INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Junjie Hu,Chaozhang Huang,Anda Gong,Huanle Chen,Shilin Liu,Bin Li,Yan Li
In the present study, we prepared cinnamaldehyde (CA) conjugated chitosan-stabilized emulsions (CSCAEs), and the influence of pH on their properties and lipolysis behavior was investigated. Compared to the emulsions stabilized by chitosan itself (CSEs), CSCAEs had better stability against pH during storage. As pH increased from 2.5 to 6.25, the viscosity and modulus of CSCAEs increased. However, when pH shifted from 6.25 to 6.5, emulsion showed lower viscosity and modulus. Confocal laser scanning microscopy results demonstrated that oil droplets still kept intact and individually distributed, and chitosan homogenously covered on the oil droplets at low pH conditions (pH 2.5, 4.0). At higher pH conditions (pH 5.0, 5.5), a few chitosan aggregates on the oil droplets were observed. At pH 6.0 and 6.25, the compact gel network structure was formed. At pH 6.5, some void was found among the chitosan gel network. In vitro simulated digestion experiments presented that pH had no significant effect on the lipolysis process of emulsions. When the oil content varied from 10% to 50%, emulsions still kept good stability against pHs, but the lipolysis extent after digestion decreased. This knowledge provides a strategy for improving stability of chitosan-stabilized emulsion against harsh pH conditions.
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Xiu-Xiu Dong,Jin-Yi Yang,Lin Luo,Yi-Feng Zhang,Chuanbin Mao,Yuan-Ming Sun,Hong-Tao Lei,Yu-Dong Shen,Ross C. Beier,Zhen-Lin Xu
Histamine (HA) is a biogenic amine that can accumulate to high concentration levels in food as a result of microbial activity and can cause toxic effects in consumers. In this work, a portable electrochemical immunosensor capable of detecting HA with high sensitivity and selectivity was developed. Prussian blue-chitosan-gold nanoparticle (PB-CS-AuNP) nanocomposite films with excellent biocompatibility were synthesized and characterized by scanning electron microscopy and energy dispersive X-ray analysis. The PB-CS-AuNP were coated onto a screen-printed electrode by one-step electrodeposition and used to conjugate the HA ovalbumin conjugate (HA-Ag). HA was determined by a competition between the coating HA-Ag and the HRP labeled HA antibody (HRP-HA-Ab). After careful optimization of assay conditions and Box-Behnken analysis, the developed immunosensor showed a linear range from 0.01 to 100 μg/mL for HA in fish samples. The average recoveries from spiked samples ranged from 97.25% to 105%. The biosensor also showed good specificity, reproducibility, and stability, indicating its potential application in monitoring HA in a simple and low cost manner.
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高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2021
·
IF 2.168
Zhu Lin,Xiaomin Cheng
A novel amphiphilic polymer, carboxymethylated hydroxypropyl chitosan (HPCMS) was successfully synthesized for delivery of doxorubicin (DOX). The chemical structure and thermal stability were characterized by FTIR, 1H NMR and TGA, respectively. In aqueous medium, HPCMS could self-assembled into micelles with a low critical aggregation concentration of 0.54 mg/mL. The DOX-loaded HPCMS micelles showed a considerable drug-loading capacity of around 13 wt%. The prepared micelles were spherical morphology with average hydrodynamic diameter 300-380 nm and zeta potential of around −13 mv. The HPCMS/DOX micelles showed a sustained and pH-dependent drug release behavior in vitro and good stability. The drug release data could be well fitted with the Higuchi kinetic model, suggesting a diffusion-controlled mechanism. The diffusional exponent values indicated non-Fickian diffusion where the diffusion of drug and polymer relaxation had an important role in the process of drug release.
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Desalination and Water Treatment
·
2024
·
IF 1
Jin-ni Wu,Wenkui Mu,Wen-bin Li,Hong-yan Deng,Tianjiang Jin,Touqeer Abbas,Yu-ting Song,Jia-peng Pan,Bixia Wang
The antibiotic adsorbability and economic performance of modified semi-carbonized fiber (SF) were investigated by using 100% chitosan (CS) to modify SF (prepared by cotton) for preparing CS-modified SF (CS-SF). Then, different ratios (0%, 10%, 20%, 50%, 100%, and 200%) of sodium alginate (SA) were used to modify 100CS-SF for preparing SA and CS-modified SF (SA/CS-SF). Batch method was used to investigate the adsorption characteristic of chlortetracycline (CTC), tetracycline (TC), and oxytetracycline (OTC) on different SA/CS-SFs. The effects of temperature, pH, and ionic strength on antibiotic adsorption were compared, and the economic performance of different SA/CS-SFs was analyzed. Results showed that (1) the Langmuir model is suitable for describing the adsorption process of antibiotics by different SA/CS-SFs. The maximum adsorption amount ( q m ) of different SA/CS-SFs for CTC, TC, and OTC were 11.17–36.36, 6.14–26.11, and 9.90–32.87 mmol/kg, respectively, ranking in the order of CTC > OTC > TC. (2) The adsorption antibiotics by different SA/CS-SFs conformed to the pseudo-first-order kinetics equation. Antibiotic adsorption on different SA/CS-SFs increased with the increase in temperature, and the adsorption was a spontaneous, endothermic, and entropy-increasing process. (3) In the pH range of 3–9 and ionic strength range of 0.01–0.2 mol/L, the adsorption amount of antibiotics on different SA/CS-SFs all increased first and then decreased with increasing pH and ionic strength, reaching the maximum value at pH = 5 and ionic strength of 0.1 mol/L, respectively. (4) The economy ( q m /price) of different SA/CS-SFs for antibiotic adsorption ranged from 7.18 to 22.91 mg/¥, and 100SA/CS-SF showed the highest economy. Compared with biochar and modified biochar, 100SA/CS-SF had higher economy in antibiotic adsorption.
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CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Jifei Cui,John F. Kennedy,Jun Nie,Guiping Ma
Amines monomers, N , N -dimethylaminoethyl methacrylate (DMAEMA), N , N -dimethylethanolamine (DMEA), 2-dimethylaminoethylamine (DMEDA) and N -methiyldiethanolamine (MDEA) were used to induce the formation of calcium carbonate (CaCO 3 ) crystals on chitosan films, by using (NH4) 2 CO 3 diffusion method at ambient temperature. The obtained CaCO 3 particles were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD) and Energy dispersive spectroscopy (EDS). The influence of reaction variables, such as the additive concentration and their types were also investigated on the products. The morphologies of CaCO 3 crystals, inter-grown in cube-shape, were controlled by DMAEMA and DMEA. It was observed that the morphologies of CaCO 3 changed from the cube grown arms to massive calcite with a hole on the face by increasing the concentrations of DMEDA and MDEA. While the precipitation grew on chitosan film without any organic additive, only single cube-shaped crystals were obtained. By these results the possible mechanisms can be proposed that electronic movement of the groups on the monomer effected ions configuration and molecules absorbed on the exposed surface, resulted the change of the surface energy, which caused the change in the morphology of CaCO 3 .
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Desalination and Water Treatment
·
2024
·
IF 1
Yongjun Sun,Aowen Chen,Wenquan Sun,Kinjal J. Shah,Huaili Zheng,Chengyu Zhu
In this work, carboxylated chitosan and acrylamide are used to synthesize a graft-modified natural polymer flocculant carboxylated chitosan-graft-acrylamide (CCSPAM) by UV-induced polymerization for copper and chromium removal. The effects of total monomer concentration, monomer mass ratio, pH value, photoinitiator concentration, and illumination time on the synthesis performance of CCSPAM were investigated regarding intrinsic viscosity (IV), grafting rate (GR), and grafting efficiency (GE). Various analytical techniques characterize the physicochemical characteristics of CCSPAM. Single factor experiments are used to investigate the effect of dosage, pH value, and reaction time on the chelation and capture of heavy metal ions by CCSPAM. The results show that the optimal IV, GR, and GE of CCSPAM achieved at total monomer concentration 30%, monomer mass ratio 1:4, pH 7.0, photoinitiator concentration 0.03%, and irradiation time 2 h are 1412.2 mL/g, 394.1%, and 84.1%, respectively. The experimental data of flocculation show that CCSPAM has a good total Cu and total Cr removal efficiency of 74.8% and 70.6% at dosage 2.0 mg/L, pH 6.0, and reaction time 2h, respectively. Fom the investigation, it is concluded that the grafted chitosan (CCSPAM) could be a be an effective and eco-friendly flocculant for removal of total Cu and total Cr ions from aqueous system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yan Li,Lingying Xie,Jingyi Liu,Sisi Tang,Hang Lei,Yuxia Zhong,Yue-Fei Zhang
In this study, an imidazole cross-linked chitosan hydrogel (I/CS-4) was synthesized through the Debus-Radziszewski reaction, resulting in a multifunctional adsorbent with both dye adsorption and antimicrobial capabilities. I/CS-4 effectively removed orange G (OG) and metanil yellow (MY) dyes under various environmental conditions, including pH, initial concentration, temperature, and contact time. The hydrogel demonstrated high stability and efficiency over a broad pH range (2−10), attributed to its abundant amino and imidazole groups, which facilitate electrostatic, hydrogen bonding, and π-π stacking interactions. The maximum adsorption capacities for OG and MY were 565.00 mg/g and 490.20 mg/g, respectively, following the Langmuir isotherm and pseudo-second-order kinetic models. Additionally, I/CS-4 showed excellent recyclability, maintaining over 80 % removal efficiency after five cycles. It also exhibited potent antibacterial activity against E. coli and S. aureus while being biocompatible. These results highlight I/CS-4's potential as an effective material for treating dye-containing wastewater, combining efficient contaminant removal with microbial inhibition.
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DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Lei Sun,Jianxin Zhao,Wei Chen,Gang Wang
The present study fabricated melatonin-loaded sodium alginate/carboxymethyl chitosan (Mel/SA-CMC) microgel as a colon-targeted therapeutic strategy for ulcerative colitis. Optimization of the SA/CMC ratio (1:1) and voltage (15 kV) produced Mel/SA-CMC microgels with maximum encapsulation efficiency (91.8 % ± 1.2 %) and loading capacity (16.4 % ± 0.1 %). Characterization techniques, including scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analyses, elucidated the physicochemical properties of the microgels. Simulated digestion experiments and pharmacokinetic analyses indicate that the microgels remain stable in the gastric environment (pH = 3.5) and release melatonin in a controlled manner in the colonic environment (T max = 4 and AUC = 16,208 pg h/mL). In a dextran sodium sulfate (DSS)-induced Caco-2 cell inflammation model, Mel/SA-CMC enhanced cell viability and attenuated oxidative stress and inflammatory response. Furthermore, administration of Mel/SA-CMC to mice with DSS-induced acute colitis alleviated the deleterious effects of DSS, as evidenced by preserved colon length (9.2 ± 0.9 cm), mitigated histological damage (histological injury score: 1.5 ± 0.5), and reduced expression of inflammatory cytokines (IL-4, IL-6, IL-1β and TNF-α). Notably, Mel/SA-CMC restored gut microbiota composition by enriching beneficial genera, including Bifidobacterium , Ruminococcus2 , and Lactobacillus , leading to elevated concentrations of short-chain fatty acids. In conclusion, the Mel/SA-CMC microgel demonstrates potent antioxidant and anti-inflammatory properties as a potential therapeutic intervention for inflammatory bowel disease.
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高影响因子
MACROMOLECULAR BIOSCIENCE
·
2024
·
IF 4.4
Dingkun Liu,Jinbing Chen,Linjuan Gao,Xing Chen,Liujun Lin,Xia Wei,Yuan Liu,Hui Cheng
Controlling infections while reducing the use of antibiotics is what doctors as well as researchers are looking for. As innovative smart materials, photothermal materials can achieve localized heating under light excitation for broad-spectrum bacterial inhibition. A polydopamine/chitosan/β-glycerophosphate temperature-sensitive hydrogel with excellent antibacterial ability is synthesized here. Initially, the hydrogel has good biocompatibility. In vitro experiments reveal its noncytotoxic property when cocultured with gingival fibroblasts and nonhemolytic capability. Concurrently, the in vivo biocompatibility is confirmed through liver and kidney blood markers and staining of key organs. Crucially, the hydrogel has excellent photothermal conversion performance, which can realize the photothermal conversion of hydrogel up to 3 mm thickness. When excited by near-infrared light, localized heating is attainable, resulting in clear inhibition impacts on both Staphylococcus aureus and Escherichia coli , with the inhibition rates of 91.22% and 96.69%, respectively. During studies on mice's infected wounds, it is observed that the hydrogel can decrease S. aureus ’ presence in the affected area when exposed to near-infrared light, and also lessen initial inflammation and apoptosis, hastening tissue healing. These findings provide valuable insights into the design of antibiotic-free novel biomaterials with good potential for clinical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yang Liu,Chuang Lang,Kai Zhang,Linlin Feng,Junying Li,Tingting Wang,Siyu Sun,Guangwei Sun
To develop a submucosal injection material with sustained submucosal lifting for endoscopic submucosal dissection (ESD), this study designed and prepared a novel composite thermosensitive hydrogel system with high pH chitosan-polyvinylpyrrolidone-β-glycerophosphate (HpHCS-PVP-GP). HpHCS improved the injectability of the hydrogels and retained the rapid gelation ability at low concentrations. The modification of PVP significantly improved the stability of low-temperature hydrogel precursor solutions and the integrity of hydrogels formed at 37 °C through hydrogen bonds between PVP and HpHCS. A mathematical model was established using response surface methodology (RSM) to e v aluate the synergistic effect of HpHCS, GP , and PVP concentrations on gelation time. This RSM model and submucosal lifting evaluation using in vitro pig esophageal models were used to determine the optimal formula of HpHCS-PVP-GP hydrogels. Although the higher PVP concentration (5 % ( w / v )) prolonged gelation time, it improved hydrogel mechanical strength , resulting in better submucosal lifting performance. The experiments of Bama mini pigs showed that the heights of the cushions elevated by the HpHCS-5%PVP-GP hydrogel remained about 80 % 1 h after injection. Repeated injections were avoided, and the hydrogel had no cytotoxicity after electric cutting. Therefore, the HpHCS-PVP-GP thermosensitive hydrogel might be a promising submucosal injection material for ESD.
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PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 11
·2286
·
IF 4.6
Jianshen Liu,Xinghua Guo,Qishi Che,Zhengquan Su
Although calcium phosphate bone cement has some advantages (it is easy to form, self-curing, and does not produce heat), some disadvantages remain that limit its clinical application. Therefore, the question of how we can modify CPC and further improve the various properties of calcium phosphate bone cement is a current research hotspot. In this paper, the preparation conditions and technology of biphasic calcium phosphate (BCP) were optimized; chitosan oligosaccharide (COSM) with MW ≤ 3000 Da was added to the optimal formulation of biphasic calcium phosphate cement particles, and its physical and chemical properties were characterized. The results showed that BCP bone cement carrier for clinical operations was successfully constructed by the high-temperature solid-state reaction method, and COSM-BCP bone cement particles were obtained by loading COSM drugs with an angiogenesis effect. Its formula is biphasic calcium phosphate powder with the molar ratio of α-TCP/β-TCP of 1. The curing time of the prepared BCP particles is 24 ± 1 min, the compressive strength is 29.58 ± 1.89 MPa, and the porosity reaches 52.09%. The loaded COSM can be released continuously and stably in vitro, and has the effect of promoting angiogenesis. The safety evaluation of COSM-BCP bone cement particles and the preliminary pharmacodynamic study of its angiogenesis in vitro provide a promising clinical application basis for the development of drug-loaded biological bone substitute materials.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zewei Ye,Qingyu Meng,Haomeng Yu,Shitao Shi,Yuanyuan Wang,Zhuyue Lan,Jiaqi Liao,Qingfeng Sun,Xiaoping Shen
Intelligently harnessing energy from the surrounding environment through various nanogenerators presents an ideal avenue to enable self-powered electronics. Herein, we developed a lightweight, flexible bilayer-structure coupled nanogenerator composed of a Hydroxypropyl cellulose (HPC)/chitosan (CTS)/carbon nanotube (CNT) film as the positive triboelectric layer, (PVDF)/polydimethylsiloxane (PDMS) aerogel as the negative layer. The triboelectric positive layer incorporates HPC and CTS biopolymers with multiple functional groups, thereby enhancing the polarity of the positive layer. Meanwhile, the incorporation of CNT in the biopolymer triboelectric film diminishes the contact impedance of the film, further increasing the voltage output (V OC ). The negative PVDF/PDMS aerogel layer, which exhibits both triboelectric and piezoelectric functions, features a high specific surface area, thus allowing for the coexistence of triboelectric and piezoelectric charges. This triboelectric-piezoelectric coupled nanogenerator displays an impressive sensitivity of 112.5 mV kPa −1 , excellent stability (maintaining consistent V OC over 10,000 cycles), mechanical robustness, and robust energy harvesting capabilities. The simultaneous generation of triboelectric charges and piezoelectric charges due to the high specific surface area is proposed for the first time, offering significant promise for diverse applications ranging from various mechano-sensing to mechanical energy collection and storage.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）