Foods
·
2026
·Vol. 15
·期 4
·642
·
IF 6
Simin Zhao,Jiao Zhang,Yuting Huang,Yanan Yuan,Ting Wu,Siyi Pan,Xiaoyun Xu
Caffeoylquinic acids (CQAs) are polyphenolic compounds widely present in daily diets, but their bioactivities are limited by poor intestinal absorption, the mechanisms of which remain incompletely understood for various isomers. This study investigated the transepithelial transport of three mono-CQAs and three di-CQAs using Caco-2 monolayers. Concurrently, the potential of five dietary flavonoids to enhance intestinal absorption by modulating efflux transporters was evaluated. Results suggest that CQAs were mainly transported via passive paracellular diffusion. The apparent permeability coefficients (Papp) of mono-CQAs were (1.49 ± 0.22) × 10−6, (1.49 ± 0.25) × 10−6, and (2.15 ± 0.57) × 10−6cm/s, which were significantly higher than those of di-CQAs. And the efflux of 5-CQA, 3,4-diCQA, and 3,5-diCQA was primarily mediated by P-gp. Among the five dietary flavonoids tested for their potential to inhibit this efflux, quercetin and kaempferol exhibited the most potent enhancing CQA uptake. They increased thePappof 5-CQA from (2.15 ± 0.21) × 10−6to (3.05 ± 0.08) × 10−6cm/s and (2.57 ± 0.17) × 10−6cm/s, respectively. Similar promoting trends were observed for 3,4-diCQA and 3,5-diCQAs. Molecular docking revealed that CQAs and these effective flavonoids share common binding residues within the P-gp pocket, providing a structural basis for the inhibition of efflux. These findings provide insights into the intestinal transport of structurally diverse CQAs and highlight the potential of dietary flavonoids to improve the oral bioavailability of CQAs.
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MATERIALS CHEMISTRY AND PHYSICS
·
2026
·
IF 5.2
Mengwen Hu,Piyu Gong,Jumiao Shi,Shuo Tao,Haibo Li,Suyuan Zeng,Lei Wang
In this work, Zn 3 (VO 4 ) 2 @Fe 3 O 4 composites were constructed and utilized as the anode materials for lithium-ion batteries. The formed Zn 3 (VO 4 ) 2 @Fe 3 O 4 composites with a Zn 3 (VO 4 ) 2 /Fe 3 O 4 weight ratio of 1:1 and 1:2 delivered the discharge capacities of 925.6 and 684.4 mA h g −1 respectively. The introduction of Fe 3 O 4 enhances the electronic/ionic transport and structural stability of the Zn 3 (VO 4 ) 2 microstructure, improves the charge transfer kinetics and pseudocapacitive behavior and stabilizes the cycling performance, thereby boosting the lithium storage capacity of the Zn 3 (VO 4 ) 2 based electrodes.
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Reaction Kinetics Mechanisms and Catalysis
·
2026
·
IF 2.1
Hu Yanan,Yang Dawei,Li Qiaoling,Yu Chengcheng
Herein, a Cr-doped Ni-Cu/(NiOH) 2 coating supported on nickel foam (Ni-Cu-Cr/NF) was fabricated via a facile one-step electrodeposition strategy and employed as an efficient electrocatalyst for the hydrogen evolution reaction (HER) in alkaline media. In 1 M NaOH, Ni–Cu–Cr/NF requires an overpotential of 30 mV to reach a current density of − 10 mA cm⁻ 2 and exhibits a Tafel slope of 55 mV dec⁻ 1 . These electrochemical results are associated with the combined effects of the multicomponent composition and an increased electrochemically active surface area (ECSA). The ECSA of Ni–Cu–Cr/NF is approximately 23.6 times that of Ni–Cu/NF. In addition, the catalyst maintains stable operation for 60 h during continuous electrolysis. This work presents a simple preparation method for the novel Ni-Cu-Cr/NF catalyst and systematically investigates the impact of Cr doping on enhancing catalytic performance, providing an effective strategy for the development of nickel-based alloy electrocatalysts. Graphical
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 9
·118223
·
IF 6.3
Lan Gao,Yun Zhang,Xi Jiang,Shihua Ding
Ga 3+ heterovalent substitution for Zn 2+ was beneficial for modifying ZnZrTa 2 O 8 ceramic. The enlarged Q × f was caused by a combination of grain size and total lattice energy U Total increase. The improvement of τ f was attributed to the increase in Ta-O bond energy. Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 ceramics exhibited optimal Q × f of 103,236 ± 2155 GHz (@7.38 GHz) and τ f = -17.65 ± 1.61 ppm/℃. The improved τ f provided great convenience for gaining temperature stable dielectric ceramics. Afterward, ZnTa 2 O 6 as a temperature compensator was added to adjust the τ f to zero. The Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 dissolved into ZnTa 2 O 6 lattice. As a result, 0.4Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 -0.6ZnTa 2 O 6 ceramic sintered at 1350 ℃ obtained the desirable dielectric properties: ε r = 28.18 ± 0.01, Q × f = 81,919 ± 394 GHz (@6.70 GHz), τ ƒ = -0.51 ± 0.06 ppm/℃.
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ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2026
·
IF 3.5
Jinnai Liu,Jiawei Tang,Hao Chen,Li Zhang,Ganlan Li,Fuli Zhang,Shaoxin Chen,Jun Yu
(S)-3-Bromo-2-(1-methoxyethyl)pyridine 1 is a key intermediate of RMC-6236. In this report, we detail the development and optimization of a highly enantioselective chemoenzymatic and kilogram-scale process for 1. The developed process for intermediate (S)-1-(3-Bromopyridin-2-yl)ethanol 3 was performed on 1 kg scale with a substrate concentration of 70.0 g/L, achieving a yield of 93.0% and an ee value of >99.9%. Subsequently, a simple and effective NaHMDS/CH3I methylation system afforded the title compound 1, in 95.0% yield and with >99.9% ee, achieving 88.4% overall yield from intermediate 1-(3-bromopyridin-2-yl)ethanone 2. This represents a notable increase compared to the early stage process (overall yield 55.5%). This optimized highly efficient and sustainable process was demonstrated during kilogram-scale production of 1.
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ANTIVIRAL RESEARCH
·
2026
·
IF 4.3
Ting Zhang,Zi-Ling Wang,Xi-Ya Li,Rong-Hua Luo,Lu-Xi Zhang,Hong-Yi Zheng,Si-Dong Xiong,Wen-Lan Yang,Yong-Tang Zheng
The continuous emergence of new SARS-CoV-2 variants limits the effectiveness of current vaccines and monoclonal antibodies, highlighting the urgent need for complementary antiviral strategies. Targeting host proteins that are exploited by the virus represents a promising approach to achieve broad-spectrum inhibition. Given the recently established proviral role of METTL3-dependent RNA m 6 A modification in SARS-CoV-2 replication, we conducted a structure-based virtual screening to repurpose compounds with acceptable safety profiles. Subsequent biochemical validation identified onvansertib and vilazodone as direct METTL3 binders and potent inhibitors of its methyltransferase activity. Notably, both compounds effectively suppressed the replication of ancestral SARS-CoV-2 and Omicron BA.2 variant in vitro . Mechanistically, each compound potentially enhanced the innate antiviral response of the host and repressed the expression of viral entry-associated host factors during infection; this observation is consistent with the established proviral role of METTL3. In summary, these findings not only substantiate METTL3 as a viable antiviral target but also lay the foundation for further research on the therapeutic potential of onvansertib and vilazodone against COVID-19.
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Nanoscale
·
2026
·
IF 5.2
Tingting Cai,Shuangshuang Zhao,Qin Fang,Huixin Chen,Xiuli Jia,DONGXU YU
Vanadium (III) oxide (V2O3) has emerged as a promising cathode material for aqueous zinc-ion batteries owing to high theoretical capacity based on reversible two-electron redox chemistry. However, the cycling stability and reaction kinetics are highly sensitive to its microstructural characteristics, which remain insufficiently understood. Here, we report a facile and scalable synthesis of V2O3 via combining oil-bath reaction and controlled calcination process, enabling precise regulation of particle morphology and microstructure through calcination time. Systematic microstructural evolution is correlated with Zinc-ion storage behavior, revealing that optimized architectures effectively promote ion transport kinetics and structural stability. Coupled with a high-concentration water-in-salt electrolyte to suppress parasitic reactions, the optimized V2O3 cathode delivers a high specific capacity of 453.8 mA h g -1 at 0.05 A g -1 , exceptional rate capability with 180 mA h g -1 retained at 10 A g -1 , and prolonged cycling stability of 210 mAh g -1 after 1000 cycles at 1 A g -1 . This work elucidates the underlying structure-property relationship governed by microstructure but also provides valuable insights into the design of highperformance cathode materials for advanced energy storage systems.
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Nature Communications
·
2026
·
IF 18.1
Yan Jiao,Liu Lai,Chen Zhihao,Zhao Qian,Han Xiaoqing,Wang Yanjing,Mu Zhengzhi,Wang Xingbo,Song Panpan,Kang Yaqing,Lu Weijie,Guo Ai-Min,Sun Qing-Feng,Zhang Haiyuan
Electron-spin dynamics represent an additional dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices ( C Au) as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 (COX-2) activity for rheumatoid arthritis intervention. Exploiting the chirality-induced spin selectivity (CISS) effect inherent to both COX-2 and C Au, we demonstrate that left-handed C Au (Lh- C Au) enhances, whereas right-handed C Au (Rh- C Au) suppresses COX-2 catalytic efficiency via spin-dependent electron transfer at the chiral nanoparticle-enzyme interfaces. To achieve targeted modulation in complex biological settings, we engineer molecularly imprinted C Au ( C Au@MIP) for selectively regulating COX-2 in inflammatory cells and collagen-induced arthritis murine model (male DBA/1 J mice). Treatment with Rh- C Au@MIP significantly reduces prostaglandin E 2 secretion and mitigates joint inflammation, achieving therapeutic efficacy comparable to conventional COX-2 inhibitors. Our findings introduce electron spin polarization as an orthogonal mechanism for enzymatic regulation, offering a bioelectronic strategy for inflammation-targeted therapy.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Xinyan Jiang,Yujie Wu,Ping Lu,Hao Zheng,Weimo Li,Guocan Jiang,Sheng Li,Zhengquan Li
Selective photocatalytic oxidation offers a sustainable pathway for hydrocarbon valorization but is limited by inert nature of molecular oxygen and sluggish interfacial electron utilization. Aurivillius-type layered oxides, with intrinsic polarization fields, facilitate directional charge migration but suffer from severe electron accumulation at surface Bi 3+ sites, leading to the formation of metallic Bi 0 and catalytic deactivation. Here we demonstrate an asymmetric dual-Bi 3+ -site control strategy by constructing a configuration with S partially filled oxygen vacancies in the surface [Bi 2 O 2 ] 2+ layers of SrBi 2 Ta 2 O 9 . This coupled modulation tailors the surface electronic structure and enables effective regulation of oxygen adsorption and activation, thereby favoring reaction pathways mediated by superoxide radicals. As a result, the optimized catalyst delivers a benzaldehyde yield of 14 mmol g −1 h −1 with 82% selectivity, while retaining 94% of its initial activity after four consecutive 8 h cycles, demonstrating both high efficiency and robust stability of S:SBTO 9–x . This work establishes a general paradigm for steering photogenerated electron dynamics through atomic-level asymmetric site engineering, providing a reasonable approach for designing efficient and durable photocatalysts suitable for selective oxidation reactions.
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2026
·
IF 3.5
Zi-Qi Zheng,Zhao-Tian Wei,Shi-Bo Jin,Zhen-Zhen Yao,Can-Xia Ma,Wen-Yun Gao,Heng Li
Acetohydroxyacid synthase (AHAS), the rate-limiting enzyme in the biosynthetic pathway of branched-chain amino acids, consists of catalytic subunits (CSU) and regulatory subunits (RSU). In this study, we prepared AHAS holoenzymes of Escherichia coli , Saccharomyces cerevisiae , Bacillus subtilis , and Pseudomonas syringae pv. Tomato DC3000 utilizing different methods. Moreover, we studied the catalytic properties of the four holoenzymes and their corresponding CSUs using pyruvate and 2-KB as a respective substrate. The results showed that the eight enzymes (four holoenzymes plus four CSUs) displayed comparable catalytic activity in pyruvate assays, indicating the presence of the RSUs seems not to influence the catalysis of the proteins obviously; while in 2-ketobutyrate (2-KB) assays, the importance of the RSUs on promoting recognition of the substrate and on luring the reactions into condensation of the substrate via stabilizing the crucial intermediate hydroxypropyl-ThDP has been demonstrated. These observations enhance our understanding of the correlation of the structure and function between AHAS full enzyme and its CSU and RSU. In addition, these findings also supply a theoretical basis for future evolution of the proteins so as to improve their catalytic efficiency and broaden their substrate spectrum.
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Journal of the Endocrine Society
·
2025
·Vol. 10
·期 3
·
IF 3.1
de Crecy Chloe A,Yang Qiang,Liu Mei,Yin Rui,Sharma Anu
ContextRegardless of age, metabolic dysfunction-associated steatotic liver disease (MASLD) occurs in 70% of adults with type 2 diabetes (T2D) and increases the risk of metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. However, many studies focus on older adults.ObjectiveTo determine the frequency of screening for MASLD in young adults with T2D attending outpatient clinics.MethodsA retrospective cohort study on young adults (aged 18-44 years) with T2D who accessed care at a tertiary care center from January 1, 2018, to December 31, 2022. At-risk MASH was diagnosed with vibration-controlled transient elastography, magnetic resonance elastography, or liver biopsy.ResultsOf 6891 participants included, 16% (n = 1100) had a diagnosis of MASLD. Those with MASLD were more likely to have cardiometabolic risk factors (83% vs 72%, P < .001) and cardiovascular disease (22% vs 16%, P < .001). Only 12% of those with MASLD underwent further investigation (1.9% of the total cohort), which was associated with dyslipidemia (odds ratio [OR], 2.4; 95% CI, 1.5-3.8), ALT >40 U/L (OR, 2.1; 95% CI, 1.4-3.0), or the use of 3 or more diabetes medications (OR, 2.1; 95% CI, 1.5-3.1). In those with further workup, 38% had at-risk MASH. The fibrosis-4 index was elevated in 16% of those with MASLD and only 28% of those with confirmed at-risk MASH or worse.ConclusionScreening for MASLD in young adults with T2D is frequently missed. There is a lack of accurate noninvasive tools in this population. Increased awareness of screening young adults with T2D for at-risk MASH is urgently needed to prevent progression to cirrhosis.
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ENVIRONMENT INTERNATIONAL
·
2026
·
IF 10.2
Linfeng Zhang,Yan Cao,Haoran Song,Qian Zhao,Anjum Mahfuza,Qun Zhao,Shugen Liu,Jianwu Shi,Xuewei Hu,Jie Li,Ping Ning,Xukang Lu,Tianyu Fu,Kebin He,Senlin Tian
Evidence for the transformation of volatile fluorotelomer alcohols (FTOHs) after respiratory uptake remains elusive, and the role of their surface activity in health risk has been overlooked. Herein, the 6:2 FTOH interaction with the pulmonary barrier formed by pulmonary surfactant (PS) and the potential for undergo transformation was investigated. It turns out that 6:2 FTOH with surface-active properties can altered the ability of PS to reduce surface tension and its compressibility modulus, decreased its phase transition enthalpy (|Δ H |, from 323.5 to 1.5 J/g). Microscopic observations showed that 6:2 FTOH incorporated into intermolecular spaces of PS and exhibited microphase segregation via fluorocarbon–hydrocarbon repulsion. Additionally, 6:2 FTOH interacted with the hydrophobic domains of PS, resulting in a decrease in lipid-protein components, accompanied by lipid peroxidation and protein carbonylation. Furthermore, in PS-containing simulated pulmonary fluid, 6:2 FTOH exhibited time-dependent reactive oxygen species accumulation, while radical content decreased with increasing concentration. 19 F NMR in conjunction with GC–MS confirmed that 6:2 FTOH undergoes transformation. Based on the identification of transformation product, potential transformation pathways of 6: 2 FTOH in pulmonary system were proposed. These findings reveal the impact of FTOH on pulmonary function and provide the first insights into its transformation in the lung, broadening the risk assessment perspective for inhaled surface-active pollutants and diverse per- and polyfluoroalkyl substances.
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