JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2013
·
IF 2.004
Zhongjian Li,Min Yao,Jun Lin,Bin Yang,Xingwang Zhang,Lecheng Lei
The selective sorption of pentachlorophenol (PCP) in a multiple solute system provides the possibility of using the cetyltrimethylammonium bromide (CTMAB)/bentonite one-step process as a promising technique for hydrophobic organics removal from wastewater. The PCP sorption mechanism, especially the effects of coexisting solutes, was studied. Compared to raw bentonite and conventional CTMAB modified organobentonite, the one-step process exhibited higher PCP removal efficiency. In a single solute system, the PCP sorption isotherm implied that the dominating sorption mechanism is a partition mechanism. The logarithms of sorption coefficients (Kd) for different organics are linearly related to the logarithm of their octanol–water partition coefficients (Kow). In a multiple solutes system, phenol and 2,4-dichlorophenol (2,4-DCP) could effectively enhance PCP sorption. The PCP sorption coefficient increases in the order: PCP/phenol < PCP/2,4-DCP < PCP/phenol/2,4-DCP. The PCP sorption enhancement is likely resulted from the interlayer space expansion and the organic carbon content increase. On the basis of the comparison between the single and the multiple solute systems, phenol and 2,4-DCP sorption coefficients decrease in the order: Kd of a single solute system > Kd of a binary solute system > Kd of a ternary solute system, and no enhancement for phenol and 2,4-DCP sorption was observed.
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MOLECULAR DIVERSITY
·
2025
·
IF 3.8
Wu Yuyu,Zhang Ximeng,Li Haocheng,Liu Xuelian,Li Jinyao
Ferulic acid, a natural active ingredient, mainly exerts antitumor activity by disrupting mitochondrial function and has the advantages of low toxicity and high efficiency. However, poor water solubility and low bioavailability have limited its further development. This article uses triphenylphosphonium salts (TPP + ) with both amphiphilicity and tumor mitochondrial targeting to modify the structure of ferulic acid, and designs and synthesizes a series of TPP + conjugated ferulic acid derivatives. Compared with ferulic acid, the water solubility, mitochondrial targeting and antitumor activity of TPP-conjugated ferulic acid derivatives were significantly enhanced. Among them, compound I 4 showed excellent anti-cervical cancer activity, mainly by reducing ATP synthesis and promoting ROS production, thus activating mitochondria-mediated apoptotic signaling to induce apoptosis in HeLa cells. I 4 also inhibited HeLa cell migration and caused cell cycle arrest to the G0/G1 phase. In the mouse model, the effective therapeutic concentration of I 4 was 2.5 mg/kg and the LD 50 was 98.11 mg/kg. I 4 demonstrated similar anti-cervical cancer activity, a larger therapeutic window and a higher safety profile than with the first-line anticancer agent cisplatin.
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RSC Advances
·
2020
·Vol. 10
·期 25
·14794-14802
·
IF 3.119
Kai Yang,Yajie Zhang,Ming Cai,Rongfa Guan,Jing Neng,Xionge Pi,Peilong Sun
Until recently, a variety of oligosaccharides from fruits, vegetables and mushrooms have demonstrated positive prebiotic effects. Ganoderma lucidum, a well-known traditional medicine and tonic in East Asia, has been utilized in the prevention and treatment of a broad range of illnesses. In this study, each of three oligosaccharides was obtained from the polysaccharide extraction by-products of sporoderm: the unbroken and broken spores of Ganoderma lucidum (UB-GLS, B-GLS). Their molecular weight distribution, monosaccharide composition and preliminary structures were analyzed using gel permeation chromatography (GPC), GC-MS, UV and FTIR, respectively. All of the oligosaccharides were found to exhibit prebiotic activities, evaluated by detecting growth stimulation on Lactobacillus in vitro. Among these, UB-O80 and B-O80 displayed the most significant effects (p < 0.05) in these groups, and UB-O80 showed higher resistance to hydrolysis by artificial human gastric juice compared with inulin, giving a maximum hydrolysis rate of 1.65%. Compared with inulin media, Lactobacillus also revealed high tolerance to lower pH levels and simulated gastric juices in UB-O80 and B-O80 media. Compared with a control in gut microbiota fermentation, the abundance of some beneficial bacteria increased and some harmful bacteria declined in the groups of UB-O80 and B-O80. In conclusion, the results suggest that GLS oligosaccharides could be exploited as promising prebiotics for the enhancement of human health.
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JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Xinran Tu,Liyang Guo,Yang Li,Guozhong Tan,Rongfeng Chen,Jingwen Wu,Guohou Miao,Lvhua Guo,Chengfei Zhang,Ting Zou,Yang Zhang,Qianzhou Jiang
Three-dimensional (3D)-printed scaffolds are a new strategy to fabricate biomaterials for treating bone defects. Here, using a 3D-printing technique, we fabricated scaffolds consisting of gelatin (Gel), sodium alginate (SA), and 58S bioactive glass (58S BG). To evaluate mechanical properties and biocompatibility of Gel/SA/58S BG scaffolds, the degradation test, compressive strength test, and cytotoxicity test were performed. The effect of the scaffolds on cell proliferation in vitro was determined by 4′,6-diamidino-2-phenylindole (DAPI) staining. To evaluate osteoinductive properties, rBMSCs were cultured on the scaffolds for 7, 14, and 21 days and the expression of osteogenesis-related genes was analyzed using qRT-PCR. To examine the bone healing properties of Gel/SA/58S BG scaffolds in vivo, we used a rat mandibular critical-size defect bone model. The scaffolds were implanted into the defect area of rat mandible and bone regeneration and new tissue formation were assessed using microcomputed tomography (microCT) and hematoxylin and eosin (H&E) staining. The results showed that Gel/SA/58S BG scaffolds had appropriate mechanical strength as a filling material for bone defects. Furthermore, the scaffolds could be compressed within certain limits and then could recover their shape. The extract of the Gel/SA/58S BG scaffold showed no cytotoxicity. In vitro, the expression levels of Bmp2, Runx2, and OCN were increased in rBMSCs cultured on the scaffolds. In vivo, microCT and H&E staining demonstrated that scaffolds induced the formation of new bone at the mandibular defect area. These results indicated that Gel/SA/58S BG scaffolds have excellent mechanical characteristics, biocompatibility, and osteoinductive properties, suggesting that it could be a promising biomaterial for the repair of bone defects.
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高影响因子
Sugar Tech
·
2021
·Vol. 24
·期 3
·832-840
·
IF 1.591
Yang Yujiao,Zheng Rui,Zhang Pingling,Wen Jing,Luo Yue,Zhao Zhengang,You Lijun,Ho Chi-Tang
Sugarcane is one of the most important crops in the world and rich in polyphenols. In this study, quercetin, apigenin, luteolin, tricin and p -coumaric acid, the major polyphenols in sugarcane, were used to evaluate the antiproliferative activities toward MCF-7 human breast cancer cells independently and in combination. These five polyphenols all showed inhibitory effects against MCF-7 cells within different dose ranges. The combinations of luteolin and three polyphenols (quercetin, apigenin, p -coumaric acid) were studied. p -Coumaric acid together with luteolin exhibited synergistic effects at all concentrations tested: the CI (Combination Index) values at 50%, 75% and 90% inhibition of MCF-7 cell growth were 0.68 ± 0.06, 0.70 ± 0.08 and 0.83 ± 0.09, respectively. Although the two-way combination of luteolin and apigenin showed moderate antagonistic effect (CI, 1.26 ± 0.24) at EC 50 , the CI value dropped as the inhibition rate increased, showing a synergistic effect at the inhibition rate above 70%. The combination of luteolin and quercetin indicated antagonistic effect at the inhibition rate above 50% (Fa 0.5, CI = 1.10 ± 0.05). p -Coumaric acid with quercetin exhibited antagonistic actions (Fa 0.5, CI = 1.62 ± 0.22) at all concentrations tested. In addition, the EC 50 values of luteolin and quercetin against MCF-7 cells decreased by 1.91 and 2.62-fold after combining with 20 µM tricin. The results provide evidence of synergistic relation among polyphenols present in sugarcane in inhibition of cancer cell growth and of their potential clinical application.
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Journal of Biomedical Nanotechnology
·
2015
·Vol. 11
·期 4
·711-721
·
IF 5.338
Yang Linjie,Jiang Jizong,Hong Jingyi,Di Jing,Liao Yonghong,Kuang Haixue,Wang Xiangtao
The objective of this study was to evaluate the feasibility of producing 10-hydroxycamptothecin nanosuspensions with high drug payload and to then determine the in vitro and in vivo characteristics of these nanosuspensions. Using cholesterol-PEG600 as a stabilizer, 10-hydroxycamptothecin
nanosuspensions were successfully prepared using a precipitation-combined high-pressure homogenization method. A satisfactory drug payload of 90.39% (w/w) was achieved. The obtained nanosuspensions were spherical, with a mean particle size of 115.0 ± 0.4 nm, and they were monodisperse
with a polydispersity index of 0.134 ± 0.001. The 10-hydroxycamptothecin remained in the same crystalline form in both the nanosuspensions and the bulk powder. In vitro, the 10-hydroxycamptothecin nanosuspensions released the encapsulated drug with nearly zero-order kinetics,
and the accumulative release reached 90% within 72 hours. In vitro cytotoxicity assay showed that the 10-hydroxycamptothecin nanosuspensions had significantly enhanced cytotoxicity against HepG2 cells compared to the commercially available 10-hydroxycamptothecin injections. The in
vivo study with H22 tumor-bearing mice and intravenous injection of the drug showed that in contrast to the 10-hydroxycamptothecin injections, the 10-hydroxycamptothecin nanosuspensions exhibited significantly enhanced biodistribution, particularly in the lung (393.40-fold AUC0–24
h, liver (192.35-fold AUC0–24 h, spleen (141.67-fold AUC0–24 h and tumor (64.21-fold AUC0–24 h. The 10-hydroxycamptothecin nanosuspensions also showed improved antitumor therapeutic efficacy over the injections (89.83% vs. 30.56%). This
suggests that cholesterol-PEG600 may be an effective stabilizer for the preparation of hydrophobic drug nanosuspensions and that 10-hydroxycamptothecin nanosuspensions are a promising drug delivery system for tumor treatment.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Pengfei Xia,Kunxi Zhang,Yan Gong,Guifei Li,Shifeng Yan,Jingbo Yin
Microgels, with large surface area per volume, show great advantages in adipose tissue engineering due to their injectability and similarity with natural extracellular matrix. However, to date, no studies have tried applying microgels to adipose tissue regeneration. Herein, based on double-bonded poly(l-glutamic acid)-g-2-hydroxyethyl methacrylate (PLGA-g-HEMA) and maleic anhydride-modified chitosan (MCS), an open porous microgel with high hydrophilicity and great injectability is successfully prepared (microgels diameters of 200–300 μm, pore diameter of 38 μm, and porosity of 88.3%). The storage modulus of 30 mg/mL of the microgel dispersions is 2000 Pa, which is similar to that of the native adipose tissue. The spheroidal stem cell shape and extensive cell–cell connections can be formed in the present microgels to promote adipogenic differentiation and realize adipose tissue regeneration. After injection in vitro, the microgels can maintain high stem cell viability up to 14 days. The extensive Oil red O staining is observed after adipogenic induction for 14 days. After 12 weeks postimplantation, adipose tissues can be regenerated well. Blood vessels are formed in the neogenerated tissues. The degradation rate of microgels roughly matches with the adipose tissue formation rate. The study offers an applicable microgel system to boost the adipose tissue regeneration.
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NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Shuwei Shen,Binbin Huang,Zhiyi Peng,Luting Yu,Lili Ren,Jia Liu,Guoguang Chen
Traditional Chinese medicine (TCM), as a significant complementary and alternative approach, has received increasing attention from medical practitioners worldwide and is now regarded as an important source for modern drug discovery owing to its special therapeutic efficiency and few side effects. In this work, a popular TCM, Ganoderma lingzhi (G. lingzhi), was used as a test drug to show how Raman spectroscopy combined with traditional chemical and biological assays could be used to monitor alternations in molecular events in G. lingzhi extract-induced cells with high sensitivity. The observations indicated that the Raman fingerprint of MDA-MB-231 cells after G. lingzhi triterpene treatment was significantly different in contrast to that of the control, and changes in the Raman bands showed that some important molecular events could be discerned, including protein denaturation, DNA fragmentation, and lipid metabolism disorder. Network pharmacology analysis further supplemented the drug's target and signaling pathways. Our work proposes an effective way for screening potential new drug products early from the complex chemical compositions of TCM, as well as for accelerating preclinical medicinal chemistry optimization cycles, playing a significant role in the development of new drugs.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jingjing Wang,Jinchuan Zhao,Zhihui Wen,Xinjie Wei,Junjie Liao,Liping Chang,Kechang Xie
CeY zeolite sorbent was reported to have a high adsorptive desulfurization selectivity for thiophene. However, only the cerium in the supercage, which is larger than the thiophene molecule, is effective for thiophene adsorption. In this case, regulating the cerium location to anchor it more in the surpercage of Y zeolite is an important issue. Herein, the glycine was used as a complexing agent with cerium to control its size, ensuring that the cerium precursor is in the supercage. G 0.1 CeY were prepared by ion exchange technique with glycine and cerium coordination from NaY. The adsorption capacity of sorbents was measured, and their physical and chemical properties were characterized by XRD, SEM, N 2 adsorption/desorption, NH 3 -TPD, and in situ FT − IR. The glycine complexation could effectively control the location of Ce, so that the G 0.1 CeY has the highest content of Ce located in the supercage. Moreover, in order to further explore the influence of zeolite type, HY was used as the raw material to prepared G 0.1 CeHY in the same way. G 0.1 CeHY has a higher desulfurization performance than that of G 0.1 CeY, whereas the Ce content in its supercage is lower. The NH 3 -TPD and Py-FT − IR results that the medium-strong Brønsted acid of the G 0.1 CeHY sorbent is also effectively for the improvement of desulfurization efficiency. The G 0.1 CeHY exhibits the hightest desulfurization effectiveness (51 %) and the highest breakthrough adsorption capacity of 5.42 mg/g.
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ARCHIVES OF TOXICOLOGY
·
2025
·
IF 6.9
Tang Wei,Zong Shimin,Du Peiyu,Yu Xuan,Li Ting,Liu Bo,Zhong Yu,Lei Wenyang,Yu Wenting,Xiao Hongjun
Cochlear hair cell death is the primary cause of cisplatin-induced ototoxicity, currently lacking widely applicable clinical methods for effective prevention and treatment. In this study, an in vivo cisplatin-induced ototoxicity model was established by intraperitoneal injection of 12 mg/kg cisplatin. We found that ablation of SIRT3 exacerbates cisplatin-induced hearing loss and cochlear hair cell damage. An in vitro cisplatin-induced ototoxicity model was established using 5 µM cisplatin in cochlear explants and OC-1 cells. We found that the absence of SIRT3 impairs cochlear hair cell glycolytic metabolism, leading to excessive accumulation of ROS and significant reduction in MMP levels, thereby promoting apoptosis. In contrast, overexpression of SIRT3 in OC-1 cells promotes cochlear hair cell survival and reduces cochlear hair cell apoptosis. Inhibition of PFKFB3 reduces glycolytic metabolism in OC-1 cells, and the protective effect conferred by SIRT3 overexpression is lost. In summary, the protective effect of SIRT3 may be mediated by the regulation of PFKFB3-dependent glycolysis and the mitigation of cisplatin-induced excessive ROS accumulation.
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Surfaces and Interfaces
·
2025
·
IF 6.3
Tianxun Gong,Mengya Yu,Zhenyi Liu,Luyu Lv,Wen Huang,Xiaosheng Zhang
Strain engineering has emerged as a powerful technique for modulating the bandgap in two-dimensional (2D) materials, including transition metal dichalcogenides (TMDCs) and graphene, which are critical for structural optimization in nanoelectronics and optoelectronics. Despite the promise of these materials, a significant challenge remains in achieving precise and controllable strain effects, particularly in graphene, to exploit its full potential in device applications. This gap in controllability limits the ability to fully leverage the sensitive changes in interfacial properties that strain can induce in 2D materials. Here, we present an approach to precisely control strain effects in monolayer graphene by applying mechanical force through a ZnO array substrate. The ZnO arrays were fabricated with controlled dimensions using lithographic templates, allowing for accurate strain modulation when graphene was wet-transferred onto the array. This method enabled effective coupling between the strain in graphene and the graphene/ZnO Schottky junction, significantly enhancing the device's optoelectronic performance. The resulting device demonstrated a broad response from ultraviolet to visible spectrum. Remarkably, the device achieved an outstanding responsivity of 39.1 mA W⁻¹ at 320 nm with a 3V bias. These findings provide a practical and innovative solution to the challenges of strain engineering in 2D materials.
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eLife
·
2024
·
IF 6.4
Zeina Salloum,Kristin Dauner,Yun-feng Li,Neha Verma,David Valdivieso-González,Víctor Almendro-Vedia,John D Zhang,Kiran Nakka,Mei Xi Chen,Jeffrey McDonald,Chase D Corley,Alexander Sorisky,Bao-Liang Song,Iván López-Montero,Jie Luo,Jeffrey F Dilworth,Xiaohui Zha
Statins are known to be anti-inflammatory, but the mechanism remains poorly understood. Here, we show that macrophages, either treated with statin in vitro or from statin-treated mice, have reduced cholesterol levels and higher expression of Jmjd3, a H3K27me3 demethylase. We provide evidence that lowering cholesterol levels in macrophages suppresses the adenosine triphosphate (ATP) synthase in the inner mitochondrial membrane and changes the proton gradient in the mitochondria. This activates nuclear factor kappa-B (NF-κB) and Jmjd3 expression, which removes the repressive marker H3K27me3. Accordingly, the epigenome is altered by the cholesterol reduction. When subsequently challenged by the inflammatory stimulus lipopolysaccharide (M1), macrophages, either treated with statins in vitro or isolated from statin-fed mice, express lower levels proinflammatory cytokines than controls, while augmenting anti-inflammatory Il10 expression. On the other hand, when macrophages are alternatively activated by IL-4 (M2), statins promote the expression of Arg1, Ym1, and Mrc1. The enhanced expression is correlated with the statin-induced removal of H3K27me3 from these genes prior to activation. In addition, Jmjd3 and its demethylase activity are necessary for cholesterol to modulate both M1 and M2 activation. We conclude that upregulation of Jmjd3 is a key event for the anti-inflammatory function of statins on macrophages.
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