, which is a simple degradation pathway without peripheral metabolism in AFB-MFC.
研究领域:
环境科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Inflammation Research
·
2023
·
IF 4.5
Yunbo Yan,Linqian Yu,Binyang Chen,Chang’an Cao,Hairong Zhao,Qiang Wang,De Xie,Yuemei Xi,Chenggui Zhang,Jidong Cheng
Background Gouty arthritis is characterized by the accumulation of monosodium urate crystals (MSU) in the synovial joints and surrounding tissues. Mastoparan M (Mast-M) is a biologically active peptide composed of 14 amino acids, extracted from wasp venom. This study aims to assess the impact of Mast-M on in vitro and in vivo gouty arthritis induced by lipolyaccharide (LPS) plus MSU crystal stimulation.Methods PMA-differentiated THP-1 macrophages were pre-treated with Mast-M or left untreated, followed by stimulation with LPS and MSU crystals. Cell lysates were collected to assess the expression of the NLRP3 inflammasome, inflammatory signaling pathways, and oxidative stress. Furthermore, to evaluate the in vivo anti-inflammatory effect of Mast-M, an experimental acute gouty arthritis mouse model was established through intra-articular injection of MSU crystals.Results Mast-M treatment demonstrated significant inhibition of the phosphorylation of MAPKs/NF-κB signaling pathways and reduction in oxidative stress expression in LPS and MSU-induced THP-1 macrophages. This resulted in the suppression of downstream NLRP3 inflammasome activation and IL-1β release. In vivo, Mast-M effectively attenuated the inflammation induced by MSU in mice with gouty arthritis. Specifically, Mast-M reduced swelling in the paws, inhibited the infiltration of neutrophils and macrophages into periarticular tissue, and decreased the activation of the NLRP3 inflammasome and IL-1β production.Conclusion Mast-M significantly improves gouty arthritis, and its potential mechanism may be achieved by inhibiting the MAPK/NF-κB pathway and alleviating oxidative stress, thus suppressing the activation of NLRP3 inflammasomes.
研究领域:
免疫学
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风湿病学
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药理学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2024
·
IF 4.8
Xiaoliang Li,Mingyan Zhou,Zhe Zhu,Zhe Wang,Xuguang Zhang,Lu Lu,Zhenrui Xie,Bingshu Wang,Yipeng Pan,Junqing Zhang,Jian Xu
Ethnopharmacological relevance Alpinia officinarum Hance ( A . officinarum ), a perennial herb known for its medicinal properties, has been used to treat various ailments, such as stomach pain, abdominal pain, emesis, and digestive system cancers. A . officinarum is extensively cultivated in the Qiongzhong and Baisha regions of Hainan, and it holds substantial therapeutic value for the local Li people of Hainan. Kaempferol, a flavonoid derived from A . officinarum , has demonstrated anticancer properties in various experimental and biological studies. Nevertheless, the precise mechanisms through which it exerts its anti-hepatocellular carcinoma (HCC) effects remain to be comprehensively delineated. Aim of the study This investigation aims to elucidate the anti-HCC effects of kaempferol derived from A . officinarum and to delve into its underlying mechanistic pathways. Materials and Methods Using ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UPLC-MS/MS) to identify active compounds in A. officinarum . HCCLM3 and Huh7 cells were used to study the anti-HCC effect of kaempferol from A . officinarum . The cytotoxicity and proliferation of kaempferol and A . officinarum were measured using CCK-8 and EDU staining. Wound-healing assays and three-dimensional tumor spheroid models were further used to evaluate migration and the anti-HCC activity of kaempferol. The cell cycle and apoptosis were evaluated by flow cytometry. Western blot and qRT-PCR were used to detect the expression of proteins and genes associated with the cell cycle checkpoints. Finally, bioinformatics was used to analyze the relationship between the differential expression of core targets in the ATM/CHEK2/KNL1 pathway and a poor prognosis in clinical HCC samples. Results UPLC-MS/MS was employed to detect five active compounds in A . officinarum , such as kaempferol. The CCK-8 and EDU assays showed that kaempferol and A . officinarum significantly inhibited the proliferation of HCC cells. A wound-healing assay revealed that kaempferol remarkably inhibited the migration of HCC cells. Kaempferol significantly suppressed the growth of tumor spheroids. In addition, kaempferol markedly induced G2/M arrest and promoted apoptosis of HCC cells. Mechanically, kaempferol significantly reduced the protein and mRNA expression levels of ATM, CHEK2, CDC25C, CDK1, CCNB1, MPS1, KNL1, and Bub1. Additionally, the combination of kaempferol and the ATM inhibitor KU55933 had a more significant anti-HCC effect. The results of bioinformatics showed that ATM, CHEK2, CDC25C, CDK1, and KNL1 were highly expressed in patients with HCC and cancer tissues, indicating that these genes have certain value in the clinical diagnosis of HCC. Conclusions Collectively, our results revealed that kaempferol from A . officinarum inhibits the cell cycle by regulating the ATM/CHEK2/KNL1 pathway in HCC cells. In summary, our research presents an innovative supplementary strategy for HCC treatment.
研究领域:
药理学
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肿瘤学
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细胞生物学
·
分子生物学
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生物信息学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Ao Gao,Wei Lu,Yuntao Liang,Zhenglong He,Jinliang Li,Yong Sun,Shuanglin Song,Xinfeng Cui,Xiang Gao
In this study, pH responsiveness of 1, 1, 1, 3, 3, 3-hexamethyldisilazane terminated m-Cresol (HTMC) in different-rank coals was investigated, and its inhibition performance regarding the spontaneous combustion of coal was explored. First, color changes in the deprotection reaction of HTMC under different acidic conditions were analyzed. Then, surface microstructures of these coals and pH values of their filtrates were tested. Subsequently, experiments were performed on different coal samples for grasping their low-temperature oxidation characteristics, weight loss rates, pore characteristics, and free radical variations. The experimental results show that HTMC can effectively protect phenolic hydroxyl groups in inhibitors, and the acidity of coal can promote the conversion rate of its deprotection reaction. For instance, in XAM coal (pH ≈ 6), sufficient H + stimulates HTMC to release massive m-Cresol which contains highly reactive phenolic hydroxyl, thereby effectively suppressing increases of the concentration and type of free radicals. The crossing point temperature (177.2 °C) and inhibition rate at 110 °C (75.9 %) of the HTMC-inhibited XAM sample are 33.1 °C and 17.9 % higher than those of the m-Cresol-inhibited one, respectively. This study confirms the applicability of pH-responsive HTMC to different-rank coals and may lay a theoretical foundation for the design of efficient reactive inhibitors.
研究领域:
化学工程
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煤科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）