ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 42
·62994-63004
·
IF 5.19
Lu Yuanyuan,Liu Xuna,Miao Yanjun,Chatzisymeon Efthalia,Pang Lina,Qi Luqing,Yang Ping,Lu Hongyan
Roles of bulk-, micron-, and nano-copper oxide (CuO) on methane production, microbial diversity, functions during thermophilic anaerobic digestion (AD) were investigated in this study. Results showed that bulk-, micron-, and nano-CuO promoted methane production by 27.8%, 47.6%. and 83.1% compared to the control group, respectively. Microbial community analysis demonstrated that different particle sizes could cause various shifts on bacteria community, while had little effect on archaeal diversity. Thereinto, bacteria belonging to phylum Firmicutes and Coprothermobacterota dominated in enhanced hydrolysis process in groups with nano-CuO and bulk-CuO, respectively, while micron-CuO had stronger promotion on the abundances of hydrolytic and fermentative bacteria belonging to families Peptostreptococcaceae, Caloramatoraceae, Erysipelotrichaceae, and Clostridiaceae, than other two CuO sizes. Metabolic pathways revealed that energy-related metabolism and material transformation in bacteria were only boosted by micron-CuO, and nano-CuO and bulk-CuO were important to methanogenic activity, stimulating energy consumption and methane metabolism, respectively.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Xiaoxuan Ji,Ying Bao,Zhen Zhang,Yujing Huang,Haibing He,Guoqing Zhang,Hongfei Liu
Poloxamer-based in situ gels face limitations in ocular drug delivery due to weak mucoadhesion and low mechanical strength. Herein, we developed an amino-functionalized poloxamer-hyaluronate graft copolymer (Am-P407-HA) to overcome these challenges. Comprehensive characterizations confirmed successful synthesis of copolymer, which interacted with mucin to enhance the mucoadhesion of poloxamer. Using timolol maleate (TM) as a model drug, an ophthalmic in situ gel (TM@Am-P407-HA) was developed. The thermosensitive gel demonstrated sustained release properties (93.07 % cumulative release over 10 h) following Fickian diffusion kinetics. In vivo fluorescence tracking indicated that the TM@Am-P407-HA prolonged the TM residence time on the ocular surface. Pharmacokinetic study of TM@Am-P407-HA revealed 4.46-fold and 2.29-fold increases in AUC 0-t for tear fluid and aqueous humor, respectively, along with 3.30-fold and 2.34-fold prolongations in residence times compared to conventional eye drops. Ocular hypertension models showed TM@Am-P407-HA provided smoother pressure reduction curve with a prolonged duration of efficacy. Moreover, biosafety evaluations confirmed excellent biocompatibility of TM@Am-P407-HA through cytotoxicity, Draize irritation, and histopathological studies. This novel graft copolymer system represents a significant advancement in ocular drug delivery, offering enhanced bioavailability and reduced dosing frequency for glaucoma therapy
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Materials Today Nano
·
2025
·
IF 8.2
Yanan Zhang,Yijia Wang,Yujie Gao,Yangxi Cheng,Danfeng Jian,Yifan Sun,Xiaotong He,Dan Yu,Jindan Wu
Personal protective equipment (PPE) can significantly reduce the negative impact of emerging infectious diseases caused by pathogenic bacteria on public health and the global economy. However, conventional PPE without self-disinfection properties cannot kill the attached microorganisms efficiently, and may cause cross-contamination and environmental damage. Herein, an efficient aggregation-induced emission photosensitizer (AIE PS), ( E )-2-(3-cyano-5,5-dimethyl- 4-(4-(1,2,2-triphenylvinyl)-styryl)furan-2(5H)-ylidene)malononitrile (TPE-TCF), was in-situ packaged within hollow nanospheres of zeolitic imidazolate framework-8 (ZIF-8) by the assistance of sodium dodecyl sulfate (SDS), to prepare TPE-TCF/SDS@ZIF-8 nanoparticles (NPs). These NPs exhibited both high reactive oxygen species (ROS) production efficiency and good stability. Then, they were assembled onto a polyacrylonitrile/polyvinyl-pyrrolidone (PPP) electrospun nanofiber mats to form composite nanofiber mats TZ-PPP via a visible light-induced dopamine (DA)-assisted co-deposition method. The electrospun nanofiber mats serve as an efficient antibacterial nano-platform, providing more adsorption sites for the composite NPs, enabling the exposed composite NPs to interact with oxygen sufficiently, and maximizing their antibacterial efficacy substantially. Importantly, the TZ-PPP composite nanofiber mats retained the initial ultra-high ROS production efficiency and superior antibacterial performance of TPE-TCF/SDS@ZIF-8 NPs. Under the irradiation of low-power white light (400-830 nm, 50 mW cm -2 ), TZ-PPP nanofiber mats were able to remove more than 99.9% (10 min) and 99.0% (40 min) of bacteria and fungi, respectively, with significant photodynamic inactivation of microorganisms. This study is an exploration of the combination of AIE PS with nanofibers, whose outstanding photodynamic antibacterial properties provide new perspectives for the development of novel medical protective materials.
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Nature Communications
·
2025
·Vol. 16
·期 1
·7484
·
IF 15.7
Xie Liangjun,Tong Haoyang,Peng Guyang,Wu Hao,Shi Wenjing,Yu Kuai,Hu Jinsuo,Jiao Lei,Dong Xingyan,Guo Fengkai,Cai Wei,Zhang Yang,Wu Haijun,Liu Zihang,Sui Jiehe
Carrier mobility has conventionally been manipulated to enhance thermoelectric performance by reducing crystal defects. Therefore, an effective strategy for optimizing carrier mobility is highly desired for nanostructured materials. In this work, InSb nanoprecipitates are formed in situ within the nanostructured MgAgSb matrix, serving as channels for accelerating charge carriers. A high carrier mobility of 93.1 cm 2 V -1 s -1 is achieved in MgAg 0.97 Sb 0.99 -0.02InSb composite at 300 K, resulting in an average power factor of 23.8 μW cm -1 K -2 from 300 K to 553 K. To address the efficiency degradation caused by the narrow operational temperature range of MgAgSb, a two-pair segmented thermoelectric module is developed. A high conversion efficiency of 12.4% is achieved under a cold-side temperature of ~293 K and a temperature difference of ~540 K, presenting an effective strategy for carrier mobility optimization and opening new avenues for medium-temperature waste heat harvesting using MgAgSb.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yunlong Hu,Zhongjun He,Wenyan Zhong,Sanqi Yang,Zhiguo Wang,Zhenggang Rao,Longlong Shu
In this study, garnet-structured Mg 3 Yb 2 Ge 3 O 12 ceramics were synthesized via conventional solid-state reaction. Ceramics sintered at 1430 °C achieved high relative densities (∼98 %) and superior microwave dielectric properties: ε ᵣ = 13.7 ± 0.2, Q × f = 11,424 ± 500 GHz, and a rare positive τ f = +71.6 ± 0.7 ppm/°C. To modulate τ f , inverse-to-normal garnet phase transformation was achieved using a compositional tuning strategy, which led to the formation of a series of Ca x Mg 3- x Yb 2 Ge 3 O 12 . Rietveld refinement of X-ray diffraction patterns confirmed a low-angle shift with increasing x , indicating progressive lattice expansion and unit-cell volume enlargement. With increasing Ca²⁺ content, τ f transitioned from positive to negative values, approaching zero near x = 0.5, while the overall dielectric performance was enhanced. This strategy provides new pathways for τ f control in A₃B₂C₃O₁₂-structured ceramics.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Hailin Yu,Huili Zhang,Chunlong Sun,Wen Yuan,Hongliang Li,Wei Jiang,Long Dong,Yingjun Wang,Hongsheng Liu
The complexity of oily sewage from oilfields has risen with the advancement of polymer flooding technology, thereby increasing the treatment challenge. In this study, a composite coagulant, PVPAM-PPFS, was proposed, inspired by octopus tentacles, with PVP as the backbone. FTIR , 1 H NMR and Rg radius of gyration were used to characterize the functional groups and conformation of PVPAM-PPFS in aqueous environments. The composite coagulant exhibits facile dispersion in water. Upon hydrolysis of PVPAM-PPFS, numerous molecular chains resembling octopus tentacles are formed and confirmed through Atomic Force Microscopy (AFM). When applied to oily sewage in oilfields, PVPAM-PPFS demonstrates enhanced interaction with emulsified oil layers, capturing colloidal particles in water and thereby facilitating efficient separation of oil, water, and flocs. Lastly, the mechanism of PVPAM-PPFS was analyzed through a combination of coagulation experiments and detection of floc morphology. PVPAM-PPFS will better interact with colloidal particles in water through increased charge neutralization, bridging adsorption, and sweeping capabilities. Significantly, an enhanced crude oil recovery rate is observed from the recovered oil droplets following the disruption of the emulsion layer.
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Current Nanoscience
·
2024
·Vol. 20
·期 2
·264-271
·
IF 1.4
Zhang Yu,Zhang Ping
Background: In this study, ampicillin sodium fluorescent carbon quantum dots were prepared by one-step hydrothermal method with ampicillin sodium as the carbon source and urea as the nitrogen source. Methods: The structure of CQDs were characterized by UV-Vis and fluorescence spectrophotometer.
The pH, reaction time and ionic strength of phenol detected by N-CQDs were optimized. The optimum experimental conditions were 40 μL ampicillin sodium N-CQDs, 2 mL buffer solution with pH 8.0, and the reaction time was 6 min. Results: Through the detection of fluorescence spectrophotometry,
p-nitrophenol had obvious fluorescence quenching phenomenon on ampicillin sodium N-CQDs, and the detection limit was 75 nM. It was used in the standard addition experiment of actual samples, and the recovery rates were more than 85%. Conclusion: Therefore, the N-CQDs could
be used as fluorescent probe to analyze the content of p-nitrophenol in the actual environment.
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JOURNAL OF SOILS AND SEDIMENTS
·
2020
·Vol. 21
·期 1
·215-234
·
IF 2.763
Wei Liang,Ding Qian,Guo Huaming,Xiu Wei,Guo Zhengcai
Purpose Heavy metal/metalloid pollution in sewage-irrigated soils (SIS) is one of the major environmental issues in China. Mobility of heavy metals/metalloids in the contaminated soils and their potential threats to groundwater are needed to be understood. This study investigated impacts of organic matter, solution pH, and water level on forms and migration of heavy metals/metalloids (As, Cr, Cu, Pb, and Cd) in the contaminated soils from a typical sewage-irrigated area in the North China Plain (NCP). Materials and methods Based on extensive field measurements, two sewage-irrigated sites and a non-sewage-irrigated site were selected in the study area. Soil samples were collected every 10 cm in a profile (no more than 1 m) from each site. The release and mobility of heavy metals/metalloids in the SIS were investigated using column experiments with two leaching stages (stage I: low water level; stage II: high water level). Deionized water, synthesized acid rain, and poultry manure extractant were used as influents for different columns to stimulate leaching of rainfall, acid rain, and compost leachate, respectively. Soil samples before and after leaching were subjected to sequential extraction for 7 target phases, evaluating the impacts of three leaching conditions on forms of heavy metals/metalloids in soils at different depths. Results and discussion Results revealed that more As and Cu were mobilized in the column with a compost leachate as the influent than the columns with organic matter-free influents, resulting from reductive dissolution, complexation, and desorption. Cr and Pb concentrations were higher in effluents from the column with low pH influent (acid rain) than those from near-neutral pH influents (rainfall and compost leachate). Proton-promoted desorption and dissolution of very amorphous Fe oxides was the major cause for mobilized Cr and Pb in porewater. Moreover, decrease in dissolved oxygen (DO) was observed with the increase in water level in the column, triggering microbial respiration of Fe/Mn oxide reductions in the presence of bioactive dissolved organic matter, which elevated concentrations of porewater heavy metals/metalloids. Conclusions This study suggested that sewage irrigation significantly increased heavy metal/metalloid contents associated with labile and bioavailable fractions in the SIS, and both the compost leachate and low pH solution should enhance the mobility of heavy metals/metalloids in the SIS and potentially contaminate groundwater.
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Autophagy
·
2024
·
IF 14.6
Tian Zhang,Ke-Gang Linghu,Jia Tan,Mingming Wang,Diao Chen,Yan Shen,Junchao Wu,Mingjun Shi,Yuxia Zhou,Lei Tang,Lirong Liu,Zheng-Hong Qin,Bing Guo
Obesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis inhibitor, whether it plays a role in the metabolism of lipids is unknown. Here, we found that TIGAR transgenic (TIGAR+/+) mice exhibited increased fat mass and trended to obesity phenotype. Non-target metabolomics showed that TIGAR caused the dysregulation of the metabolism profile. The quantitative transcriptome sequencing identified an increased levels of LRRK2 and RAB7B in the adipose tissue of TIGAR+/+ mice. It was confirmed in vitro that TIGAR overexpression increased the levels of LRRK2 by inhibiting polyubiquitination degradation, thereby suppressing macroautophagy and chaperone-mediated autophagy (CMA) while increasing lipid accumulation which were reversed by the LRRK2 inhibitor DNL201. Furthermore, TIGAR drove LRRK2 to interact with RAB7B for suppressing lysosomal degradation of lipid droplets, while the increased lipid droplets in adipocytes were blocked by the RAB7B inhibitor ML282. Additionally, fat-specific TIGAR knockdown of TIGAR+/+ mice alleviated the symptoms of obesity, and adipose tissues-targeting superiority DNL201 nano-emulsion counteracted the obesity phenotype in TIGAR+/+ mice. In summary, the current results indicated that TIGAR performed a vital function in the lipid metabolism through LRRK2-mediated negative regulation of macroautophagy and CMA in adipocyte. The findings suggest that TIGAR has the potential to serve as a viable therapeutic target for treating obesity and its associated metabolic dysfunction.
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CHEMISTRY & BIODIVERSITY
·
2023
·Vol. 20
·期 5
·e202201190
·
IF 2.9
Busra Dincer,Ahmet Bulent Yazici,Irfan Cinar,Erdem Toktay,Jale Selli,Elif Cadirci,Zafer Bayraktutan,Esra Yazici
The pathophysiological mechanism behind the link between antipsychotic drugs and sexual dysfunction is still unknown. The goal of this research is to compare the potential effects of antipsychotics on the male reproductive system. Fifty rats were randomly assigned into the five groups indicated: Control, Haloperidol, Risperidone, Quetiapine and Aripiprazole. Sperm parameters were significantly impaired in all antipsychotics-treated groups. Haloperidol and Risperidone significantly decreased the level of testosterone. All antipsychotics had significantly reduced inhibin B level. A significant reduction was observed in SOD activity in all antipsychotics-treated groups. While GSH levels diminished, MDA levels were rising in the Haloperidol and Risperidone groups. Also, the GSH level was significantly elevated in the Quetiapine and Aripiprazole groups. By causing oxidative stress and altering hormone levels, Haloperidol and Risperidone are damaging to male reproductivity. This study represents useful starting point for exploring further aspects of the underlying mechanisms reproductive toxicity of antipsychotics. Graphical
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RSC Advances
·
2016
·Vol. 6
·期 21
·16941-16951
·
IF 3.289
Chang Su,Guang-Ming Zeng,Ji-Lai Gong,Chun-Ping Yang,Jia Wan,Liang Hu,Shan-Shan Hua,Yan-Yan Guo
Manufactured in numerous factories, and contained in various consumer products, carbon nanotubes (CNTs) and sulfonamide antibiotics (SAs) may be released into the environment by many pathways. The sorption behavior of CNTs on SAs may increase the environmental and health risks when exposed to SAs–CNTs composites. In this study, we investigated the mobility of SAs in sediment columns in the presence/absence of CNTs. Three kinds of SAs (sulfamethoxazole, sulfapyridine, and sulfadiazine) and two kinds of CNTs (multi-walled carbon nanotubes, MWCNTs and single-walled carbon nanotubes, SWCNTs) in sediments from the Xiangjiang River were investigated in this study. The results showed that the SAs were of high mobility in sediment columns. However, CNTs with a concentration of 4.8 mg g−1 in the sediment could dramatically retain SAs, which might be due to the limited transport of CNTs and their high adsorption capacities of SAs. The percentage of SAs retention in sediment became higher when CNTs existed in the inflow, suggesting that a strong CNTs-associated SAs reaction might occur in the sediment. The findings in this study indicated that CNTs in the sediment environment or river system can reduce the mobility of SAs, which should be taken into account when evaluating the potential environmental risks of SAs and CNTs.
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RSC Advances
·
2016
·Vol. 6
·期 72
·68371-68378
·
IF 3.289
Zhen Liu,Shaojie Han,Chong Xu,Yuwen Luo,Na Peng,Chenyang Qin,Mingjiong Zhou,Wenqin Wang,Liwei Chen,Shigeto Okada
A novel polymer binder, synthesized via in situ thermal cross-linking of water-soluble polyvinyl alcohol (PVA) and poly(ethylene imine) (PEI) precursor, is applied as a functional network binder to enhance the electrochemical performance of a silicon anode. The Si anode with PVA–PEI binder exhibits high specific capacity (3072.9 mA h g−1) in the initial cycle, high initial coulombic efficiency of 83.8% and excellent long-term cycling stability (1063.1 mA h g−1 after 300 cycles). Furthermore, the Si anode containing PVA–PEI binder also exhibits excellent rate performance, reaching a high specific capacity of 1590 mA h g−1 even at high current density of 10 A g−1. These outstanding electrochemical properties are ascribed to the reversibly-deformable polymer network and the binder's strong adhesion to the silicon particles. This low-cost and eco-friendly polymer binder has great potential to be used for silicon anodes in next generation Li-ion batteries.
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