Polymer Chemistry
·
2011
·Vol. 2
·期 6
·1389-1397
·
IF 0
Chaojian Chen,Gongyan Liu,Xiangsheng Liu,Shaopeng Pang,Congshan Zhu,Liping Lv,Jian Ji
Photo-responsive biocompatible micelles were constructed from amphiphilic hyperbranched polyphosphate based polymer (denoted as HPHEEP-DNQ) and applied in the controlled release of coumarin 102. HPHEEP-DNQ was designed and synthesized by modification of hydrophilic hyperbranched polyphosphate (HPHEEP) with hydrophobic, light-responsive 2-diazo-1,2-naphthoquinone (DNQ) molecules. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements revealed that the polymer can self-assemble into spherical micelles with an average diameter of about 186 nm in aqueous solution. The critical micelle concentration (CMC) of the micelles was 0.025 mg mL−1 determined by fluorescence spectroscopy using Nile Red as a fluorescence probe. By illuminating the micelles with 365 nm UV light, light triggered destabilization procedure was investigated by TEM and DLS. In addition, model drug coumarin 102 was successfully encapsulated into the micelles and the controlled release behavior under 365 nm UV light was investigated by fluorescence spectroscopy. Cell viability tests against two types of cells indicated that the micelles have excellent biocompatibility. These photo-responsive and biocompatible polymeric micelles self-assembled from hyperbranched polyphosphate based polymer might have great potential as smart carriers in the field of drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
Materials
·
2020
·Vol. 13
·期 2
·440
·
IF 3.057
Youxiong Zheng,Yan Tang,Jianwei Yu,Lan Xie,Huiyou Dong,Rongsheng Deng,Fuhua Jia,Bingxin Liu,Li Gao,Junyuan Duan
Building novel functional nanomaterials with a polymer is one of the most dynamic research fields at present. Here, three amphiphilic block copolymers of 8-hydroxyquinoline derivative motifs (MQ) with excellent coordination function were synthesized by Reversible Addition-Fragmentation Chain Transfer Polymerization (RAFT) polymerization. The coordination micelles were prepared through the self-assembly process, which the MQ motifs were dispersed in the hydrophobic polystyrene (PSt) blocks and hydrophilic Poly(N-isopropylacrylamide (PNIPAM)) blocks, respectively. The dual-emission micelles including the intrinsic red light emission of quantum dots (QDs) and the coordination green light emission of Zn2+-MQ complexes were built by introducing the CdSe/ZnS and CdTe/ZnS QDs in the core and shell precisely in the coordination micelles through the coordination-driven self-assembly process. Furthermore, based on the principle of three primary colors that produce white light emission, vinyl carbazole units (Polyvinyl Carbazole, PVK) with blue light emission were introduced into the hydrophilic PNIPAM blocks to construct the white light micelles that possess special multi-emission properties in which the intrinsic red light emission of QDs, the coordination green light of Zn2+-MQ complexes, and the blue light emission of PVK were synergized. The dual and multi-emission hybrid micelles have great application prospects in ratiometric fluorescent probes and biomarkers.
研究领域:
高分子化学
·
纳米材料科学
·
生物标记物研究
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 112
·111217-111225
·
IF 3.289
Sijie Zhao,Huiru Yang,Cai Zuo,Lu Sun,Liwei Ma,Hua Wei
Star-shaped polymers are attractive as drug carriers due to the integration of relatively easy synthesis compared to the preparation of hyper-branched dendrimers and their potential ability to form unimolecular nanoparticles with enhanced stability to survive the high dilution-associated deformation and subsequently premature drug release in the body fluids and blood during circulation. Clearly, the star structure exerts a significant effect on their bioproperties and potential applications. In this study, three star-shaped amphiphilic copolymers with the same polymer compositions but different star structures were synthesized to investigate the effect of star architecture on their properties as well as potential applications as drug carriers. Three different branched alcohols, 2-(hydroxymethyl) propane-1,3-diol, pentaerythritol and dipentaerythritol with 3, 4, and 6 respective hydroxyl groups were chosen as the starting core to generate the target star-shaped amphiphilic block copolymers composed of hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(oligoethyleneglycol methacrylate) (POEGMA) with 3, 4, and 6 corresponding star arms by a combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Dynamic light scattering (DLS) measurements and pyrene fluorescence probe technique confirmed the capability of the resultant star-shaped amphiphilic copolymers to form unimolecular micelles with average diameters smaller than 50 nm in an aqueous phase. A comparison of the drug loading capacity revealed that the micelles of 4-star-PCL–POEGMA (4s-PCL–POEGMA) exhibited the highest drug loading content (DLC) of all the three formulations. More importantly, in vitro doxorubicin (DOX) release study showed unique pH-mediated drug release behaviors, i.e., dramatically accelerated release at pH 6.0 but a much slower profile at pH 7.4, from these generally recognized “pH-insensitive” 4-arm star-shaped micelles. An acid-triggered degradation and an acid–base titration were performed to further reveal that such interesting pH-responsive drug release behaviors were attributed primarily to the hydrophilic corona of OEG brushes. This study is believed to provide a new insight into the structure–bioproperties relationship of star-shaped polymers, thus should be useful for the future design and development of novel star-shaped polymers for controlled drug delivery.
研究领域:
高分子药剂学
·
纳米医学
·
药物控释
·
生物材料
·
药剂学
·
肿瘤治疗
·
纳米载体
✓ 已验证
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2017
·
IF 4.421
Xuepeng Wu,Yongping Huang,Sisi Fang,Caili Dai,Hao Li,Zhongliang Xu,Mingwei Zhao
CO 2 -responsive wormlike micelles based on monomer erucic acid 3-(N,N-dimethylamino)propylamide (EADP) with or without sodium salicylate (NaSal) in aqueous solution were studied and compared with “pseudo” gemini system. The “pseudo” gemini system were formed by a mixture of EADP and maleic acid (MA) with molar ratio between 2:1–1:1. Different morphological transformations of microstructures in response to EADP concentrations, additives and CO 2 stimuli were further investigated in these systems, the wormlike micelle or vesicles can be obtained. The mechanism of these transitions were further investigated by rheology, cryo-TEM and DFT calculation, the results showed that the mechanism behind this transition involved reversible reaction of CO 2 with EADP. The mechanism in this research may give further evidence to the self-assembly of CO 2 -responsive surfactants.
研究领域:
胶体化学
·
材料科学
·
表面活性剂研究
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2017
·
IF 1.591
Lei Liu,Cunchuan Zheng,Hongsheng Lu
We reported two simple and novel CO2-responsive surfactant wormlike micellar systems consisting of commercial anionic surfactant sodium oleate (NaOA) and common hydrophobic tertiary amine N,N-dimethylcyclohexylamine (DMCHA), N,N-dimethylbenzylamine (DMBA). The conductivity, pH, and rheological measurements demonstrated the CO2-sensitive flowing behavior and property, which were attributed to the spherical-wormlike micelles transition, verified by cryogenic transmission electron microscopy (Cryo-TEM) and dynamic laser light scattering (DLS) measurements. Moreover, the transition can be easily cycled more than three times without deterioration of viscosity. Combined with the species distribution curve and 1H NMR spectra, a mechanism of the intermolecular electrostatic interaction and hydrophobic effects was proposed.
研究领域:
化学
·
材料科学
·
胶体与表面化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Changling Sun,Xiaoying Li,Xiaodong Du,Teng Wang
In this study, we reported a redox-responsive drug delivery system (DDS) based on heparosan and deoxycholic acid conjugates (HSDs) for effective treatment of laryngopharyngeal carcinoma. The amphiphilic HSDs can self-assemble into stable nanoscale micelles in aqueous medium with favorable drug loading capacity for doxorubicin (DOX). The HSD micelles can exhibit glutathione (GSH)-triggered drug release behavior and reach a nearly 100% release rate in a high GSH level (10 mM) environment. Moreover, FaDu cancer cells can internalize HSD micelles by clathrin-mediated endocytosis, which is energy dependent, fast, and effective. The DOX@HSD induced inhibition of FaDu cancer cells can achieve a minimum of 10-fold selectivity relative to that of COS-7 normal cells. Overall, the redox-responsive DDSs show good biocompatibility and are promising in the clinical treatment of laryngopharyngeal carcinoma.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2018
·Vol. 56
·期 10
·1067-1077
·
IF 2.588
Yuanfeng Gao,Chang-Ming Dong
Stimuli-responsive polypeptides are receiving much attention for drug delivery systems and tissue engineering scaffolds; however, it is challenging to construct multiple-responsive polypeptides and one-component polymeric hydrogels. Herein, a novel type of triple redox/temperature-responsive diselenide-containing poly(methoxydiethylene glycol- l -glutamate) homopolypeptide was facilely synthesized by selenocystamine-initiated ring-opening polymerization in DMF at 30 °C, and their chemical structures and physical properties were fully characterized by means of 1 H NMR, GPC, FT-IR, WAXD, and CD. They self-assembled into spherical micelles in aqueous solution, which possess a lower critical solution temperature, redox-responsiveness inherited from diselenide bond, and the triple stimuli-sensitive self-assembly behaviors, as characterized by means of turbidity, DLS, TEM, and zeta potential measurements. The diselenide-containing homopolypeptides formed supramolecular hydrogels at room temperature, exhibiting a thermal gel–sol transition. The rheological tests evidence that the mechanical modulus of the hydrogel is independent of angular frequency within 100 rad/s and at 25 °C, in which the storage modulus of G′ is order of magnitude greater than the loss modulus of G″, displaying a solid-like elastic behavior. Moreover, the mechanical modulus of the hydrogel can be tuned by changing the chain length of the homopolypeptide, the 10-mM 1,4-dithiothreitol (DTT) reduction, and 1 mM H 2 O 2 oxidation, respectively. Consequently, this work provides a simple strategy to fabricate triple-stimuli responsive polypeptide micelles and one-component hydrogels. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56 , 1067–1077
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 32
·期 8
·3113-3122
·
IF 3.665
Zhiming Chen,Weiqiu Wen,Jianwei Guo
Natural chitosan (CS) is composed of a larger hydrophilic skeleton with great biocompatibility. A hypoxia sensitive amphiphilic conjugate (CS-NBCF) was synthesized by conjugating CS with nitrobenzyl chloroformate (NBCF). Subsequently, nano micelles with high stability (CMC = 0.0030 mg/ml) were formed by self-assembly of the polymers in deionized water. The hypoxia-responsive function was demonstrated by examining the size variations of polymeric micelles under the hypoxia conditions. Doxorubicin (DOX) was encapsulated into the micellar core, the drug loading and encapsulation efficiency of DOX were 15.0% and 52.6%, respectively. The in vitro release experiments showed that DOX could be released rapidly in hypoxic environment, and the release amount was up to 68% in 24 h. It was found from the cytotoxicity experiment that that the toxicity of the blank micelles was low, while DOX-loaded micelles exhibited a good anti-cancer effect under hypoxic conditions, and the cell inhibition rate of MCF-7 was high up to 63%. As a result, the demonstrated properties endowed as-developed polymeric micelles with promising application as drug delivery system in tumor treatment.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Liming He,Xianyan Qin,Donghao Fan,Chenglan Feng,Qin Wang,Jiyu Fang
The nontargeted distribution and uncontrolled in vivo release of drugs impede their efficacy in the treatment of rheumatoid arthritis (RA). Delivering drugs to arthritic joints and releasing drugs on demand are a feasible solution to achieve the effective treatment of RA. In this paper, we report a facile method to assemble dual-stimuli responsive polymeric micelles from polyethylene glycol–phenylboric acid–triglycerol monostearate (PEG–PBA–TGMS, PPT) conjugates with the aim of delivering dexamethasone (Dex) to arthritic joints and controlling the release of Dex by inflammatory stimuli. We show that the release of Dex from the PPT micelles is accelerated in response to acidic pH and overexpressed matrix metalloproteinases. In an adjuvant-induced arthritis model, the PPT micelles preferentially accumulate in arthritic joints and show an excellent therapeutic efficacy after being intravenously administrated. Our results highlight the potential of the dual stimuli-responsive micelles as a promising therapeutic option for the effective treatment of inflammatory diseases.
研究领域:
药学
·
纳米技术
·
生物医学工程
·
炎症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Pei Liu,Xiaomei Pei,Chaowang Li,Rong Li,Zhao Chen,Binglei Song,Zhenggang Cui,Danhua Xie
A pH-switchable wormlike micellar system with high viscoelasticity was prepared by mixing N-(3-(dimethylamino) propyl) stearamide (SAM) and phthalic acid (PA) at the molar ratio of 2:1. By simple in situ neutralization reaction, SAM and PA could dynamically combine to fabricate a pseudo-oligomeric surfactant without additional inorganic salts. Through the results of surface activity, rheology and Small-angle X-ray scattering (SAXS), it was found that the pseudo-oligomeric surfactant was readily to form viscoelastic wormlike micelles and showed remarkable thickening ability. The maximum zero shear viscosity ( η 0 ) was up to 9.4 × 10 3 Pa·s, which was higher than most of wormlike micelles formed by the conventional covalently linked oligomeric counterparts. The viscoelastic fluid formed by the pseudo-oligomeric surfactant was highly sensitive to pH, whose viscosity could be decreased to 0.001 Pa·s instantly by adding a small amount of acid or alkali.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2021
·
IF 3.981
Xiuting He,Zhongcheng Cao,Nuannuan Li,Liuxiang Chu,Jiazhen Wang,Chunyan Zhang,Xiaoyan He,Xiaoyan Lu,Kaoxiang Sun,Qingguo Meng
7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded polyethylene glycol-GPLGVRG-poly β-benzyl- l -aspartic acid (PEG-GPLGVRG-PBLA) self-assemblies were successfully prepared using a classical nanoprecipitation method to give an enzyme-responsive nano-drug delivery system. The PEG-GPLGVRG-PBLA/SN-38 self-assemblies were characterized by transmission electron microscopy , dynamic light scattering , and high-performance liquid chromatography. The encapsulation efficiency was 91.7 ± 1.21% and the drug loading was 16.6 ± 0.93%. The 12 h in vitro release of SN-38 from PEG-GPLGVRG-PBLA/SN-38 treated with MMP-2 was 73.2 ± 2.05%, which was significantly higher than that for the group without MMP-2, demonstrating the enzyme-responsiveness of the nano-drug delivery system. In addition, the cellular uptake and tumor accumulation of PEG-GPLGVRG-PBLA were better than those of PEG-PBLA, and the blank PEG-GPLGVRG-PBLA showed high biocompatibility . These findings indicate that the enzyme-responsive nano SN-38 delivery system could provide new opportunities in tumor therapy.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Lei Liu,Shuaichao Wang,Peilan Qi,Shiyong Song,Yanwei Yang,Jiahua Shi,Guang Han
Poly(ethylene glycol)-poly(ε-caprolactone) (PEG-b-PCL) micelles have been widely used as drug delivery vehicles for cancer therapies. Because of the lack of functional groups, the use of PEG-b-PCL in drug delivery system is greatly limited and structural modifications is needed. In this work, chemical modification at the terminus of PEG-b-PCL was performed via the “grafting from” polymerization method. A poly(dopamine methyl acrylamide) segment was introduced containing multiple catechol groups, which could attach bortezomib (BTZ) to the chain of the polymer through the formation of a pH-sensitive borate bond. This method greatly enhanced the loading capacity of BTZ into the micelles. Additionally, the controlled release of BTZ in response to the acidic environment of a tumor was realized. High loading capacity, stimuli-responsiveness, biodegradability, and compatibility were integrated in the PEG-b-PCL-based system. In vitro and in vivo studies demonstrated that superior tumor inhibition without obvious side effects can be achieved by the BTZ-loaded PEG-b-PCL-b-PDMA micelles.
研究领域:
药学
·
材料科学
·
纳米技术
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）