MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yuan Wang,Bihong Zhang,Yun Tang,Faqiong Zhao,Baizhao Zeng
A molecularly imprinted polymer/ Au nanoparticles-MoS 2 -graphene/GCE sensor was fabricated and used for the electrochemical detection of rutin. The rose-like Au nanoparticles-MoS 2 -graphene composite (AuNPs-MoS 2 -GN) was fabricated by using a one-pot hydrothermal method. Graphene acted as an efficient matrix for the growth of MoS 2 nanoflower (NF), and the edges of the MoS 2 NF subsequently loaded AuNPs. The AuNPs-MoS 2 -GN composite had large specific surface area, good conductivity and high catalysis, and showed excellent electrochemical response to rutin. To improve the selectivity, rutin imprinted chitosan film was electrodeposited on the AuNPs-MoS 2 -GN/GCE. The obtained molecularly imprinted sensor had strong adsorption capacity for rutin. Under the optimized conditions, the sensor showed a low detection limit (i.e. 4 nmol L −1 ) and a wide detection range (i.e. 0.01–45.0 μmol L −1 ). It also displayed high stability and selectivity. When the sensor was applied to the determination of rutin in real samples satisfactory results were achieved.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jiahui Tong,Yifan Zhao,Xiao Ning,Hongyi Peng,Jingyu Yan,Danlei Qin,Feng Tian,Xiuping Wu,Chunfang Wang,Bing Li
Wound healing is often impeded by bacterial infections, excessive reactive oxygen species (ROS), and inflammatory responses, challenges that traditional dressings inadequately address. Rutin, a natural flavonoid recognized for its antioxidant and anti-inflammatory effects, is limited in biomedical applications because of its low solubility in water. This research presents a novel approach using nitrogen and zinc-doped rutin-derived carbon dots (ZR-CDs), which enhances both antioxidant activity and bioavailability by leveraging the nanoscale properties and surface modifiability of carbon dots. The ZR‑CDs are covalently integrated into an oxidized hyaluronic acid (OHA)/Pluronic F‑127 hydrogel through Schiff‑base chemistry, yielding an injectable, shape‑adaptive composite hydrogel (ZCD@OF), aimed at promoting the healing of infected wounds. In vitro, ZR-CDs exhibit excellent biocompatibility, free-radical scavenging, and protection against ROS-induced cellular dysfunction. The ZCD@OF hydrogel exhibited robust antibacterial efficacy while maintaining favorable rheological properties for wound coverage. In vivo on an infected wound model, ZCD@OF significantly accelerates wound closure, promotes angiogenesis and collagen deposition, and suppresses pro-inflammatory cytokines (IL-6, TNF-α). This study highlights the therapeutic potential of ZCD@OF hydrogel in complex wound treatment, illustrating its capacity to synergistically integrate carbon dot with advanced biomaterial strategies for improved therapeutic outcomes.
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Yijia Jia,Shiyan Sun,Dongmeng Zhang,Xinyue Yan,Hui Man,Yuyang Huang,Baokun Qi,Yang Li
The stabilities and levels of protein-lipid co-oxidation of algae oil-in water (O/W) emulsions coated with the soybean protein 7S/11S or their rutin covalent conjugates were studied during storage. After 96 h of storage, the emulsions stabilized with the covalent conjugates exhibited decreased droplets sizes and ζ-potentials and increased concentrations of adsorbed proteins. Therefore, the covalent binding of rutin in different mixing ratios (at 7S/11S:rutin molar ratios of 1:10 and 1:20) improved the physical stabilities of the emulsions compared with those of the emulsions stabilized by native 7S/11S. The 7S/11S-rutin covalent conjugates, which formed interfacial barriers and exhibited good free radical scavenging properties, inhibited protein oxidation (with lower contents of protein carbonyls, Nʹ-formyl-L-kynurenine, and Schiff bases, and decreased intensities of intrinsic tryptophan fluorescence) and lipid oxidation (with lower contents of lipid hydroperoxide and malondialdehyde) as storage time increased. The electronic nose test distinguished the flavor characteristics of the emulsions coated with different protein-based stabilizers. These results reveal the viability of utilizing soybean protein-rutin conjugates in protein-stabilized algae oil-fortified emulsions with enhanced storability.
✓ 已验证
DOI
PubMed
高影响因子
Pharmaceutics
·
2026
·Vol. 18
·期 7
·872
·
IF 6.9
Weinan Li,Sisi Yan,Yingying Gao,Yuhan Fu,Yutong Mei,Yanhong Wang,Zhixin Yang
Background: The highly heterogeneous and dynamically evolving tumor microenvironment leads to the development of drug resistance and recurrence in traditional therapies. Although immunotherapy demonstrates unique advantages, its clinical utility remains constrained by the suboptimal immunogenicity and the limited effect of monotherapy. Herein, a hybrid drug delivery system based on a spatiotemporal hierarchical controlled-release strategy was proposed to achieve dual immunotherapy with immune checkpoint blockade (ICB) and immunogenic cell death (ICD) to promote synergistic anti-tumor therapy.Methods: A liposome–micelle hybrid drug delivery system (RUT-RPP-LP) was constructed using a lipid bilayer composed of dioleoyl phosphatidylethanolamine/hemisuccinyl cholesterol to encapsulate rutin (RUT) and to form an inner cavity-encapsulated resveratrol micelle (RPP). RUT-RPP-LP was characterized, and its pH sensitivity and release behavior were investigated. Subsequently, a colon cancer tumor-bearing mouse model was constructed to evaluate the in vivo targeted anti-tumor effect and biological safety. On this basis, the combined mechanism of ICB and ICD was preliminarily explored.Results: RUT-RPP-LP possessed excellent formulation characteristics, stability, and biocompatibility, achieving graded controlled release of drugs via responding to the TME and lysosomal acidity, respectively. Obviously, RUT-RPP-LP could specifically target the tumor site, induce the occurrence of ICD, and simultaneously block the PD-1/PD-L1 immune checkpoint signaling pathway, thereby enhancing the function of T cells and inducing apoptosis of tumor cells.Conclusions: The RUT-RPP-LP based on the hierarchical controlled-release strategy exerted a spatiotemporally coordinated enhancement of anti-tumor immunity, and may provide a novel combinatorial approach to overcome the low response of immunotherapy in solid tumors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Yupei Sun,Yanhui Yi,Yaxi Xu,Xiangyang Zhang,Xiaofeng Mou,Feng Zhao,Jianzeng Xin,Sheng Liu
Meat color directly affects consumers’ purchase intention of meat, which is mainly affected by myoglobin (Mb). The extract of Flos sophorae immaturus (FSI) and its main active ingredient rutin (52% of the FSI extract) show potential in preserving beef color. In this study, their protective effects and mechanisms were investigated by spectral analysis, molecular docking, and molecular dynamics simulation. Results indicated that rutin exhibited superior color protection: Beef treated with rutin maintained higher redness and brightness during 7 days of 4 °C storage, with MetMb% maintained at 45–47% and stable pH values around 5.5. Mechanistically, rutin spontaneously formed stable noncovalent complexes with Mb mainly through van der Waals forces and hydrogen bonds, inducing Mb aggregation, altering its secondary structure, reducing surface hydrophobicity and solubility, and enhancing thermal stability (denaturation temperature increased from 77.80 to 133.25 °C). These findings provide a theoretical foundation for developing novel natural meat color protectants.
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2023
·
IF 6.1
Yilin Wang,Jia Chen,Chenxi Wang,Li Zhang,Yaqi Yang,Chao Chen,Yixi Xie,Pengcheng Zhao,Junjie Fei
As a common antioxidant and nutritional fortifier in food chemistry, rutin has positive therapeutic effects against novel coronaviruses. Here, Ce-doped poly(3,4-ethylenedioxythiophene) (Ce-PEDOT) nanocomposites derived through cerium-based metal-organic framework (Ce-MOF) as a sacrificial template have been synthesized and successfully applied to electrochemical sensors. Due to the outstanding electrical conductivity of PEDOT and the high catalytic activity of Ce, the nanocomposites were used for the detection of rutin. The Ce-PEDOT/GCE sensor detects rutin over a linear range of 0.02–9 μM with the limit of detection of 14.7 nM (S/N = 3). Satisfactory results were obtained in the determination of rutin in natural food samples (buckwheat tea and orange). Moreover, the redox mechanism and electrochemical reaction sites of rutin were investigated by the CV curves of scan rate and density functional theory. This work is the first to demonstrate the combined PEDOT and Ce-MOF-derived materials as an electrochemical sensor to detect rutin, thus opening a new window for the application of the material in detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2023
·
IF 6
Jie Tang,Lincai Peng,Ahmad Ali,Siyu Zhao,Ziyue Zeng,Ke Yuan,Shun Yao
As the famous naturally occurring flavonoid , rutin exists in many foods , beverages, and their processed functional products. To realize highly efficient analysis for it, a novel supramolecular hydrogel was developed as the electrode modification material for sensor. Here 12 amino acid-based ionic liquids ([C n mim][AA]) were synthesized and 6 of them could self-aggregate to form hydrogels. Especially, all the hydrogels possessed dual sensitivities to temperature and pH, as well as relatively excellent electrocatalytic performance. A three-layer electrochemical sensor [C n mim][AA]/MWCNTs/CS/GCE was prepared by decorating glass carbon electrode (GCE) with hydrogels, multiwalled carbon nanotubes (MWCNTs) and chitosan (CS) to detect rutin. After comprehensive characterization, computation and systematic investigation, the results indicated that Ipa was linearly related to the concentration of rutin in the range of 0.5–5 μM and 5–100 μM with a limit of detection (LOD) of 0.05 μM (S/N = 3). The selectivity, repeatability, stability and potential in electrochemical analysis of the developed supramolecular sensor were proved after analysis of black tartary buckwheat tea and related health-care pills.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 22
·8021
·
IF 4.927
Tao Zhang,Qingxue Ji,Jiayi Song,Haiming Li,Xing Wang,Haiqiang Shi,Meihong Niu,Tingting Chu,Fengshan Zhang,Yanzhu Guo
The poor water solubility, large particle size, and low accessibility of cellulose, the most abundant bioresource, have restricted its generalization to carbon dots (CDs). Herein, nitrogen and sulfur co-doped fluorescent carbon dots (N, S-CDs) were hydrothermally synthesized using cellulose nanocrystals (CNC) as a carbon precursor, exhibiting a small particle size and excellent aqueous dispersion. Thiourea was selected as a nitrogen and sulfur dopant to introduce abundant fluorescent functional groups into N, S-CDs. The resulting N, S-CDs exhibited nanoscale size (6.2 nm), abundant functional groups, bright blue fluorescence, high quantum yield (QY = 27.4%), and high overall yield (16.2%). The excellent optical properties of N, S-CDs endowed it to potentially display a highly sensitive fluorescence “turn off” response to rutin. The fluorescence response for rutin allowed a wide linear range of 0–40 mg·L−1, with a limit of detection (LOD) of 0.02 μM, which revealed the potential of N, S-CDs as a rapid and simple sensing platform for rutin detection. In addition, the sustainable and large-scale production of the N, S-CDs in this study paves the way for the successful high-value utilization of cellulose.Keywords:cellulose nanocrystals;carbon dots;hydrothermal method;fluorescent sensing
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 22
·7761
·
IF 4.927
Yuhong Li,Jianxiong Tang,Yueli Lin,Jiejun Li,Yaqi Yang,Pengcheng Zhao,Junjie Fei,Yixi Xie
Rutin, a natural flavonol glycoside, is widely present in plants and foods, such as black tea and wheat tea. The antioxidant and anti-inflammatory effects of flavonoids are well known. In this study, a new electrochemical rutin sensor was developed using multiwalled carbon nanotubes/aluminum-based metal–organic frameworks (MWCNT/CAU-1) (CAU−1, a type of Al-MOF) as the electrode modification material. The suspension of multiwalled carbon tubes was dropped on the surface of the GCE electrode to make MWCNT/GCEs, and CAU−1 was then attached to the electrode surface by electrodeposition. MWCNTs and CAU−1 were characterized using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Due to the synergistic effect of CAU−1 and MWCNT-COOH, the prepared sensor showed an ultrasensitive electrochemical response to rutin. Under optimized conditions, the sensor showed a linear relationship between 1.0 × 10−9~3.0 × 10−6M with a detection limit of 6.7 × 10−10M (S/N = 3). The sensor also showed satisfactory stability and accuracy in the detection of real samples.Keywords:electroanalysis;pyrolysis;carbon materials;drug analysis;modified electrode
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2023
·
IF 5.6
Pierre Dramou,Yiyang Sun,Xu Ni,Fangqi Wang,Hua He
In this study, a three-dimensional nanocomposite with magnetic features made of magnetic iron oxide nanoparticles (Fe 3 O 4 ), graphene oxide (GO) and halloysite nanotube (Hal) was prepared and introduced for rutin separation from real sample based on magnetic solid phase extraction (MSPE) process. Hal was modified with chitosan (Hal-COS) and showed positive charge, which can combine with GO by electrostatic force self-assembly to fabricate Hal-GO. Based on this, in-situ growth of magnetic sphere on the surface of Hal-GO demonstrated high specific surface area, chemical and thermal stability, water solubility, and capacity of easy separation in aqueous solution. Several characterizations including FT-IR, HRTEM , TGA and XRD evidenced the successful synthesis of the nanocomposite. The results showed that the optimum adsorption pH was 6 and the optimum adsorption temperature was 25 °C. In addition, further experiments showed that the adsorption process conformed to the Langmuir adsorption model and pseudo-second-order kinetic model , which indicated that the maximum equilibrium adsorption capacity was 107.8 mg g −1 and the maximum equilibrium adsorption time was 120 min. With the optimized conditions, the methodological validation experiments showed that the linear range of MSPE based on Fe 3 O 4 @(Hal-GO) combined with HPLC was 10–100 μg mL −1 , the correlation coefficient of the fitting equation was 0.9991, the LOD and LOQ reached 0.87 μg mL −1 and 2.9 μg mL −1 respectively. It was confirmed that prepared Fe 3 O 4 @(Hal-GO) supported efficient enrichment of rutin when the results were compared to those of other studies.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2024
·
IF 1.6
Zixuan Wang,Ganghui Chu,Juan Peng,Shiyi Chen
Internal reference probes can effectively eliminate internal and external interferences. Hence, finding a suitable internal reference probe is the key to ratiometric electrochemistry. In this study, a simple and sensitive ratiometric electrochemical sensor for the determination of rutin was prepared for the first time using rhodamine B (Rh B) as an internal reference probe. The modified electrochemical sensor was constructed by electrodepositing gold nanoparticles (AuNPs) on a glassy carbon electrode followed by drop-coating chitosan-immobilized rhodamine B (CS@Rh B). Rh B has a dual function in that it has a stable electrochemical signal (1.18 V) (vs. Ag/AgCl) that is completely separated from the oxidation peak of rutin (0.52 V) to serve as an internal reference probe. At the same time, it synergistically enhances the electrochemical signal of rutin with AuNPs. When differential pulse voltammetry was used for the determination of rutin, the current ratio of IRutin/IRh B was employed as the signal for rutin determination with a wide linear range (0.1 to 70 μM) and a low detection line (0.028 μM). The recoveries for the determination of rutin in Coreopsis tinctoria and Buckwheat tea were 95.4%–106% and 95.3%–104%, respectively. This work successfully demonstrated the feasibility of Rh B as an internal reference probe.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Yamin Nie,Xiuli Tao,Haowen Zhang,Ya-qin Chai,Ruo Yuan
Ligand-protected gold nanoclusters (Au NCs) are promising electrochemiluminescence (ECL) emitters because of their striking optical properties and excellent biocompatibility, but free vibration and rotation of their ligand result in low ECL efficiency, dramatically limiting their applications. Herein, using the ligand of Au NCs as one of the building units, a Au NC-based metal–organic framework (Au NC-based MOF) was constructed by the coordination-assisted self-assembly strategy, which not only impedes the ligand rotation-induced energy dissipation but also diminishes the self-quenching effect due to the spatial distribution of Au NCs. As a proof of concept, the prepared GSH-Au NCs@ZIF-8 gives rise to a 10-fold enhanced anodic ECL efficiency compared to that of densely aggregated GSH-Au NCs with triethylamine as the coreactant. Based on high ECL efficiency of GSH-Au NCs@ZIF-8, a “signal off” sensing platform was proposed with rutin as a model analyte, achieving a low detection limit of 10 nM. Therefore, the strategy paves an effective and alternative methodology to enhance ECL efficiency of metal NCs, considerably broadening their potential applications in sensing analysis, clinical diagnosis, and light-emitting devices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）