OPTICAL MATERIALS
·
2025
·
IF 4.2
Pei Zhang,Mengmeng Li,Yibo Zheng,Linjiao Ren,Zirui Qin,Qingfang Zhang,Rubin Qi,Jitao Zhang,Liying Jiang,Dongke Li
The isoreticular metal organic frameworks-3 (IRMOF-3)/non-stoichiometric thiol-ene (OSTE) and 2-aminoterephthalic acid (BDC-NH 2 )/OSTE composites were synthesized via a photo-induced click reaction. Interestingly, through polymerization with OSTE, both the fluorescence lifetime and intensity of IRMOF-3 increased. Moreover, its two lifetimes merged into one, which could be ascribed to the inhibition of the dynamic non-radiative quenching process by the OSTE network. In contrast, the ligand maintained a single lifetime with only minor changes. The dilution effect of the thiol-ene mixed solution could effectively reduce the static photo-induced electron transfer process between the ligand and toluene molecules. After the post-synthetic polymerization (PSP) treatment, the photoluminescence quantum yield (PLQY) of IRMOF-3 was increased from 7.2 % (in toluene) to 42.3 %, and that of the pure BDC-NH 2 ligand was significantly enhanced from 1.8 % (in toluene) to 76.0 %. Moreover, when a commercially available 370-nm light-emitting diode (LED) chip was individually encapsulated by the two composites, it could emit intense indigo light. This rapid PSP treatment via the OSTE polymer holds promise for application in other excellent luminescent MOFs.
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高影响因子
PLoS One
·
2025
·Vol. 20
·期 6
·e0324586
·
IF 2.6
Jie Yuan,Chongyong Gao,Wang Xin,Fanlin Meng,Hong Zhang
Background
Ulcerative colitis (UC) is a recurrent inflammatory condition of the bowel with a multifaceted pathogenesis, including programmed cell death, oxidative stress, and immune-mediated inflammation. As a recently identified type of cell death, disulfidptosis has an unclear role in UC.
Methods
We analyzed clusters of disulfidptosis-related genes (DRGs) and immune cell infiltration in 361 patients with UC from the GSE73661and GSE92415 datasets. Differentially expressed genes (DEGs) were identified using unsupervised clustering methods, and hub genes were selected using machine learning algorithms. Additionally, potential key components of potential traditional Chinese medicines for the treatment of UC were predicted based on hub genes. Finally, experimental validation was performed through qRT-PCR, western blotting, and immunohistochemistry.
Results
We identified two molecular clusters related to disulfidptosis, each showing significant heterogeneity in gene expression and immune profiles. Hub genes associated with disulfidptosis, CXCL1, HMGCS2, AQP8, and SLC26A2, were further screened and validated. Additionally, potential traditional Chinese medicines for UC were predicted. 3’-Methoxydaidzein (MHD), a key constituent of Puerariae Radix, inhibited LPS-induced inflammatory responses in Caco2 cells and alleviated DSS-induced colonic injury in UC mice via upregulation of SLC26A2.
Conclusion
DRGs demonstrate strong discriminatory power in distinguishing UC subtypes. Cluster with high expression of SLC26A2 showed a UC phenotype with a milder degree of damage. Additionally, we identified the hub gene SLC26A2 as playing a significant role in UC, and MHD demonstrates potential as a targeted therapeutic strategy for UC.
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PubMed
高影响因子
Foods
·
2026
·Vol. 15
·期 4
·624
·
IF 6
Na Liu,Wenguang Jiang,Huixuan Zhou,Xinyi Hao,Guotian Liu,Wenwu Bao,Xinming Zhou,Tengfei Xu,Yan Xu
Grapevine leafroll-associated virus (GLRaV) is a globally widespread disease that causes substantial economic losses in the wine industry. In severely affected vineyards, GLRaV can reduce grape yield by 20–40%. This study aimed to evaluate the effects of GLRaV infection on polyphenolic and volatile organic compound contents, as well as on the sensory profiles of the resulting wines. A comparative analysis was conducted between GLRaV-3-infected and healthy Cabernet Sauvignon grapes and their corresponding wines. Results show GLRaV-3 significantly alters grape and wine quality. In infected grapes, sugar content decreased while titratable acidity increased. Polyphenol composition was notably altered: phenolic acids and flavonols increased by 22.46% and 15.27%, respectively, whereas flavanols decreased by 17.86%. The levels of aldehydes and C6compounds also rose significantly in the berries. Wines produced from infected grapes showed lower alcohol content and reduced dry extract. Phenolic acids and flavanols were decreased, but total flavonols increased by 12.54%. Among volatile compounds, alcohols, phenols, and fatty acids were elevated, while esters declined by 13.36%. These chemical changes directly influenced sensory attributes. Compared with wines from healthy grapes, those from infected grapes exhibited improved tannin texture and longer aftertaste. However, they were inferior in color intensity, aroma intensity, body fullness, and varietal typicity.
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PubMed
高影响因子
Food & Function
·
2026
·
IF 6.3
Jiahui Huang,Long Chen,Haojie Yu,Shishuai Zhou,Jianzhong Guan,Chen Xu
Hepatic osteodystrophy (HOD) is a bone condition associated with metabolic issues, primarily caused by impaired reverse cholesterol transport in the liver–bone axis, frequently linked to chronic non-alcoholic fatty liver disease (NAFLD). This impairment leads to an abnormal accumulation of cholesterol in bone tissue, hindering new bone formation and causing bone degradation. The study discussed here demonstrates that the administration of omega-3 polyunsaturated fatty acids (ω-3) in a rat model of HOD improves lipid metabolism by promoting peripheral reverse cholesterol transport. By reinstating the cholesterol transport process in the liver–bone axis, this treatment reduces excessive cholesterol accumulation in bones, enhances the bone microenvironment, and ultimately helps to alleviate bone loss and lessen liver damage. In summary, the results highlight the potential advantages of a diet rich in ω-3 fatty acids for combating bone loss related to NAFLD.
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PubMed
高影响因子
FOOD MICROBIOLOGY
·
2026
·
IF 5.4
Wenzhi Li,Jiling Ma,Youhua Long,Weizhen Wang,Xianhui Yin,Zhuzhu Zhang,Bingce Wang,Lu Yang,Hujun Qin
Botryosphaeria dothidea is one of the primary pathogens responsible for kiwifruit soft rot, leading to significant postharvest economic losses. Streptomyces spp., known for producing abundant volatile organic compounds (VOCs), have emerged as a crucial biological resource for controlling postharvest diseases. This study employed wheat grain cultures of Streptomyces albidoflavus SC-3 to produce VOCs, with the aim of systematically evaluating their antifungal mechanisms against B. dothidea . The VOCs emitted by SC-3 showed remarkable antifungal activity against B. dothidea , effectively inhibiting mycelial growth and suppressing sclerotia germination. Through optimization of culture conditions including inoculation volume, culture temperature, incubation time, and dosage of wheat grains, the antifungal efficacy of VOCs produced by SC-3 was significantly improved. Strain SC-3 VOCs reduced the pathogenicity of B. dothidea in kiwifruit, thereby delaying the progression of fruit soft rot. The VOCs induced abnormal hyphal morphology and compromised cell wall and membrane integrity of B. dothidea . Transcriptomic analysis further revealed that these VOCs primarily function by disrupting energy metabolism, impairing cell membrane integrity, and disturbing redox homeostasis-related metabolic pathways. GC-MS analysis identified three antifungal VOCs, including carvone, 3,5-di-tert-butylphenol, and 3-butylidenephthalide. Carvone exhibited the strongest inhibitory effect with EC 50 value of 0.03 μL mL −1 , suggesting that it serves as the key active compound against B. dothidea . In conclusion, Streptomyces albidoflavus SC-3 VOCs, primarily carvone, effectively control kiwifruit soft rot by inhibiting the pathogen B. dothidea through multiple mechanisms.
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PubMed
高影响因子
ACS Applied Energy Materials
·
2019
·
IF 0
Jing Yang,Zhen Huang,Peng Zhang,Gaozhan Liu,Xiaoxiong Xu,Xiayin Yao
Developing solid electrolytes with high lithium-ion conductivity is crucial to realize high-performance all-solid-state lithium batteries. The substitution of ions with larger ionic radius can enlarge the Li+ migration tunnels and therefore enhance the lithium-ion conductivity. In this work, Ti4+ is employed to partially replace Ge4+ in Li2O–Al2O3–GeO2–P2O5 glass-ceramics electrolyte in order to improve its conductivity. The highest total lithium-ion conductivity of 1.07 × 10–3 S cm–1 at room temperature is obtained from Li1.5Al0.5Ge1.5(PO4)3-7.5 wt % TiO2 sample sintered at 900 °C for 6 h. The bulk and grain boundary conductivities are 1.67 × 10–3 S cm–1 and 2.99 × 10–3 S cm–1, respectively, which are superior than that of the pristine Li1.5Al0.5Ge1.5(PO4)3 counterpart. Both bulk and grain boundary conductivities of the sample have been significantly improved, which could be attributed to the increase of bottleneck sizes of the Li+ migration tunnels and the decrease of grain boundary area. All-solid-state lithium batteries employing LiFePO4 as cathode and solid electrolyte as separator and ionic conductor are assembled. A reversible capacity of 132.3 mAh g–1 is delivered after 200 cycles under a current density of 0.1C with a capacity retention ratio of 91.1%, showing the solid electrolyte is ideal for all-solid-state lithium-battery applications.
研究领域:
材料科学
·
固体离子学
·
储能技术
·
电化学
·
陶瓷与玻璃
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DOI
RSC Advances
·
2015
·Vol. 5
·期 54
·43489-43495
·
IF 3.84
Yinghui Bian,Jinshe Chen,Shaotang Xu,Lijun Zhu,Yulu Zhou,Yuzhi Xiang,Daohong Xia
Novel metal-free tetra-(3-phenyprop-2-allyloxy) phthalocyanine (TPAO-Pc) was synthesized and characterized by nuclear magnetic resonance spectrum (1H NMR), MALDI-TOF MS, Fourier-transform infrared (FT-IR) and UV-Visible absorption (UV-Vis) spectra. The effects of concentrations and solvents on the properties of self-assembly were investigated via absorption and fluorescence spectra, transmission electron microscopy (TEM). TPAO-Pc was stable in most organic solvents, such as toluene, acetone and dimethylsulfoxide (DMSO). However, the TPAO-Pc exhibited the tendency of forming “face-to-face” stacking mode self-assemblies (H-aggregate) in DMSO–water and acetone–water mixed solutions. Self-assembly of the TPAO-Pc was also demonstrated by fluorescence spectra. The TEM images displayed the core–shell nanospheres and dendritic nanostructure of TPAO-Pc formed in the DMSO–water and acetone–water mixed solutions, respectively. The mechanism of the self-assemblies growth was proposed on the basis of the experimental results. The morphology of the TPAO-Pc self-assemblies was related with the selected solvent conditions and the aggregation time. H-bond, π–π interaction may be the main driving force for the formation of core–shell nanospheres and dendritic nanostructure.
研究领域:
材料科学
·
纳米技术
·
超分子化学
·
有机化学
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Yumeng Zhang,Yuanqi Lv,Lin Chen,Haizhou Wu,Yingyang Zhang,Zhiyao Suo,Shuxin Wang,Yuxin Liang,Xinglian Xu,Guanghong Zhou,Xianchao Feng
Nowadays, natural antioxidants abundant in polyphenols have been widely used to substitute synthetic antioxidants in meat products. In general, high doses of natural antioxidants are required to provide comparative antioxidant effects as synthetic antioxidants. Noticeably, the qualities of meat products can be jeopardized due to interactions between polyphenols and myofibrillar proteins (MPs). In this study, methyl-β-cyclodextrin was used to increase the polyphenol loading amount by preventing interactions between polyphenols and proteins. Solubility, electrophoresis, fluorescence spectroscopy, and surface hydrophobicity analyses indicated that methyl-β-cyclodextrin could dose-dependently inhibit epigallocatechin-3-gallate-induced attacks on MPs under oxidative stress. Gel strength, cooking loss, confocal laser scanning microscopy, dynamic rheological testing, and Raman spectrum during gelation were further analyzed to investigate the effects of methyl-β-cyclodextrin on the qualities of epigallocatechin-3-gallate-treated emulsion gel. Methyl-β-cyclodextrin addition prevented modification of the secondary structure of MPs caused by epigallocatechin-3-gallate. In consequence, the gel and emulsifying properties of MPs were significantly improved. Moreover, β-cyclodextrins could partly inhibit oxidative attacks on MPs and thus increase their solubility. These results indicated that methyl-β-cyclodextrin addition effectively enhanced epigallocatechin-3-gallate loading capacity in meat products.
研究领域:
食品科学与技术
·
蛋白质化学
·
多酚-蛋白质相互作用
·
氧化稳定性
·
功能食品
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2022
·
IF 5.477
Shangyan Zhou,Wei Liao,Zhengcheng Wang,Qian Zhou,Jin Long,Meida Chen,Qingmei Wang
Background Developing an economical and durable high-activity Pt-based electrocatalyst to alleviate the slow kinetics of the oxygen reduction reaction (ORR) is crucial for fuel cells. The shape-controllable Pt 3 Ni alloy catalyst with high electrocatalytic properties is regarded as one of the most efficacious electrocatalysts capable of accelerating ORR kinetics. Methods Here, sub-3 nm Pt-rich Pt 3 Ni dodecahedrons (DCs) has been developed via surfactant-driven shape evolution route as effective electrocatalysts for ORR. Significant findings The Pt 3 Ni DCs exhibit 4.3-fold improvement for mass activity and 4.7-fold improvement for specific activity respect to pristine Pt/C catalyst. Moreover, the remaining specific activity on Pt 3 Ni DCs is 6.7 times larger relative to pristine Pt/C catalyst after 20,000 scanning cycles. Such electrocatalytic performance enhancement is attributed to the ensemble effect including the dodecahedrons shape and synergistic effect between Pt and Ni atoms. We believe that our synthetic approach would provide new avenues toward the formation of polyhedron structures.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 47
·期 5
·2257-2263
·
IF 3.925
Shiyu Nie,Fengfeng Chen,Tianbo Shen,Tingting Wang,Ningyu Di,Junkuo Gao
Adjusting the internal porous environment of MOFs to enhance their adsorption properties is considered an effective strategy to improve their gas separation performance. Herein, 1-ethyl-3-methyl-imidazolium acetate ([Emim][Ac]) was encapsulated in UiO-66 by an impregnation method for the improvement of carbon dioxide (CO2) capture performance. The synthesis and detailed characterizations of the developed [Emim][Ac]@UiO-66 are reported, and the effect of the loading amount of [Emim][Ac] on the CO2 separation performance was also studied. The obtained [Emim][Ac]@UiO-66 could efficiently show the synergistic effect of the adsorption of CO2 between [Emim][Ac] and UiO-66. The optimized [Emim][Ac]@UiO-66 exhibited a much higher CO2 adsorption capacity at 298 K and 1.0 bar, affording 2 times the CO2 uptake than its original UiO-66. In addition, the CO2/N2 selectivity and CO2/CH4 selectivity of [Emim][Ac]@UiO-66-3.5% are significantly higher than those of UiO-66. This study for designing various MOF-encapsulated ionic liquids potentially paves the way for the development of highly efficient absorbents for gas separations.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 45
·21009-21019
·
IF 4.682
Lin Lingyin,Zhou Yanfang,Chen Piaoyi,Xiao Qinglin,Ye Guodong
Transcatheter arterial embolization is an established treatment for hepatocellular carcinoma (HCC). However, the existing embolic materials still have some shortcomings, e.g., particle clumping can cause catheter occlusion. In this study, after the synthesis of monomer glyceryl triallyl ether monomer (GE), amorphous embolic agent (PGE) was synthesized by photopolymerization in the presence of GE and photoinitiator. Combined with RT-IR, TG and GPC, we verified that the polymerization followed a photo-driven radical-mediated [3 + 2] cyclopolymerization mechanism (PRMC) through experimental and modeled NMR. The macromolecular properties such as polymerization profile and morphology were studied by TG and SEM–EDS. Finally, the degradation, swelling and migration behavior of PGE were characterized, which indicated that PGE could embolize HCC by blocking the blood supply. In this study, PRMC prevented GE polymerization from degradative chain transfer with 70% yield in an hour, and 200–350 µm PGE was synthesized using this mechanism suitable for clinical use. Graphical abstract
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高影响因子
EUROPEAN JOURNAL OF NEUROSCIENCE
·
2022
·Vol. 57
·期 1
·64-77
·
IF 3.698
Weimin Ni,Jie Zhang,Bing Wang,Feng Liang,Long Bao,Pengfei Li,Yan Fang
Obesity is a major health crisis in the modern society. Studies have shown that the consumption of a high-fat diet (HFD) induces hypothalamic inflammation and leptin resistance, which consequently favours body mass gain. Actin related protein 2/3 complex subunit 1 (ARPC1B), an actin-binding protein, is highly expressed in immune cells. Recent studies have shown that ARPC1B has a certain anti-inflammatory effect. While ARPC1B expression is decreased in the hypothalamus of mice fed a HFD, the role of ARPC1B in HFD-induced obesity remains unclear. Thus, we investigated whether ARPC1B up-regulation in the hypothalamic arcuate nucleus (ARC) could inhibit the development of obesity. Herein, ARPC1B overexpression lentiviral particles were stereotaxically injected into the ARC of male C57BL/6J mice (7 weeks old) fed with HFD. Overexpression of ARPC1B in the hypothalamic ARC attenuated HFD-induced ARC inflammation, reduced body-weight gain and feed efficiency. Furthermore, up-regulation of ARC ARPC1B improved the glucose tolerance and reduced subcutaneous/epididymal fat mass accumulation, which decreased the serum total cholesterol, serum triglyceride and leptin levels. In addition, upon ARPC1B overexpression in the hypothalamic ARC, intraperitoneal injection of leptin increased the phosphorylation level of signal transducer and activator of transcription 3 (STAT3), an important transcription factor for leptin's action, in the ARC of obese mice. Accordingly, we suggest that up-regulation of ARPC1B in the hypothalamic ARC may improve the HFD-induced hypothalamic inflammation and leptin resistance. Our findings demonstrate that ARPC1B is a promising target for the treatment of diet-induced obesity.
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高影响因子
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