Nature Communications
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2026
·
IF 18.1
Liu Han,Wu Baohu,Hou Lei,Wu Peiyi
Developing artificial muscles with simultaneous high actuation performance and mild activation conditions is highly needed but still challenging. Here we broke the limitations through a hierarchical structure design of a dual-stimuli-responsive shape memory polymer (SMP) network, achieved by integrating a double-tail quaternary ammonium surfactant with poly(acrylic acid) via ionic complexation. Notably, the double‑tail surfactant exhibits a phase transition around 42 °C, enabling the mild‑temperature‑triggered actuation. The SMP‑based artificial muscle features a hierarchically nanophase‑separated structure, consisting of water‑responsive hydrophilic PAA domains and thermally responsive hydrophobic PAA/surfactant complex crystalline domains, thus decoupling the actuation stress and strain by different stimuli. The nanostructured artificial muscle achieves an actuation stress of up to 6.4 MPa (isometric) and an actuation strain of up to 79% (load-free), both under heating to ~42 o C, surpassing most existing actuators. Furthermore, the system exhibits self-reversible, force-free cyclic actuation. Our work offers a viable route for multi-scale structural engineering toward high-performance soft actuators.
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Nature Water
·
2026
·
IF 30.7
Liu Fu,Hao Fengkun,Sun Mingzi,Wang Helin,Yao Ning,Wang Yunhao,Wang Juan,Chen Peng,Ma Xintao,Zhou Jingwen,Xiong Yuecheng,Ma Yangbo,Wang Guozhi,Guo Liang,Meng Xiang,Shao Mingzheng,Wang Chaohui,Wang Miao,Qian Fangren,Ye Chenliang,Xi Shibo,Huang Bolong,Fan Zhanxi
Phase control of alloy nanomaterials can modulate their atomic/electronic structures towards various electrocatalytic applications. However, the controlled synthesis of high-entropy nanoalloys (HENAs) with unconventional phase remains challenging. Here we report the one-pot synthesis of RhCuNiInSb HENAs with the unconventional 2H phase through regulating the nucleation/growth kinetics. Compared with the face-centred cubic phase counterpart, 2H RhCuNiInSb HENAs exhibit superior electrocatalytic nitrate reduction performance at low nitrate concentration. Ex/in situ studies reveal the accelerated deoxygenation/hydrogenation kinetics and distinct reaction pathway. Theoretical calculations demonstrate the electronic optimizations induced by the face-centred-cubic-to-2H phase transition, where the electronic redistribution and p – d elemental interactions improve the surface electroactivity. When operated in flow cell, 0.5 l of simulated wastewater can be efficiently converted into the value-added ammonia-derived product within 10 h. With a 20-h electrolysis, the NO 3 − -N concentration in real industrial and agricultural wastewater can be both reduced above the World Health Organization standard for drinking water.
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Foods
·
2026
·Vol. 15
·期 16
·2867
·
IF 6
Peipei Ma,Runrun Zhang,Chen Li,Qiao He,Xinhui Zhang,Zhixiang Cai
Staphylococcus aureus(S. aureus) is a prominent foodborne pathogen that poses a continuous threat to global public health and food safety due to its possession of a variety of toxins and its multidrug resistance. Medium-chain fatty acids (MCFAs), notably lauric acid (LA), exhibit strong antimicrobial properties, but their application is heavily constrained by poor water solubility. In this study, optimized LA emulsions stabilized by chitosan (CS) and polyvinyl alcohol (PVA) were evaluated for their antibacterial activity and detailed mode of action againstS. aureusATCC 6538. The antibacterial activities were evaluated by the maximum inhibition zone, with the 20 CS-PVA/DLTA-LA formulation exhibiting stable dispersion and potent antibacterial activity at 1%. The underlying antibacterial mechanisms againstS. aureuswere specifically focused on cell membranes and peptidoglycan. Therein, the binding of emulsion droplets to the anionic bacterial surface was driven by electrostatic attraction. Membrane degradation was also observed with membrane dysfunctions involving membrane depolarization, increased permeability, and fluidity reduction triggered by their subsequent insertion into the lipid bilayer, which may cause cell dysmetabolism, disintegration, and eventual cell death. Overall, these findings substantiate that LA emulsions disruptS. aureusby operating potentially multi-targeted effects involving cell membrane disruption and peptidoglycan interference, offering a promising alternative approach warranting further investigation for foodborne pathogen control.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Jingjing Zhang,Hui Cao,Bing Li,Fuying Wang,Qin Duan,Yaru Li,Jinjin Pei,Hui Wang,Juan Carlos Mejuto,Jesús Simal-Gándara,Haolin Zhang
Heterocyclic amines (HCAs) are carcinogenic contaminants formed during meat thermal processing, and the traditionally recognized inhibitory effects of flavonoids on HCA formation remain controversial. Dihydromyricetin (DMY) and baicalein (BAI) both exhibited dose-dependent bidirectional effects on PhIP formation in a PhIP chemical model. At low concentrations (DMY 125–250 μM, BAI 125–1000 μM), PhIP levels gradually increased to nearly 210% and 300% of control, respectively, mainly driven by amination-related reactions of flavonoid thermal degradation products that promoted phenylacetaldehyde accumulation. At high concentrations (≥2000 μM), PhIP was suppressed to <50% (DMY) and <20% (BAI) of control via potent radical scavenging and phenylacetaldehyde trapping. The bidirectional regulation may be governed by a dynamic balance between amination-driven promotion and the dual inhibitory pathways for PhIP formation. This study explains how flavonoids lead to contradictory effects on HCA formation in cooked meat and provides a mechanistic foundation for their application.
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Yuting Zhang,Jia He,Shanshan Zhang,Qi Lin,Jieping Cao,Zhenping Liu,Huikai Shao,Jinxian Huang
A thiolated graphene/AuNPs nanointerface was constructed to enhance electron transfer. • An electropolymerized EMIP layer enabled selective epitope-based recognition of AFP. • A sensitive epitope-imprinted electrochemical biosensor was developed for AFP analysis. • The sensor exhibited a wide linear range (0.001–100.0 ng mL −1 ) and a low LOD of 0.069 pg mL −1 . • The biosensor enabled reliable AFP determination in spiked human plasma samples. Alpha-fetoprotein (AFP) is a clinically important serum biomarker for the early diagnosis of hepatocellular carcinoma. However, conventional AFP detection methods often suffer from limited sensitivity, selectivity and operational complexity. In this work, an electrochemical biosensor based on an epitope molecularly imprinted polymer (EMIP) was developed for the sensitive and selective determination of AFP. The sensing interface was constructed by electropolymerization of o -phenylenediamine ( o -PD) on a gold electrode sequentially modified with thiolated graphene (G–SH) and gold nanoparticles (AuNPs), using the AFP C-terminal dodecapeptide (KLISKTRAALGV) as the epitope template. The excellent analytical performance of the biosensor can be attributed to the synergistic integration of the EMIP recognition layer, G–SH, and AuNPs, which provide highly selective molecular recognition, an enlarged electroactive surface area and accelerated interfacial electron transfer. Under the optimized conditions, the proposed biosensor exhibited a wide linear range of 0.001–100.0 ng mL −1 , and a low detection limit of 0.069 pg mL −1 , together with excellent selectivity against NMP22, bovine serum albumin (BSA), human serum albumin (HSA), and neuron-specific enolase (NSE), good reproducibility, and satisfactory storage stability. Satisfactory recoveries obtained in spiked human plasma samples demonstrated its potential applicability for AFP determination in complex biological matrices. This work provides a sensitive and robust platform for AFP determination and highlights the potential of epitope-imprinted electrochemical biosensors for hepatocellular carcinoma screening and clinical biomarker monitoring. An epitope-imprinted electrochemical biosensor integrating an electropolymerized EMIP film with a thiolated graphene/AuNPs nanointerface was developed for AFP detection. The biosensor combines highly selective molecular recognition with enhanced electron transfer, achieving a 0.069 pg mL −1 detection limit and successful analysis of spiked human plasma samples. Download: Download high-res image (303KB) Download: Download full-size image
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Peng Luo,Yang-Biao Xue,Wu Bin,Lin-Feng Gu,Hai-Tao Jiang,Mei-kun Ke,Yi-Fei Xu,Zuo-Shan Wang,Min Zheng
The rapid expansion of wearable and portable electronics has driven increasing demand for fiber-based moisture electricity generators (FMEGs) capable of operating under ambient conditions. However, achieving efficient ion generation, directional transport, and charge separation simultaneously in fibrous architectures remains challenging due to the absence of coordinated structural design. Here, a hierarchical FMEG is constructed by integrating a bilayer hygroscopic hydrogel with vertically aligned zeolitic imidazolate framework-L (ZIF-L) nanosheet arrays via in situ growth and cyclic freeze-thaw assembly. The bilayer hydrogel establishes coupled water and proton concentration gradients to provide a sustained driving force for ion migration, while the ZIF-L nanosheet channels enable selective ion transport and improve interfacial charge regulation. Benefiting from this synergistic architecture, the device delivers an open-circuit voltage of ∼0.9 V and a power density of 82.3 µW cm −2 , while maintaining stable operation over 90 h under ambient conditions. Furthermore, the device can be woven into textiles to power electronic devices and enable self-powered finger motion encoding and respiration monitoring. This work provides a generalizable structural paradigm for constructing high-performance FMEGs for wearable energy harvesting and sensing systems.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Sijia Zheng,Huige Ren,Yingying Zhou,Xing Yu,Wenrui Zheng,Jianfeng Zhang,Lingqi Huang,Zhihai Cao
Pressure-sensitive sensors that can respond to tiny signals are key to various medical and healthcare monitoring applications. Developing wearable sensors that combine high sensitivity in real time, flexibility, and biological and environmental safety is challenging. In this paper, a biomass-based conductive silicone elastomer is designed via ultraviolet curing. The deep eutectic solvents are well dispersed within the silicone matrix via hydrogen bonding to ɑ-lipoic acid moieties within the network. Along with the bottlebrush topology of the network, the engineered material exhibits ultra-softness (Young's modulus 159 kPa), excellent rebound, and fatigue resistance under repeated high strains. Meanwhile, the engineered sensor shows outstanding electrical sensitivity to deformation in the range of 0–20 kPa. These features enable precise, real-time monitoring of subtle signals, including respiration, abdominal and chest movements, wrist pulse, and facial expressions. The green conductive silicone elastomer shows great potential in the development of portable Polysomnography and other high-end wearable devices in the future.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
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IF 5.2
Yuling Wang,Jingru Li,Epiphane K. Silli,Fan Tang,Shujing Ren,Wei Liu,Huixia Lv
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation, oxidative stress, and epidermal barrier dysfunction. Current therapies often provide incomplete long-term control and may cause adverse effects. Baicalin (BAI), a natural flavonoid with potent anti-inflammatory and antioxidant activities, is a promising candidate for AD treatment; however, its topical application is limited by poor solubility, weak skin penetration, and insufficient retention. To address these challenges, we developed a hyaluronic acid-baicalin conjugate (HA-BAI) that combines enhanced aqueous dispersibility with CD44-associated targeting and intrinsic barrier-supportive properties. HA-BAI exhibited excellent aqueous dispersibility (>220 mg/mL) across different formulation media, whereas free BAI remained poorly soluble (∼0.05 mg/mL). In vitro , HA-BAI exhibited excellent cytocompatibility, suppressed nitric oxide and pro-inflammatory cytokines, enhanced IL-10 expression, and promoted barrier-related proteins in keratinocytes. Ex vivo permeation studies demonstrated enhanced skin accumulation and prolonged retention, with 3.28-fold greater skin-associated fluorescence than the free fluorescent probe at 12 h. In a DNFB-induced AD mouse model, HA-BAI markedly alleviated dermatitis severity, reduced splenomegaly, improved histopathological features, and restored epidermal barrier homeostasis, showing superior therapeutic performance compared with the dose-normalized HA and BAI physical mixture. Collectively, HA-BAI represents a bioactive macromolecular platform that integrates targeted delivery with intrinsic therapeutic functionality for localized treatment of AD. Download: Download high-res image (409KB) Download: Download full-size image
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FASEB JOURNAL
·
2026
·Vol. 40
·期 16
·e72219
·
IF 4.3
Lingyu Zhang,Lina Cai,Yashi Cai,Weiyi Ke,Linqian Zhou,Xiaoman Zhou,Ran Ran,Xudong Wang,Yuhua Yang,Weixu Huang,Jianming Zou,Huifeng Chen
Fractionated low dose ionizing radiation (LDIR) can induce various biological effects, which are key potential triggers for the development of radiation‐induced lung injury (RILI). This study aims to investigate the effects of fractionated LDIR on early‐stage cellular senescence, as well as on the levels of oxidation‐antioxidation and DNA damage repair, in mouse lung tissue. C57BL/6J mice were exposed to fractionated LDIR, and subsequent assays were performed to evaluate the biological effects. Compared with the control group, mice in all dose groups showed the following changes: varying degrees of pathological alterations in lung tissue; elevated SA‐β‐Gal activity and upregulated expression of senescence‐related genes in lung tissue; increased serum levels of urea, blood glucose (BG), and triglycerides (TG), along with reduced high‐density lipoprotein cholesterol (HDL‐C) levels; increased levels of oxidative damage markers in lung tissue, accompanied by elevated total antioxidant capacity (T‐AOC) and superoxide dismutase (SOD) activity, but decreased reduced glutathione (GSH) levels; upregulated expression of nuclear factor erythroid 2‐related factor 2 ( Nrf2 ) and its downstream genes; and increased DNA damage markers in lung tissue, as well as elevated mRNA and protein levels of the DNA repair gene O6‐methylguanine‐DNA methyltransferase ( MGMT ). The oxidative damage and DNA damage potentially induced by fractionated LDIR exceeded the compensatory capacity of the repair systems, probably leading to a dual dynamic imbalance in both oxidation‐antioxidation and DNA damage repair. These may contribute to the progression of cellular senescence in lung tissue and the initiation of early‐stage RILI. Fractionated LDIR‐induced oxidative and DNA damage may have exceeded the compensatory capacity of the endogenous defense systems, giving rise to a dual dynamic imbalance in both oxidation‐antioxidation and DNA damage repair pathways. Such dual homeostatic imbalance is likely to facilitate the progression of cellular senescence within lung tissue and the initiation of early‐stage RILI.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Ke Yujiang,Huang Lemei,Che Chaohui,Chen Yihui,Zhan Junyong,Wu Kui
The solubility of 8-Hydroxyquinoline (8-HQ) was investigated
in
16 pure solvents, including eight alcohols (methanol, ethanol, n -propanol, isopropanol, n -butanol, isobutanol, n -pentanol, isopentanol), four ketones (2-butanone, 2-pentanone,
cyclopentanone, cyclohexanone), three esters (ethyl formate, methyl
acetate, ethyl acetate) and acetonitrile. The stability of the crystalline
form during dissolution was confirmed by X-ray powder diffraction
(XRPD), and the melting properties were characterized via differential
scanning calorimetry (DSC). Five thermodynamic models, namely the
modified Apelblat equation, the λ h model, the
nonrandom two-liquid (NRTL) model, the Wilson model, and the Yaws
model, were employed to correlate the experimental solubility data.
The fitting performance of each model was assessed using the coefficient
of determination ( R 2 ), relative average
deviation (RAD), and root-mean-square deviation (RMSD). The results
demonstrate that the molar solubility of 8-HQ increases monotonically
with temperature, and all five models provide satisfactory correlation
of the experimental data. Furthermore, mixing thermodynamic properties
(Gibbs free energy, enthalpy, and entropy) calculated from Wilson
model parameters reveal that mixing between 8-HQ and every solvent
is spontaneous and entropy-driven. This work provides a comprehensive
solubility database for 8-HQ, offering essential thermodynamic evidence
and model support for the design of high-yield crystallization processes.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Chuansen Qin,Huan Lu,Yichen Jia,Shuisheng Cao,Hongyan Wang,Haixiang Wang
Background Citri Reticulatae Pericarpium (CRP) authentication and flavonoid-related quality evaluation commonly rely on chromatographic or spectroscopic techniques, which are accurate but require specialized instrumentation. This study aims to develop a standardized colorimetric image-based machine-learning workflow for rapid CRP origin-aging classification and flavonoid-equivalent prediction. Results Representative flavonoid monomers were used to compare chromogenic responses in aluminum chloride and sodium nitrite-aluminum nitrate systems. CRP samples were analyzed using standardized image acquisition, color reference normalization, fixed ROI extraction, engineered RGB descriptors, and inverse sRGB gamma correction for regression modeling. For CRP classification, a 480-record model-development set and a 120-record independent held-out validation set were constructed at the image-group level. Through the two chromogenic systems, RF classifier achieved held-out accuracies of 0.9500, 0.9917, and 0.9500 for geographical-origin, aging-year, and combined origin-aging classification, respectively. For flavonoid-equivalent prediction, gamma correction improved the RF external validation R 2 from 0.9502 to 0.9789 and reduced the external RMSE from 5.4186 to 3.5231. Spike-recovery values were 104.27 % ± 8.94 %, 102.07 % ± 6.36 %, and 96.74 % ± 6.45 % at the 200, 400, and 800 μg/mL addition levels, respectively. Significance The proposed workflow integrates chromogenic reaction, standardized image acquisition, color feature extraction, gamma correction, and machine learning into a low-cost analytical strategy for CRP authentication. The results indicate that the method can serve as a useful tool for rapid and efficient quality evaluation for CRP.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Wanqiu Chen,Fei Cheng,Jinghong Qiu,Zongliang Du,Xu Cheng,Haibo Wang,Xiaosheng Du
Tri-domain architecture perfectly decouples water paths from hydrophobic PCM. • Hydrogel interface ensures rapid capillary flow and a 4.5 kg·m −2 ·h −1 vapor rate. • Confined n -eicosane actively buffers thermal energy for all-weather evaporation. • In-situ grown ZnO nanoparticles deliver ∼99% broad-spectrum antibacterial rates. Interfacial solar evaporation is a promising strategy for sustainable desalination, yet its practical deployment is restricted by solar intermittency, phase-change material (PCM) hydrophobicity, and biological fouling. To address these challenges, a bioinspired, spatially decoupled tri-domain phase-change evaporator was developed. A delignified and carbonized wood scaffold was employed to confine an n -eicosane PCM core with a phase-change enthalpy of 168.2 J/g, while its aligned microchannels supported photothermal conversion and directional transport. A polydopamine/sodium alginate hydrogel skin was further integrated to reconstruct a highly wettable interface, decreasing the water contact angle from 96.9° to 19.2° and functionally separating the interfacial water-supply pathway from the internal hydrophobic thermal-storage domain. In addition, in situ grown ZnO nanoparticles provided antibacterial functionality, enabling approximately 99% inactivation of both E. coli and S. aureus in the final hydrogel-coated evaporator. The optimized PH@ZH-PCM exhibited thermal conductivities of 0.43 and 0.46 W m −1 K −1 in the dry and wet states, respectively, and achieved a peak 5-min-interval apparent evaporation rate of approximately 2.8 kg m −2 h −1 under 1 sun irradiation. Outdoor day-to-night and illumination–dark experiments further demonstrated its adaptability to fluctuating solar irradiation and post-illumination thermal-buffering capability. Moreover, the evaporator maintained continuous evaporation in NaCl solutions with concentrations of up to 20 wt%, exhibited reversible surface salt deposition and cleaning recovery, and produced freshwater with a Zn concentration of only 0.0080 mg L −1 . This spatially decoupled architecture provides a promising platform for efficient outdoor day-to-night solar desalination under variable environmental conditions. Download: Download high-res image (166KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）