INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Ying Zeng,Hao Chen,Guangjin Hu,Rui Cai,Yujie ChenYang,Zhixing Huang,Benyong Han
Eight novel amino acid (AA)–based trifluoromethanesulfonate ionic liquids (ILs; named [AAH][CF 3 SO 3 ]-ILs) were synthesized via neutralization reactions from natural AAs and trifluoromethanesulfonate (CF 3 SO 3 H). The catalytic performance of [AAH][CF 3 SO 3 ]-ILs in biodiesel preparation was evaluated with oleic acid and methanol as substrates. Among the eight [AAH][CF 3 SO 3 ]-ILs, the proline trifluoromethanesulfonate ([ProH][CF 3 SO 3 ]) catalyst displayed the best catalytic activity. The optimal process conditions for the response surface methodology (RSM) were as follows: [ProH][CF 3 SO 3 ] loading = 14.99 wt%, MeOH-to-oleic acid molar ratio = 17.94:1, reaction time = 1.95 h, and temperature = 71°C, and an oleic acid conversion rate of 98.97% was obtained. A first-order reaction kinetics of [ProH][CF 3 SO 3 ]–catalyzed oleic acid esterification showed an activation energy of 18.25 kJ·mol −1 and a frequency factor of 14.04 min −1 . ΔH, ΔS, and ΔG of oleic acid esterification reaction were 15.42 kJ·mol −1 , −0.232 kJ·mol −1 ·K −1 , and 97.32 kJ·mol −1 , respectively. The catalytic activity of [ProH][CF 3 SO 3 ] did not considerably change after eight reuse cycles, demonstrating its excellent stability and reusability. When applied as a catalyst, [ProH][CF 3 SO 3 ] dissolved in the reaction medium during the esterification reaction, enabling efficient homogeneous catalysis . After the reaction, phase separation automatically occurred between biodiesel (methyl oleate) and the catalyst, minimizing the product separation and purification process. The application of [ProH][CF 3 SO 3 ] in this study provides an environmentally friendly technique for biodiesel production . [ProH][CF 3 SO 3 ] is a promising renewable catalyst that it can be used to catalyze fatty acid esterification for biodiesel preparation instead of traditional catalysts.
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RSC Advances
·
2019
·Vol. 9
·期 59
·34457-34464
·
IF 3.049
Lingmei Yang,Huiwen Li,Jun ying Fu,Ming Li,Changlin Miao,Zhongming Wang,Pengmei Lv,Zhenhong Yuan
In this article, a novel nano-rod-shaped SAPO-11 molecular sieve (SAPO-11-A-F) with a thickness of ca. 100 nm was successfully fabricated by the in situ seed-induced steam-assisted method using the cationic surfactant cetyltrimethylammonium bromide (CTAB) as a mesoporous template and a nonionic copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), F127, as the crystal growth inhibitor. The fabricated nano-rod-shaped SAPO-11-A-F possessed nanocrystalline size, a hierarchical porous structure, and enhanced acidic sites. The added CTAB was mainly used to enhance the mesoporous structure and acid, and F127 acted as a grain growth inhibitor. According to the orientation growth mechanism of the molecular sieves, the crystallization mechanism of the nano-rod-shaped hierarchical porous molecular sieves with different crystallization times was investigated. It was found that the nano-rod-shaped molecular sieves were formed by the accumulation of nano-sheets. Compared to three nickel catalysts with different silicoaluminophosphate SAPO-11 molecular sieves in the hydroisomerization of oleic acid to iso-alkanes, the bifunctional catalyst of 7% Ni/SAPO-11-A-F had higher isomeric selectivity (79.8%); in particular, the isomeric octadecane showed stronger selectivity, indicating that the nano-rod-shaped SAPO-11 molecular sieve is more beneficial for the hydrodehydration reaction.
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MOLECULES
·
2025
·Vol. 31
·期 1
·122
·
IF 4.6
Xinyue Ma,Qinqing Zhang,Ying Yang,Yuqi Zhan,Xiangyu Zhang,Yanli Zhao,Jinlian Li,Dongmei Wu
Fatty acid vesicles (FAVs) are promising nanocarriers, but their application is limited by a narrow, alkaline pH formation window that mismatches the weak acidity of physiological environments, such as skin. To overcome this, we developed composite vesicles using oleic acid (OA) and the non-ionic surfactant Tween 40 (TW40). pH titration confirmed that the OA/TW40 system successfully broadened the vesicle formation window from 8.2–10.08 to 3.1–7.2, aligning it with the physiological pH range. The bioactive flavonoid luteolin (LUT) was efficiently encapsulated into these OA/TW40-FAVs, achieving a high encapsulation efficiency (EE) of 87.13% and a drug loading capacity (DLC) of 9.58. The formulation demonstrated superior topical delivery performance: the cumulative transdermal flux (933.08 µg·cm−2) and skin retention (68.18 µg·cm−2) were both approximately double that of the free LUT solution. Furthermore, the OA/TW40/LUT-FAVs provided sustained drug release and exhibited synergistically enhanced antioxidant and antimicrobial activities compared to free LUT or blank vesicles. Collectively, these findings establish OA/TW40 composite vesicles as a robust and efficient nanoplatform for the topical delivery of bioactive compounds.
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Journal of Energy Chemistry
·
2023
·
IF 13.1
Tao Chen,Xin Li,Yong Wang,Feng Lin,Ruliang Liu,Wenhua Zhang,Jie Yang,Rongfei Wang,Xiaoming Wen,Bin Meng,Xuhui Xu,Chong Wang
Low-dimensional halide perovskites have become the most promising candidates for X-ray imaging, yet the issues of the poor chemical stability of hybrid halide perovskite, the high poisonousness of lead halides and the relatively low detectivity of the lead-free halide perovskites which seriously restrain its commercialization. Here, we developed a solution inverse temperature crystal growth (ITCG) method to bring-up high quality Cs 3 Cu 2 I 5 crystals with large size of centimeter order, in which the oleic acid (OA) is introduced as an antioxidative ligand to inhibit the oxidation of cuprous ions effieiently, as well as to decelerate the crystallization rate remarkalby. Based on these fine crystals, the vapor deposition technique is empolyed to prepare high quality Cs 3 Cu 2 I 5 films for efficient X-ray imaging. Smooth surface morphology, high light yields and short decay time endow the Cs 3 Cu 2 I 5 films with strong radioluminescence, high resolution (12 lp/mm), low detection limits (53 nGy air /s) and desirable stability. Subsequently, the Cs 3 Cu 2 I 5 films have been applied to the practical radiography which exhibit superior X-ray imaging performance. Our work provides a paradigm to fabricate nonpoisonous and chemically stable inorganic halide perovskite for X-ray imaging.
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MEDICINAL CHEMISTRY RESEARCH
·
2022
·Vol. 31
·期 12
·2209-2219
·
IF 2.351
Chen Yu,Zhang Shaojun,Lu Yanxia,Li Lujun,Shi Yu,Lei Yueyue,Yang Xinyu,Wu Zhengzhi
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease associated with hepatic lipid accumulation, insulin resistance, oxidative stress, and inflammation. The CFLAR-JNK pathway plays a decisive role in the development of NAFLD. EJ1 is a new hexacyclic triterpenic acid isolated from Euscaphis japonica , a traditional herbal medicine with anti-NAFLD effect. The present study was aimed to evaluate the hepatoprotective effect of EJ1 against NAFLD in vitro and the underlying mechanisms. The biochemical parameters related to lipid accumulation, insulin resistance, oxidative stress, and inflammation in oleic acid-induced HepG2 cellular model of NAFLD were measured. In this study, EJ1 was found to significantly decrease TG and TC contents. Meanwhile, EJ1 increased hepatocellular glucose uptake and improved insulin resistance by increasing the phosphorylation levels of pIRS1, pAKT and PI3K. Furthermore, EJ1 decreased the intracellular ROS and MDA, promoted the antioxidant enzymes activity including SOD and GSH-Px. Moreover, EJ1 reduced the levels of cellular NO and mRNA of TNF-α, IL-6 and IL-8. Further investigation showed that EJ1 treatment led to up-regulation of CFLAR protein expression and down-regulation of JNK protein phosphorylation. These results revealed that EJ1 has the potential to alleviate lipid accumulation, insulin resistance, oxidative stress, and inflammatory responses in OA-treated HepG2 cellular model of NAFLD, representing a promising leading compound for NAFLD, possibly by activating the CFLAR-JNK pathway.
Graphical abstract
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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 97
·期 8
·2055-2067
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IF 3.709
Xiaolong Liu,Jingye Ma,Minxin Wang,Hong Yuan
BACKGROUND A series of mesoporous Pt@KIT−6/SAPO−11 catalysts with SiO 2 :Al 2 O 3 molar ratios of 0.3, 0.4, or 0.5 and Pt loadings of 0.4, 0.8, or 1.2 wt% were prepared via an in situ encapsulation process using a PEO − PPO − PEO triblock copolymer (EO 20 PO 70 EO 20 , P123) as the mes. China 750001 oporous template and KIT−6 molecular sieves as the silicon source. RESULTS These catalysts were characterized by transmission electron microscopy (TEM), specific surface area analysis, and pyridine–infrared spectroscopy (Py − IR). The results showed that Pt nanoparticles with particle sizes of 3–7 nm were uniformly dispersed on the supports. These materials also exhibited good mesoporous structures with specific surface areas of 138–197 m 2 /g and average pore sizes of 7.1–9.9 nm. The specimens having a SiO 2 :Al 2 O 3 molar ratio of 0.4 also showed an orderly strip−shaped pore structure. The Py − IR results indicated that the catalysts had both Brønsted acid and Lewis acid sites, with total acid contents in the range of 77.8–131.1 μmol/g. CONCLUSION The decarboxylation of oleic acid using these materials under CO 2 was examined. The catalyst with a SiO 2 :Al 2 O 3 molar ratio of 0.4 and a Pt loading of 0.8 exhibited the best catalytic performance and a C8 − C17 alkanes yield as high as 85.1% at 340 °C by using a catalyst−to−oil mass ratio of 1:10 and a reaction time of 5 h. This performance was attributed to the ordered mesoporous structure of this catalyst along with its high surface area (173 m 2 /g), good crystallinity (92.8%), suitable acid content (98.6 μmol/g), and abundant Pt metal active sites. © 2022 Society of Chemical Industry (SCI).
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Materials Today Bio
·
2022
·
IF 10.761
Wei Pei,Ling Cai,Xing Gong,Li Zhang,Jiarong Zhang,Ping Zhu,Huijun Jiang,Chao Wang,Shoulin Wang,Jin Chen
Despite its prominent therapeutic efficacy, chemotherapy has raised serious concerns due to the severe adverse effects and multidrug resistance evoked, which propels the search for safe and green therapeutic agents. BAMLET (bovine α-lactalbumin made lethal against tumor cell) is a well-known protein-based anticancer agent of selective tumoricidal activity. Here, we prepared oleic acid-modified mesoporous silica nanoparticles (OA-MSNs) conjugated with bovine α-lactalbumin, a lipoprotein complex resembling BAMLET formed on the surface of MSNs (MSN-BAMLET) to load the anticancer drug of docetaxel (DTX). Compared to that of OA-MSNs/DTX, the obtained MSN-BAMLET/DTX with a sustained and pH-responsive drug release behaviors exhibited good biocompatibility and enhanced cytotoxic effect against cancer cells. Moreover, the presence of lipoprotein complex in MSN-BAMLET contributed to the improved dispersion of the composite in solution and the inhibitory effect on the migration of cancer cells. Furthermore, the adsorption profiles of protein corona on the obtained nanoparticles were analyzed. It was found that the marked low amount and abundance of plasma proteins were adsorbed on the α-lactalbumin coated siliceous composite demonstrated its long circulation property. Finally, in vivo study showed that MSN-BAMLET/DTX contributed to the effective cancer ablation and the prolonged survival. Therefore, the constructed MSN-BAMLET of the mesoregular structure and peculiar tumoricidal effect provides a manipulable nanoplatform as drug nanocarrier for therapeutic applications.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2022
·Vol. 103
·期 4
·2146-2154
·
IF 4.125
Jing Li,Mengting Wang,Guangxin Liu,Wei Wang,Aijun Hu,Jie Zheng
Background A starch-lipid complex is a new type of resistant starch, which is of great importance for the prevention of chronic diseases such as diabetes. Most starch-lipid complexes usually need to be treated by heating to make them suitable for a variety of applications, and starch-based foods are generally not edible without a heat-treatment process. However, the digestion and structural properties of the starch-lipid complex will be changed after heating. In this study, microwave and conventional heating were used to treat debranched quinoa starch-oleic acid complexes (DQS-OA) with different water addition conditions, and the effects of the two methods on the physicochemical, digestive, and structural properties of DQS-OA were compared. Results The results of in vitro digestibility showed that the resistant starch content (235.34–269.55 g kg −1 ) of the conventional heating-treated samples was significantly higher than that the microwave-treated samples (141.51–157.99 g kg −1 ). Moreover, after microwave treatment, the short-range molecular order and crystalline structure of DQS-OA were destroyed and the particle size became smaller. In contrast, the thermal stability, enthalpy, and crystallinity of the complexes after conventional heating were improved. The ratio at 1047/1022 cm −1 of complexes has also been increased. Conclusion This study demonstrated that conventional water-bath heating was better than microwave heating in increasing digestion resistance, improving the short-range and long-range molecular order, and promoting the formation of DQS-OA. With an increase in water addition, the influence of microwave or water-bath treatment on the properties of DQS-OA became greater. © 2022 Society of Chemical Industry.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yunjun Liu,Liyuan Ma,Yuanjie Guo,Huiying Kuang,Yixiang Liu
This study constructed a self-assembly non-covalent oleic acid (OA) and ovalbumin (OVA) complex via an ultrasonic coupled pH-driven approach to simultaneously improve the water dispersibility, stability, and bioaccessibility of lutein (LUT). The results showed that homogeneous, stable hydrophilic OA-OVA particles were obtained in optimized conditions (an OVA concentration of 4.0 mg/mL, pH 9.0, ultrasonic conditions of 200 W for 2 min, and OA-OVA molar ratios of 2:1–20:1), with the LUT encapsulation efficiency (EE) exceeding 88.9%. Furthermore, Fourier transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) confirmed complete LUT encapsulation in the OA-OVA particles, displaying spherical particle formation with smooth surfaces. The OA-OVA complexes effectively improved the thermal and storage stability of LUT and significantly enhanced its bioaccessibility. These findings suggest that fatty acid-protein complexes may have potential application value as carotenoid delivery vectors.
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Current Research in Food Science
·
2023
·
IF 6.3
Jing Du,Meng-yao Lv,Hai-long Zhang,Shen-sheng Xiao,Shuang-yi Zheng,Xue-dong Wang
The aim of this study was to understand the potential of endogenous gluten inhibiting the digestibility in vitro of wheat starch (WS) in starch-fatty acid-protein system. Therefore, the influences of gluten and whey protein isolate (WPI) on the properties, multi-scale structure and in vitro digestibility of WS in WS-oleic acid (OA)-protein system were compared. The results of digestibility in vitro indicated that the ternary system of starch-fatty acid-protein showed higher resistant starch (RS) content as well as lower rapidly digestible starch (RDS) content than the binary system of WS-OA, demonstrating protein decreased WS digestion of WS-OA system. The results of pasting properties showed that gluten and WPI both increased the viscosities of WS-OA system during the cooling period due to the formation of WS-OA-protein ternary complex. The results of swelling power and solubility analysis showed that gluten and WPI both decreased the swelling power and solubility of WS-OA binary system. Laser Confocal Raman and X-ray diffraction (XRD) studies indicated that gluten and WPI both increased the ordered degree of WS-OA binary system by decreasing the full width at half maximum (FWHM) of the peak at 480 cm −1 and increasing crystallinity degree. Strikingly, compared with WPI, gluten had greater effects on the digestibility in vitro , pasting properties and ordered degree of WS in WS-OA-protein system. Therefore, gluten as an endogenous protein has the potential application in reduction the enzymatic digestibility of WS by regulating the reassembly of starch and fatty acid during thermal processing.
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Research
·
2023
·
IF 11
Qiang Wang,Tian Yang,Shiyou Li,Chen Xu,Chong Wang,Yuxuan Xiong,Xing Wang,Jiangling Wan,Xiangliang Yang,Zifu Li
Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells (CSCs). However, the innate drawbacks, including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors, have become bottlenecks for clinical applications of photodynamic therapy. Here, we develop a mitochondria-targeting hemicyanine–oleic acid conjugate (CyOA), which can self-assemble into supramolecular nanoparticles (NPs) without any exogenous excipients. CyOA is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia, resulting in 50.4-fold higher phototoxicity against breast cancer stem cells (BCSCs) compared to SO3-CyOA NPs that cannot target to mitochondria. In 4T1 and BCSC tumor models, CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer Hiporfin. This study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Huijing Chen,Qi Zhao,Guoxiang Chi,Kewei Chen,Zhirong Wang,Jianquan Kan
Lipids have been used to regulate dough's processing characteristics; however, how they affect gluten properties remains unclear. In this study, the effects of different acid-based glycerolipids and thermomechanical treatments on gluten functionalities were investigated. The results demonstrated that exogenous oleic acid-based lipids regulate gluten secondary structure. Oleic acid increased the α-helix content and improved the viscoelasticity of gluten, whereas triolein and rapeseed oil reduced the viscoelasticity and enhanced its tensile properties. Thermomechanical treatment promoted the aggregation and formation of more disulfide bonds in gluten, whereas clear fluorescence quenching was observed in gluten-containing exogenous lipids. Moreover, molecular simulation analysis indicated that hydrogen bond and hydrophobic interactions are key non-covalent forces that promoted the interaction of exogenous lipids and gluten. Compared with other oleic acid-based glycerolipids, monoolein-gliadin systems exhibited the highest binding energies (−20.6 kJ/mol). Our results deepen the understanding of why oils and fats regulate the processing characteristics of wheat-based foods.
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