CATALYSIS TODAY
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2018
·
IF 4.667
Yuexin Peng,Ling Zhang,Yiwen Jiang,Shichao Han,Qiuyan Zhu,Xiangju Meng,Feng-Shou Xiao
Catalytic combustion is considered as an efficient and economic technology to remove VOCs, and Al-ZSM-5 zeolite supported palladium catalysts (Pd/Al-ZSM-5) with good performances in this kind of reactions have been reported. In this work, it is found that Fe-ZSM-5 supported palladium catalyst (Pd/Fe-ZSM-5) exhibit higher catalytic activity in toluene combustion than the Pd/Al-ZSM-5, which is strongly related to more Pd 0 active species and higher concentration of absorbed oxygen species of Pd/Fe-ZSM-5 than those of Pd/Al-ZSM-5. More importantly, Pd/Fe-ZSM-5 has a good catalyst life and water-resistant ability, which should be potentially significant for practical applications in environment protection.
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MOLECULAR PHARMACEUTICS
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2018
·
IF 4.556
Sida Ruan,Yuanyuan Gu,Bo Liu,Huashan Gao,Xiongwei Hu,Haiping Hao,Liang Jin,Ting Cai
Glucagon-like peptide 1 (GLP-1) has recently received significant attention as an efficacious way to treat diabetes mellitus. However, the short half-life of the peptide limits its clinical application in diabetes. In our previous study, a novel GLP-1 analog (PGLP-1) with a longer half-life was synthesized and evaluated. Herein, we prepared the PGLP-1-loaded poly(d,l-lactide-co-glycolide) microspheres to achieve long-term effects on blood glucose control. The incorporation of zinc ion into the formulation can effectively decrease the initial burst release, and a uniform drug distribution was obtained, in contrast to native PGLP-1 encapsulated microspheres. We demonstrated that the solubility of the drug encapsulated in microspheres played an important role in in vitro release behavior and drug distribution inside the microspheres. The Zn-PGLP-1 microspheres had a prominent acute glucose reduction effect in the healthy mice. A hypoglycemic effect was observed in the streptozotocin (STZ) induced diabetic mice through a 6-week treatment of Zn-PGLP-1-loaded microspheres. Meanwhile, the administration of Zn-PGLP-1 microspheres led to the β-cell protection and stimulation of insulin secretion. The novel GLP-1 analog-loaded sustained microspheres may greatly improve patient compliance along with a desirable safety feature.
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MINERALS ENGINEERING
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2018
·
IF 2.707
Wanghuan Guo,Fan Yang,Zhigang Zhao,Qiuxia Liao,Chunqing Cai,Yang Zhang,Ruixi Bai
To achieve an adsorbent that has better absorption and extraction performance, carboxymethyl-diethylammoniumethyl cellulose (CMDEAEC), a low-cost cellulose-based ionic liquid that possesses a nanoscale particle size and good swellability to increase the contact area, was prepared through a one-step reaction. The chemically modified cellulose was verified by Fourier transform infrared spectroscopy, elemental analysis and scanning electron microscopy. As an adsorbent, CMDEAEC was used for selective recovery of metal ions. The effects of pH, adsorbent dose, initial concentration, and contact time on metal ion adsorption were examined. CMDEAEC was found to exhibit selectivity only for Au(III). Additionally, the adsorption process follows the Langmuir isotherm model and the pseudo-second-order kinetics model. Furthermore, the desorption of ions from CMDEAEC and the regeneration capacity of CMDEAEC were investigated. In conclusion, as an efficient, low-cost, easily obtained and environmentally friendly adsorbent, CMDEAEC is expected to be used for the selective recovery of gold.
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Plasmonics
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2018
·Vol. 14
·期 1
·187-195
·
IF 2.366
Zhang Pengfei,Liu Le,He Yonghong,Chen Xiaoxia,Ma Kaijie,Wei Dong
We describe an Au-MgF 2 -Au trilayered waveguide-coupled surface plasmon resonance (WCSPR) sensor in this article. The characteristics of this sensing structure are compared with those of the conventional single-layered gold surface plasmon resonance (SPR) sensor theoretically and experimentally. The experiment results show that WCSPR can provide not only seven times smaller refractive index resolution in the bulk sensing application but also more accurate measurement results for the biomolecular interaction analysis than the conventional single-layered gold SPR. What’s more, this high-resolution sensor is easy to build and not sensitive to film thickness variations. The Au-MgF 2 -Au trilayered WCSPR may provide a simple and convenient chip-based strategy for performance enhancement of SPR sensors without varying the hardware and software of measurement instruments.
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SENSORS AND ACTUATORS B-CHEMICAL
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2018
·
IF 5.667
Cheng-Yu Li,Ya-Feng Kang,Bei Zheng,Chun-Miao Xu,Chong-Yang Song,Dai-Wen Pang,Hong-Wu Tang
We report a new upconversion nanoparticles (UCNPs) based luminescent resonance energy transfer (LRET) analytical platform by making use of optical tweezers technology. The LRET model is designed by simultaneously conjugating Yb 3+ and Er 3+ co-doped UCNPs (as the donors) and tetramethyl rhodamine (TAMRA) molecules (as the acceptors) on microspheres to fabricate complex microspheres. Upon a single complex microsphere entering the three-dimensional potential well formed with a tightly focused 980 nm Guassian-shaped laser beam, it is optically trapped and concurrently the upconversion emission is excited, whereby the donor signals are transferred to the acceptors. As a proof-of-concept investigation, microRNA-21 sequences are selected as the targets, by which the distance between the two perfectly matched luminophors is controlled to several nanometers via nucleic acid hybridization. Without the involvement of luminescence amplification strategies, the proposed single microsphere based LRET method shows highly competitive sensitivity with a limit of detection down to 114 fM and satisfactory specificity towards microRNAs detection. Moreover, its practical working ability is demonstrated by credibly quantifying the absolute contents of miRNA-21 sequences in three cancer cell lines and even tracing the targets in as few as 100 cancer cells. Thus, this favorable analytical methodology provides an alternative for bioassays and holds certain potential in biomedical applications.
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JOURNAL OF MEMBRANE SCIENCE
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2018
·
IF 6.578
Weicheng Fu,Xueye Wang,Junjian Zheng,Mingxian Liu,Zhiwei Wang
Membrane fouling remains as a critical issue limiting the widespread applications of membrane-based technologies for water and wastewater treatment . In this work, an electrochemical ceramic membrane reactor (ECMR), in which ceramic membrane with built-in Ti mesh acted as cathode/filter and Ti/SnO 2 -Sb-Ce as anodes, was developed for mitigating membrane fouling during wastewater treatment. Linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) of Ti/SnO 2 -Sb-Ce electrode demonstrated favorable electrochemical properties . Filtration tests with influent wastewater containing 50 mg/L sodium alginate (SA) showed that TMP increase rate for the ECMR was decreased by 23.9–72.7% compared to the control, dependent on the exertion modes of electric field in this reactor. It was found that all the oxidants contributed to the enhanced antifouling performance of the ECMR due to in-situ membrane cleaning effects while the hydrogen peroxide and active chlorine (Cl T ) played a more important role compared to superoxide anions and hydroxyl radicals. SA was oxidized to a smaller size after reacting with reactive oxygen species (ROS) and Cl T , benefiting the mitigation of membrane fouling in ECMR.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2018
·
IF 3.779
Xiaohua Liu,Xixi Qin,Huiming Ji,Mingjing Wang
Er 1-x Yb x FeO 3 (x = 0, 0.3, 0.7, 1) sensing materials were synthesized via sol-gel method and annealing. The obtained porous Er 0.7 Yb 0.3 FeO 3 solid solution had the highest response value (Rg/Ra = 2.8) to 0.5 ppm butanone and the optimal selectivity compared with Er 1-x Yb x FeO 3 (x = 0, 0.7, 1) sensing materials. The combination of Er 3+ and Yb 3+ rare-earth elements in A site of AFeO 3 , and proper proportion of Er to Yb make contribution to gas sensing properties of Er 0.7 Yb 0.3 FeO 3 because they create the proper structure which has more electronic density of states near the Fermi level and the proper band-gap structure in Er 0.7 Yb 0.3 FeO 3 according to the first-principle calculation results and UV–Vis diffusion spectra. Therefore, the better electronic structure of Er 0.7 Yb 0.3 FeO 3 increases the amount of absorbed oxygen species on surface of materials, which is proved by the XPS results, and then enhances the response to target gas. In conclusion, Er 0.7 Yb 0.3 FeO 3 has the great potential as gas sensing material used in detecting butanone and other hazardous gases.
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Micromachines
·
2018
·Vol. 9
·期 6
·274
·
IF 2.222
Zihao Li,Chenggang Zhu,Zhihe Guo,Bowen Wang,Xiang Wu,Yiyan Fei
The detection of small molecules has increasingly attracted the attention of researchers because of its important physiological function. In this manuscript, we propose a novel optical sensor which uses an optofluidic microbubble resonator (OFMBR) for the highly sensitive detection of small molecules. This paper demonstrates the binding of the small molecule biotin to surface-immobilized streptavidin with a detection limit reduced to 0.41 pM. Furthermore, binding specificity of four additional small molecules to surface-immobilized streptavidin is shown. A label-free OFMBR-based optical sensor has great potential in small molecule detection and drug screening because of its high sensitivity, low detection limit, and minimal sample consumption.Keywords:label-free sensor;optofluidic microbubble resonator;detection of small molecules
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Polymer Chemistry
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2018
·Vol. 10
·期 2
·228-234
·
IF 4.927
Chao Chen,Xiaofeng Guo,Jinhong Du,Bonnie Choi,Houliang Tang,Anchao Feng,San H. Thang
Miktoarm star (MAS) polymers are polymers with a number of distinct arms connected to a central core. Owing to their exclusive structure, MAS polymers have been extensively studied in recent years. To exploit their biomedical applications the combination of nucleic acids, peptides and saccharides are desired. In this study, RAFT polymerization of three monomers with markedly different properties, N,N-dimethylaminoethyl methacrylate (DMAEMA, cationic), n-butyl methacrylate (BMA, hydrophobic) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA, hydrophilic) was conducted using an RGD peptide based RAFT agent as a chain transfer agent (RGD-CTA). With a disulphide dimethacrylate (DSDMA) redox-cleavable cross-linker, the above linear polymers were combined via an “arm-first” technique to access MAS polymers containing peptide arms. These MAS polymers showed excellent biocompatibility, cell staining performance and rapid redox responsiveness. The novel MAS polymers have potential as a prospective platform for intracellular drug/gene delivery for cancer therapy.
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MICROCHIMICA ACTA
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2018
·Vol. 185
·期 12
·1-8
·
IF 5.705
Zhang Feng,Liu Hua,Liu Qing,Su Xingguang
A ratiometric fluorescence method is described for the determination of the anticancer drug 6-mercaptopurine (6-MP). The method is based on the use of fluorescent MoS 2 quantum dots (MQDs) and of the enzyme horseradish peroxidase (HRP). In the absence of 6-MP, HRP catalyzes the oxidation of o-phenylenediamine (OPD) by H 2 O 2 to form 2,3-diaminophenazine (DAP). This leads to quenching of the violet fluorescence of MQDs (measured at excitation/emission wavelengths of 360/415 nm), while the strong yellow fluorescence of DAP (peaking at 560 nm) becomes increasingly strong. In the presence of 6-MP, however, it will be preferentially oxidized by the HRP/H 2 O 2 system to form a disulfide dimer. Hence, less H 2 O 2 is available for the oxidation of OPD and less DAP will be formed. This results in the recovery of the violet fluorescence and a decrease of the yellow fluorescence. The ratio of the two signals can be used to quantify either H 2 O 2 or 6-MP. Linear responses are observed for H 2 O 2 in 0.5–140 μM concentration range, and for 6-MP in the 0.5–70 μM concentration range, with detection limits of 0.1 μM and 0.29 μM, respectively. The method was applied to the determination of 6-MP in spiked human urine and gave satisfactory results.
Schematic of an enzymatic fluorometric method for determination of 6-mercaptopurine (6-MP). It is based on the presence of 6-MP that can inhibit the HRP-catalyzed oxidation of o-phenylenediamine (OPD) to form 2,3-diaminophenazine (DAP). Hence, the fluorescence resonance energy transfer (FRET) between DAP and MoS 2 quantum dots (MQDs) is suppressed.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 42
·6858-6864
·
IF 4.776
Wenying Li,Jiayan Wang,Jiacheng Zhu,Yue-Qing Zheng
Nanomaterial-based artificial enzymes (nanozymes), as an emerging generation of artificial enzymes, have received extensive attention in recent years owing to their striking merits. In this study, the obtained Co3O4 nanocrystals exhibited catalase-like activity and could catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2, and a clear absorption peak at 652 nm can be observed. It was verified that the catalytic activity for the oxidation of TMB originated from the oxygen, which is generated by Co3O4 catalyzed H2O2 decomposition. Upon addition of glutathione (GSH), the catalytic ability of the Co3O4 nanocrystals was inhibited. And, the changes of absorbance at 652 nm could be utilized to quantify the concentration of GSH. Under the optimized conditions, the proposed assay showed good linear relationships and a low detection limit towards GSH. Moreover, the Co3O4 nanocrystals had excellent stability and can maintain the catalytic activity for a long time. Thus, a simple, sensitive and selective nanozyme-based biosensor was developed for the colorimetric detection of GSH.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Weixiang Li,Di Shu,Hongliang Han,Zhanfang Ma
Nanogel as a multifunctional carrier was used to fabricate immunoprobe. The obtained immunoprobe was applied in a competitive amperometric immunosensor and exhibited an excellent analytical performance for the detection of tumor marker. The nanogel was easily fabricated by irradiation of the mixture of glucose, sodium citrate and sodium alginate by microwave, which exhibits excellent adsorbent ability for multivalence metal ions. The immunoprobe was constructed by functionalizing such uniform nanogels with multivalence metal ions (Cu 2+ as model) as redox species and gold nanoparticles for immobilizing antibody. The signal of Cu 2+ from the nanogel can be directly measured without acid dissolution and pre-concentration, which substantially simplified the detection steps. Besides, the response current can be amplified by glucose because Cu 2+ is an electro-catalyst for the oxidation of glucose. Polyaniline hydrogel with a three dimensional network structure and π–π conjugated structure was used to fabricate immunosensing substrate, which extremely improved the specific surface area and conductivity of the modified electrode. Under optimal conditions, the current changes of square wave voltammetry were used to detect neuron specific enolase (as a model analyte) with a broad linear ranging from 0.01 to 1000 ng mL −1 and a ultralow detection limit of 4.6 pg mL -1 (S/N = 3). This work provides a new strategy for designing multifunctional immunoprobes.
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