JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2025
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IF 3.1
Xiaolin Wu,Qiao Yu,Yuzhao Hou,Xuemei Zhang,Simon Sani Ocholi,Liming Wang,Ziping Yan,Jie Li,Lifeng Han
Cholestatic liver disease(CLD) is caused by impaired bile flow due to obstruction of the biliary tract, and long-term exposure to bile acids in the liver triggers inflammation, eventually leading to liver toxicity and liver fibrosis. Emodin-8- O-β -D-glucopyranoside(EG) is anthraquinone compound that is widely found in traditional Chinese medicine. It possessed antioxidative and anti-inflammatory activities. However, the effect of EG on cholestatic liver injury(CLI) has not been explored. In this study, Alpha-naphthyl isothiocyanate(ANIT)-induced CLI mice were used to investigate the anti-cholestasis and hepatoprotective effects of EG through serum biochemical index detection, non-targeted metabolomics, lipidomics, and intestinal flora 16S rRNA sequencing. The results suggested that EG restores homeostasis of the gut microbiome while regulating bile acids metabolism and lipid-related metabolic pathways to reduce liver damage in ANIT-induced cholestasis. This study provides a new perspective on the mechanism of EG, and help offer a more natural approach to managing liver damage.
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MATERIALS & DESIGN
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2024
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IF 7.6
Lijie Wang,Li Wan,Jianxin Wu,Yeke Chen,Yuting Yang,Tian Deng,JingTing Wu,Weiwei Xue,Li Song,Fang Dai
The guided tissue regeneration (GTR) procedure has become an important process for the treatment of periodontal tissue regeneration, using the membrane as a mechanical barrier to generate a distance across the defect that subsequently allowing bone regeneration. Due to the complexity of periodontal microenvironment caused by bacterial infections, inflammation, and fibrous tissue penetration, the guided tissue regeneration membrane is required to have antibacterial and barrier functions. We developed a loaded methylene blue @ ZIF-8 and hydroxyapatite gradient thermoplastic polyurethane Janus membrane for antibacterial osteogenic and barrier. This Janus membrane with a porous gradient structure was prepared to use phase-conversion method. The rough layer facilitated cell growth and promoted periodontal bone regeneration, whereas the smooth layer isolated the growing fiber tissue.The rapid release of reactive oxygen species in the early stage and continuous release of zinc ions by methylene blue @ZIF-8 can achieve long-term synergistic antibacterial effect, with antibacterial rates of 84 % and 72 % against Escherichia coli and Staphylococcus aureus, respectively, which can effectively reduce the local inflammation caused by bacteria. In summary, we applied the Janus membrane to a rat periodontal bone defect model, and the membrane showed good surgical performance, barrier properties, osteogenic properties, and antibacterial effects, which could have broad application prospects in the treatment of periodontal bone defects.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
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2024
·Vol. 171
·期 6
·066502
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IF 3.1
Guang Li,Xiangmei Tang,Kuang Sheng,Can Fang,Yiduo Zeng,Zhaomin Lu,Yaping Wang,Hu Zhou,Qingfeng Yi
Carbon-based electrocatalysts derived from zeolitic imidazolate framework-8 (ZIF-8) have garnered significant attention, owing to their structural advantages, high surface area, and tunable active sites. Herein, we report the synthesis of heteroatom sulfur (S) modified ZIF-8 derived carbon nanocages (ZnS@N/S-C) for oxygen electrocatalysis through self-assembly and two-step pyrolysis. The resultant ZnS@N/S-C exhibits catalytic activity towards oxygen reduction reaction (ORR) with high half-wave potential (0.86 V) and stability (91.4%), separately, which is comparable to or superior to Pt/C. Furthermore, the application of ZnS@N/S-C as a cathode for Zn-air batteries (ZABs) demonstrates performance metrics such as an open-circuit voltage of 1.407 V, a power density of 114.4 mW cm−2, and a specific capacity of 764.6 mAh gZn−1, etc surpassing Pt/C. The performance of ZnS@N/S-C can be attributed to the fact that the introduction of S significantly increases the specific surface area, pore volume, and defect extent of the catalyst, while optimizing the electronic structure and generating ZnS active nanocrystals. This work employs a simple sulfurization strategy to enhance the ORR activity of ZIF-8-derived Zn-based catalysts with fully filled 3d orbitals, providing guidance for the development of such materials.
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MOLECULAR PHARMACEUTICS
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2024
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IF 4.5
Wanjun Han,Zheyue Bo,Ting Liang,Han Liu,Lanjing Li,Zhening Guo,Ru Huan,Bruno Hagenbuch,Chunshan Gui
Organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 are two highly homologous transport proteins. However, OATP1B1- and 1B3-mediated estradiol-17β-glucuronide (E17βG) uptake can be differentially affected by clotrimazole. In this study, by functional characterization on chimeric transporters and single mutants, we find that G45 in transmembrane domain 1 (TM1) and V386 in TM8 are critical for the activation of OATP1B3-mediated E17βG uptake by clotrimazole. However, the effect of clotrimazole on the function of OATP1B3 is substrate-dependent as clotrimazole does not stimulate OATP1B3-mediated uptake of 4′,5′-dibromofluorescein (DBF) and rosuvastatin. In addition, clotrimazole is not transported by OATP1B3, but it can efficiently permeate the plasma membrane due to its lipophilic properties. Homology modeling and molecular docking indicate that E17βG binds in a substrate binding pocket of OATP1B3 through hydrogen bonding and hydrophobic interactions, among which its sterol scaffold forms hydrophobic contacts with V386. In addition, a flexible glycine residue at position 45 is essential for the activation of OATP1B3. Finally, clotrimazole is predicted to bind at an allosteric site, which mainly consists of hydrophobic residues located at the cytoplasmic halves of TMs 4, 5, 10, and 11.
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Xingyu Kang,Jianhui Lv,Lei Han,Bin Huang,Huizhang Zhao,Dong Wang,Hairui Fang
Nitrogen oxide (NO 2 ) is common by-products of industrial production, posing significant health risks to workers. Therefore, real-time monitoring of NO 2 is crucial. In this study, innovative In 2 O 3 -ZnO nano-materials were prepared by combining In 2 O 3 with ZIF-8 via electrospinning, for detecting trace amounts of NO 2 at room temperature (RT). Compared to pure In 2 O 3 , the In 2 O 3 -ZnO nano-materials (V2) with a 10 % weight ratio of ZIF-8 exhibited a significantly higher response (389.99) and a faster response time (16.9 s) to NO 2 under ultraviolet (UV) irradiation at RT. The superior gas sensing performance of the V2 nano-materials is attributed to the formation of n-n heterojunctions, enhanced optical absorption, increased oxygen vacancy ratio, and excellent dispersion among the nano-materials. The results demonstrate that V2 nano-materials can detect NO 2 at parts-per-billion (ppb) levels at RT, making them suitable for monitoring trace amounts of NO 2 in open environments. Furthermore, a portable real-time NO 2 monitoring device was constructed using V2 as the sensing material, an LM358-based amplifier circuit for data acquisition, an STM32F103C8T6 microcontroller as the main control unit, and a buzzer as an alarm device. Compared to devices using a helical Ni-Cr wire as an indirect heat source, this integrated NO 2 detection device offers real-time alarms with lower energy consumption. This application not only enhances worker health and safety in industrial environments but also demonstrates higher energy efficiency in practical application.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2024
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IF 4.8
Feng-Ling Tang,Li-Wei Xie,Lin-Feng Tang,Hai-Yan Lu,Rui-Qiu Zhu,Di-Fan Wang,Ye Tian,Shang Cai,Ming Li
The small intestine exhibits remarkable sensitivity to ionizing radiation (IR), which significantly hampers the effectiveness of radiotherapy in the treatment of abdominal and pelvic tumors. Unfortunately, no effective medications are available to treat radiation-induced intestinal damage (RIID). Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside), is a coumarin derivative extracted from the Chinese herb Cortex Fraxini. Several studies have underscored the anti-inflammatory, antibacterial, antioxidant, and immunomodulatory properties of fraxin. However, the efficacy of fraxin at preventing or mitigating RIID remains unclear. Thus, the present study aimed to investigate the protective effects of fraxin against RIID in vitro and in vivo and to elucidate the underlying mechanisms. The study findings revealed that fraxin markedly ameliorated intestinal injuries induced by 13 Gy whole abdominal irradiation (WAI), which was accompanied by a significant increase in the population of Lgr5 + intestinal stem cells (ISCs) and Ki67 + progeny. Furthermore, fraxin mitigated WAI-induced intestinal barrier damage, and reduced oxidative stress and intestinal inflammation in mice. Transcriptome sequencing of fraxin-treated mice revealed upregulation of IL-22, a pleiotropic cytokine involved in regulating the function of intestinal epithelial cells. Moreover, in both human intestinal epithelial cells and ex vivo cultured mouse intestinal organoids, fraxin effectively ameliorated IR-induced damage by promoting the expression of IL-22. The radioprotective effects of fraxin were partially negated in the presence of an IL-22-neutralizing antibody. In summary, fraxin is demonstrated to possess the ability to alleviate RIID and maintain intestinal homeostasis , suggesting that fraxin might serve as a strategy for mitigating accidental radiation exposure- or radiotherapy-induced RIID.
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SURFACE & COATINGS TECHNOLOGY
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2025
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IF 6.1
Lei Wu,Qiuyan Ye,Kun Zhang,Xiaoyan Guo,Jiaqiao Li,Yongnan Chen,Fan Fang,Hantao Chang
The inherent porous structure of Micro-arc oxidation (MAO) coatings may facilitate penetration of corrosive ions into the substrate, thereby compromising its corrosion resistance. In this work, the metal-organic framework (MOF) ZIF-8 was employed to seal the micropores in the MAO coating of titanium alloy (MAO-Ti) through a secondary growth method involved initially physically pre-loading crystal seeds into the micropores, followed by solvent thermal synthesis. Consequently, an excellent cohesive pore-sealing coating known as ZIF-8@MAO was successfully developed. The anchoring effect between ZIF-8 in the micropores and the substrate forms a solid blocking layer, which can effectively avoid the issue of traditional sealing layers detaching easily. Additionally, the arranged ZIF-8 crystals on the surface of MAO-Ti imparts excellent hydrophobicity and high stability to the alloy, evidenced by contact angle tests conducted under various solution environments, where the water contact angles (WCAs) exceeded 140°. Moreover, ZIF-8 microcrystals act as effective sealants for the micropores of MAO-Ti, effectively safeguarding the internal titanium alloy matrix against chloride ion infiltration and ensuring long-term corrosion resistance. Electrochemical tests assessing the corrosion resistance of the coatings revealed a significant improvement in the corrosion resistance of the ZIF-8@MAO pore-sealing coating compared to the primary MAO-Ti coating. The charge transfer resistance ( R ct ) increased from 2.05 × 10 4 Ω/cm 2 to 1.287 × 10 9 Ω/cm 2 , while the current density ( I corr ) declined from 2.03 × 10 −8 A/cm 2 to 2.65 × 10 −13 A/cm 2 .
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FOOD CHEMISTRY
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2025
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IF 9.8
Yunpeng Shao,Yue Niu,Wenlong Deng,Zicheng Zhang,Ruien Yu,Linyu Mei
In this study, we prepared large-area polydimethylsiloxane (PDMS) 3D flexible films deposited with silver nanoparticles (Ag NPs) by assembling Ag NPs on ordered micron-column (MC) arrays fabricated using SU-8 colloidal lithography (Ag NP@SU-8-MC). The large-scale, highly ordered 3D MC array flexible film offers numerous adsorption sites for densely packed Ag NPs. High-density sub-nanometer gaps between Ag NPs create spatial hot spots, enhancing the electromagnetic field. The results indicate that this flexible substrate achieves a detection limit of 10 −15 M for rhodamine 6G (R6G), with a relative standard deviation of less than 8 %, demonstrating excellent SERS sensitivity and uniformity. Furthermore, leveraging its high viscosity and flexibility, the ‘pasting-extraction’ method was employed to detect carbendazim and thiram on the surfaces of tomatoes and apples, achieving detection limits of 10 −10 M and 10 −11 M, respectively. Overall, this work presents a practical approach for preparing flexible and sensitive SERS substrates for food safety applications.
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Small Methods
·
2024
·
IF 10.7
Chunyang Li,Yujian Li,Shaoyan Wu,Gui Li,Juan Li,Yan Zhao,Huan Cai,Jia Shu,Mingxuan Song,Qing Fu,Jianbo Yuan,Xin Gao,Zhujun Ai,Xiaosong Li,Rui Chen,Zhong Zuo
Catalytic nanoparticle@metal-organic framework (MOF) composites have attracted significant interest in point-of-care testing (POCT) owing to their prominent catalytic activity. However, the trade-off between high loading efficiency and high catalytic activity remains challenging because high concentrations of nanoparticles tend to cause the misjoining and collapse of the MOFs. Herein, a facile strategy is reported to encapsulate high concentrations of platinum (Pt) nanoparticles into zeolitic imidazolate framework-8 (ZIF-8) using polydopamine (PDA) as a support for Pt@ZIF-8 and as a flexible scaffold for further immobilization of Pt nanoparticles. The resulting composite (Pt@ZIF-8@PDA@Pt) exhibits ultrahigh Pt nanoparticle loading efficiency, exceptional catalytic activity, stability, and a bright colorimetric signal. Following integration with lateral flow immunoassay (LFIA), the detection limits for pre- and post-catalysis detection of B-type natriuretic peptide (NT-proBNP) are 0.18 and 0.015 ng mL −1 , respectively, representing a 6-fold and 70-fold improvement compared to gold nanoparticle-based LFIA. Moreover, Pt@ZIF-8@PDA@Pt-based LFIA achieves 100% diagnostic sensitivity for NT-proBNP in a cohort of 184 clinical samples.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Hui Yingfei,Wang Mingyue,Liu Yinsheng,Peng Liping,Tian Jiaying,Ren Borong,Guo Hao,Yang Wu
In this study, a ratiometric fluorescent sensor CdTe QDs@ZIF-8 with butterfly spectra is successfully constructed by in situ encapsulating mercaptopropionic acid-modified CdTe quantum dots in zeolitic imidazolate framework-8 (ZIF-8) with a simple strategy, and used for the detection of tetracycline in fluorescence/smartphone colorimetry dual-mode. ZIF-8 not only reduces the agglomeration of the quantum dots but also surprisingly generates a new green fluorescence signal at 524 nm while the red fluorescence of the CdTe quantum dots at 650 nm quenches when tetracycline is added. The two opposing fluorescence signals create a butterfly-shaped fluorescence spectrum, allowing the sensor to detect tetracycline over a linear range of 0–70 μM with the detection limit (LOD) of 0.0155 μM by using a ratiometric fluorescence technique. What is more, based on the obvious color change of the fluorescent sensor gradually from red to green under UV light, a highly stable point-of-care testing sensor has been developed for on-site detection of tetracycline through color recognition by smartphones, which can be used for real-time detection of this antibiotic in the range of 0–1000 μM with the LOD of 0.0249 μM. This work provides a simple and efficient method for the on-site detection of tetracycline. Graphical Abstract
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ANALYTICA CHIMICA ACTA
·
2024
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IF 5.7
Jiahui Yang,Yao Lin,Xi Wang,Yuanyuan Li,Yurong Deng,Chengbin Zheng
Background Arsenic contamination of drinking water has become a public health challenge over the world, particularly in Bangladesh, India, and China. Compared to the most used field test kits of waterborne arsenic, miniature microplasma atomic spectrometry retains advantages of accuracy, elemental specificity, and less matrix interference. Despite increased interest in arsenic detection by using miniature microplasma spectrometry, the improvements of its analytical performance, manufacturing cost and consistency still remain significant challenges. Results Herein, a miniature, battery-operated, and integrated hydride generation point discharge optical emission spectrometer (HG-μPD-OES, 116 mm length × 92 mm width × 104 mm height) was printed with a simple 3D printer and used for the highly sensitive and element-specific determination of arsenic by coupling to a dispersive solid-phase extraction (d-SPE) using zeolitic imidazolate framework-8 as adsorbent. The d-SPE simplifies sample treatment, significantly alleviates the interference arising from transition metal ions and improves sensitivity. A LOD of 0.07 μg L −1 for arsenic was obtained with relative standard deviations (RSDs, n = 11) better than 3.8 %. Significance The 3D printing technique significantly improves the manufacturing cost and fabricating consistency of HG-μPD-OES. LOD were remarkably improved 27-fold compared to those obtained by conventional HG-μPD-OES, providing a promising method for the reliable, sensitive, and convenient field analysis of waterborne arsenic even its concentration as low as 0.2 μg L −1 . The practicability and accuracy of the proposed method have been successfully verified via the field analysis of waterborne arsenic in a Certified Reference Material (GBW(E)080390) and a series of river and lake water samples.
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JOURNAL OF CATALYSIS
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2024
·
IF 6.5
Xin-Yu Chang,Hong-Wei Li,Yuqing Wu
The composites of H 2 N-ZIF-8 supported gold nanoclusters (AuNCs@H 2 N-ZIF-8) were prepared by UV-induced photochemical reduction method in the methanol–water solution. The photochemical reaction was attributed to the generation of free radical as. CH 2 ·–OH, which reduced Au(III) to Au(0) and produced monodisperse AuNCs (<2.5 nm) in the mesoporous of H 2 N-ZIF-8. The generated AuNCs@H 2 N-ZIF-8 show oxidase-like properties to catalyze the oxidation of TMB, ABTS and OPD under mild conditions. Besides, the mechanism study by EPR shows that the composites can promote oxygen to generate singlet oxygen ( 1 O 2 ) and superoxide radicals ( ·O 2 - ), endowing it excellent catalytic activity of oxidation. Further studies revealed that the large number of exposed small AuNCs in the mesoporous pores of H 2 N-ZIF-8 and the highly active 211 crystalline facets formed at the edges contribute to the ROS generation intrinsically. Therefore, the present study demonstrates the significance of photochemical reduction method to prepare highly efficient oxidase-like materials, opening up a new avenue to construct noble metal materials as ultra-small nanozyme.
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