Carbon Energy
·
2026
·
IF 24.2
Kaiming Li,Ben Huang,Aihao Xu,Kai Nie,Xianhai Bai,Qian Ning,Guodong Wang,Shiming Qiu,Huibing He,Yang Ren,Jing Xu,Xucai Yin
The inherent hydroxide-rich (OH⁻) environment in alkaline media facilitates the two-electron oxygen reduction reaction (2e − ORR). However, the strong interaction between alkali metal cations and solvated water molecules significantly reduces the connectivity of the hydrogen bond network within the alkaline electric double layer, thereby severely impeding rapid proton transport at the electrode surface. Herein, we rationally designed ZnO with oxygen vacancies-driven [Fe(CN) 6 ] 3− coordination (denoted as Fe(CN) 6 -ZnO-V O ) as an efficient 2e − ORR catalyst for H 2 O 2 electrosynthesis. We demonstrate that the locally coordinated [Fe(CN) 6 ] 3− establishes pathways for rapid proton transfer at the electrode surface by forming a hydrogen bond network with interfacial water molecules. Concurrently, this configuration significantly reduces the energy barrier of the *OOH intermediate. These synergistic effects collectively optimize the electrocatalytic performance for H 2 O 2 production under alkaline conditions. As expected, the Fe(CN) 6 -ZnO-V O delivers a significantly increased current density of 130 mA cm −2 that is much higher than ZnO (32 mA cm −2 ), as well as a superior H 2 O 2 production rate of 9.41 mol g cat −1 h −1 and a high faradaic efficiency of exceeds 90%. Our study highlights the crucial role of interfacial hydrogen-bonding connectivity and provides theoretical and technical guidance for developing reliable strategies to enhance the electrocatalytic properties of 2e − ORR.
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Journal of Energy Storage
·
2026
·
IF 9.8
Mingdong Du,Yanxia Liu,Chenxing Wang,Fulai Qi,Mingyu Shi,Wenjing Liu,Shengnan He,Zhijun Wu,Zhenglong Li,Chenchen Li,Hongge Pan
Lithium (Li) metal is the ideal anode material for building future large-scale energy storage batteries. Nevertheless, Li metal anodes suffer from incompatibility with conventional carbonate-based electrolytes, which possibly leads to severe Li dendrite growth, undesirable electrolyte decomposition, and rapid deterioration of the cycling performance. To address these challenges, the traditional commercial electrolyte is doped with cerium bis(trifluoromethanesulfonyl)imide (Ce(TFSI) 3 ) for enhanced Li anode stability. The low migration rate of Ce 3+ leads to formation of a Ce-enriched corrosion resistant solid electrolyte interphase (SEI), while the TFSI − anion enables a significant enhancement of inorganic components within the SEI, thus facilitating uniform Li + deposition and mitigation of detrimental electrolyte decomposition. The resulting electrolyte exhibits superior electrochemical stability against Li anodes. This is evidenced by a Li||Li symmetric cell that cycles steadily for over 1300 h at a current density of 1 mA cm −2 and a capacity of 1 mAh cm −2 , along with a exchange current density of 1.3183 mA cm −2 . Additionally, Li||LiFePO 4 full cell demonstrates 76.8% capacity retention (110.39 mA cm −2 ) after 900 cycles at 1 C. This work illustrates the significant impact of a corrosion-resistant interface on Li anode performance and offers a valuable idea for constructing high-durability SEI layers.
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Nanoscale Horizons
·
2026
·
IF 6.6
Juxin Gao,Hengze Ding,Qinghua Wu,Yuhang Hu,Yifan Yan,Minming Chen,Chunjie Wang,Zhuang Liu,Liangzhu Feng
Ferroptosis, characterized by iron-dependent lipid peroxidation, represents a promising therapeutic target for cancer treatment. Strategies that disrupt intracellular antioxidant systems to induce ferroptosis in cancer cells have been extensively explored. Herein, we developed a pH-responsive phototheranostic agent (designed as FSB 4 Ca NPs) by encapsulating conjugated boron dipyrromethene tetramers (B4) within ferric ion-sulfasalazine metallo-network polymercoated calcium carbonate hollow nanoparticles. Sulfasalazine, a known ferroptosis inducer that inhibits System X c --mediated cysteine influx, synergizes with ferric ion-driven glutathione (GSH) depletion to collectively amplify intracellular lipid peroxidation. In addition to serving as a second near-infrared (NIR-II) fluorophore for tracking the in vivo distribution of FSB 4 Ca NPs, B4 mediates a photothermal effect that significantly enhances lipid peroxidation induction by boosting the Fenton catalytic activity of ferrous ions. Combined with localized 915-nm laser irradiation, intravenously administrated FSB 4 Ca NPs achieved substantial tumor suppression in mouse models, with a complete remission rate of 80%. This study establishes a facile strategy for developing long-circulating NIR-II phototheranostic agents with self-amplified lipid peroxidation induction capacity, enabling photothermally augmented ferroptosis for cancer therapy.
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Food & Function
·
2026
·
IF 6.3
Jiahui Huang,Long Chen,Haojie Yu,Shishuai Zhou,Jianzhong Guan,Chen Xu
Hepatic osteodystrophy (HOD) is a bone condition associated with metabolic issues, primarily caused by impaired reverse cholesterol transport in the liver–bone axis, frequently linked to chronic non-alcoholic fatty liver disease (NAFLD). This impairment leads to an abnormal accumulation of cholesterol in bone tissue, hindering new bone formation and causing bone degradation. The study discussed here demonstrates that the administration of omega-3 polyunsaturated fatty acids (ω-3) in a rat model of HOD improves lipid metabolism by promoting peripheral reverse cholesterol transport. By reinstating the cholesterol transport process in the liver–bone axis, this treatment reduces excessive cholesterol accumulation in bones, enhances the bone microenvironment, and ultimately helps to alleviate bone loss and lessen liver damage. In summary, the results highlight the potential advantages of a diet rich in ω-3 fatty acids for combating bone loss related to NAFLD.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Boruo Yang,Mei Lan,Jin Liu,XuanYi Liu,Weihao Xiong,Luan Lin,Min Zhang,Peng Liang
BACKGROUND Triglyceride-type n-3 polyunsaturated fatty acids (n-3 PUFAs) are often used to improve the quality of meat products, while the potential of phospholipid-type n-3 PUFAs remains underexplored. This study evaluated the gel and flavor quality of minced pork gel (MPG) with marine-sourced large yellow croaker roe phospholipids (LYPLs) as phospholipid-type n-3 PUFA supplements. RESULTS The addition of LYPLs increased the n-3 PUFA content in MPG and caused no visually significant color changes. Textural properties, water-holding capacity and binding water percentage increased with the incorporation of LYPLs, with the best MPG quality obtained at 1.6% LYPLs. The addition of LYPLs enriched flavor compounds such as aldehydes, ketones and alcohols in MPG while enhancing the perception of saltiness and freshness of MPG. CONCLUSION LYPLs can be successfully applied as a potential n-3 PUFA supplementation in gel-form meat products and subsequently improve their quality and flavor attributes. This study informs using LYPLs as phospholipid-type n-3 PUFA supplements in meat products. © 2025 Society of Chemical Industry.
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eFood
·
2025
·Vol. 6
·期 5
·e70086
·
IF 5.7
Jun Hu,Weijie Zhou,Dawei Sun,Tingxin Yu,Kuanchen Huang,Chujie Liang,Xusheng Li,Jianxia Sun,Weibin Bai
Cyanidin-3-O-glucoside (C3G), widely reported for ameliorative effects on insulin resistance and blood glucose levels, is often attributed to modulating insulin signaling pathways. However, previous studies based on the target fishing method of chemical proteomics have identified C3G's ability to covalently bind target proteins, including insulin-degrading enzyme (IDE), an Alzheimer's disease pathway protein closely related to metabolism. The specific interactions of anthocyanins with their target proteins and their correlation with activity remain unverified. Therefore, elucidating the relationship between C3G's bioactivity and target proteins is crucial. In this study, we employed various methods to clarify the binding and activity effects of C3G on IDE. CETSA-WB revealed that C3G binds to IDE and significantly enhances its thermal stability. Insulin and fluorescent peptide substrate measurements identified C3G's enzymatic inhibitory activity with an IC 50 of 109.6 μM. The preparation of recombinant human IDE ( rh IDE) allowed us to directly confirm the covalent binding of C3G to IDE. Furthermore, the silencing of IDE in cells negated the significant improvement in insulin resistance by C3G. These findings unveil a potential novel molecular mechanism by which C3G may regulate metabolic pathways, offering guidance for understanding how anthocyanins exert their functions through interactions with target proteins.
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Pharmaceutics
·
2025
·Vol. 17
·期 10
·1307
·
IF 5.5
Ruoqing Guan,Xiangjun He,Yuxing Dai,Guangye Huang,Zhaoyun Xue,Jianwen Chen,Peiqing Liu
Background/Objectives: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive loss of lung function and poor prognosis. Cryptotanshinone (CTS), a small-molecule compound extracted from Salvia miltiorrhiza, possesses diverse pharmacological activities but suffers from poor oral bioavailability, which restricts its clinical development, particularly in pulmonary fibrosis. DST-3, a newly synthesized derivative of CTS, was designed to overcome these limitations.Methods: The antifibrotic effects of DST-3 were investigated in a bleomycin-induced pulmonary fibrosis model in C57BL/6 mice through lung function assessment, histopathological evaluation, hydroxyproline quantification, and cytokine profiling. In vitro, TGF-β1-stimulated MRC5 fibroblasts were employed to explore the mechanism of action, focusing on STAT3/Smad signaling via Western blotting and molecular binding assays. Furthermore, a validated HPLC–MS/MS method was developed for DST-3, and its pharmacokinetic profile was characterized in Sprague–Dawley rats and compared with that of CTS.Results: DST-3 markedly attenuated pulmonary fibrosis in vivo, as evidenced by improved lung function, reduced collagen deposition, and decreased proinflammatory cytokine levels. In vitro, DST-3 inhibited TGF-β1-induced fibroblast activation by directly binding to STAT3 and suppressing STAT3/Smad signaling. Pharmacokinetic analysis demonstrated that, compared with CTS, DST-3 exhibited more rapid absorption, a higher peak plasma concentration, a greater area under the curve (AUC), improved hepatic metabolic stability, and enhanced lung tissue exposure.Conclusions: Our study demonstrates that DST-3 exerts potent antifibrotic effects in vivo and in vitro, primarily through STAT3 pathway inhibition. Its improved pharmacokinetic characteristics further support its potential as a promising candidate for the treatment of pulmonary fibrosis.
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Physica Status Solidi-Rapid Research Letters
·
2020
·Vol. 14
·期 4
·1900723
·
IF 2.291
Yadan Deng,Jingzan Jiang,Jun Sun,Yufeng Hu,Qiuhong Cui,Zhenbo Deng,Zhidong Lou,Yanbing Hou,Feng Teng
Fabrication of nanowires in polymer films can dramatically enhance the mobility of thin-film transistors (TFTs). Unlike the popular method of forming nanowires after spin-coating films, here a water-bath method to fabricate the micrometer-long nanowires in the poly(3-hexylthiophene) (P3HT) solution is introduced, which is suitable for large-area printing electronic application. The resulting transistor exhibits significantly enhanced mobility and excellent device stability. However, the threshold voltage of the device is increased, compared with the amorphous film device. The underlying mechanism of the mesoscale crystalline induced threshold voltage increase has been rarely studied. The temperature-dependent characteristics imply that the activation energy of the device with nanowires is higher than that of the amorphous one, indicating nanowires can introduce deep traps. This suggests that the charge transport is mainly limited by the deep traps at the junctions between the nanowires considering the trap density inside the nanowires is significantly low. The deep traps introduced by the junctions can increase the threshold voltage as the device needs higher voltage to fill these traps in the channel before the device is turned on. This explains why the devices with nanowires have an increased threshold voltage while their mobilities are dramatically enhanced.
研究领域:
材料科学
·
凝聚态物理
·
有机电子学
·
薄膜晶体管
·
半导体器件物理
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Journal of Hazardous Materials Advances
·
2026
·
IF 9.1
Jiawei Li,Gaiyuan Chen,Min Chen,Zhengxin Wu,Yong Liu
Uranium (U) tailings, generated as byproducts of U mining and milling, pose significant disposal challenges owing to their large volume, radiotoxicity, and chemically heterogeneous mineral composition. Herein, we report a microwave–assisted route for preparing (1– x )Sr 0.5 Zr 2 (PO 4 ) 3 – x CePO 4 ( x = 0, 0.2, 0.4, 0.6, 0.8, 1) [strontium zirconium phosphate(SZP)–cerium phosphate(CP)] composite ceramics while incorporating real U tailings as a Si/Al–rich secondary waste component. The raw–batch U–tailing loading was 39.7–47.0 wt% for the designed compositions and 45.4 wt% for the optimized SZP–CP–0.8 batch. Compared with reagent–derived SZP–CP systems, the present work focuses on the practical utilization and stabilization of actual U tailings during ceramic waste−form preparation. The phase assemblage, microstructure, density, Vickers hardness, Ce surface valence, and 42–day PCT chemical durability were evaluated. The optimized SZP–CP–0.8 ceramic exhibited a density of 4.32 g ·cm –3 , a porosity of 0.12%, and low normalized leaching rates after 42 days, with Sr, P, and Si of approximately 10 −4 g ·m −2 ·d −1 , Ce of approximately 10 –7 g ·m –2 ·d –1 , and Zr of approximately 10 –8 g ·m –2 ·d –1 , supporting the feasibility of microwave–sintered SZP−CP composites for treatment and disposal of U tailings and simulated divalent/tetravalent radionuclides. Quantitative phase refinement, statistically representative grain–size analysis, replicate–vessel leaching uncertainty, and radionuclide–specific leaching of native trace elements from tailings are identified as future work rather than over interpreted from the present dataset.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Lihua Li,Wenzhi Zhang,Huichao Chen,Zhigang Zhao,Meifang Wang,Jiexia Chen
In this work, a method for the visual and electrochemical detection of the breast cancer marker CA15–3 was developed based on the etching reaction of gold/silver core-shell nanoparticles (Au@Ag NPs) by mercury ions (Hg 2+ ). Two kinds of nanocomplex of silicon dioxide nanospheres-antibodies-mercury ions (SiO 2 NSs-Ab-Hg 2+ ) and Au@Ag NPs-antibodies (Au@Ag NPs-Ab) were first prepared in the visual detection. In the presence of antigen, a sandwich structure of immuno-complex was formed through the specific recognition reaction of antigen and antibody. Then, after the addition of pH 4.6 CPBS, redox reaction occurred between Hg 2+ and silver shell. With the increase of the amount of antigen, the silver shell was etched thinner and thinner, and the color changed obviously. Visual detection of CA15–3 could be realized in the range of 30–300 U/mL. In addition, we adopted the DPV signals generated by Hg 2+ etching of silver shell to realize the electrochemical detection of CA15–3. The detection concentration range was 0.1–200 U/mL with a detection limit of 0.05 U/mL.
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Journal of Cleaner Production
·
2023
·
IF 11.1
Yicong Wang,Sisuo Zhang,Richard L. Smith,Xiaoning Liu,Xinhua Qi
Effective removal of both nitrogen and phosphorus from water is of great importance for maintaining the safety of the environment. In this work, ordered mesoporous carbon electrode materials containing La(OH) 3 and Fe 3 C components (La#OMC-Fe 3 C) were prepared by combining solvent evaporation induced self-assembly and impregnation methods. The ordered pores in La#OMC-Fe 3 C facilitated electron transfer at the electrode-solution interface during nitrate reduction and provided voids for phosphate removal . In the electrochemical system, Fe 3 C in the electrode supplied electrons for nitrate reduction and gave the electrode a high degree of stability, whereas La(OH) 3 selectively removed phosphate, thus avoiding byproduct precipitation from solution. The electrode material maintained efficient electrochemical nitrogen and phosphorus removal over a wide range of conditions including pH (3–11) and aqueous environments containing multiple ions (Cl − , SO 4 2− , K + , Na + , Ca 2+ , Mg 2+ ) or actual aqueous environments (seawater). After 10 cycles, the performance of La#OMC-Fe 3 C for nitrogen and phosphorus removal remained above 97%. This work realizes the simultaneous removal of nitrogen and phosphorus in the electrochemical system, and solves the problems of precipitation in water and non-circulation of electrodes, which can provide a new strategy for the treatment of eutrophic water in practical production.
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ChemSusChem
·
2023
·Vol. 16
·期 12
·e202300133
·
IF 8.4
Changqu Lin,Hao Yang,Xin Gao,Yue Zhuang,Caojian Feng,Hongli Wu,Haifeng Gan,Fei Cao,Ping Wei,Pingkai Ouyang
Graphical An alkali catalytic system for the selective conversion of N -acetyl- d -glucosamine (NAG) into unsubstituted 3-acetamidofuran (3AF) via retro-aldol condensation has been developed. 3AF with 73.9 % yield is obtained in the presence of a ternary Ba(OH) 2 −H 3 BO 3 −NaCl catalytic system. Aminofurans are widely used in drug synthesis as aromatic modules analogous to aniline. However, unsubstituted aminofuran compounds are difficult to prepare. In this study, a process for the selective conversion of N -acetyl- d -glucosamine (NAG) into unsubstituted 3-acetamidofuran (3AF) is developed. The yield of 3AF from NAG catalyzed by a ternary Ba(OH) 2 −H 3 BO 3 −NaCl catalytic system in N -methylpyrrolidone at 180 °C for 20 min can reach 73.9 %. Mechanistic studies reveal that the pathway to 3AF starts with a base-promoted retro-aldol condensation of the ring-opened NAG, affording the key intermediate N -acetylerythrosamine. Judicious selection of the catalyst system and conditions enables the selective conversion of biomass-derived NAG into 3AF or 3-acetamido-5-acetylfuran.
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