JOURNAL OF CONTROLLED RELEASE
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2025
·
IF 11.5
Huilan He,Yun Zheng,Jinlong Ji,Chunlian Ye,Yu Sun,Yuwei Peng,Ying Zhang,Zhiyuan Zhong
Radiotherapy (RT) induces immunogenic cell death but also promotes immunosuppression, cancer stemness and immune evasion, thus compromising anti-tumor immune response and leading to cancer recurrence and metastasis. Here, we developed liposomal all-trans retinoic acid nanoparticles (LATRA) to simultaneously mitigate cancer stemness and remedy suppressive tumor microenvironment, which on one hand decreases tumorigenicity and sensitizes tumors to RT and on the other hand stimulates dendritic cell maturation and reprograms macrophages toward a pro-inflammatory M1 phenotype. In murine colorectal tumor model, RT combined with LATRA essentially reduces tumor burden, prevents recurrence and induces a durable immune response with memory effects. Notably, LATRA effectively eradicates residual tumor cells in post-surgery 4 T1 breast tumor model, avoiding tumor relapse and lung metastasis. Liposomal all-trans retinoic acid offers a new and promising strategy to empower radiotherapy-induced anti-tumor immunity.
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xue Wang,Hongxia Liu,Yingying Liu,Danyang Zhang,Lei Zhu,Guoqing Wang,Hongping Chen,Yunfeng Chai
Tea ( Camellia sinensis ) is rich in purine alkaloids, particularly caffeine, yet other alkaloids have garnered less attention. In this study, a pair of stereoisomers cis - and trans -cinnamoylagmatines, alkaloids with a guanidine skeleton, have been identified in tea. Their structures were characterized using ultra-high-performance liquid chromatography/Q-Exactive orbitrap mass spectrometry and were confirmed by comparison with authentic reference standards obtained through organic synthesis. The total contents of cis- and trans- cinnamoylagmatines in various made teas with different fermentation degree and fresh leaves of different tea plant varieties were quantified to be from 1.76 ± 0.024 to 111.74 ± 11.30 mg kg −1 . In the α-glucosidase activity assay, trans -cinnamoylagmatine demonstrated superior inhibitory efficiency (IC 50 : 0.288 ± 0.011 mg mL −1 ) compared to the widely used diabetes medication acarbose. This study sheds light on the presence of natural guanidine alkaloids in tea and their potential role in reducing the risk of diabetes.
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Molecular Catalysis
·
2022
·
IF 5.089
Changjun Yang,Shuai Xu,Fanchang Peng,Wenyao Zhou,Quan Zhou,Xi Chen,Bingguang Zhang,Kejian Deng
The cis / trans isomeric effects of cobalt thioporphyrazine (CoPz) bearing 1,4-dithiin (A) and bis(butylthio) (B) groups on their photocatalytic performance were investigated by photocatalytic selective aerobic oxidation of 5-hydroxymethylfurfural (HMF) in aqueous solution under simulated sunlight. The results demonstrated that the cis -CoA 2 B 2 consistently showed higher photocatalytic activity than the trans -CoA 2 B 2 , especially in alkaline solution. Meanwhile, the cis -CoA 2 B 2 favored oxidizing HMF to 2,5-furandicarboxylic acid (FDCA), while the trans -CoA 2 B 2 preferred yielding 2,5-diformylfuran (DFF). Under alkaline conditions, the yield of FDCA can reach 73% with a selectivity of 95% in the presence of cis -CoA 2 B 2 after reacting 14 h, while 37% of DFF yield with a selectivity of 81% can be achieved in the presence of trans -CoA 2 B 2 after reacting 12 h. The relationship between the structure of cis / tr ans isomers and their photocatalytic performance was further explored by density functional theory (DFT) calculations. The active species originated from cis -CoA 2 B 2 and trans -CoA 2 B 2 were also examined by trapping experiments.
研究领域:
化学
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材料科学
·
催化反应
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TALANTA
·
2026
·
IF 6.7
Mingqi Yang,Jiali Hu,Zhenlin Zhang,Liting Huang,Yahan Yu,Dexing Qiu,Yexin Zu,Yanyan Liu,Zhenyu Lin
Infection with hepatitis B virus (HBV) represents a major challenge to global health, especially in areas of inadequate healthcare infrastructure, rapid and on-site detection plays a crucial role in effective disease management and control. Consequently, it is necessary to develop some simple but sensitive HBV screening techniques. In this work, a homogeneous electrochemical biosensor was constructed for sensitive and specific HBV DNA detection through the integration of CRISPR/Cas12a target recognition and magnetic bead-based separation. The sensor exploits the collateral cleavage activity of CRISPR/Cas12a protein upon recognition of target double-stranded DNA, enabling the degradation of methylene blue-labeled single-stranded DNA captured on magnetic beads (MBs). Then the MBs are separated and redissolved in the solution and the electrochemical response of the system can be tested in homogeneous solution. The electrochemical signal has relationship with the concentration of HBV DNA within a range of 10 fM - 10 nM, and the LOD is 3.74 fM. The sensor demonstrates excellent selectivity and biological stability, which has potential application in clinical diagnosis, especially in resource-limited environments.
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Jiarui Tong,Xiangrong Zhu,Xiumei Chen,Nengguo Tao
Chinese bayberry is a highly fragile and perishable fruit that requires protective and functional packaging to maintain its postharvest quality. In this study, a novel bio-based aerogel was developed using a gelatin/dialdehyde starch matrix reinforced with cellulose nanofibrils (CNF) via Schiff-base crosslinking and freeze-drying. The as-prepared aerogel exhibited superior compressibility, elasticity, and biodegradability. This aerogel was further functionalized by loading trans-2-hexenal (E2H) and combined with 1-methylcyclopropene (1-MCP) treatment, thereby constructing a postharvest preservation system for Chinese bayberry with the triple functionality of ethylene inhibition, antifungal activity, and cushioning performance. The optimal aerogel formulation (30% CNF content) demonstrated robust mechanical performance and sustained E2H release behavior, which followed first-order kinetics. In vitro and in vivo assays confirmed its significant inhibitory effect against Penicillium citrinum , the primary postharvest pathogen of bayberry. Storage experiments at 4 °C revealed that the synergistic effect of E2H-loaded aerogel pads and 1-MCP treatment effectively reduced decay, preserved firmness and nutritional quality, and extended the shelf life of bayberries to 18 d, significantly surpassing the control group which lost commercial value after 8 d. Furthermore, the aerogel completely degraded in soil within two weeks, confirming its potential as an eco-friendly packaging material. This work, integrating both protective and active preservation functionalities, provides a sustainable and efficient packaging approach for fragile fruit.
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高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2023
·
IF 7
Xingxing Yuan,Kuixian Meng,Shiwei Shi,Yaoyanbing Wu,Xiumei Chen,Qiuli OuYang,Nengguo Tao
This study investigated the efficacy of trans-2-hexenal in preventing green mold on postharvest citrus fruit and its mode of action against imazalil-resistant Penicillium digitatum Pdw03. Trans-2-hexenal inhibited Pdw03 at a minimum inhibitory concentration (MIC) and a minimum fungicidal concentration (MFC) of 0.25 mL L −1 . Trans-2-hexenal reduced the incidence of green mold, which is a plant volatile compound with potent antifungal properties . Ultrastructural analysis revealed that trans-2-hexenal altered the mitochondrial structure of Pdw03. Trans-2-hexenal also increased the amount of reactive oxygen species, which hindered mitochondrial energy metabolism of Pdw03, resulting in mitochondrial structural damage and malfunction, and a decrease in mitochondrial membrane potential. In addition, RNA-seq analysis revealed that trans-2-hexenal altered the expression of some energy metabolism genes associated with the tricarboxylic acid (TCA) cycle, glycolysis, and oxidative phosphorylation of Pdw03. Superoxide dismutase , catalase , glutathione S-transferase, and glutathione peroxidase activities were altered, and expression of the relevant gene was also quantified by real-time fluorescence quantitative PCR . Trans-2-hexenal damaged ribosomes, primarily by downregulation of the ribosomal structural component-associated genes RPL3 , RPS18 , RPL12 , RPL26 , RPL13A , RPL9 , RPL23 , and RPL4 , and then by reducing protein synthesis to achieve the inhibitory effect.
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INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Dicheng Ma,Tao Zhang,Guoxian Wang,Chong Cao,Wei Mu,Beixing Li,Daolong Dou,Feng Liu
Trans -2-hexenal (T2H) shows satisfactory antagonistic activity against Fusarium graminearum , but its strong volatility and poor water solubility limit its further application in Fusarium head blight (FHB) control. In this study, T2H-loaded polyurea microcapsules (PU MCs) with different particle sizes were successfully prepared by an interfacial polymerization method, and the effect of MC encapsulation on the physical property limitations and bioactivity of T2H was evaluated. After being encapsulated, lipophilic T2H could be stably dispersed in water. MC encapsulation reduced the fumigation toxicity of T2H but increased its contact toxicity. The smaller the particle size was, the higher the toxicity of PU MCs to F. graminearum was. After 6 d of application, the inhibition rate of T2H against F. graminearum decreased by 77.26%, while that of T2H-loaded PU MCs with small particle sizes (T2H-loaded PU MCs-S) decreased by 54.29%, indicating that MC encapsulation prolonged the inhibition time of T2H. The results of the inoculation assay showed that MC encapsulation improved the inhibitory effect of T2H on F. graminearum infection and DON production in stored wheat kernels. Furthermore, seed soaking with T2H-loaded PU MCs-S reduced the pathogenic fungal load of wheat seeds and had no significant effect on seed germination. In conclusion, T2H encapsulated in MCs can be developed as a plant protection product for postharvest and presowing treatment of wheat.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2019
·Vol. 2019
·期 9
·1212-1219
·
IF 2.578
Xin Yu Deng,Kai Chen,Ming-Dong Chen,Li Bin Lü,Zhu Tao
Graphical The probe responds to Cs + cations in alkali metal systems, Ba 2+ and Sr 2+ cations in alkaline earth metal systems; Eu 3+ , Tm 3+ , and Yb 3+ cations in lanthanide systems, and Cr 3+ , Fe 3+ , and Hg 2+ cations in systems containing transition and other metal cations, by obvious fluorescence quenching. Based on the study of a known host–guest inclusion complex comprising cucurbit[6]uril (Q[6]) and a hemicyanine dye, trans -4-[4-(dimethylamino)styryl]-1-pyridinium iodide ( t -DSMI), a water-soluble symmetric tetramethylcucurbit[6]uril (TMeQ[6]), was selected to construct a t -DSMI-based probe to test the response to various metal cations in neutral water. The experimental results revealed that the probe responded to Cs + cations in alkali metal systems, Ba 2+ and Sr 2+ cations in alkaline earth metal systems, Eu 3+ , Tm 3+ and Yb 3+ cations in lanthanide systems, and Cr 3+ , Fe 3+ and Hg 2+ cations in systems containing transition and other metal cations, via obvious fluorescence quenching.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Jingyu Ren,Nan Jiang,Kefeng Shang,Na Lu,Jie Li,Yan Wu
In this study, trans-ferulic acid (FA) was degraded by water falling film dielectric barrier discharge (DBD) plasma coupled with CoOOH catalyst. The results reveal that CoOOH improved the degradation of FA by DBD plasma through an apparent catalytic effect. 98.2% of FA was degraded in 10 min by DBD + CoOOH (0.5 g/L dosage) system at 11.2 kV applied voltage, which was 23.8% higher than that in a sole DBD system; the corresponding energy yield ( G 50 ) was increased by 186% and the synergistic intensity for FA degradation reached up to 2.76. The evolution of reactive species reveals that the synergistic effect of DBD plasma and CoOOH catalyst can be attributed to the catalytic conversion of O 3 and H 2 O 2 into ·OH on the active sites of CoOOH surface. The results of Lewis acid sites, X-ray photoelectron spectroscopy and Raman spectroscopy suggest that the abundant oxygen vacancies and Lewis acid sites, which are offered by the lattice OH groups in CoOOH, serve as the catalytic active sites of CoOOH. According to the detected byproducts by liquid chromatograph/mass spectrometer, a possible FA degradation pathway was also tentatively proposed.
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JOURNAL OF SEPARATION SCIENCE
·
2022
·Vol. 45
·期 8
·1425-1433
·
IF 3.614
Fei-Hua Wang,Xiao-Feng Guo,Yao-Cheng Fan,Hai-Bin Tang,Wei Liang,Hong Wang
Trans -fatty acids are unsaturated fatty acids that are considered to have health risks. 1,3,5,7-Tetramethyl-8-butyrethylenediamine-difluoroboradiaza- s -indacene is a highly sensitive fluorescent labeling reagent for carboxylic acids developed by our lab. In this study, using this precolumn fluorescent derivatization reagent, a rapid and accurate high-performance liquid chromatography with fluorescence detection method was developed for the determination of two trans-fatty acids in food samples. Under the optimized derivative conditions, two trans-fatty acids were tagged with the fluorescent labeling reagent in the presence of 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide at 25°C for 30 min. Then, the baseline separation of trans - and cis -fatty acids and their saturated fatty acid with similar structures was achieved with less interference using a reversed-phased C 18 column with isocratic elution in 14 min. With fluorescence detection at λ ex /λ em = 490 /510 nm, the linear range of the TFAs was 1.0-200 nM with low detection limits in the range of 0.1–0.2 nM (signal-to-noise ratio = 3). In addition, the proposed approach was successfully applied for the detection of trans-fatty acids in food samples, and the recoveries using this method ranged from 96.02 to 109.22% with low relative standard deviations of 1.2–4.3% ( n = 6).
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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2022
·
IF 5.785
Jing Zhang,Yungu Zheng,Zhenyang Yu
The reproductive toxicities over generations are essential to assess the long-term impacts environmental fluoroquinolone antibiotics (FQs). In the present study, the multi-generational effects of ofloxacin (OFL) and norfloxacin (NOR) on reproduction were studied on Caenorhabditis elegans from 9 successive generations (F1-F9). Results showed that OFL showed no effects in F1, stimulation in F2 to F4, and inhibition F5 to F9. The effects of NOR also showed oscillation between stimulation and inhibition across generations. Further biochemical analysis demonstrated that the reproductive toxicities of OFL and NOR were more closely connected with total cholesterol (TCHO), progesterone (P) and testosterone (T), than major sperm protein (MSP) and vitellogenin (Vn). Moreover, OFL and NOR also showed significant trans-generational reproductive toxicities in T4 and T4′, the great-grand-daughter of F1 and F9. Differences between T4 and T4′ and between OFL and NOR, indicated influences of multi-generational exposure and urged more exploration on different mechanisms between FQs.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2021
·
IF 3.178
Yuechao Cao,Xuxing Wan,Wei Li,Jian Liu,Rongliang Liu,Songgu Wu
trans-p -Methoxycinnamic acid ( t -PMCA) is a cinnamic acid derivative with various pharmacological effects such as anti-colon cancer, antifungal, hepatoprotective, hypoglycemic, etc. In this paper, the solubilities of t -PMCA in 12 organic solvents were determined in the range of 283.15 K-323.15 K using gravimetric method. The solubility of t -PMCA increased with the increasing of temperature. Meanwhile, the experimental solubility data were verified and correlated using four thermodynamic models (Apelblat equation, λ h equation, Van’t Hoff equation and NRTL equation), and the relative standard deviations (ARD%) were all less than 7%. The simulated data agree well with those experimental data. In addition, the Hansen solubility parameter model and solvent properties were used to explain the dissolution behavior of t -PMCA in 12 organic solvents. The results showed that the dissolution behavior of t -PMCA was not determined by a single factor, but was the result of the comprehensive effect of various solubility parameters. In order to reveal the dissolution behavior of t -PMCA, the single-crystal structure of t -PMCA was analyzed, and molecular simulations (including Hirshfeld surface analysis, surface electrostatic potential, and radial distribution function) were performed, which showed that H ⋯ H and O ⋯ H contacts play a dominant role in the crystal arrangement and that there are hydrogen bonding interactions between t -PMCA and solvent molecules. Finally, the thermodynamic properties ( Δ mix G, Δ mix H, and Δ mix S ) of t -PMCA during the mixing process were calculated using the NRTL equation, and the results indicated that it is an entropy-driven spontaneous process.
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