JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2022
·Vol. 102
·期 2
·400-411
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IF 2.606
Yue Wenda,Liang Jun,Wang Honghai,Zhang Yu,Li Chunli,Su Weiyi
In the entrapment of enzymes by sol-gel method, the special procedures for obtaining the unique structure of xerogel are sometimes destructive to enzymes, while the internal structure of xerogels is easily broken. To solve the above problems, we present an economical, bio-friendly procedure for the entrapment of Candida antarctica lipase B in silica xerogel. In this procedure, an encapsulation-structured enzyme-carrying silica xerogel was produced by controlling the evaporation rate of the solvent at ambient pressure during drying, while tetramethoxysilane and methyltrimethoxysilane were used as the co-precursors. The xerogel synthesis was modified and optimized for improving the stability and reusability of the enzyme, while the xerogel characteristic structure was preserved. Moreover, the effects of the co-precursors amount on the mechanical strength, pore structure, hydrophobicity, enzyme loading, and enzyme stability of the enzyme-carrying silica xerogels were systematically investigated. And the best performance was observed at the co-precursors content of 30.28 wt%. Finally, the catalytic performance of the enzyme-carrying silica xerogels on the transesterification of n -butanol with ethyl acetate was demonstrated.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 6
·e6648
·
IF 4.072
Zehao Yu,Zijie Song,Chunshan Lu,Ying Bai,Jiayun Li,Jun Liu,Peng Liu,Jiajian Peng
Hydrosilylation employing metal–organic frameworks (MOFs) as the catalyst are promising because of their high catalytic reactivity and sustainability of heterogeneous catalyst. A highly simple and efficient method for the hydrosilylation of olefins catalyzed by an air-stable MOF-cobalt catalysts is developed. This approach is featured by 0.1% of Co-MOFs catalyst with excellent reactivity, recyclability, and good functional group tolerance. The Co-MOFs can catalyze hydrosilylation of styrene or its derivatives with Ph 2 SiH 2 in the presence of NaBHEt 3 . Moreover, the catalysts we developed show excellent stability, and the activity is not significantly reduced after repeating the cycle for five times.
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MOLECULES
·
2022
·Vol. 27
·期 8
·2550
·
IF 4.927
Lingzhi Liang,Xia Ren,Junyi Xu,Yurong Ma,Yunlin Xue,Tao Zhuang,Guisen Zhang
Olanzapine is a commonly used drug in the treatment of schizophrenia, but its clinical application has been restricted by metabolic-related side effects. In order to mitigate the weight gain side effects caused by olanzapine, other drugs with different targets were selected for combined use and evaluated in animal models of schizophrenia. SEP-363856 is a novel psychotropic agent which is under phase III clinical trials for schizophrenia treatment. The aim of the research was to evaluate whether co-administration of olanzapine and SEP-363856 exerts synergistic anti-schizophrenic effects in the apomorphine (APO)-induced climbing test, the MK-801-induced hyperactivity test, and the Morris water maze test, and therefore reduces the weight gain side effects induced by olanzapine. Through isobolographic analysis, the results showed a synergistic interaction in the climbing test; the experimental ED30(3 mg/kg) was significantly smaller (p< 0.05) than the theoretical ED30(5 mg/kg). Additionally, such potentiating effects appeared additive in the MK-801 challenge experiment. Co-treatment with an effective dose of olanzapine and a low dose of SEP-363856 reversed MK-801-induced cognitive impairment symptoms in mice. Moreover, combination treatment with olanzapine and SEP-363856 controls sustained weight gain in mice with chronic exposure to olanzapine. These results support further clinical trials to test the effectiveness of co-treatment of olanzapine and SEP-363856 for controlling symptoms and weight gain in patients with schizophrenia during antipsychotic treatments.Keywords:olanzapine;SEP-363856;schizophrenia;synergistic;side effects
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ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Chunyang Wei,Chengzhuang Yu,Shanshan Li,Jiyu Meng,Tiejun Li,Jingmeng Cheng,Feng Pan,Junwei Li
Digital polymerase chain reaction (PCR) plays important roles in the detection and quantification of nucleic acid targets, while there still remain challenges including high cost, complex operation, and low integration of the instrumental system. Here, in this work, a novel microfluidic chip based on co-flow step emulsification is proposed for droplet digital PCR (ddPCR), which can achieve droplet generation, droplet array self-assembly, PCR amplification, and fluorescence detection on a single device. With the combination of single-layer lithography and punching operation, a step microstructure was constructed and it served as the key element to develop a Laplace pressure gradient at the Rayleigh–Plateau instability interface so as to achieve droplet generation. It is demonstrated that the fabrication of step microstructure is low cost, easy-to-operate, and reliable. In addition, the single droplet volume can be adjusted flexibly due to the co-flow design; thus, the ddPCR chip can get an ultrahigh upper limit of quantification to deal with DNA templates with high concentrations. Furthermore, the volume fraction of the resulting droplets in this ddPCR chip can be up to 72% and it results in closely spaced droplet arrays, makes the best of CCD camera for fluorescence detections, and is beneficial for the minimization of a ddPCR system. The quantitative capability of the ddPCR chip was evaluated by measuring template DNA at concentrations from 20 to 50 000 copies/μL. Owing to the characteristics of low cost, easy operation, excellent quantitative capability, and minimization, the proposed ddPCR chip meets the requirements of DNA molecule quantification and is expected to be applied in the point-of-care testing field.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Yuxuan Feng,Shuhui Chen,Kaisheng Hua,Hui Li,Dong Jiang,Lujie Sheng,Dan Zhao,Jizhong Ren
Thermally rearranged(TR) polymers are usually prepared at an insert atmosphere and display high gas permeability, but their low gas selectivity results in high energy consumption. Thermal oxidation is an effective method to enhance the gas selectivity of microporous polymers. In this work, the effect of oxygen in the purge environment on imide-to-benzoxazole conversion and membrane structures was investigated. 1% oxygen content of the purge environment could restrain imide-to-benzoxazole conversion of 6FDA-DETDA/bisAPAF hydroxyl block polyimide(bHPI) membranes effectively, and oxygen induced the oxygen bridge formation, improving the gas selectivities of the resulting thermal-oxidative membranes with the increased oxygen content. Thermal-oxidative PBOCI membranes (TO-PBOCI) based on block poly(benzoxazole-co-imide)(PBOCI) precursor membranes were prepared to enhance gas separation performance of microporous polymers. The stable polybenzoxazole structures and microphase separation of polybenzoxazole blocks maintained membrane structures and the gas transport channels in the thermal-oxidative process at high temperature. Significantly, the remaining hydroxyl groups in PBOCI precursor membranes were beneficial for oxygen bridge formations of TO-PBOCI membranes, enhancing H 2 /CH 4 selectivity. As a result, the TO-PBOCI membranes treated at a high temperature kept high H 2 permeability and H 2 /CH 4 selectivity, surpassing the 2008 Robeson upper bound. The study about TO-PBOCI membranes promotes a better understanding of the polymeric materials and process development of microporous polymer membranes for hydrogen separation applications.
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RSC Advances
·
2022
·Vol. 12
·期 19
·11843-11852
·
IF 4.036
Qi Guo,Xinglong Hou,Wei Xu,Junli Liu
Ni3Co1/ELAC catalyst, prepared by the enzymatically hydrolyzed lignin activated carbon as a carrier and a 3 : 1 ratio content of nickel and cobalt, can selectively convert furfural to cyclopentanol (CPL) in aqueous solution. We used activated carbon prepared by the phosphoric acid method as the carrier, and investigated the effect of the carrier on the catalyst activity. The ratio of bimetal (Ni, Co) content and reaction conditions (reaction temperature, reaction time, initial H2 pressure) have also been investigated in the furfural hydrogenation. With the optimal Ni3Co1/ELAC catalyst, the conversion rate of furfural and the selectivity of CPL were 100% and 94.1%, respectively. In this process, some important catalysts were studied by XRD, XPS, ICP-AES, BET and TEM characterization. Through experimental results and other people's research, we deduced a reasonable reaction path and verified it by replacing the reaction substrate and solvents. Finally, the experiment proved that the formation of CPL by furfural required the occurrence of a rearrangement reaction and the participation of aqueous solution.
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Biofuels Bioproducts & Biorefining-Biofpr
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2022
·Vol. 17
·期 2
·355-362
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IF 5.239
Yanqian Gu,Shasha Liu,Gang Wu,Yinlong Wu,Shoujun Zhang,Yong Huang,Shu Zhang,Hong Zhang
Biomass is the sole carbon-containing renewable resource on Earth, and has high potential for the production of platform chemicals. Phenol, one of the most important platform chemicals, is generally derived from lignin conversion. In this study, the production of phenol from co-pyrolysis of cellulose and sodium borohydride at different mass ratios is investigated in detail. The results show that even a small amount of sodium borohydride (cellulose–sodium borohydride = 10:1) could effectively promote the conversion of cellulose to phenol through cellulose-derived levoglucosan intermediates. As the mass ratio of cellulose–sodium borohydride decreased, the relative content of phenol in the products significantly increased, and could be as high as 11.0% when the ratio of cellulose to sodium borohydride was 2:1. Glycosidic bonds in cellulose were considered to play an important role in its catalytic conversion. Furthermore, the resulting solid product could be used as a B-doping carbon material, which is desirable in various research fields. This study provided a novel method for the highly efficient utilization of cellulose. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Ning Liu,Dong Cao,Wenhao Liu,Huimin Zhang,Yinhai Zhu,Le Chang,Dengfeng Wu,Daojian Cheng
Constructing highly efficient and low cost electrocatalysts for oxygen evolution reaction (OER) is pivotal to various energy storage and conversion devices. In this work, five different rare earth (RE) metals doped (La, Ce, Pr, Nd, Er) Ag-nanoparticles-decorated α-Co(OH) 2 nanostructured electrocatalysts, which are grown on nickel foam (NF), are successfully prepared by a facile one-step hydrothermal approach. It is found that La-doped 2D ultrathin (∼2.0 nm) CoAg nanosheets arrays (denoted as La–CoAg/NF) can demonstrate the highest electrochemical activity towards OER in 1 M KOH solution among these RE-doped electrocatalysts. It delivers the lowest overpotential at 10 mA cm −2 (233 mV), the smallest Tafel slope (44.3 mV dec −1 ) and extraordinary stability for 35 h with no significant change during harsh OER process. The reasons for the enhanced performance may come from unique ultrathin 2D nanostructure and La-induced strong electronic interaction among Co, Ag, and La atoms. This work provides an essential insight to the development of RE-metal doped electrocatalysts for energy conversion.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Chuanyi Xu,Guanrong Yang,Jie Li,Shanqing Zhang,Yueping Fang,Feng Peng,Shengsen Zhang,Rongliang Qiu
The persistence and wide dispersion of antibiotics have a severe impact on the ecological environment. Developing an effective method with universal applicability to remove pollutants is pretty necessary. Herein, a bimetallic oxides (Co 3 V 2 O 8 ) heterogeneous material was successfully prepared and used to activate the persulfate (PS) for purification of tetracycline (TC) wastewater. By exploring the reaction conditions and influencing factors, the removal rate of 50 mg⋅L -1 TC reached 87.1% by Co 3 V 2 O 8 /PS system, and the reaction rate constant was up to 0.0271 min −1 . As a highly efficient catalyst for the activation of PS, Co 3 V 2 O 8 /PS system produces radicals of SO 4 •− , •OH, •O 2 – and 1 O 2 in the reaction process due to the Co(II) and V(IV) exchange electrons with S 2 O 8 2- and O 2 . Simultaneously, the internal electron exchange occurs between Co(II)/Co(III) and V(IV)/V(V), which stabilizes the content of Co(II) and V(IV). This work provides a novel activator for PS activation to degrade contaminants and contributes to a better understanding of the PS activation mechanism by transition compound.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
·
IF 6.371
Shijia Fan,Changjiang Zhou,Haoran Xu,Jingcai Xu,Hui-Min Wen,John Q. Xiao,Jun Hu
Giant magnetoresistance (GMR) effect exhibits high potential applications in ultrahigh density magnetic recording, magnetic sensors and electronic devices. Many methods were developed to improve the GMR, such as changing the diameters or content ratio of Co to Cu etc. In this work, we have successfully grown a new Co/Cu multilayered magnetic nanowires arrays (MNAs) with gradient diameter (GDMNAs). Very interestingly, we demonstrate much enhanced GMR in the GDMNAs. Moreover, it shows higher thermal stability simultaneously. This is a novel strategy to improve GMR. Generally, the diameter ( d ) and edge-to-edge separation ( s ) of MNAs play a significant role in determining the magnetic properties . If d < s , exchange interaction dominants. If d > s , dipolar interaction dominates. When we design a new GDMNAs with d < s at one end and d > s at the other, much better multilayered structures are observed on the larger end. Surprisingly, the magnetic anisotropy is found to be dominated by the portion of MNAs with d < s . Combining both properties in GDMNAs, we achieve the highest GMR value of 27% in reported Co/Cu MNAs. This design strategy not only reveals new interesting physics, which remains to be understood, but also useful to other applications based on MNAs.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
·
IF 24.319
Pan Li,Xinbao Li,Yang Wang,Pengfei Shen,Xinbo Zhu,Yingying Zhu,Zan Wu
A low-cost, high-performance catalyst for phenol steam reforming (PSR) at low temperature was prepared by introducing waste coal ash into Co/Al 2 O 3 . The optimized content of coal ash in the catalyst were ranged from 50 to 65 wt%, presenting over 97% phenol conversion and 92% H 2 yield at low temperature of 450 °C. The stability for the best catalyst with an ash content of 50 wt% exceeded 85 h. Two-step reduction of Co 3 O 4 to Co 0 via CoO was identified by in-situ XRD. DFT calculations showed that phenol adsorption and decomposition were preferred on the FeCo bimetal surface rather than the single Co surface. H 2 O adsorption and dissociation fascinated on the CaO incorporated Al 2 O 3 surface. Both Fe and Ca in the coal ash improved the catalyst performance in PSR at low temperature. This work gives an opportunity to solve the drawbacks of high reaction-temperature and low catalyst-stability in PSR, and furthermore benefits to get a deep insight into the reaction mechanism of PSR over the catalyst.
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Catalysis Science & Technology
·
2022
·Vol. 12
·期 14
·4486-4497
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IF 6.177
Si Liu,Zhenfu Wang,Kun Chen,Linling Yu,Qinghong Shi,Xiaoyan Dong,Yan Sun
Chiral amines are valuable intermediates widely applied in the pharmaceutical industry. As an alternative to classical synthetic methods for the production of chiral amines, biocatalytic cascade synthesis for these molecules from their alcohol precursors has been developed. However, currently available enzyme cascade systems remain unstable and unsustainable in the practice of chiral amine synthesis. Herein, the catalytic cascade system of chimeric amine dehydrogenase (AmDH) and alcohol dehydrogenase (ADH) fused with silica binding peptide (SiBP) was site-specifically co-immobilized on silica nanoparticles (SNPs). SiBP enabled the fusion enzymes to firmly bind to SNPs, and both the single immobilized enzymes showed higher catalytic efficiencies (kcat/Km) than their free counterparts to different degrees. Using 10 mM (S)-2-hexanol as the substrate, the co-immobilized enzyme system (SiBP–ADH&SiBP–AmDH@SNPs) showed 90% (R)-2-aminohexane yield after 48 h reaction, which was 1.85-fold higher than the free enzyme system due to the enhanced catalytic efficiency of the immobilized enzymes and the possible proximity effect of the SiBP–ADH&SiBP–AmDH@SNPs. The catalyst productivity of the SiBP–ADH&SiBP–AmDH@SNPs was 11 to 34 times higher than literature data, demonstrating the high economic benefits and catalytic efficiency of this system in producing chiral amines. SiBP–ADH&SiBP–AmDH@SNPs retained 87% of its original activity after eight cycles of reuse. These results highlighted the potential of the co-immobilization system for the effective and sustainable synthesis of chiral amines in industrial practice.
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