INTERNATIONAL DAIRY JOURNAL
·
2026
·
IF 3.1
Yi-han Cai,Fang Huang,Si-ying Yan,Xiao-jin Lin,Shu-ling Huang,Shao-fu Feng,Jie-ying Chen,Yan-yan Huang,Xin-An Zeng,Xiang-ze Jia
MPNs with four polyphenols enhanced coating stability and polyphenol adhesion. • Coating traits linked to molecular size and hydroxyl group number. • Encapsulated L. fermentum CYH-108 improves yogurt fermentation and storage quality. • Microcapsules construct a more stable yogurt protein gel network. • Mechanism of microcapsules regulating probiotics and quality is partially clarified. Probiotic stabilization was achieved by microencapsulation using metal ion-coordinated self-assembly. Limosilactobacillus fermentum (LF) were encapsulated within metal-polyphenol networks (MPNs) constructed from tannic acid (TA), gallic acid (GA), epigallocatechin (EGC), epigallocatechin gallate (EGCG) and Fe 3+ . MPN deposition on bacteria was evidenced by adhesion rate, size, zeta potential, and TEM imaging. The encapsulation exhibited negligible cytotoxicity while imposing controlled suppression on their growth. In yogurt, the microcapsules mitigated the rate of pH reduction and enhanced bacterial survival during freeze-drying and storage. Yogurt supplemented with EGCG@L accumulated the highest concentrations of organic acids. Instrumental flavor analysis revealed an altered volatile profile in microcapsule-fortified yogurt. The MPN coating formed a crosslinked protective membrane. EGCG and TA showed superior coating stability and probiotic protection. This study demonstrates MPN application in functional probiotic yogurt, reveals the intrinsic stabilization mechanisms, and guides polyphenol selection for probiotic coating. Created with BioGDP.com . Download: Download high-res image (323KB) Download: Download full-size image
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高影响因子
MATERIALS & DESIGN
·
2026
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IF 8.2
Yanchuan Pu,junjie Zhao,Jianhang Zhao,Jinpeng Lou,Tao Jin,Haiyan Zhao,Wenji Wang
Tea polyphenols preserves chondrocyte homeostasis by mitigating mitochondrial stress. • Tea polyphenols protects chondrocytes by suppressing the PI3K/Akt signaling pathway. • Cartilage-affinity liposomes enhance local retention and in vivo efficacy of Tp. Tea polyphenols (Tp) have been reported to possess anti-inflammatory and antioxidant properties, but their application in osteoarthritis (OA) therapy is limited by poor bioavailability and lack of mechanistic clarity. Here, we show that Tp attenuates IL1β-induced chondrocyte inflammation, oxidative stress, and catabolic gene expression (MMP13, MMP3, ADAMTS5) while restoring COL2 levels. Transcriptomic analysis identifies the PI3K/Akt pathway as a key mediator of Tp’s chondroprotective effects, which was confirmed using the PI3K/Akt agonist YS-49. Tp also preserves mitochondrial membrane potential and reduces mitochondrial ROS production. To improve intra-articular delivery, we developed a cartilage-affinity peptide-modified liposomal nanocarrier (LipTp-T) with favorable size, stability, high encapsulation efficiency, and good biosafety. The peptide modification enhances chondrocyte uptake and prolongs joint retention beyond one week. In a mouse OA model, LipTp-T outperforms free Tp in preserving cartilage integrity, lowering OARSI scores, and suppressing ADAMTS5 and MMP13 expression, while consistently inhibiting the PI3K/Akt axis. Collectively, these findings demonstrate that Tp protects against OA by suppressing the PI3K/Akt pathway, and that cartilage-targeted liposomal delivery significantly enhances its therapeutic efficacy. Download: Download high-res image (193KB) Download: Download full-size image
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高影响因子
Foods
·
2026
·Vol. 15
·期 11
·1897
·
IF 6
Jiayi Zhang,Shengyang Shi,Yingxi Chen,Sufang Zhang,Chaofan Ji
Kombucha quality is largely governed by polyphenol transformation during fermentation. However, interaction between substrate composition and microbial communities regulating phenolic transformation and quality formation remains unclear. In this study, six tea substrates (white, green, yellow, black, oolong, and mint tea) were fermented using three defined microbial communities (SMC1-SMC3) and a traditional symbiotic culture of bacteria and yeast (SCOBY) to evaluate carbon metabolism, phenolic transformation, antioxidant activity, and sensory quality. After 10 d of fermentation, SMC2 and SMC3, containing acetic acid bacteria, showed stronger acidification (pH 2.2–2.5) and lower ethanol (0.34–0.52 mg/mL) than SMC1 (13.09–15.88 mg/mL). Phenolic transformation was substrate-dependent: total phenolics and flavonoids decreased in green tea, both increased in white tea, while flavonoids increased in oolong and black tea. Meanwhile, rutin decreased in white and green tea, whereas gallic acid accumulated in yellow, black, and oolong teas and was positively correlated with antioxidant activity. Sensory evaluation showed SMC3 achieved higher overall acceptability in most substrates, whereas SCOBY performed best in mint tea. These findings indicate substrate-microbiota interactions play a key role in phenolic transformation and quality formation in kombucha. Rational matching of tea substrates with defined microbial communities enables coordinated optimization of antioxidant activity, ethanol control, and sensory quality.
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PubMed
高影响因子
DESALINATION
·
2025
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IF 9.8
Bingbing Yuan,Zhihui Zhang,Yuxin Ding,Xiao Chen,Siheng Zhao,Lihong Liu,Ping Hu,Shengchao Zhao,Kuo Chen,Juhui Jiang,Dongxiao Yang,Q. Jason Niu
High-performance polyamide (PA) reverse osmosis membranes with enhanced water permeability and water-NaCl permselectivity are crucial for cost-effective and energy-efficient desalination. This study introduces a dual-step design strategy combining conventional interfacial polymerization (IP) with diazotization-coupling reactions to optimize membrane performance. By chemically grafting dendrimers and polyphenols onto nascent PA nanofilms, we engineered a composite desalination layer with reduced mass density (from 1.09 ± 0.013 g cm −3 to 1.22 ± 0.049 g cm −3 ) and increased porosity. Structural analysis reveals that thicker nanofilms exhibit lower densities due to dendrimer-induced nanovoid formation. The optimized membrane (G4D-tannic acid composite) achieves a water flux of 96.7 kg m −2 h −1 and more than 99 % NaCl rejection, surpassing both the original IP membrane and commercial benchmarks. These results demonstrate that covalent modification of PA layers through tailored coupling reactions can simultaneously enhance permeability and selectivity, advancing the design of next-generation desalination membranes.
研究领域:
材料科学
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化学工程
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环境科学
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DOI
高影响因子
Chemosensors
·
2025
·Vol. 13
·期 4
·142
·
IF 3.7
Wei-Zhi Zhang,Chen-Fei Zhang,Shou-Nian Ding
The Monkeypox virus (MPXV), a DNA virus classified under the Orthpoxvirus genus alongside variola virus, has recently garnered significant global health attention due to its increasing transmission and emerging genomic mutations. Point-of-care testing is essential for effective clinical response and outbreak mitigation. In this article, we developed a novel class of colored microspheres designed for application in a lateral flow immunoassay (LFIA) platform targeting MPXV-specific biomarkers. Polystyrene-maleic anhydride (SMA-MAA) microspheres were synthesized with a high-temperature soap-free emulsion polymerization optimized in our lab. Subsequent alkali and acid treatments were employed to introduce porosity into the microsphere matrix. Solvent Red 27 and Disperse Red 60 were incorporated via solvent-swelling and thermal-swelling methods, respectively, to generate high brightness (HB) carriers. A surface coating composed of a tannic acid–iron (TA–Fe3⁺) coordination complex was applied to form a stable metal–polyphenol film (MPF). This coating not only minimized dye leaching by establishing a robust shell but also improved dye distribution, thereby enhancing overall color intensity. The final HB-LFIA system, configured in a sandwich immunoassay format, demonstrated favorable sensitivity and linear detection range for Monkeypox antigen, indicating strong potential for clinical diagnostic use.
研究领域:
病毒学
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医学诊断
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材料科学
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DOI
高影响因子
MEDICAL ONCOLOGY
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2025
·Vol. 42
·期 5
·1-11
·
IF 3.5
Wang Jingsi,Deng Xufeng,Li Manyuan,Liu Xiaobing,Liu Quanxing
The treatment of lung cancer with azacitidine (AZA) is urgently in need of a novel delivery material due to its limitations, including a short half-life, high cytotoxicity, and poor tumor targeting. To overcome these limitations, the coordination of Gallic acid-catechin-gallate with Fe 3+ and its encapsulation on the surface of mPDA loaded with AZA (mA@EF) was prepared. mA@EF exhibited a uniform distribution of regular spherical particles with good stability and drug release properties. In cell experiments, mA@EF effectively inhibited cell viability, promoted cellular uptake, and downregulated the expression of DNA methyltransferases. Moreover, mA@EF demonstrated good biosafety. In animal experiments, mA@EF showed strong tumor-targeting and retention activity, and significantly inhibited the growth of tumor. This discovery provided a feasible dosing regimen for AZA treatment in lung cancer patients.
研究领域:
药剂学
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肿瘤学
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生物材料科学
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DOI
PubMed
高影响因子
IBRO Neuroscience Reports
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2025
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IF 2.9
Wei Nong,Xiaoli Chen,Yixin Chen,Xueping Feng,Wen Kong,Rui Chi,Li Yan,Zhiquan Wei
Extracellular β-amyloid protein (Aβ) plaques are prominent pathological feature of Alzheimer's disease (AD). Aβ oligomers and plaques induce sustained microglial activation via the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/interferon regulatory factor 5 (IRF5) signaling pathway. This microglial activation-mediated neuroinflammation can accelerate neuronal cell senescence. Consequently, the regulation of the AMPK/mTOR/IRF5 pathway presents a potential therapeutic target for AD, as it may inhibit neuroinflammation and delay neuronal cell senescence. Mangiferin, a bioactive natural polyphenol extracted from the leaves of Mangifera indica Linn ., has garnered significant attention for its anti-inflammatory properties. However, it remains unclear whether mangiferin can modulate the AMPK/mTOR/IRF5 pathway to inhibit microglial activation-mediated neuroinflammation and delay neuronal cell senescence. This study employed both cellular and animal models of neuronal cell senescence to explore the effects of mangiferin on the regulation of the AMPK/mTOR/IRF5 pathway, aiming to inhibit neuroinflammation and delay neuronal cell senescence in vitro and in vivo . Specifically, SH-SY5Y neuroblastoma cells were subjected to a neuroinflammatory microenvironment induced by Aβ1–42-mediated HMC3 microglial activation to induce neuronal cell senescence in vitro . Additionally, SAMP8 accelerated aging mice were utilized as an aging animal model. The results indicate that mangiferin significantly enhances AMPK phosphorylation in microglial cells, inhibits mTOR activation, and downregulates IRF5 expression. These effects collectively suppress microglial activation and markedly reduce the production of pro-inflammatory cytokines by activated microglia. Consequently, there is a decrease in the proportion of neurons arrested in the G0/G1 phase and a reduction in the number of senescence-associated β-galactosidase (SA-β-gal) positive neurons. Furthermore, mangiferin significantly decreases the expression of neuronal cell senescence markers P16Ink4a and P21Cip1. Collectively, these findings suggest that mangiferin effectively regulates the AMPK/mTOR/IRF5 pathway, inhibits neuroinflammation mediated by microglial activation, and delays neuronal cell senescence. This study underscores the potential of mangiferin for the treatment of neuroinflammation and neurodegenerative diseases.
研究领域:
神经生物学
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药理学
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老年医学
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Xiao Chen,Meizhou Sun,Lujiao Zhang,Yang Hu,Zhiwei Yang,Shun Duan,Fu-Jian Xu,Juehua Jing
Infected bone defect is a critical problem in clinical practice of orthopedics. To solve this problem, implants with dual-functional surfaces which possess both antibacterial and osteogenic properties have extensive applications. However, there remains a pressing need to develop a convenient strategy for preparing such surfaces facilely. In this study, we reported a novel one-step polyphenol-based surface functionalization strategy for preparing two fibrous membranes with antibacterial and osteogenic capabilities. The formation of RGD-HHC36 (RH) or RGD-polyhexamethylene guanidine (RP) coating was fabricated by Michael reaction with poly (tannic acid) (PTA) to produce dual-functional fibrous membranes (PLA-RH and PLA-RP, respectively). The surfaces of PLA-RH and PLA-RP exhibited increased roughness and hydrophilicity. In vitro tests revealed that PLA-RH and PLA-RP could eradicate over 99% of clinically common pathogenic bacteria while exhibiting significant improvements in the adhesion, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Moreover, RNA-Seq analysis revealed that the up-regulation of Chrdl1 played a key role in promoting ossification through activation of the CHRDL1 - BMP4 pathway. The favourable in vivo anti-infection and osteogenesis-promoting performances were demonstrated in an infected bone defect model. PLA-RH and PLA-RP inhibited bacterial infection in the early stage, and enhanced osteogenesis in the late stage. This study provides a facile and universal strategy for designing and fabricating dual-functional surfaces for antibacterial application and tissue regeneration simultaneously.
研究领域:
生物医学工程
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组织工程
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材料科学
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Zhaohui Yan,Zhiyuan Zheng,Sijia Cao,Renzhao Zhang,Yudan Zhang,Ting Zhang,Jingbo Liu,Xuanting Liu
Probiotics are susceptible to environmental factors during processing, storage, and digestion, which greatly limits their beneficial effects. This study constructed and characterized polyphenol-modified ovalbumin-lysozyme (OVA-LYS) complex coacervates and evaluated their stability as probiotic delivery carriers during environmental stresses and gastrointestinal digestion. The results demonstrated that the coupling of catechin (C), epicatechin (EC), and epigallocatechin (EGC) with heteroprotein enhanced the complexes structure, and the probiotic microcapsules showed favorable properties in terms of physicochemical properties. Notably, C-HPCC microcapsules were more effective in encapsulating probiotics (99.43 %). Furthermore, the protection efficiency of microcapsules treated with heating, storage, and digestion consistently followed C-HPCC > EC-HPCC > EGC-HPCC > HPCC order, which was attributed to the stronger affinity between C and heteroprotein. Finally, a novel flavored fermented milk with multiple functions was formulated using probiotic microcapsules as fermentation agents. Overall, this research provided valuable inspiration for novel functional food development with higher bioavailability.
研究领域:
食品科学与技术
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营养学
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微胶囊化
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功能食品
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益生菌递送
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Lei Huang,Xueting Zhao,Jinmao Lv,Xinliang Zhang,Zhihong Dong,Anqi Liu,Jiefeng Pan,Xiaocheng Lin
Controllable assembly of covalent organic framework (COF) nanosheets into two-dimensional (2D) layered membranes is crucial to prepare advanced membranes. However, the prevalence of disordered stacking of COF nanosheets often leads to tortuous or overlapped pores and sacrifices membrane permeability. Further, membrane stability is often questioned due to weak interlayer interactions. Herein, a three-dimensional (3D) polyphenol-mediated interlayer engineering strategy was proposed for manipulating the interlayer channels and interactions of COF membranes for simultaneous enhancement of membrane permeability and stability. The COF membranes (TTSBI/TFTA-TG (Cl) ) were prepared via vacuum-assisted self-assembly method with TFTA-TG (Cl) COF nanosheets as the building host and 3D polyphenols 5,5′,6,6′-Tetrahydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobiindane (TTSBI) as intercalating guests. The stereoscopic spirocyclic architecture of TTSBI provides rigid interlayer support to expand the 2D nanochannels within the COF membranes, which optimizes the water molecule transport pathway to enhance water permeance. The multiple interactions (e.g., electrostatic and cation-π interactions) between TTSBI and COF nanosheets strengthen the interlayer combination, thereby enhancing the structural stability of the COF membrane. The as-prepared TTSBI/TFTA-TG (Cl) membrane exhibited water permeance of 77.3 L m −2 h −1 ·bar −1 (approximately 2.5 times that of the pristine TFTA-TG (Cl) membrane) with methylene blue rejection above 91 %. Furthermore, the TTSBI/TFTA-TG (Cl) membrane can effectively reject dye molecules with molecular weight of ≥800 Da, and simultaneously demonstrate superior stability. This polyphenol-mediated interlayer engineering strategy may provide new insights into the construction and manipulation of the channels in COF membranes for high-permeability separation application.
研究领域:
材料科学
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膜技术
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纳滤
·
环境工程
·
超分子化学
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DOI
高影响因子
Science Bulletin
·
2025
·
IF 21.1
Xueqian Zhang,Hongtao Li,Bo Liang,Zikun Zou,Zhen Yang,Shaohui Xiong,Lei Yang,Xu Wang,Yang Chen,Yuanting Xu,Yiwen Li
Hydrogel-based evaporators have shown great potential in interfacial solar steam generation due to their unique water activation effect. However, the slow water transport still remains a significant challenge limiting the continuous and rapid evaporation. Herein, we introduced polyphenol-mediated pore engineering as a new design strategy to construct hierarchically porous hydrogel evaporators, which exhibited an exceptional water transport rate over two orders of magnitude higher than that of ordinary hydrogels. By incorporating gallic acid (GA), a natural polyphenol, into a polyvinyl alcohol (PVA) matrix and applying a directional freezing process followed by ferric ion (Fe 3+ ) coordination, we achieved a dual-scale porous architecture composed of vertically aligned micron channels and GA-induced micropores. This hierarchical structure skillfully balanced the conflicting demands of water transport and water activation. Simultaneously, GA further regulated the water state by increasing the content of intermediate water, thereby significantly reducing the evaporation enthalpy, which finally achieved an admirable evaporation rate of 3.82 kg m −2 h −1 under one sun irradiation. More importantly, the long-term stability and exceptionally low production cost of this natural molecule-based evaporator enabled an important step towards the possibility of large-scale practical applications. It is believed that this polyphenol-mediated hierarchical porous structured hydrogel provides a new paradigm to accelerate water transport and reduce evaporation enthalpy for efficient and stable solar evaporation.
研究领域:
材料科学
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物理化学
·
能源工程
·
环境科学
·
纳米技术
·
高分子化学
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Chengge Fang,Ling Ma,Timson Chen,Ya Chen,Zhizhen Li,Xiaodong Yan,Jing Wang
Metal polyphenolic networks (MPNs) are becoming more and more attractive for nontoxic hair dyeing, but their coloring effect is not satisfactory because of the limited interfacial deposition and the absence of internal deposition. Moreover, there is a lack of understanding of the driving factors of the interfacial deposition of MPNs on hair. Herein, we develop a simple yet efficient strategy that transforms disulfide bonds of the hair into thiol groups by thioglycolic acid (TGA) to highly enhance the coloring effect of MPNs at a low temperature. The highly reactive thiol groups react with Fe2+ to form Fe–S bonds, greatly facilitating the interfacial and internal deposition of MPNs and thus resulting in rapid coloration and high darkness. Moreover, the TGA-assisted MPNs-dyed (TGA/MPN) hair shows high resistance to washing with a shampoo. Further, it is found that the connection of thiol groups to the MPNs endows the TGA/MPN hair with similar mechanical and structural properties to the natural white hair and even enables simultaneous hair dyeing and perming. This study offers a novel universal strategy for hair dyeing and permeation with MPNs.
研究领域:
材料科学
·
生物学
·
化学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）