Nature Communications
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2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Pan Xin,Zhuang Yixi,He Wei,Lin Cunjian,Mei Lefu,Chen Changjian,Xue Hao,Sun Zhigang,Wang Chunfeng,Peng Dengfeng,Zheng Yanqing,Pan Caofeng,Wang Lixin,Xie Rong-Jun
Mechanoluminescence (ML) sensing technologies open up new opportunities for intelligent sensors, self-powered displays and wearable devices. However, the emission efficiency of ML materials reported so far still fails to meet the growing application requirements due to the insufficiently understood mechano-to-photon conversion mechanism. Herein, we propose to quantify the ability of different phases to gain or lose electrons under friction (defined as triboelectric series), and reveal that the inorganic-organic interfacial triboelectricity is a key factor in determining the ML in inorganic-organic composites. A positive correlation between the difference in triboelectric series and the ML intensity is established in a series of composites, and a 20-fold increase in ML intensity is finally obtained by selecting an appropriate inorganic-organic combination. The interfacial triboelectricity-regulated ML is further demonstrated in multi-interface systems that include an inorganic phosphor-organic matrix and organic matrix-force applicator interfaces, and again confirmed by self-oxidization and reduction of emission centers under continuous mechanical stimulus. This work not only gives direct experimental evidences for the underlying mechanism of ML, but also provides guidelines for rationally designing high-efficiency ML materials.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 4
·1-13
·
IF 5.3
Li Yang,Long Feng,Han Shitong,Wang Yi,Zhu Anna
Timely and accurate detection of the virus is of great significance to prevent the virus’s harm and control the epidemic. Here, an aptasensor based on the principle of promoting hybridization through aptamer conformational change was designed to quantitatively detect the spike (S) protein of SARS-CoV-2. When the S protein binds to the 3' end of the aptamer, the 5' end of the aptamer tansforms into a straight hybridization region, which will greatly facilitate the hybridization with complementary DNA (cDNA). In the absence of S protein, hybridization is less likely to occur due to the complex G-quadruplex structure of aptamer. According to this principle, cDNA is modified onto magnetic beads (MBs) or onto the optical fiber probe of an evanescent wave fluorescence aptasensor (EWFA) detection platform to capture the fluorescently labeled aptamer-S protein conjugate, two kinds of quantitative detection methods for SARS-CoV-2 S protein were established. In particular, simple, rapid and sensitive detection could be obtained based on the EWFA detection platform, in which the whole detection procedure including the measurement and regeneration takes only 14 min, the LOD is 5.34 ng/mL, the linear response range is 141.49 to 9507.36 ng/mL, and the optical fiber probe could be reused for 19 times. The EWFA detection platform is also potentially applicable to detect other protein biomarkers only by replacing the specifically modified optical fiber probes. Graphical
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Journal of Sustainable Metallurgy
·
2024
·Vol. 10
·期 2
·893-902
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IF 2.5
You Conglin,Li Dongdong,Fan Yanfei,Gao Dandan,Han Li,Zeng Dewen
Lithium aluminum layered double hydroxide chlorides (LADH-Cl) are the only industrial-level lithium sorbents. However, as an applied material, the composition-structure-property-performance relation is far from well constrained, leaving the manufacture and application of LADH-Cl lithium sorbents empirical rather than rational. Herein, we studied the phase evolution of gibbsite phase Al(OH) 3 in concentrated LiOH aqueous solution, suggesting the formation of lithiated lithium aluminum layered double hydroxide (LADH-OH) with Al:Li molar ratio 2. However, LADH-OH is not an active ingredient as a lithium sorbent. The neutralization of LADH-OH with a dilute HCl aqueous solution resulted in the formation of the active LADH-Cl phase. Unlike the traditional LADH-Cl phase (g-LADH-Cl) generated from direct LiCl intercalation of gibbsite, LADH-OH derived LADH-Cl (b-LADH-Cl) has a topological parent of bayerite instead of gibbsite. This is one of the most important roots for different performances. Another source for the different performance is very likely from variations of the particle size and morphology when the raw gibbsite reacted with LiCl or LiOH aqueous solution. Nevertheless, we found that the limiting-delithiation of b-LADH-Cl is still the same as g-LADH-Cl, that is only maximum 1/3 lithium can be delithiated from the LADH-Cl phase without any decomposition into gibbsite or bayerite. This concluded that b-LADH-Cl and g-LADH-Cl have the same reversible lithium “sorption–desorption” capacity, even through different lithium affinity and sorption kinetics. Also, notably, the “sorption–desorption” performance of the optimal sorbent is very sensitive to the properties of service brines. These results substantially enlarged our knowledge of the LADH-Cl phase and provided a demo of the rational manufacture of lithium sorbent. Graphical Abstract
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Bioresources and Bioprocessing
·
2024
·Vol. 11
·期 1
·1-10
·
IF 4.3
Mei Jianfeng,Han Yanchao,Zhuang Shihang,Yang Zhikai,Yi Yu,Ying Guoqing
Biliverdin, a bile pigment hydrolyzed from heme by heme oxygenase (HO), serves multiple functions in the human body, including antioxidant, anti-inflammatory, and immune response inhibitory activities. Biliverdin has great potential as a clinical drug; however, no economic and efficient production method is available currently. Therefore, the production of biliverdin by the biotransformation of exogenous heme using recombinant HO-expressing yeast cells was studied in this research. First, the heme oxygenase-1 gene ( HO1 ) encoding the inducible plastidic isozyme from Arabidopsis thaliana , with the plastid transport peptide sequence removed, was recombined into Pichia pastoris GS115 cells. This resulted in the construction of a recombinant P. pastoris GS115-HO1 strain that expressed active HO1 in the cytoplasm. After that, the concentration of the inducer methanol, the induction culture time, the pH of the medium, and the concentration of sorbitol supplied in the medium were optimized, resulting in a significant improvement in the yield of HO1. Subsequently, the whole cells of GS115-HO1 were employed as catalysts to convert heme chloride (hemin) into biliverdin. The results showed that the yield of biliverdin was 132 mg/L when hemin was added to the culture of GS115-HO1 and incubated for 4 h at 30 °C. The findings of this study have laid a good foundation for future applications of this method for the economical production of biliverdin. Graphical Abstract
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Advanced Fiber Materials
·
2024
·
IF 17.2
Ma Juan,Qian Lili,Jin Fei,Zheng Weiying,Li Tong,Wei Zhidong,Wang Ting,Feng Zhang-Qi
With the advancement of flexible bioelectronics, developing highly elastic and breathable piezoelectric materials and devices that achieve conformal deformation, synchronous electromechanical coupling with the human body and high-fidelity collection of biological information remains a significant challenge. Here, a nanoconfinement self-assembly strategy is developed to prepare elastic phenylalanine dipeptide (FF) crystal fibers, in which FF crystals form a unique Mortise-Tenon structure with oriented styrene-block-butadiene-block-styrene molecular beams and thereby obtain elasticity (≈1200%), flexibility (Young’s modulus: 0.409 ± 0.031 MPa), piezoelectricity (macroscopic d 33 : 10.025 ± 0.33 pC N −1 ), breathability, and physical stability. Furthermore, elastic FF crystal fibers are used to develop a flexible human physiological movement sensing system by integrating Ga–In alloy coating and wireless electronic transmission components. The system can undergo conformal deformation with human skin and achieve high-fidelity capture of biological information originating from human body motions to prevent diseases (such as Parkinson’s disease). In addition, this system also displays superior sensitivity and accuracy in detecting subtle pressure changes in vivo during heartbeats, respiration, and diaphragm movement. Therefore, elastic FF crystal fibers hold great potential for developing new flexible electromechanical sensors that are capable of conformal deformation with the human body, enabling precision medical diagnosis and efficient energy harvesting. Graphical Abstract
A schematic illustration depicting the utilization of styrene-block-butadiene-block-styrene (SBS) fibers as a self-assembly nanoconfinement carrier for phenylalanine dipeptide (FF) has been provided, showcasing the formation mechanism of elastic FF crystal fibers featuring a distinctive Mortise-Tenon structure.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Xue Tianwei,Peng Li,Liu Chengbin,Li Ruiqing,Qiu Rongxing,Qian Yunyang,Guan Xinyu,Shi Shanshan,Xu Guangkuo,Zhu Lilin,Yang Shuliang,Li Jun,Jiang Hai-Long
The quality of covalent organic frameworks (COFs) crucially influences their mechanistic research and subsequent practical implementations. However, it has been widely observed that the structure damage induced by the activation procedure could compromise the quality of COFs. Here we develop a self-sacrificing guest method for synthesizing high-quality two-dimensional COFs (SG-COFs) by incorporating salt guests into the pores of the COF structure. These introduced salts play an indispensable role in supporting COF pores and mitigating quality loss during the activation process. Interestingly, due to the unique characteristic of salts decomposing into gases upon heating, this method can ultimately enable the synthesis of highly pure, high-quality COFs without the presence of residual guest molecules. The resulting sixteen COFs display superior crystallinity and porosity compared to those synthesized using conventional routes. Moreover, these high-quality SG-COFs have demonstrated to be highly efficient adsorbents for removal of per- and polyfluoroalkyl substances.
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Nature Sustainability
·
2024
·
IF 25.7
Kong Xiangdong,Ni Jie,Song Zhimin,Yang Zhengwu,Zheng Jiana,Xu Zifan,Qin Lang,Li Hongliang,Geng Zhigang,Zeng Jie
Hydroxylamine is an important nitrogenous feedstock for the chemical industry. Conventional hydroxylamine synthesis methods utilize ammonia as the nitrogen source and require harsh reaction conditions, leading to unfavourable environmental footprint. Here we develop a plasma-electrochemical cascade pathway (PECP) powered by electricity for sustainable hydroxylamine synthesis directly from ambient air and water at mild conditions. In the first step, the plasma treatment of ambient air and water delivers a nitric acid solution with a concentration of up to 120.1 mM. Subsequently, the obtained nitric acid is selectively electroreduced to hydroxylamine using a bismuth-based catalyst. The faradaic efficiency for hydroxylamine reached 81.0% at −1.0 V versus reversible hydrogen electrode. As a result, this PECP method achieves a high hydroxylamine yield rate of 713.1 μmol cm −2 h −1 with a selectivity of 95.8%. Notably, both steps of the PECP method are operated at room temperature. Overall, our work provides a viable approach for efficient hydroxylamine synthesis from simpler feedstock at milder conditions, contributing to the sustainability transformation of the chemical industry.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·
IF 10.6
Jing Zhang,Liyuan Zhao,Along Liang,Xueyan Geng,Mengmeng Hou,Haojie Cheng,Shouren Zhang,Baocheng Yang,Junbo Li,Jian Chen
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease which is closely related with the overproduced reactive oxygen species (ROS), increased pro-inflammatory cytokines and disordered intestinal microbes. However, current therapeutic methods usually ignored the interrelation among the pathogenesis, and mainly focused on a single factor, inducing clinical outcomes unsatisfied. Herein, biocompatible infinite coordination polymers of drugs (Ce-SASP-RS ICPs) composed of Ce ions, FDA-approved drug sulfasalazine (SASP) and natural ingredient resistant starch (RS) were developed for synergistic treatment of IBD. The proper Ce 3+ /Ce 4+ ratio in Ce-SASP-RS ICPs can endow them with SOD-like activities, POD-like activities and •OH scavenging ability, which guarantee Ce-SASP-RS ICPs to simultaneously kill bacteria and maintain ROS balance through cascade reactions. Owing to the recovered redox balance microenvironment, SASP in Ce-SASP-RS ICPs can better play their anti-inflammatory function. Moreover, benefitting from the recovered metabolic balance of ROS and inflammatory cytokines in colon, resistant starch can also function better in modifying gut microbiota through generating short-chain fatty acids. Collectively, Ce-SASP-RS ICPs can synergistically restore intestinal metabolic microenvironment through modulating redox balance, attenuating inflammation and modifying intestinal flora. Hence, in view of the mutual influences among IBD pathogenesis, this work presents a synergistic intervention approach for effectively treating IBD.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-15
·
IF 10.6
Wang Xiaobo,Cai Chengyuan,Lv Weiqi,Chen Kechen,Li Jiaxin,Liao Kaitong,Zhang Yanqun,Huang Hongxin,Lin Ying,Rong Zhili,Duan Xiaopin
CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant challenge for its widespread application. In this study, we design a novel short peptide-conjugated bioreducible polymer named TSPscp as a safe and effective delivery vector for the CRISPR system. Our results show that TSPscp markedly boosts transcriptional activation and genome editing activities of multiple CRISPR systems as confirmed by decomposition-seq and Deep-seq, which is resulted from its capability in facilitating delivery of plasmid DNA by promoting cellular uptake and lysosomal escape. Additionally, TSPscp further enhances genome editing of CRISPR by delivery of minicircle DNA, a condensed form of regular plasmid DNA. More importantly, TSPscp significantly improves delivery and genome editing of CRISPR system in vivo. In summary, our study highlights TSPscp as a promising delivery tool for CRISPR applications in vivo.Graphical Abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Li Suiqin,Wang Shibin,Wang Yuhang,He Jiahui,Li Kai,Gerken James B.,Stahl Shannon S.,Zhong Xing,Wang Jianguo
Electrochemical alcohol oxidation (EAO) represents an effective method for the production of high-value carbonyl products. However, its industrial viability is hindered by suboptimal efficiency stemming from low reaction rates. Here, we present a synergistic electrocatalysis approach that integrates an active electrode and aminoxyl radical to enhance the performance of EAO. The optimal aminoxyl radical (4-acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl) and Ni 0.67 V 0.33 -layered double hydroxide (LDH) are screen as cooperative electrocatalysts by integrating theoretical predictions and experiments. The Ni 0.67 V 0.33 -LDH facilitates the adsorption and activation of N -(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)acetamide (ACTH) via interactions with ketonic oxygen, thereby improving selectivity and yield at high current densities. The electrolysis process is scaled up to produce 200 g of the steroid carbonyl product 8b (19-Aldoandrostenedione), achieving a yield of 91% and a productivity of 243 g h -1 . These results represent a promising method for accelerating electron transfer to enhance alcohol oxidation, highlighting its potential for practical electrosynthesis applications.
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INTERNATIONAL MICROBIOLOGY
·
2024
·
IF 2.3
Zhang Mingle,He Zhimin,Xu Xiaoyi,Ji Fan,Wang Bin
This study investigates the advantages of combined microbial degradation of polycyclic aromatic hydrocarbons (PAHs) in reducing the inhibitory effects of high-concentration eluents commonly used in soil washing. A microbial synergistic strategy was proposed using Arthrobacter sp. SZ-3 and Pseudomonas putida B6-2 as the key bacteria in the presence of Tween 80. The results show that in systems with Tween 80, the SZ-3 strain exhibits a strong capacity to degrade three types of PAH compounds, while the B6-2 strain follows multiple degradation pathways. Mixed bacteria achieved degradation rates 60.70% higher than single bacteria at varying concentrations of Tween 80. Additionally, the average growth rates of mixed bacteria increased by 1.17–1.37 times, aligning with the changes in the functional group. Protein activity detection within each degradation system corresponded with growth quantity and the cyclic variation characteristics of ETS enzyme activity. Notably, the ETS activity of mixed bacteria was 150% higher than that of single bacteria. At a Tween 80 concentration of 500 mg/L, the degradation rates of PAHs (Phe, Flu, Pyr) by mixed bacteria were significantly higher than those by single bacteria. The catechol 1,2-dioxygenase activity of mixed bacteria was 2.30 times higher than that of single bacteria. While Tween 80 did not alter the PAH degradation pathways, it significantly influenced the accumulation amount and duration of the characteristic intermediate product. This provides a reference for the remediation of recalcitrant pollutants under conditions involving high-concentration surfactants.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 27
·期 1
·1-14
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IF 2.1
Zhang Ziying,Liu Feng,Li Jiale,Wang Bing
Photothermal therapy (PTT), as a non-invasive and selective treatment strategy, has garnered extensive research interest. Photothermal agents (PTAs) are critical components of PTT, whose light-absorbing and thermosensitive properties enable effective conversion of light energy into heat, creating localized high-temperature regions. However, PTAs often face challenges with degradation in vivo, and standalone PTT is insufficient for complete tumor cell ablation. In this study, we successfully developed a biodegradable nanoplatform for synergistic photothermal-photodynamic therapy. This platform is based on degradable antimonene nanosheets, further functionalized with a chitosan coating, and loaded with the photosensitizer Ce6. In vitro experiments demonstrated that this nanoplatform exhibits excellent biocompatibility and biodegradability. Upon laser excitation, the platform induces localized thermal effects for cell ablation and promotes reactive oxygen species generation, leading to superior anti-tumor efficacy compared to monotherapies. These findings suggest that this multifunctional nanoplatform can significantly enhance the therapeutic efficiency of synergistic phototherapy, presenting a promising candidate for cancer treatment.
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