JOURNAL OF MOLECULAR STRUCTURE
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2023
·
IF 3.8
Na Li,Baijian Feng,Yongguang Bi,Fansheng Kong,Zhong Wang,Shaofan Tan
Tea polyphenols (TP) is popular due to strong biological activity, however, the instability of TP limits its application. In this study, inclusion complexes (TP-SBE) of TP with sulfobutyl ether β-cyclodextrin (SBE) were synthesized to improve the stability and bioactivity of TP. To retain more active components and obtain powder with good morphology, TP-SBE was prepared by freeze-drying and characterized by Ultraviolet-visible, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Thermogravimetric-differential scanning calorimetry and X-ray Diffraction Spectroscopy, which showed that the TP was successfully encapsulated by SBE and the thermal stability was improved. The effects of mass ratio, inclusion temperature, stirring speed, and inclusion time on the encapsulation rate of the synthesized TP-SBE were also determined, and the encapsulation rate reached 98.29% ± 1.65% under the optimal conditions. The in vitro activity assay showed that the IC 50 of TP-SBE on 2,2-Diphenyl-1-picrylhydrazyl and 2,2-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) was 16.24±0.99 μg/mL and 5.13±0.17 μg/mL, and the scavenging effect on free radicals and α-glucosidase was more substantial than that of TP. The release of TP slowed down by SBE encapsulation and showed pH-selective. These data suggested that TP can be developed as a nutraceutical with antioxidant and hypoglycemic properties.
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高影响因子
Clinical and Experimental Gastroenterology
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2023
·
IF 2.4
Meng Xu,Ke Che,Cong Wang,Ya-Ru Chen,Meng-Yuan Chen,Guang-Lei Zhang,Hao Yu,Hao-Nan Xu,Ya-Bao Li,Ping Sheng,Hao Chen
Introduction Cholestasis is a common liver disorder that currently has limited treatment options. Gardenia Iridoid Glucosides (GIG) have been found to possess various physiological activities, such as cholagogic, hypoglycemic, antibacterial, and anti-inflammatory effects. The objective of this study was to investigate the effects of GIG on bile acid enterohepatic circulation and explore the underlying mechanism in cholestatic rats.Methods In order to identify key pathways associated with cholestasis, we conducted Gene Ontology (GO) Enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. In vivo experiments were then performed on alpha-naphthylisothiocyanate (ANIT)-treated rats to assess the impact of GIG. We measured bile flow and various biomarkers including total bilirubin (TB), total bile acids (TBA), total cholesterol (TC), malondialdehyde (MDA), glutamic-pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), and total superoxide dismutase (T-SOD) in the serum. We also examined the expression levels of bile salt export pump (BSEP), ATP-binding cassette subfamily B member 4 (ABCB4), far-nesoid X receptor (FXR), small heterodimer partner (SHP), cholesterol 7α-hydroxylase (CYP7A1), and sodium taurocholate cotransporting polypeptide (NTCP) in liver tissue. In vitro experiments were conducted on primary hepatocytes to further investigate the mechanism of action of GIG on the expression of SHP, CYP7A1, NTCP, and FXR.Results Our in vivo experiments demonstrated that GIG significantly increased bile flow and reduced the levels of TB, TBA, TC, MDA, GPT, and GOT, while increasing T-SOD levels in ANIT-treated rats. Addi-tionally, GIG ameliorated liver tissue damage induced by ANIT, upregulated the expression of BSEP and ABCB4, and modulated the protein expression of FXR, SHP, CYP7A1, and NTCP in model rats. In vitro experiments further revealed that GIG inhibited the expression of SHP, CYP7A1, and NTCP by suppressing the expression of FXR.Conclusion This study provides new insights into the therapeutic potential of GIG for the treatment of cholestasis. GIG demonstrated beneficial effects on bile acid enterohepatic circulation and liver biomarkers in cholestatic rats. The modulation of FXR and its downstream targets may contribute to the mechanism of action of GIG. These findings highlight the potential of GIG as a therapeutic intervention for cholangitis.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yan-Fei Mu,Chao Zhang,Meng-Ran Zhang,Wen Zhang,Min Zhang,Tong-Bu Lu
Up to now, the majority of the developed photocatalytic CO2 reduction systems need to use expensive sacrificial reductants as electron source. It is still a huge challenge to drive the photocatalytic CO2 reduction using water as an electron source. Herein, we report a facile strategy for the construction of direct Z-scheme heterojunction of LF-FAPbBr3/α-Fe2O3, which is manufactured by the in situ and two-step controlled growth of ligand-free formamidinium lead bromide (LF-FAPbBr3) nanocrystals on the surface of α-Fe2O3 nanorods. The matchable energy levels and direct contact between LF-FAPbBr3 and α-Fe2O3 significantly accelerate the interfacial charge transfer, with a charge separation efficiency (ηseparation) of 93%, much higher than that of 11% shown by the ligand-capped FAPbBr3/α-Fe2O3 heterojunction. The resulting efficient separation and raised redox ability of photogenerated carriers endow the LF-FAPbBr3/α-Fe2O3 heterojunction with an outstanding photocatalytic performance for CO2 reduction (to CO and CH4) coupled with water oxidation (to O2), achieving a highest electron consumption rate of 175.0 μmol g–1 h–1 among the reported metal halide perovskite-based photocatalysts, which are 5 and 11 times higher in comparison with those of sole LF-FAPbBr3 and ligand-capped FAPbBr3/α-Fe2O3, respectively.
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CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Jing Deng,Cheng Ye,Anhong Cai,Linyi Huai,Shiqing Zhou,Feilong Dong,Xueyan Li,Xiaoyan Ma
As a typical iron-based oxide semiconductor with abundant reserves, α-Fe 2 O 3 has been widely used in the domain of photocatalysis and environmental remediation. Here, sulfur doped α-Fe 2 O 3 (S-α-Fe 2 O 3 ) has been successfully fabricated through coprecipitation, hydrothermal and calcination processes and applied to activate persulfate (PS) for carbamazepine (CBZ) degradation under UV irradiation. Systematic characterizations were conducted to analyze the morphology, structure and chemical composite of S-α-Fe 2 O 3 . UV/PS/S-α-Fe 2 O 3 process showed remarkably enhanced photocatalytic performance for CBZ degradation. The degradation rate constant (7.78 × 10 −2 min −1 ) was about 2.2 and 14.1 times as high as that of UV/PS/α-Fe 2 O 3 (3.60 × 10 −2 min −1 ) and UV/PS (5.53 × 10 −3 min −1 ) processes, respectively. With increasing PS concentration and photocatalyst dosage, the removal efficiency of CBZ both increased. UV/PS/S-α-Fe 2 O 3 process can efficiently and steadily operate in a wide pH range of 3.0–8.0. The introduction of water matrix species (i.e. chloride, bicarbonate, nitrate and humic acid) exerted different effects on CBZ degradation. S-dopant was doped via forming ≡Fe III -SO 4 2- bond on S-α-Fe 2 O 3 surface, and doped sulfur functioned as surface electrons trapping centers derived from DFT study. The band gap value of S-α-Fe 2 O 3 was reduced and the separation efficiency of photogenerated electrons and holes was improved. Hydroxyl radicals, sulfate radicals, superoxide radicals and holes all contributed to CBZ destruction. Furthermore, two major routes of CBZ degradation were proposed as hydroxylation and deamination, then followed by decarbonxylation, ketonization and ring cleavage based on the results of HPLC-MS and DFT calculation.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2021
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IF 4.952
Weili Xu,Kangxing Lv,Wei Mu,Shaobo Zhou,Yang Yang
The aim of this study was to develop an oil-in-water (O/W) emulsion using whey protein isolate (WPI)-chitosan (CN) complex to encapsulate α-tocopherol and to characterize their stability and bioaccessibility in vitro . The O/W emulsions prepared under the optimal conditions (mass ratio of WPI:CN = 1: 1, corn oil containing 5 g/100 g of α-tocopherol) exhibited a monomodal distribution (d = 803.3 ± 6.9 nm) with encapsulation rate of 86.3 ± 2.3%. The emulsions were stable under NaCl (0–150 mmol/L), sugar (0–5 g/100 g), 55 °C for 30 min, pH 5–6.5, even storage for 20 d at 4 °C and 25 °C. During gastric digestion, WPI situated at the surface of emulsion particles can be digested into small molecular peptides by pepsin, but the structure of the core-shell particles remained due to the cross-linking with CN. During intestinal digestion, the structure of the particles disintegrated over the digestion time, and the inner-oil phase was released. Release profiles of the α-tocopherol and free fatty acids showed a burst effect followed by slow release. These results suggest that the WPI-CN complex could be used to achieve a controlled and sustainable release of liposoluble bioactive compounds from O/W emulsions.
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高影响因子
Journal of Energy Storage
·
2021
·
IF 6.583
Weizhi Gong,Mingjun Wang,Yi An,Junli Wang,Liexing Zhou,Yi Xia,Chunjian Wang,Kun Dong,Cheng Pan,Rongfeng Zhou
Cycling stability and specific capacitance are two of important performance parameters for pseudocapacitive electrodes under frequent charging and discharging. Herein, we present a facile solvothermal approach to rationally design and fabricate chiffon-like and hydrotalcite-like α-Co(OH) 2 nanoflakes for extrinsic pseudocapacitive electrode, which exhibits linear galvanostatic discharge behavior and superior charge-storage performance, including high capacitance of 475 F g −1 at 1 A g −1 , excellent rate capability and superb cycling stability with capacitance retention of 93.9% after 10000 cycles at 10 A g −1 . The superior performance is mostly attributed to the good electrical conductivity and stable microstructure of the hydrotalcite-like α-Co(OH) 2 nanoflakes and the abundant redox active sites on the chiffon-like nanoflakes with short and facile electron transport. In addition, other α-Co(OH) 2 samples with different morphologies and size as contrast are prepared and discussed, indicating that the morphology/size design and optimization of the α-Co(OH) 2 could greatly improve the electrochemical energy-storage performance. The findings demonstrate that the chiffon-like and hydrotalcite-like α-Co(OH) 2 nanoflakes have a great practical application potential in long-life and high-performance supercapacitors . This study also presents a facile way to design and prepare nanoflake-like materials with adjustable lateral size and thickness from spherical morphology consisting of nanoflakes.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2020
·Vol. 25
·期 1
·267-278
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IF 2.646
Yao Shaowei,Zhang Guifang,Zhang Xingxiang,Zhao Yabin,Shi Zhiqiang
In this work, α-Fe 2 O 3 double-layer hollow spheres with carbon coating (DLHS@C) are synthesized by a general “penetration-heterogeneous nucleation” approach using carbonaceous sphere templates combined with subsequent annealing. This hierarchy hollow sphere structure with carbon coating rationally combines three advantage aspects: shorten transport length for lithium ions and charges, sufficient void space to buffer the volume expansion, and enhanced electric conductivity. When tested for lithium storage, α-Fe 2 O 3 DLHS@C composite electrode exhibits a high initial discharge capacity of 1735 mAh g -1 and the reversible capacity of 823 mAh g -1 after 100 cycles at the current density of 100 mA g -1 in the voltage range of 0.01–2.5 V (vs. Li + /Li) and retains a capacity of 470 mAh g -1 even at a large current density of 500 mA g -1 after 500 cycles. The α-Fe 2 O 3 DLHS@C electrode demonstrates excellent electrochemical properties with high capacity, good cycling stability, and excellent rate capability as potential anode material for lithium ion batteries.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
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2020
·Vol. 56
·期 4
·1788-1800
·
IF 2.773
Huanhuan Dong,Xin Yin,Wusigale,Hao Cheng,Narangerel Choijilsuren,Xing Chen,Li Liang
Summary Ligand-binding proteins were proposed as ideal carriers for the co-encapsulation of bioactive compounds. Multiple compounds co-encapsulated in food formulation may give rise to different effects on bioactivity and stability. The protein effect on the interplay between bioactive compounds was investigated for selecting suitable co-encapsulation strategy. α-Tocopherol, resveratrol and epigallocatechin-3-gallate (EGCG), as model compounds, interacted with bovine serum albumin (BSA) to form tri-ligand complexes when added in the sequence. For ferric-reducing antioxidant power, the mixtures of α-tocopherol and resveratrol,α-tocopherol and EGCG, resveratrol and EGCG were respectively additive, antagonistic and synergistic, while their ternary mixture were antagonistic. For ABTS+ scavenging capacity, all pairs were antagonistic. BSA improved FRAP of α-tocopherol, resveratrol and EGCG mixture but decreased their ABTS inhibition. Although structural stability and antioxidant activity of resveratrol decreased when alone interacted with BSA, they were improved when α-tocopherol and EGCG were co-presented. Mixing the antioxidants improved their stability and the complexation with BSA can further stabilise them. BSA could thus be a suitable carrier for co-encapsulation/protection of α-tocopherol, resveratrol and EGCG in functional foods.
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 47
·20797-20805
·
IF 3.288
Hongmi Liu,Rujie Xiong,Peng Zhong,Guangli Li,Jun Liu,Jingtao Wu,Ying Liu,Quanguo He
In this study, an ultrasensitive voltammetric sensor was constructed for the simultaneous detection of dopamine (DA) and uric acid (UA) using shuttle-like α-Fe2O3 nanoparticle/nitrogen-doped graphene nanocomposites (Fe2O3–NG). The surface morphologies, crystalline structures, and electrochemical properties of Fe2O3–NG were investigated by scanning electron microscopy, powder X-ray diffraction, cyclic voltammetry, and AC impedance spectroscopy. Coupling shuttle-like α-Fe2O3 with NG nanosheets not only enlarges the electrochemically active surface area and prevents the agglomeration of α-Fe2O3 NPs or NG nanosheets, but also increases the electroconductivity of α-Fe2O3 NPs and boosts its catalytic ability, thereby affording more electroactive sites for the adsorption and oxidation of target analytes. As expected, the Fe2O3–NG/GCE shows extraordinary electrocatalytic oxidation capacities toward DA and UA over two wide dynamical response concentration ranges of 0.5–10 μM and 10–100 μM, with low detection limits (LOD) of 0.080 and 0.075 μM for DA and UA, respectively. Moreover, the Fe2O3–NG/GCE shows high anti-interference ability against several potential interferences and retains stable voltammetric responses for at least a week. Finally, the Fe2O3–NG/GCE achieves the simultaneous determination of DA and UA in human serum with reliable results.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2020
·
IF 7.864
Ruiyang Zhang,Tao Ran,Yuehan Cao,Qian Zhang,Fan Dong,Guidong Yang,Ying Zhou
Catalysis oxidization has been known to be an effective technique in environmental remediation. However, low efficiency for oxygen activation and difficult recovery of the catalysts in powdery form significantly limit the practical application. In this work, a new-type monolithic α-Ni(OH)2/Ni-foam was fabricated by the hydrothermal process. We found that H atoms of α-Ni(OH)2 can significantly promote oxygen activation, which endows it with favorable NO and NO2 oxidization confirmed by theoretical calculation and in situ DRIFTS. Furthermore, the introduction of Ni foam accelerated the pollutant gas transfer and charge carriers’ separation because of its abundant porous structure and high conductivity and its monolithic property simplified the recycling operation. Consequently, the obtained α-Ni(OH)2/Ni-foam achieved an excellent NO oxidation (69.0%) and no toxic NO2 was detected under visible light illumination (λ > 420 nm), indicating its highly promising potential in environmental remediation. Our work provides a conceptually different fresh perception to promote oxygen activation for highly efficient gas purification.
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高影响因子
JOURNAL OF POROUS MATERIALS
·
2020
·Vol. 27
·期 6
·1639-1648
·
IF 2.183
Zhang Tiantian,Li Bin,Zhang Xiaoli,Wang Jiao,Wei Longhui,Zhao Binxia,Li Binglin
N,N′-dimethyl-N-(4-pyridyl)-1,2-ethanediamine (DMPE) as a special N-alkylation precursor of 4-dimethylaminopyridine (DMAP) was grafted on the surface of γ-chloropropylated functionalized mesoporous silica MCM-41 to prepare immobilized DMAP. Characterization results of small angle X-ray diffraction, thermogravimetry and derivative thermogravimetry, Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray and transmission electron microscopy indicated that DMAP was successfully covalently bound to the surface of MCM-41. The highest loading of DMAP reached 0.9 mmol/g, which was 2.5 times higher than that of DMAP immobilized on the normal silica gel. The prepared immobilized DMAP as nucleophilic heterogeneous catalysts was successfully used for the acetylation reaction to produce α-tocopherol acetate. The highest yield reached 90.1% under the optimal condition which was summarized as follows: immobilized DMAP 100 mg, substrates mole ratio (acetic anhydride/α-tocopherol) 3:1, reaction temperature 50 ℃, stirring intensity 500 rpm, reaction in toluene for 12 h. The recyclability and stability of the DMAP grafted MCM-41 were excellent, as demonstrated by its use 20 times during batch operation without any loss of productivity.
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高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Weiping Jin,Zhifeng Wang,Dengfeng Peng,Wangyang Shen,Zhenzhou Zhu,Shuiyuan Cheng,Bin Li,Qingrong Huang
The co-existence of polysaccharides and enzymes in the food matrix could form complexes that directly influence the catalytic efficacy of enzymes. This work investigated the self-assembly behaviors of α-amylase and charged polysaccharides and fabricated the α-amylase/polysaccharides complex coacervates. The results showed that the linear charge density of polysaccharides had a critical impact on the complex formation, structure, and enzyme protection under acidic conditions. At low pH, α-amylase formed compact and tight coacervates with the λ-carrageenan. However, α-amylase/pectin coacervates dissociated when the pH was lower than 3.0. The optimized binding ratio of α-amylase/λ-carrageenan was 12:1, and α-amylase/pectin was 4:1. Finally, the α-amylase/λ-carrageenan complex coacervates effectively immobilized the enzyme and almost 70% of enzyme activity remained in coacervates after exposure to pH3.0 for 1 h. This study demonstrates that the change in the linear charge density of polysaccharides could regulate the enzyme-catalyzed process in food processing by a simple and fine-controlled method.
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高影响因子
危险品化学品经营许可证（带存储）