JOURNAL OF RARE EARTHS
·
2025
·
IF 7.2
Xiaoshuai Zhang,Xi Wang,Tao Yin,Xuping Han,Panlai Li,Xiaoyan Yu,Zixuan Wang,Chengrun Liu,Zhijun Wang
The market demand for environmentally controlled agricultural indoor lighting is gradually increasing due to environmental pollution and drastic changes in the natural climate. Generally, matrix K 3 YSi 2 O 7 (phase 1) is difficult to synthesize compared to K 3 YSi 2 O 7 (phase 2), which has been illustrated by theoretical calculations. In this paper, large quantities of pure phase K 3 YSi 2 O 7 (phase 1) matrix were obtained by the substitution engineering strategy (Ca 2+ →Y 3+ ). Subsequently, Eu 2+ was doped to obtain a thermally stable ultra-wideband deep red light-emitting phosphor with an emission band centered at 721 nm and a full width at half maximum of 186 nm under 450 nm light excitation. It is noteworthy that compared with K 3 YSi 2 O 7 :Eu (phase 2), K 3 Ca 0.3 Y 0.7 Si 2 O 7 :Eu 2+ (phase 1) is superior in terms of emission wavelength, full width at half maximum, and thermal stability. Furthermore, the spectrum resemblance between its emission spectrum and the photosensitive pigment P fr was calculated to be 97.5%, which set the stage for subsequent plant lighting applications. Finally, light-emitting diode devices were prepared using K 3 Ca 0.3 Y 0.7 Si 2 O 7 :Eu 2+ phosphor for plant lighting experiments, and plants grown under deep red light emitting diode light show more luxuriant growth. The results show that the phosphor K 3 Ca 0.3 Y 0.7 Si 2 O 7 :Eu 2+ has promising applications in indoor plant culture. Meanwhile, the successful implementation of ion substitution engineering also provides a new strategy for transitions in host systems.
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高影响因子
MOLECULES
·
2019
·Vol. 24
·期 3
·420
·
IF 3.06
Bang-Jin Wang,Ai-Hong Duan,Jun-Hui Zhang,Sheng-Ming Xie,Qiu-E Cao,Li-Ming Yuan
Porous organic cages (POCs) have attracted extensive attention due to their unique structures and tremendous application potential in numerous areas. In this study, an enantioselective potentiometric sensor composed of a polyvinyl chloride (PVC) membrane electrode modified with CC3-R POC material was used for the recognition of enantiomers of 2-amino-1-butanol. After optimisation, the developed sensor exhibited enantioselectivity towardS-2-amino-1-butanol (logKS,RPot= −0.98) with acceptable sensitivity, and a near-Nernstian response of 25.8 ± 0.3 mV/decade within a pH range of 6.0–9.0.Keywords:enantioselective potentiometric sensor;2-amino-1-butanol;chiral porous organic cage;CC3-R;PVC membrane electrode
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zheng Xing,Wenhao Yang,Chen Zhao,Yuhui Wang,Xiaolian Jiang,Song Qian,Yun Chu,Jiang Xia,Cheng Wang,Jianhao Wang
Androgenetic alopecia (AGA), the preeminent form of clinical hair loss, poses a significant challenge to patients. Growth factors (GFs) have been investigated for the treatment of hair loss. However, the issue of their optimal intra-dermal delivery remains a formidable obstacle. Type XVII collagen (COL17), which plays a crucial role in regulating the hair follicle aging process, has emerged as a highly promising candidate for hair loss treatment. Considering these constraints, we developed an I GF-1 loaded borate- m odified rh C OL 17 MN platform (I-mCOL17 MNs) for the treatment of AGA. The mCOL17 MNs are engineered to precisely control the release of bioactive payloads in response to dynamic changes in the microenvironment. A comprehensive investigation was conducted to verify the physicochemical characteristics, as well as the in vitro and in vivo biological activities of the MNs. Our findings demonstrate that, when contrasted with the clinically utilized drug minoxidil, our MN exhibits a remarkable capacity to enhance neovascularization, alleviate tissue-based inflammatory responses, and promote hair regeneration in murine models of AGA. Overall, this MN represents a novel, safer, and more efficient strategy for the treatment of AGA, offering new hope for patients suffering from this prevalent condition.
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高影响因子
Frontiers in Pharmacology
·
2025
·
IF 4.8
Jinpeng Lv,Duo Meng,Huansha Zhang,Wenhui Xu,Xiaohong An,Chuanwei Yin,Kun Zou,Rongyin Gao
Introduction: Apigenin, a natural flavonoid with well-established antioxidant, anticancer, and anti-inflammatory activities, has recently attracted attention for its pigmentation-promoting effects. However, the underlying molecular mechanisms driving its melanogenic activity remain incompletely understood.Method: To investigate apigenin‘s effects on melanogenesis, human epidermal melanocytes (HEMCs), zebrafish embryos, and human skin explants were treated with apigenin. Melanin content, dendrite formation, and melanosome maturation were evaluated using spectrophotometry and transmission electron microscopy. Key signaling molecules and proteins involved in melanogenesis and melanosome transport were assessed by Western blotting and immunohistochemistry. The role of the c-KIT receptor was further explored through pharmacological inhibition and genetic knockdown approaches. Functional pigmentation was evaluated by assessing UVB-induced DNA damage markers.Results: Apigenin (10 μM) significantly increased melanin production by 1.8-fold in HEMCs, enhanced dendritic morphology, and promoted stage III–IV melanosome formation. Mechanistically, apigenin induced melanogenesis independently of the MC1R/cAMP/PKA pathway by directly binding to the c-KIT receptor, activating the Raf-1/ERK/RSK cascade, and upregulating MITF. This led to elevated expression of tyrosinase, TRP-1, TRP-2, and melanosome transport proteins Rab27a and Cdc42. Inhibition or knockdown of c-KIT abrogated these effects. In vivo, apigenin restored pigmentation in PTU-induced depigmented zebrafish and increased melanin content by 1.3-fold in human skin explants. Histological analysis confirmed effective melanin transfer to keratinocytes. Additionally, apigenin-treated skin showed reduced UVB-induced DNA damage, indicating enhanced photoprotection.Discussion: These findings demonstrate that apigenin stimulates melanogenesis through a novel c-KIT-dependent signaling pathway and promotes functional pigmentation with photoprotective benefits. Given its dietary origin, favorable safety profile, and multifaceted mechanisms, apigenin holds promise as a therapeutic agent for vitiligo and a natural pigmentation enhancer for dermatological use.
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高影响因子
CELL PROLIFERATION
·
2025
·
IF 5.6
Changsen Bai,Jialei Hua,Donghua Meng,Yue Xu,Benfu Zhong,Miao Liu,Zhaosong Wang,Wei Zhou,Liming Liu,Hailong Wang,Yang Liu,Lifang Li,Xiuju Chen,Yueguo Li
Glutaminase-1 (GLS1) has garnered considerable interest as a metabolic target in cancer due to its heightened involvement and activity. However, the precise fate of glutaminolysis catalysed by GLS1 in cancer cells remains elusive. We found that GLS1 knockout led to significant suppression of cancer cell proliferation, which can be reversed or partially restored by supplementation of glutamate or non-essential amino acids that can be converted into glutamate. The addition of spliceosomal KGA or GAC ameliorates cancer cell growth in vitro and in vivo, providing both simultaneously completely reverse the effect. The primary metabolic fate of glutamate produced through glutaminolysis in cancer cells is mainly used to produce glutathione (GSH) for redox homeostasis, not entering the tricarboxylic acid cycle or synthesising nucleotides. GSH monoethyl ester (GSH-MEE) effectively rescues the inhibition of cancer cell proliferation caused by GLS1 knockout. Deletion of GLS1 results in an elevation of reactive oxygen species (ROS) and malondialdehyde (MDA), a reduction of NADPH/NADP + ratio, and an augmented susceptibility of cells to ferroptosis. Glutathione Peroxidase 4 (GPX4) and GPX1 exhibit complementary roles in redox regulation, with GLS1 knockout promoting GPX4 degradation. Pharmacological inhibition of GLS1 synergises with GPX4 inhibitor to suppress tumour growth. Dual targeting of GPX4 and GPX1 presents a potent anti-cancer strategy. This metabolic mechanism facilitates a deeper comprehension of the abnormal glutamine metabolism in cancer cells, establishing a theoretical basis for the potential clinical utilisation of GLS1 inhibitors and presenting novel perspectives for advancing combinatorial therapeutic approaches.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Ding Qu,Mengying Jiao,Haijiao Lin,Chunli Tian,Guowei Qu,Jingwei Xue,Lingjing Xue,Caoyun Ju,Can Zhang
Controlled release and tumor-selective distribution are highly desirable for anticancer nanomedicines. Here, we design and synthesize an anisamide-conjugated N -octyl- N,O -maleoyl- O -phosphoryl chitosan (a-OMPC) which can form amphiphilic micelles featuring pH-responsive release and high affinity to sigma-1 receptor-overexpressed tumors for paclitaxel (PTX) delivery. Thereinto, maleoyl and phosphoryl groups cooperatively contribute to pH-responsive drug release due to a conversion from hydrophile to hydrophobe in the acidic microenvironment of endo/lysosomes. We demonstrated that PTX-loaded a-OMPC micelles (PTX-aM) enhanced the cellular internalization via the affinity between anisamide and sigma-1 receptor, rapidly released drug in endo/lysosomes and elevated the cytotoxicity against PC-3 cells. The in vivo studies further verified that PTX-aM could largely accumulate at the tumor site even after 24 h of administration, resulting in obvious inhibition effect and prolonged survival period in PC-3 tumor xenograft-bearing mice. Moreover, OMPC showed no obvious hemolytic and acute toxicity. Collectively, this chitosan derivate holds a promising potential in application of prostate cancer-targeted drug delivery system.
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ANTIVIRAL RESEARCH
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2015
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IF 3.938
Shaoyang Zhang,Limei Zhong,Bing Chen,Ting Pan,Xue Zhang,Liting Liang,Qianwen Li,Ziying Zhang,Hui Chen,Jie Zhou,Haihua Luo,Hui Zhang,Chuan Bai
HIV-1 Vif protein is one of the most crucial accessory proteins for viral replication. It efficiently counteracts the important host restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G, A3G) which is lethal to HIV-1 by causing G to A mutation of viral genome. Vif protein mediates degradation of APOBEC3G via the complicated protein–protein interactions of Vif, APOBEC3G, Elongin C/B and Cullin 5. The importance of Vif–APOBEC3G complex makes it a good potential target to develop new therapeutics of HIV-1. We identified a potent HIV-1 replication inhibitor (ZBMA-1, IC 50 = 1.01 μM) that efficiently protected APOBEC3G protein by targeting Vif–APOBEC3G complex. The co-immunoprecipitation and docking studies indicated that compound ZBMA-1 affected the binding of Elongin C with Vif protein.
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RSC Advances
·
2016
·Vol. 6
·期 30
·25427-25434
·
IF 3.289
Zulin Hua,Qin Qin,Xue Bai,Xin Huang,Qi Zhang
A highly efficient enzyme-based screen printed electrode (SPE) was developed based on the covalent immobilization of tyrosinase (Tyr) on 1-formylpyrene (1-FP) functionalized reduced graphene oxide (rGO). Here, the bifunctional molecule 1-FP was assembled onto rGO sheets. Subsequently, a Tyr molecule was immobilized on the 1-FP forming a biocompatible nanocomposite, which was further coated onto the working electrode surface of the SPE. The performance of as-prepared biosensor was investigated by the detection of phenol in the presence of molecular oxygen. Wide linear range, low detection limit and high sensitivity were obtained with this biosensor due to the good conductivity of rGO as well as the high bioactivity of Tyr well retained by the 1-FP/rGO platform. Finally, the proposed biosensor was successfully employed for the detection of phenol in real water samples with satisfactory results. These findings suggest that this novel biosensor could offer great potential for rapid, cost-effective and on-field analysis of phenolic compounds.
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Biomicrofluidics
·
2020
·Vol. 14
·期 3
·
IF 2.504
Wu Qirui,Wang Xiaohong,Liu Jinfeng,Wu Jinbo,Zhang Yuan,Zhao Lijuan,Wen Weijia,Gong Xiuqing
Metal-organic frameworks (MOFs) have attracted considerable attention as novel nanoporous materials that combine the properties of organic and inorganic porous materials. HKUST-1 is one of the most well-developed and representative MOFs with wide applications in gas storage and separation, adsorption, and capture. In this study, we used microfluidics, an advanced technique of manipulation of small fluid volumes in microscale or even nanoscale channels, to investigate the effect of sodium dodecyl sulfate (SDS) on the growth of HKUST-1 crystals. We directly observed the morphological evolution of HKUST-1 crystals through droplet arrays with the SDS concentration gradient. The morphology of HKUST-1 evolved from cubic to cuboctahedron and finally to octahedron with increasing SDS concentration. The study results demonstrated the important role played by anions in solution in the structural regulation of HKUST-1.
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高影响因子
TETRAHEDRON
·
2023
·
IF 2.1
Jianping Zhang,Jinming Liu,Gengwen Yin,Wenlong Hou,Haiquan Zhang
Nucleophilic substitution reaction of 1,7-dibromo-perylene diimide derivatives can expend the chemical structure and photophysical properties of perylene diimide. Here, we reported firstly the synthesis and mechanism of 1-bromo-7-hydroxyl perylene diimide derivative by the 1,7-dibromo-perylene diimide derivative in electron donor solvents (such as, NMP, DMF and etc) and under visible light irradiation . The structure of 1-dibromo-7-hydroxyl perylene diimide was confirmed by HR-MS, UV–Vis absorption spectra and comparison of UV–Vis absorption spectra with product from the heating chemical reaction. Furthermore, the 1-bromo-7-hydroxyl-perylene diimide derivative showed a higher optical response to some metal ions , such as Fe 3+ , Cu 2+ and etc.
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高影响因子
MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Hong Qian Dai,Yuan Lu,Zhi Hin Ou,Min Xu
Fe3O4-APTES-CS2 was prepared by modification of Fe3O4 with 3-aminopropyltriethoxysilane (APTES) and carbon disulfide (CS2). Lipase was covalently bonded to Fe3O4-APTES-CS2 to obtain the immobilized lipase Fe3O4-APTES-CS2-lipase. The textural characteristic of Fe3O4-APTES-CS2-lipase was assessed by scanning electron microscopy. The optimal immobilization conditions were 2.5 mg/mL lipase, pH 7.0, 35 °C, 3 h. The loading amount of lipase was 119.0 mg/g carrier. The immobilization efficiency reached 57%. (R)-(+)-N-acetyl-1-methyl-3-amphetamine was synthesized by Fe3O4-APTES-CS2-Li- pase. The conversion, enantiomeric excess of (R)-(+)-N-acetyl-1-methyl-3-amphet-a- mine and E value reached 36.8%, 98.5% and 132, respectivel.
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RSC Advances
·
2016
·Vol. 6
·期 54
·48590-48598
·
IF 3.289
Yu Shang,Bo Jin,Rufang Peng,Zhicheng Guo,Qiangqiang Liu,Jun Zhao,Qingchun Zhang
A series of nitrogen-rich heterocyclic 1H,1′H-5,5′-bistetrazole-1,1′-diolate salts, namely, 1,2,4-triazolium (2), 3-amino-1,2,4-triazolium (3), 4-amino-1,2,4-triazolium (4), 3,5-diamino-1,2,4-triazolium (5), 2-methylimidazolium (6), imidazolium (7), pyrazolium (8), 3-amino-5-hydroxypyrazolium (9), dicyandiamidine (10), and 2,4-diamino-6-methyl-1,3,5-triazin (11), was synthesized with cations. These energetic salts were fully characterized through FT-IR, 1H NMR, 13C NMR, and elemental analysis. The structures of 2, 3·7H2O, 6·2H2O, 8, and 10·4H2O were further confirmed through single crystal X-ray diffraction. Their thermal stabilities were investigated through differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The results indicated that all of the salts possess excellent thermal stabilities with decomposition temperatures ranging from 225.7 °C to 314.0 °C. On the basis of the Kamlet–Jacobs formula, we carefully calculated their detonation velocities and detonation pressures. All of the salts, except 11, exhibit promising detonation performances with a detonation pressure of 20.23–28.69 GPa and a detonation velocity of 7050–8218 m s−1. These values are much higher than those of TNT. The impact sensitivities of the compounds were determined via a Fall hammer test. All of the compounds show excellent impact sensitivities of >50 J, and this finding is higher than that of TATB (50 J). Therefore, these ionic salts with excellent energetic properties could be applied as new energetic materials.
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