Food & Function
·
2023
·
IF 6.1
Zouyan HE,Hanyue Zhu,Jianhui Liu,Erika Kwek,Ka Ying Ma,Zhen-Yu Chen
Trimethylamine-N-oxide (TMAO), originating from dietary trimethylamine-containing nutrients such as choline, has been recognized as a risk factor for atherosclerosis. Mangiferin is a bioactive xanthone initially extracted from mango (Mangifera indica). The present study aimed to investigate the effect of mangiferin on TMAO-induced atherogenesis in mice fed a high-choline diet. Female ApoE-/- mice were randomly divided into three groups and fed either a control diet, a high-choline diet with 1% free choline, or an experimental diet with 1% free choline plus 0.5% mangiferin for 15 weeks. Our results showed that a high-choline diet elevated plasma TMAO level, accelerated atherogenesis, promoted cholesterol accumulation, and reduced the generation of short-chain fatty acids (SCFAs) by gut microbes. Mangiferin alleviated inflammation, and lowered plasma total cholesterol level by facilitating the elimination of neutral and acidic sterols in feces, resulting in a 16.7-29.0% reduction in aortic atherosclerotic lesions. Notably, mangiferin could favorably remodel the composition of gut microbiota by fostering the growth of the beneficial taxa Akkermansia, Parabacteroides, and Bifidobacteriaceae, while reducing the relative abundance of the pathogenic genus Helicobacter. This modulation led to a decrease in plasma lipopolysaccharide level, enhanced production of total SCFAs by gut microbes, and reduced susceptibility to atherosclerosis. In conclusion, mangiferin exhibited its ability to alleviate TMAO-induced atherosclerosis through its anti-inflammatory, cholesterol-lowering, and gut microbial modulatory activities.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Hai Liang,Jianjiang Wang,Wanting Wang,Yingli Wang,Xinzhong Deng,Zhishuang Xue,Yang Sun,Gaohong He,Xuehua Ruan
Developing efficient biochar (BC) adsorbent for pollution removal has been a long-term exploration. However, the negative charge surface of pristine BC seriously impedes the transfer of anionic dye through the pore of BC and results in low adsorption capacity. Herein, N-doping enriched porous MgO-modified biochar (MBC) was successfully prepared through a facile nitrate activation method for anionic acid fuchsin (AF) removal. The N-doped group of secondary amine in MBC changes the surface charge of BC and facilitate the AF adsorption onto MgO . The as-prepared MBC exhibited superior adsorption capacity of 328 mg⋅g −1 . The adsorption process was well aligned with the Freundlich and pseudo-second-order kinetics models indicating a hybrid physicochemical adsorption mechanism. Further mechanism investigation indicates that N-doped group, MgO and functional groups in biochar matrix primarily contribute to AF adsorption. The mechanism includes: electrostatic attraction, π-π interaction, hydrogen bonding and pore filling. This research provides an environmentally friendly nitrate activation strategy for BC, which overcomes the inherent defects of BC in negative charge surface and provides a facile way of biomass valorization for pollution removal from the aquatic environment.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Na Huang,Ning Zhao,Ce Zhang,Chunhao Li,Xia Wei,Yang Zhang,Yongsheng Bao,Shuai Wang
Based on the goal to improve the humidity index of the microenvironment and enhancing human comfort, this study used electrospinning to prepare several photoresponsive films with reversible regulation of wettability and microenvironmental humidity from copolymers of acrylated spiropyran (SPA), N-isopropylacrylamide (NIPAm), and methyl methacrylate (MMA). According to the photoisomerization mechanism of spiropyran, the simple ultraviolet (UV)–visible light (vis) reversible light radiation change makes the spiropyran unit switch between the polar ring-opened form and the nonpolar ring-closed form. Utilizing this transition can easily regulate the wettability of the film surface and microenvironmental humidity. The experimental results show that poly(SPA1-co-NIPAm2-co-MMA8) nanowire film has the best ability to regulate wettability and humidity; the wettability can vary within a range of 13° and the microenvironmental humidity up to 7.2%.
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Materials
·
2023
·Vol. 16
·期 15
·5478
·
IF 3.4
Yaohui Xu,Liangjuan Gao,Pingkeng Wu,Zhao Ding
A cubic fluorite-type CeO2with mesoporous multilayered morphology was synthesized by the solvothermal method followed by calcination in air, and its oxygen storage capacity (OSC) was quantified by the amount of O2consumption per gram of CeO2based on hydrogen temperature programmed reduction (H2–TPR) measurements. Doping CeO2with ytterbium (Yb) and nitrogen (N) ions proved to be an effective route to improving its OSC in this work. The OSC of undoped CeO2was 0.115 mmol O2/g and reached as high as 0.222 mmol O2/g upon the addition of 5 mol.% Yb(NO3)3∙5H2O, further enhanced to 0.274 mmol O2/g with the introduction of 20 mol.% triethanolamine. Both the introductions of Yb cations and N anions into the CeO2lattice were conducive to the formation of more non-stoichiometric oxygen vacancy (VO) defects and reducible–reoxidizable Cen+ions. To determine the structure performance relationships, the partial least squares method was employed to construct two linear functions for the doping level vs. lattice parameter and [VO] vs. OSC/SBET.Keywords:CeO2;doping;solvothermal;oxygen storage capacity;porous
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2023
·
IF 3.8
Yanjing Li,Shilong Dong,Lili Wang,Xiaoyan Sun,Wenying Zhao,Shuguang Xiang
LLE data of cyclooctane/3-methylpentane + benzene/toluene + N -methylpyrrolidone (NMP) at 298.15 K and 313.15 K under a pressure of 101.3 kPa were measured in this work. The Othmer-Tobias and Hand equations were adopted to validate the reliability of LLE data, where the correlation coefficients ( R 2 ) were close to unity, indicating the high reliability of the experimental data. The experimental data were analyzed using the distribution coefficient ( D ) and separation factor ( S ), and the effect of NMP extracting benzene and toluene from aromatics was explored. Meanwhile, the reason for the different extraction efficiencies of benzene and toluene using NMP was analyzed by quantum chemical calculations. The NRTL and UNIQUAC thermodynamic models were used to correlate the liquid–liquid equilibrium data, and the relevant binary interaction parameters were obtained. The calculated root mean square deviation (RMSD) were all less than 0.0063, indicating that the obtained binary interaction parameters can be used to simulate and calculate the extraction of aromatics using NMP.
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International Journal of Applied Ceramic Technology
·
2023
·
IF 2.1
Mengwen Zhang,Na Cao,Fanyu Meng,Lutong Yang,Binyang Jiang,Jinsheng Li,Lei Fan,Shoulei Yang
High-toughness Al 2 O 3 –Ti(C,N) composites reinforced by cBN particles were prepared by the new oscillating pressure sintering technique. The density, phase, and microstructure evolution of the Al 2 O 3 –Ti(C,N)-cBN composites sintered at different temperatures were studied, and their effects on the mechanical properties were investigated. The results show that when the sintering temperature increases from 1300 to 1500°C, the heat preservation time shortens, whereas the density and interface bonding strength of the composites increase. In addition, cBN particles can play the role of crack bridging and be pulled out when the composites fracture, improving the toughness of the Al 2 O 3 –Ti(C,N)–cBN composites. However, when the sintering temperature further rises to 1600°C, a new phase of TiB 2 forms, and the solid solubility of C and N in Ti(C,N) increases, leading to a decrease in density and mechanical properties. As a result, when the Al 2 O 3 –Ti(C,N)–cBN composite is sintered at 1500°C, its mechanical properties reach the maximum values of 21.5 GPa, 5.7 MPa m 1/2 , and 731 MPa for hardness, fracture toughness, and flexural strength, respectively.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 23
·5575-5588
·
IF 4.3
Liu Yuanyuan,Han Yutong,Zhu Wenjie,Luo Qingming,Yuan Jing,Liu Xin
Glycosylation is one of the most common types of post-translational modifications in mammals. It is well known that N-glycans play a key role in cell adhesion, differentiation, synapsis, and myelination during the development of the mammalian central nervous system (CNS). Neuropathological symptoms (such as epilepsy and Alzheimer’s disease) are usually accompanied by N-glycosylation changes. In this study, we extracted N-glycan chains from eight regions of the mouse brain, and combined high-throughput, high-resolution matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) with the Fmoc N-hydroxysuccinimide ester (Fmoc-OSU) derivatization method to improve the sensitivity of glycan detection to characterize the total N-glycans in the mouse brain. A total of 96 N-glycan moieties were detected. An exhaustive examination of the relative abundance of N-glycans, coupled with a comparative analysis of differences, has uncovered discernible variations of statistical significance, including high mannose, fucosylated, sialylated, and galactosylated N-glycans. According to our investigations, a thorough and regionally specific cartography of glycans within the brain can facilitate the investigation of glycan-mediated mechanisms related to both the developmental trajectory and functional output of the brain. Additionally, this approach may serve as a basis for identifying potential biomarkers that are relevant to various brain-associated pathologies. Graphical Abstract
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Russian Journal of Physical Chemistry B
·
2023
·Vol. 17
·期 3
·695-701
·
IF 1.4
Wang Y.,Dong X.,Jiang B.,Dai X.,Song H.
Abstract An alternative route to synthesize Ni 2 P–N/TiO 2 in N 2 atmosphere instead of H 2 atmosphere by thermal treatment method was proposed, and the Ni 2 P–N/TiO 2 catalyst was investigated in benzofuran hydrodeoxygenation (BF HDO) performance. X-ray diffraction (XRD), transmission electron microscope (TEM), N 2 -adsorption specific surface area measurements, CO uptake and X-ray photoelectron spectroscopy (XPS) were used to characterize the catalysts. The results showed that, the Ni 2 P–N/TiO 2 catalyst possessed a smaller and highly dispersed Ni 2 P particles on the catalysts showed a higher benzofuran hydrodeoxygenation conversion (91.9%) and ethylcyclohexane selectivity (70.4%).
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CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Yi-Fan Xue,Jie Feng,Jin-Yao Ma,Wen-Ying Li
C–N bond breaking is a difficult but crucial step in the quinoline removal of coal-based liquids. Noble metal catalysts have higher C–N bond breaking activity, but their surface bond breaking mechanism is unclear. Atomic layer deposition creates more metal-oxide sites and generates different active species, which facilitates the mechanism study. For this reason, we used atomic layer deposition to deposit TiO 2 on the catalyst surface and suggested a more complete C–N bond breaking mechanism in this study. The particle size and pore structure of the catalyst did not change significantly after the deposition, and the hydrogen adsorption was reduced when there were too many layers deposited and the surface Pt sites were occupied to a high degree. TiO 2 is extremely susceptible to reduction to Ti 3+ under hydrogen, and can change the nature of the electron density of Pt through oxygen vacancies, creating Ti 3+ -Pt δ− sites that are prone to protonation reactions. That means, the occurrence of these protonation reactions not only easily breaks the C–N bond, but also accelerates the rate of C–N bond cleavage due to the increased H coverage on the surface of the xcTi-PtAl catalysts. And the Ti 3+ -Pt δ− sites in catalyst had a stronger adsorption effect on the nitrogen-containing compounds, which in turn lowered the energy barriers of bond cleavage. It is concluded that protonation is a necessary step before the C–N bond can be broken. The subsequent steps were showed by the DFT calculations that the nitrogen-containing compounds adsorbed on the Ti 3+ -Pt δ− sites undergo β-H fracture after the protonation reaction, with the elimination reaction cleaving the C–N bond. The xcTi-PtAl catalysts by atomic layer deposition of Ti not only improve the C–N bond breaking performance, but also improve bond breaking stability by a factor of four compared to the Pt/Al 2 O 3 catalysts.
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Frontiers in Chemistry
·
2023
·
IF 5.5
Jing-Jing Xu,Jiao Luo,Heng Xi,Jin-Bu Xu,Lin-Xi Wan
A series of novel N -aryl-debenzeyldonepezil derivatives ( 1–26 ) were designed and synthesized as cholinesterase inhibitors by the modification of anti-Alzheimer’s disease drug donepezil, using Palladium catalyzed Buchwald-Hartwig cross-coupling reaction as a key chemical synthesis strategy. In vitro cholinesterase inhibition studies demonstrated that the majority of synthesized compounds exhibited high selective inhibition of AChE. Among them, analogue 13 possessing a quinoline functional group showed the most potent AChE inhibition effect and significant neuroprotective effect against H 2 O 2 -induced injury in SH-SY5Y cells. Furthermore, Compound 13 did not show significant cytotoxicity on SH-SY5Y. These results suggest that 13 is a potential multifunctional active molecule for treating Alzheimer’s disease.
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Solar RRL
·
2023
·Vol. 7
·期 20
·2300369
·
IF 7.9
Haoyu Wang,Shuanghong Wu,Haolin Zhang,Xianghua Yao,Furong Wang,Peng Huang,Xiaodong Liu
The light-soaking (LS) effect has been reported to limit the accuracy and stability of device power output of perovskite solar cells (PSCs) and it is significant to develop effective approaches and strategies to eliminate the LS effect in PSCs. There are very few reports on suppressing the LS effect in CsPbI 2 Br-based all-inorganic PSCs. Herein, a method to eliminate the LS effect by synchronous passivation of anionic and cationic defects in CsPbI 2 Br perovskite film is demonstrated. The 4-(chlorosulfonyl)benzoic acid (CSBA) is added into perovskite precursor and the in situ generation of I 3 − effectively passivates the anionic halogen vacancy defects in CsPbI 2 Br. In the meantime, the Lewis base groups on CSBA coordinate with Cs + and Pb 2+ to passivate the cationic defects. This zwitterionic passivation effect of CSBA remarkably cuts off the path of defect-induced charge recombination and thus eliminates the LS effect. This work offers a deep opinion for future researchers to modulate the LS effect of all-inorganic PSCs.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Tao Liu,Shuhan Liu,Yihan Shi,Zhuoran Zhang,Sheng Ding,Kexin Hou,Wen Zhang,Xin Meng,Fan Li
The ideal hemostatic agents should be able to stop bleeding quickly and avoid secondary bleeding caused by adhesion with blood clots during dressing change. Herein, a hydrophobic electrospun nanofiber membrane was prepared for achieving hemostasis , rationally targeting both attributes, via doping N -alkylated chitosan ( N -CS) grafted with octadecyl into chitosan/polyethylene oxide (PEO). In vitro and in vivo coagulation tests showed that CPNs doped with small amounts of N -CS (CPN31) could significantly shorten hemostasis time and promote the formation of more stable and stronger blood clots. In particular, the whole blood clotting time of CPN31 (58.8 ± 2.2 s) was significantly lower than that of chitosan/PEO (CPN0) nanofiber membrane (67 ± 3.5 s) and the medical sterile gauze (86.7 ± 0.6 s). Furthermore, due to the hemophobic nature of CPNs, blood wetting of the dressing was severely limited and blood can coagulated at the site of liver injury in rats, thus reducing blood loss and allowing rapid removal of the dressing without triggering secondary hemorrhage. The CPN31 exhibited excellent hemostasis properties, easy to remove, blood compatibility, biocompatibility and promoting fibroblast proliferation properties. This hydrophobic CPNs is a promising biological adhesive for hemorrhage control.
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