Nanomaterials
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2023
·Vol. 13
·期 6
·1111
·
IF 5.3
Wen-Xin Liu,Wei-Na Zhou,Shuang Song,Yong-Gang Zhao,Yin Lu
A new type of magnetic nanomaterial with Fe3O4as the core and organic polymer as the shell was synthesized by seed emulsion polymerization. This material not only overcomes the problem of insufficient mechanical strength of the organic polymer, it also solves the problem that Fe3O4is prone to oxidation and agglomeration. In order to make the particle size of Fe3O4meet the requirement of the seed, the solvothermal method was used to prepare Fe3O4. The effects of the reaction time, amount of solvent, pH value, and polyethylene glycol (PEG) on the particle size of Fe3O4were investigated. In addition, in order to accelerate the reaction rate, the feasibility of preparing Fe3O4by microwave was studied. The results showed that under the optimum conditions, the particle size of Fe3O4could reach 400 nm and had good magnetic properties. After three stages of oleic acid coating, seed emulsion polymerization, and C18 modification, the obtained C18-functionalized magnetic nanomaterials were used for the preparation of the chromatographic column. Under optimal conditions, stepwise elution significantly shortened the elution time of sulfamethyldiazine, sulfamethazine, sulfamethoxypyridazine, and sulfamethoxazole while still achieving a baseline separation.Keywords:solvothermal method;chromatographic packing materials;magnetic Fe3O4particles;C18-functionalized magnetic nanomaterials
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Journal of Food Measurement and Characterization
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2023
·
IF 3.4
Du Juan,Liu Kai,Liu Jialei,Zhao Dianbo,Bai Yanhong
Herein, a novel core-shell material Fe 3 O 4 @MIL-100(Fe) was synthesized for developing a novel LFIA by a two-step solvothermal method with good magnetic properties and high specific surface area. It was used as both magnetic separation and label agents in LFIA for the detection of Listeria monocytogenes . The enrichment of target bacteria can be achieved quickly and easily by direct adsorption of Fe 3 O 4 @MIL-100(Fe) on the bacteria and by the action of an applied magnetic field. It was beneficial in separation and concentration of target bacteria from food samples. The Fe 3 O 4 @MIL-100(Fe)-bacterial was then detected by the anti- Listeria monocytogenes antibody on the T line under the capillary action of the LFIA strip, resulting in the formation of a visible orange band. Under the optimal conditions, there was a good linear relationship between the intensity of the T line and the quantity of Listeria monocytogenes in the range of 10 5 -10 8 CFU mL − 1 , with a visual detection limit of 3.3 × 10 6 CFU mL − 1 . The strip showed strong specificity for L. monocytogenes , and the detection could be finished in 45 min, without the needing of pre-treatment. Thus, the proposed Fe 3 O 4 @MIL-100(Fe)-based strip was simple prepared, label-free, low cost, rapid and convenience.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 17
·7441-7455
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IF 4.5
Wang Yijie,Li Qiulan,Xia Qinghai,Yang Yaling,Yang Dezhi
Sensitive and effective detection of xanthine oxidase (XOD) is essential for assessing human health. Herein, a dual-enzyme-based cascaded reaction system was developed for xanthine and xanthine oxidase assay based on the peroxidase (POD)-like catalytic activity of Fe 3 O 4 @MWCNTs/Hemin nanocomposite. The XOD could catalyze xanthine to produce H 2 O 2 , which is subsequently converted by Fe 3 O 4 @MWCNTs/Hemin into hydroxyl radicals (·OH) to oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) to produce a light blue. Notably, it is demonstrated that the modification of MWCNTs and Hemin could significantly enhance the POD-like activity from 9.78 × 10 −8 M s −1 ( V max value of Fe 3 O 4 ) to 23.34 10 −8 M s −1 ( V max value of Fe 3 O 4 @MWCNTs/Hemin), which makes the detection of xanthine oxidase more sensitive. By using the smartphone to capture the colorimetric signal of oxidized TMB (oxTMB), the assay can detect xanthine and XOD as low as 0.250 µM and 0.216 mU mL −1 , respectively. The reliability of the method in human serum suggested satisfactory spiked recoveries in the range of 92.350–105%. This work provided a new insight for Fe 3 O 4 -based nanozyme design and monitoring XOD level in blood. Graphical Abstract
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MOLECULES
·
2023
·Vol. 28
·期 12
·4573
·
IF 4.6
Yunxi Huang,Zhanling Ding,Yutong Li,Fengna Xi,Junjie Liu
The simple and accurate monitoring of blood glucose level is of great significance for the prevention and control of diabetes. In this work, a magnetic nanozyme was fabricated based on loading nitrogen-doped carbon dots (N-CDs) on mesoporous Fe3O4nanoparticles for the colorimetric detection of glucose in human serum. Mesoporous Fe3O4nanoparticles were easily synthesized using a solvothermal method, and N-CDs were then prepared in situ and loaded on the Fe3O4nanoparticles, leading to a magnetic N-CDs/Fe3O4nanocomposite. The N-CDs/Fe3O4nanocomposite exhibited good peroxidase-like activity and could catalyze the oxidation of the colorless enzyme substrate 3,3′,5,5′-tetramethylbenzidine (TMB) to blue TMB oxide (ox-TMB) in the presence of hydrogen peroxide (H2O2). When the N-CDs/Fe3O4nanozyme was combined with glucose oxidase (Gox), Gox catalyzed the oxidization of glucose, producing H2O2and leading to the oxidation of TMB under the catalysis of the N-CDs/Fe3O4nanozyme. Based on this mechanism, a colorimetric sensor was constructed for the sensitive detection of glucose. The linear range for glucose detection was from 1 to 180 μM, and the limit of detection (LOD) was 0.56 μM. The recovered nanozyme through magnetic separation showed good reusability. The visual detection of glucose was also realized by preparing an integrated agarose hydrogel containing the N-CDs/Fe3O4nanozyme, glucose oxidase, and TMB. The colorimetric detection platform has an enormous potential for the convenient detection of metabolites.Keywords:colorimetric detection;magnetic nanozyme;nitrogen-doped carbon dots;mesoporous Fe3O4nanoparticle;glucose
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CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Yaling Wang,Maolin Wang,Qing Xie,Xiyun Cai
We report new activated persulfate systems with cyclodextrin (CD)-coated Fe 3 O 4 @Fe 0 nanoparticles (Fe 3 O 4 @Fe 0 -CD) that are characterized by both highly activating persulfates and rapidly accessing hydrophobic PAHs. Fe 3 O 4 @Fe 0 -β-CD displays chain-like structure of core–shell Fe 3 O 4 @Fe 0 nanoparticles coated with a CD layer (about 5.9 nm). CD coating stabilizes the polycrystalline structure of Fe 3 O 4 @Fe 0 nanoparticles and accelerates mass transfer of PAHs in water, thereby making Fe 3 O 4 @Fe 0 -β-CD intrinsically stable and reactive. Fe 3 O 4 @Fe 0 -β-CD/PS, featured by high yields of highly reactive Fe(IV), had about 30-fold rate constants of naphthalene (Nap) in water as much as Fe 3 O 4 @Fe 0 /PS. Fe 3 O 4 @Fe 0 -β-CD/PS completely removed Nap in water during 13 of total 18 supplementations of Nap and/or PS, whereas Fe 3 O 4 @Fe 0 /PS completely removed Nap only at the first supplementation of Nap. Likewise, Fe 3 O 4 @Fe 0 -β-CD/PS completely removed Nap in simulated groundwater, and degraded four PAHs in soils by >63%. This study may provide a technical basis for the developments of new PS activators to remove recalcitrant hydrophobic contaminants in water and soils.
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SENSORS
·
2023
·Vol. 23
·期 7
·3508
·
IF 3.9
Linlin Zhuang,Qiannan You,Xue Su,Zhimin Chang,Mingfeng Ge,Qian Mei,Li Yang,Wenfei Dong,Li Li
Exosomes derived from cancer cells have been recognized as a promising biomarker for minimally invasive liquid biopsy. Herein, a novel sandwich-type biosensor was fabricated for highly sensitive detection of exosomes. Amino-functionalized Fe3O4nanoparticles were synthesized as a sensing interface with a large surface area and rapid enrichment capacity, while two-dimensional MXene nanosheets were used as signal amplifiers with excellent electrical properties. Specifically, CD63 aptamer attached Fe3O4nanoprobes capture the target exosomes. MXene nanosheets modified with epithelial cell adhesion molecule (EpCAM) aptamer were tethered on the electrode surface to enhance the quantification of exosomes captured with the detection of remaining protein sites. With such a design, the proposed biosensor showed a wide linear range from 102particles μL−1to 107particles μL−1for sensing 4T1 exosomes, with a low detection limit of 43 particles μL−1. In addition, this sensing platform can determine four different tumor cell types (4T1, Hela, HepG2, and A549) using surface proteins corresponding to aptamers 1 and 2 (CD63 and EpCAM) and showcases good specificity in serum samples. These preliminary results demonstrate the feasibility of establishing a sensitive, accurate, and inexpensive electrochemical sensor for detecting exosome concentrations and species. Moreover, they provide a significant reference for exosome applications in clinical settings, such as liquid biopsy and early cancer diagnosis.Keywords:exosomes;Ti3C2MXene;magnetic nanoparticles;electrochemical biosensor;synergistic amplification
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BIORESOURCE TECHNOLOGY
·
2022
·
IF 11.889
Lanting Wang,Tianxiao Liu,Jing Xu,Zhiwei Wang,Zhongfang Lei,Kazuya Shimizu,Zhenya Zhang,Tian Yuan
Fe 3 O 4 addition in anaerobic fermentation of food waste (FW) is promising for enhancing volatile fatty acids (VFAs) production. However, the large amount of Fe 3 O 4 in the digestate fertilizer leads to the waste of resources and possible toxicity to organisms. Thus, this study investigated the feasibility of Fe 3 O 4 recycling for VFAs enhancement in anaerobic fermentation of FW and performed the cost-benefit evaluation of this process. Results revealed that Fe 3 O 4 could be successfully recycled twice with recovery rates of 71.5% and 65.5%, respectively. X-ray diffraction analysis revealed a slight change to the Fe 2 O 3 -like structure after 2-time recycling. The VFAs yields were enhanced by 17.2% and 17.0% in Cycles 1 and 2 owing to the enhanced activities of hydrolytic and acid-forming enzymes. The net income of the Fe 3 O 4 recycling process was about 13-fold higher than that of the conventional treatment process, suggesting a promising and economically feasible strategy for enhancing VFAs production.
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Foods
·
2023
·Vol. 12
·期 2
·285
·
IF 5.2
Maiquan Li,Lingli Luo,Jiayin Li,Yingzi Xiong,Ling Wang,Xia Liu
Long-term use of norfloxacin (NOR) will cause NOR residues in foods and harm human bodies. The determination of NOR residues is important for guaranteeing food safety. In this study, a simple, selective, and label-free colorimetric chemosensor for in situ NOR detection was developed based on Fe3O4magnetic molecularly imprinted nanoparticles (Fe3O4MMIP NPs). The Fe3O4MMIP NPs showed good peroxidase-like catalytic activity to 3,3′,5,5′-tetramethylbenzidine (TMB) and selective adsorption ability to NOR. The colorimetric chemosensor was constructed based on the Fe3O4MMIP NPs-H2O2-TMB reaction system. The absorbance differences were proportional to the concentrations of NOR in the range of 10–300 ng/mL with a limit of detection at 9 ng/mL. The colorimetric chemosensor was successfully applied to detect NOR residue in milk. The recovery range was 78.2–95.81%, with a relative standard deviation of 2.1–9.88%. Together, the proposed colorimetric chemosensor provides a reliable strategy for the detection of NOR residues in foods.Keywords:Fe3O4MMIP NPs;peroxidase-like catalytic activity;colorimetric chemosensor;norfloxacin detection
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MICROCHIMICA ACTA
·
2022
·Vol. 190
·期 1
·1-9
·
IF 6.408
Wang Yu-Xin,Shen Xiao-Fang,Feng Yong-Wei,Pang Yue-Hong
Based on covalent organic framework (COF) 1,3,5-tris-(4-formylphenyl)benzene-benzidine (TFPB-BD) in situ grown on Fe 3 O 4 hollow microspheres and combined with gas chromatography-flame thermionic detector, a rapid and simple stir bar sorptive-dispersive microextraction method was developed for the determination of five triazole pesticides (paclobutrazol, hexaconazole, flusilazole, propiconazole, and tebuconazole). The synthesized TFPB-BD/Fe 3 O 4 microspheres were characterized by transmission electron microscope, vibrating sample magnetometer, and thermogravimetric analysis, which showed that the material has strong magnetism and higher load capacity of COF. Under optimal conditions, the extraction equilibrium could be achieved within 9 min with detection limits of 0.17–1.48 μg L −1 ( S / N = 3) and a linear range of 5–1000 μg L −1 . The developed method was applied to the determination of trace triazole pesticides in apples, pears, and cabbages with recoveries from 81 to 117%. Graphical abstract
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Jidong Wang,Yating Zhang,Min Dong,Zhaopeng Liu,Binbin Guo,Haipeng Zhang,Liming Gao
Detecting and analyzing circulating tumor cells(CTCs) is significant for early diagnosis, management, and personalized treatment of tumors. Herein, a smart magnetic aptamer modified Fe 3 O 4 @ZIF-8 core/shell structured nanoparticle (NPs) was successfully constructed using for capture and simultaneous pH- and NIR-irradiation responsive release of CTCs. Taking MCF-7 as model CTCs, it could be captured ca. 60 % in low-concentration artificial blood by aptamer (SYL3C) on the surface of Fe 3 O 4 @ZIF-8 NPs. After magnetic separation, the ZIF-8 shell in aptamer-modified Fe 3 O 4 @ZIF-8 NPs carrying captured CTCs would disintegrate within 20 min under the synergistic effect of an acidic environment (pH=6.0) and NIR irradiation leading to the release of CTCs with high cell viability , which was benefited for the subsequent culture and analysis. This magnetic and core/shell structured device integrated high-efficiency capture, quick isolation and perfect release into one system, which showed great potential s for the detection of CTCs in the clinic.
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Materials
·
2023
·Vol. 16
·期 3
·1189
·
IF 3.4
Jing Wang,Ke Shan,Yanhua Tang,Na Wu,Nan Li
Magnetic cellulose/Fe3O4beads (CFBs) were fabricated by dispersing Fe3O4particles in a microcrystalline cellulose (MCC) matrix. The CFBs were characterized by X-ray diffraction (XRD), vibrating sample magnetometry (VSM), energy dispersive X-ray spectrometry (EDS), Brunauer–Emmett–Teller (BET) analysis and scanning electron microscopy (SEM). The adsorption behaviors of CFBs were studied by chlortetracycline hydrochloride (CTC) adsorption experiments. By means of adsorption kinetics and isotherms, the adsorption mechanisms were explored. The results show that quasi-spherical CFBs with a BET surface area as high as 119.63 m2/g were successfully tailored, with the high saturation magnetization (Ms > 40 emu/g) guaranteeing the magnetic separation of CFBs from wastewater. The process of adsorbing CTC onto CFBs involves monolayer chemical adsorption, and the maximum adsorption capacity for CTC estimated by the Langmuir model is 89.53 mg/g. The CFB product shows better adsorption performance in acidic solution than in basic solution.Keywords:magnetic cellulose/Fe3O4;adsorption;CTC;adsorption kinetics
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Wanling Cai,Wei Zhang,Zuliang Chen
Metal-organic frameworks (MOFs) have a high specific surface area and inherent biodegradability due to their unique structure and composition . As well, owing to the properties of nanomaterials and especially their magnetic features, Fe 3 O 4 nanoparticles and MOFs composite materials have great potential in the design and application of drug release. The present work: firstly, investigated norfloxacin loading in magnetic metal organic framework (Fe 3 O 4 @ZIF-8); and secondly, studied the release of norfloxacin and its antibacterial activity . Results showed the release efficiencies reached 97 % at 310 K after 84 h (pH 7.4). Drug release behavior was tested at various pH levels and it was found that Fe 3 O 4 @ZIF-8 has pH-sensitive properties. Furthermore, the release model calculation illustrated that the release process fitted well to the Bhaskar model. The magnetic properties of Fe 3 O 4 @ZIF-8 confirmed that the composite has potential application for a targeted drug delivery system. The mechanism of pH-responsive norfloxacin release was combined with diffusion , ion exchange and electrostatic repulsion. Furthermore, the antibacterial activities of Fe 3 O 4 @ZIF-8 and NOR-Fe 3 O 4 @ZIF-8 were tested against Escherichia coli . Results showed that Fe 3 O 4 @ZIF-8 had good biocompatibility while NOR-Fe 3 O 4 @ZIF-8 can deter or inhibit the actions of microorganisms .
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