NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Liezhi Cao,Qiang Gao,Xiaoming Zuo,Yong Kong,Haiying Chen
Iron-based metal organic framework (Fe-MOF) is first synthesized by using tetra(4-carboxyphenyl)-porphyrin (TCPP) as the organic building blocks, which is then co-encapsulated with doxorubicin (DOX) in the oxidized sodium alginate (OSA)/carboxymethyl chitosan (CMCS) hydrogels cross-linked through the Schiff base reaction. The imine bonds (–HC=N–) between OSA and CMCS can be hydrolyzed in the acidic tumor microenvironment (TME), resulting in the release of DOX and Fe-MOF. The Fe-MOF can be further decomposed by the acidic TME to release TCPP and Fe3+. Oxygen molecules are catalyzed to singlet oxygen (1O2) by the photosensitizer TCPP upon exposure to near infrared (NIR) light, and the generated 1O2 can bring about photodynamic therapy (PDT). Additionally, the released Fe3+ can be reduced to Fe2+ by glutathione (GSH), which can react with H2O2 in the TME through the Fenton reaction to generate hydroxyl radicals (·OH) for chemodynamic therapy (CDT). Due to the synergistic therapy of PDT, CDT and chemotherapy, the Fe-MOF/DOX/OSA/CMCS hydrogels exhibit significant cytotoxicity against murine breast cancer cell line 4T1.
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高影响因子
FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Abel Wend-Soo Zongo,Kaili Gao,Xiaohua Nie,Yuanchao Lu,Jose Manuel Lorenzo,Ningxiang Yu,Xianghe Meng
pH and temperature influence the gelation behavior of TGNP. • Alkaline (pH 10) conditions enhance solubility and favor gel formation • Gels formed at pH 10 under heating (95 °C) exhibit high viscosity and gel strength • Gelation is primarily driven by hydrophobic interaction and disulfide cross-linking Understanding the gelation behavior of novel plant protein under varying pH and temperature conditions is crucial for designing food systems with tailored texture, stability, and functional properties. In this study, we investigated the effects of pH and temperature on the aggregation behavior and heat-induced gelation of TGNP. The results showed that TGNP gelation was strongly influenced by both pH and heating temperature. Near the isoelectric point (pH 4), the protein exhibited minimal solubility (8%) and large particle size (>3000 nm) due to extensive aggregation, conditions that were unfavorable for the formation of a well-developed gel network. In contrast, strongly acidic (pH 2), neutral (pH 7), and alkaline (pH 10) conditions improved protein solubility (62%, 81% and 89%, respectively) and reduced particle sizes (400–900 nm), promoting better molecular dispersion and facilitating heat-induced gelation. Alkaline conditions particularly enhanced protein unfolding, exposing buried hydrophobic residues and sulfhydryl groups, which promoted hydrophobic interactions and disulfide cross-linking. These interactions resulted in the formation of the strongest and most stable heat-induced gels. Rheological analysis further revealed that stable elastic gels with higher viscosity, gel strength, and water-holding capacity were predominantly formed at neutral and alkaline pH, especially after heating at 95 °C. Disulfide bonds and hydrophobic interactions were identified as the primary forces governing TGNP gel network formation, although their relative contributions varied with pH and temperature. Overall, these findings provide new insights into the gelation mechanism of TGNP and highlight its potential as a novel functional protein ingredient for food systems requiring low gelation concentrations. Download: Download high-res image (128KB) Download: Download full-size image
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Yuzhu Zhou,Yanfei Liu,Yufeng Feng,Lilin Wu,Bingbing Cai,Zhixing Liang,Changchun Wen,Yan-Cheng Liu,Hong Liang
Melanoma is an aggressive skin malignancy that originates from melanocytes. It remains a major clinical challenge because of its high drug resistance, frequent relapse, and metastatic potential. Although chemodynamic therapy (CDT) can selectively kill cancer cells by generating hydroxyl radicals (·OH) in the tumour microenvironment (TME), its efficacy is often limited by insufficient reactive oxygen species (ROS) production. In this study, we used a hyaluronic acid (HA)-modified Fe-based metal-organic framework (MOF) co-loaded with the chemotherapeutic drug norcantharidin (NCTD) and gold nanoparticles (AuNPs) to develop a pH/glutathione dual-responsive MOF-AuNPs-NCTD@HA (MAuN@HA) heterostructure nanozyme that amplifies ROS generation for synergistic chemotherapy/CDT against melanoma. Within the weakly acidic TME, the MAuN@HA dissociates, releasing iron ions and NCTD, enabling combined chemotherapy and Fe-mediated CDT. The integrated gold nanozyme executed cascade catalytic reactions, enabled by enhanced catalase-, peroxidase-, and oxidase-like activities along with the Russell effect, generating a burst of diverse ROS (including singlet oxygen, superoxide anion, and ·OH) and amplifying oxidative stress. Notably, HA modification conferred active tumour targeting. In a B16 tumour-bearing mouse model, the MAuN@HA heterostructure nanozyme potently suppressed melanoma progression. Overall, this study presented a TME-responsive nanozyme strategy that combined cascade catalysis with drug release to achieve an effective ROS-amplified synergistic therapy against melanoma. A pH/glutathione-dual-responsive drug-loaded heterostructure nanozyme for reactive oxygen species-augmented synergistic chemotherapy/chemodynamic therapy against melanoma. Download: Download high-res image (270KB) Download: Download full-size image
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PEST MANAGEMENT SCIENCE
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2026
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IF 4.2
Longfei Bian,Ruisi Chen,Rong Zhao,Xiaoyuan Wang,Guiji Yin,Lutao Yang,Wenneng Wu,Yuru Chen,Saijie Song
BACKGROUND Kiwifruit soft rot is a devastating post-harvest disease that leads to significant economic losses in the kiwifruit industry. Although chemical pesticides can effectively inhibit pathogenic fungi, their conventional formulations still have disadvantages such as poor stability, low utilization rate, and high environmental risks. Therefore, developing environmentally friendly and multifunctional smart pesticide delivery system (PDS) is key to achieving sustainable plant disease control. RESULTS In this study, we developed a multifunctional PDS by using β -cyclodextrin ( β -CD)-modified mesoporous silica nanoparticles (MSN) as a nanocarrier for prochloraz (Pro) delivery. The nanopesticide (Pro-MSN- β -CD) exhibited high loading efficiency (68.74%) and demonstrated pH- and α -amylase-responsive controlled release behavior. In addition, it also exhibited enhanced foliar adhesion and rain erosion resistance performance. In vitro antifungal assays showed 100% inhibition of Botryosphaeria dothidea at 1 μg mL −1 . Post-harvest trials on kiwifruit revealed superior protective (67.50%) and curative (58.59%) efficacy against soft rot. Biosafety assessments confirmed minimal phytotoxicity in mung bean germination tests. CONCLUSION The Pro-MSN- β -CD nanopesticide offered an efficient, biosafe, and environmentally friendly solution for controlling kiwifruit soft rot. Its stimuli responsive release and enhanced targeting performance provided a sustainable strategy for post-harvest disease management, contributing to the advancement of precision agriculture. © 2026 Society of Chemical Industry.
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高影响因子
International Journal of Nanomedicine
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2026
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IF 8.7
Yunchao Wu,Xin Xu,Zhen Zhu,Fengyi Du,Guojun Zheng
Purpose Monotherapy with photothermal therapy (PTT) hardly achieves durable and significant antitumor efficacy. To further improve the therapeutic effect against tumors, in this study, the chemotherapeutic agent thioridazine (THZ) was loaded into a gel network formed by the Schiff base cross-linking of amino-functionalized graphene quantum dots (NH2-GQDs) and oxidized dextran. A pH-responsive injectable carbon dot composite hydrogel delivery system (NTD@Gel) with dual effects of photothermal therapy and chemotherapy was thereby constructed.Methods The techniques including HRTEM, XPS, FTIR, SEM and rheological tests were employed to verify the successful fabrication of NTD@Gel and characterize its physicochemical properties. In vitro and in vivo experiments were conducted to comprehensively evaluate the antitumor efficacy and biosafety of this hydrogel.Results NTD@Gel exhibited excellent photothermal conversion performance and biocompatibility, and enabled the rapid and sustained release of THZ in the acidic microenvironment. In vitro experiments confirmed that NTD@Gel could synergistically kill Hep1-6 hepatocellular carcinoma cells through photothermal ablation and THZ-induced oxidative damage, and inhibited the oncogenic Akt/Stat3 signaling pathway activation. In vivo experiments demonstrated that NTD@Gel combined with near-infrared laser irradiation significantly inhibited tumor growth, reduced CD133 and CD326 expression on tumor cells, effectively prolonged the survival time of tumor-bearing mice, and caused no obvious pathological damage in the major organs of mice.Conclusion NTD@Gel can significantly enhance the therapeutic efficacy against hepatocellular carcinoma and reduce the risk of metastasis and recurrence through the synergistic effect of photothermal therapy and chemotherapy.
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International Journal of Nanomedicine
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2026
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IF 8.7
Jiaqi Li,Zheng Zhong,Yuhe Tan,Xiaohong Ma,Ruohong Wang,Guoyao Gao,Xian Zhang,Ziqing Zhou,Yin Zhao,Jia Liu,Xufang Sun
Background The multifaceted pathogenesis of diabetic retinopathy (DR) involves numerous pathways, among which oxidative stress and Rho-associated kinase (ROCK) signaling are critically implicated. The failure of current anti-VEGF monotherapies to address these key pathological processes limits their efficacy. While the ROCK inhibitor Fasudil is a promising candidate, its clinical translation for DR is hindered by poor ocular retention and lack of target specificity.Methods We engineered a reactive oxygen species (ROS)- and pH-dual responsive polydopamine nanoplatform (Fasudil@PDA) to deliver Fasudil while concurrently scavenging oxidative stressors.Results The Fasudil@PDA nanoparticles achieved a high drug loading capacity of ~28%. The release kinetics were specifically engineered to be responsive to the DR microenvironment. Under high ROS conditions in vitro, the platform demonstrated a sustained and efficient release profile, achieving a cumulative release of 87.3% over 56 days — demonstrating remarkable longevity. Separately, the pH-responsive drug release capability was also confirmed under acidic conditions. The platform effectively neutralized multiple ROS species in vitro and significantly restored endothelial barrier integrity by inhibiting the ROCK/MLC pathway. In a laser-induced choroidal neovascularization model, a single injection suppressed pathological angiogenesis by 45%. In diabetic mice, the same treatment markedly reduced vascular leakage, attenuated neuroinflammation, and restored retinal function, with b-wave amplitudes recovering to near-normal levels.Conclusion This study establishes a multi-faceted nanotherapeutic strategy that synergizes sustained, long-acting ROCK inhibition with innate antioxidant activity. Designed to be activated by the pathological cues of DR, including acidic pH and ROS, our approach precisely targets multiple pathological pathways, offering a promising and translatable paradigm for overcoming the limitations of current monotherapies.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Juan Zhou,Hao Li,Mingting Lv,Yumeng Bao,Jinghua Chen
To overcome the clinical limitations of amphotericin B (AmB), such as poor aqueous solubility, significant systemic toxicity, and dose-dependent nephrotoxicity, we developed a pH-responsive nanodelivery system (HH18@AmB) based on engineered human serum albumin (HSA) fused with 18 histidine residues (HH18). The histidine-rich design enables HH18 to undergo hydrophobicity-driven self-assembly, encapsulating AmB within uniform nanoparticles with an average size of ~150 nm and a high drug-loading capacity of 23.08 ± 2.93%. In vitro release studies confirmed a sustained, pH-dependent drug release profile under acidic conditions mimicking the microenvironment of fungal infections. Notably, the encapsulated AmB remains predominantly in the monomeric state, which is associated with reduced toxicity. Cytotoxicity assays demonstrated that HH18@AmB exhibited significantly enhanced biocompatibility against RAW 264.7 macrophages and HEK 293 T renal cells, maintaining cell viability above 65%, while retaining potent antifungal activity. The minimum inhibitory concentration against Candida albicans was determined to be 4 μg/mL, and at this concentration, HH18@AmB inhibited biofilm formation by 55%. In vivo pharmacokinetic evaluation revealed a prolonged circulation time, with the half-life (t₁/₂) extended by 2.12-fold and the area under the curve (AUC 0-t ) increased by 9.39-fold compared to free AmB. Moreover, HH18@AmB exhibited reduced renal accumulation, indicating alleviated nephrotoxicity. By integrating pH-responsive drug release, HSA-mediated stability, and markedly improved safety profile, HH18@AmB represents a promising nanotherapeutic strategy to enhance the clinical utility of AmB, particularly for the treatment of drug-resistant fungal infections.
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高影响因子
ACS Applied Nano Materials
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2026
·Vol. 9
·期 35
·16823-16837
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IF 5.8
Wang Jiayu,Yan Herui,Li Fan,Chen Zhuoming,Xin Binjie,Wu Yu
Diabetic wounds remain difficult to treat due to bacterial
resistance,
a localized weakly acidic microenvironment, imbalanced oxidative stress,
and poor dressing conformity. To address these challenges, this study
developed an injectable pH-responsive nanocomposite hydrogel using
phenylboronic acid-modified chitosan (PBCS), tannic acid (TA), and
porphyrinic metal–organic framework PCN-224 nanoparticles,
featuring with superior tissue adhesiveness, self-healing, and pH-responsiveness.
The hydrogel was fabricated using PBCS as the matrix and TA as the
cross-linker, establishing a dual-cross-linked network sustained by
dynamic boronate ester bonds and multiple hydrogen bonds, into which
the porphyrinic metal–organic framework (MOF) PCN-224 was subsequently
loaded. This hydrogel precisely senses and exploits the endogenous
weakly acidic microenvironment of the infected wound, triggering the
dissociation of boronate ester bonds to achieve the on-demand release
of TA, as well as the smart regulation of the network’s swelling
behavior. The synchronously released polyphenol component, TA, imparts
excellent antioxidant activity to scavenge excess free radicals and
re-establish oxidative stress balance. Meanwhile, under 660 nm laser
irradiation, PCN-224 generated reactive oxygen species and a mild
photothermal effect, enabling combined photodynamic and photothermal
antibacterial activity. Collectively, the PBCS-TA/PCN-224 nanocomposite
hydrogel integrates pH-responsive behavior, antioxidant activity,
and light-triggered antibacterial functionality, supporting its potential
application in infected diabetic wounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Xixi Zhu,Ying Feng,Haiqi Zhang,Jinfeng Wang,Qian Wang,Shaoyu Chen,Xungai Wang
A biobased hydrogel film was fabricated using sodium alginate and anthocyanin. • The film exhibits sensitive color changes for visual wound infection monitoring. • Antibacterial activity is achieved without additional drugs. • On-demand dissolution triggered by EDTA enables pain-free removal and recycling. Wound status monitoring has emerged as a promising strategy to enable timely intervention for effective wound infection management and promote wound healing. Herein, a recyclable alginate hydrogel film with pH-sensing and antibacterial functions was developed as a smart wound dressing. The hydrogel film (SA-Anth) was fabricated via a two-step process, i.e., an evaporation-induced self-assembly of sodium alginate solution doped with anthocyanin and glycerin, followed by Ca 2+ -mediated ionic cross-linking using CaCl 2 . Taking advantage of the pH-responsiveness of anthocyanin, the hydrogel film exhibited distinct color changes from red-purple at pH 5.0 to violet-blue at pH 7.3 and further to green at pH 9.0, suggesting its potential for visual monitoring of wound pH variations associated with infection. The incorporation of anthocyanin endowed the film with antibacterial activity, achieving bacterial reduction rates of 90.48% against E. coli and 98.10% against S. aureus . The hydrogel film also exhibited wound-dressing-relevant properties, including appropriate physicochemical performance, a low hemolysis ratio, and good in vitro cytocompatibility. In an S. aureus -infected rat full-thickness wound model, SA-Anth treatment enhanced wound closure and improved histological features of tissue repair compared with the control treatments. Furthermore, the de-crosslinking of the ionically crosslinked network was triggered by the addition of EDTA, enabling the recovery of the alginate component. The SA-Anth hydrogel film integrates pH-responsive visual indication, antibacterial activity, favorable biocompatibility, infected-wound repair performance, and EDTA-assisted material recovery, providing a promising platform for intelligent wound-dressing applications.
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Food Packaging and Shelf Life
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2026
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IF 10.8
Peng Shan,Jian Du,Zhihang Xu,Chenglong Fu,Jinwen Hu,Yehan Tao,Chao Li,Jijuan Cao,Dong Lv,Haisong Wang
The proliferation of halophilic bacteria severely shortens the shelf life of high-salt foods. However, in emulsion-based active packaging systems, abundant salt ions can readily destabilize the emulsion structure through ionic complexation, resulting in the burst release of active agents and ultimately weakening preservation efficiency. Here we reported an ion-shielding strategy for salt-resistant emulsions in which tea polyphenol-grafted sodium polyacrylate (PNa@TP) forms robust interfacial stabilizing shell, while curcumin (Cur) serves as an active model. Molecular dynamics simulations showed that hydrophobic aromatic rings of tea polyphenol (TP) assemble into continuous hydrophobic domains at the oil–water interface, effectively preventing hydrated ions from approaching and disrupting interfacial structure. Consequently, PNa@TP–Cur emulsions maintain a unimodal size distribution and excellent macroscopic stability for over 30 days under high-salinity conditions up to 2.0 M in NaCl, KCl, and CaCl 2 solutions, whereas pristine PNa emulsions undergo rapid phase separation within 24 h. Moreover, reversible interactions between ammonia and sodium carboxylate groups dynamically modulate polymer interchain associations, enabling synergistic pH-responsive release of the encapsulated agent. As proof of concept, composite films containing these emulsions effectively extended the refrigerated shelf life of salted pork and sea shrimp during storage. This work establishes a general ion-shielding design paradigm for emulsion-based smart materials operating in high-ionic-strength environments.
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Small
·
2025
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IF 12.1
Bocong Zou,Hulin Wang,Runchao Dong,Jia Zhang,Zhiheng Liu,Yan Lin,Zhicheng Zhu,Xiangyang Hu,Weijun Li,Dongdong Zhang,Xiaoxiao Li,Lin Wang,Huan He,Weiyou Yang,Fengmei Gao,Shanliang Chen
The precise control of the surface properties of low-dimensional nanostructures is a prerequisite for preserving the intrinsic material quality and manipulating the carrier transport behavior to enhance optoelectronic device performance. Herein, a high-responsivity photoelectrochemical (PEC) ultraviolet (UV) photodetector (PD) based on SiC/TiO 2 heterojunction nanowires is developed. The surface of SiC nanowires is decorated with high-quality TiO 2 nanoparticles through a simple hydrothermal process, and a type-II heterojunction is established. The fabricated SiC/TiO 2 heterojunction nanowire PEC PD exhibited excellent photoresponsivity with high responsivity (50.97 mA W −1 ), detectivity (1.07 × 10 12 Jones), and external quantum efficiency (16.85%) under 375 nm ultraviolet illumination. Response and decay times are as low as 0.3 and 0.1 ms, respectively—these values are within the state-of-the-art range for semiconductor nanostructure–based PEC PDs reported thus far. The device also exhibits excellent photoresponsivity and long-term stability under different light intensities, even in harsh universal-pH liquid environments, including acidic, neutral, and alkaline solutions with different concentrations. The elevated photodetection performance of the device is primarily attributed to the effective synergistic effect of the formation of a type-II charge transfer pathway in the SiC/TiO 2 heterostructure, the optimal load capacity of TiO 2 nanoparticles, and the excellent inherent corrosion resistance of SiC and TiO 2 .
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Regenerative Biomaterials
·
2025
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IF 8.1
Lu Xianwen,Hu Sitong,Zhang Zhaowenbin,Bao Jing,Cao Bangping,Xie Jian,Chang Jiang,Yang Chen,Wang Xiaohong,Su Jiansheng
Periodontitis, a chronic inflammatory disorder primarily induced by bacterial infection and exacerbated by excessive oxidative stress, leads to the destruction of alveolar bone. Diabetes mellitus intensifies this oxidative stress in periodontal tissues and disrupts the oral microbiome, thereby aggravating periodontal conditions and complicating the management of periodontitis. The development of materials that possess comprehensive therapeutic effects, including antibacterial, antioxidant, and osteogenic properties, for the treatment of diabetic periodontitis (DP) remains at the forefront of research. In this study, we introduced a copper hydrogen phosphate (CuHP) composite hydrogel, which exhibited multi-enzymatic activities at varying pH levels. This hydrogel was synthesized by encapsulating CuHP within a commercially available sodium alginate (SA) matrix. In vitro analyses explored the pH-responsive enzymatic activities, biocompatibility, and the antioxidant, osteogenic, and antibacterial properties of the resultant SA/CuHP composite hydrogel. At neutral pH, the hydrogel primarily exhibited catalase-like activity, providing it with antioxidant capabilities that reduced the inhibitory effects of oxidative stress on osteogenesis in bone marrow mesenchymal stem cells. In mildly acidic conditions, the hydrogel displayed peroxidase-like activity, catalysing the production of more potent reactive oxygen species and exhibiting significant antibacterial efficacy against Aggregatibacter actinomycetemcomitans. Furthermore, the SA/CuHP hydrogel continuously released copper ions, which synergistically enhance its osteogenic and antimicrobial efficacies. In vivo studies demonstrated that this composite hydrogel significantly inhibited bacterial growth and promoted bone regeneration in a rat model of DP. These findings suggest that the SA/CuHP hydrogel holds substantial potential for the treatment of periodontitis in patients with diabetes.
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