Nature Communications
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2026
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IF 18.1
Tang Yu,Li Jiale,Li Yanfang,Ran Pan,Zou Weixin,Yan Shicheng,Dong Lin
Achieving stable and selective electrocatalytic nitrate reduction (NO 3 RR) at high current densities demands a fundamental understanding of the hydrogenation mechanism. We demonstrate that alloying cobalt with ruthenium (RuCo) switches the dominant hydrogenation pathway from the Eley-Rideal (E-R) mechanism, involving solvated protons, to the Langmuir-Hinshelwood (L-H) mechanism, utilizing adsorbed protons. Microkinetic modeling, in situ spectroscopy and density functional theory (DFT) calculations reveal that the competitive E-R pathway on pure Co causes sluggish hydrogenation kinetics and low Faradaic efficiency. In contrast, the L-H pathway on RuCo sustains high hydrogen coverage ( θ H ≈ 0.45), enabling efficient hydrogen-atom transfer for high-rate and deep hydrogenation. Leveraging this mechanistic insight, we achieve a satisfactory ammonia yield rate of 135.53 ± 1.18 mg h −1 cm −2 with 100% Faradaic efficiency and robust 1000-h stability at 1 A cm⁻². This work provides critical understanding of electrochemical hydrogenation pathways for designing efficient catalysts operating under industrially relevant conditions.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Fan Yao,Ang Cao,Bing Zhou,Shengyong Lu,Jianhua Yan,Damien Debecher,Yaqi Peng
The synergistic removal of NO and chlorinated volatile organic compounds (CVOCs) using bifunctional catalysts has emerged as a cutting-edge strategy in environmental catalysis. However, achieving both efficient NOx selective catalytic reduction and CVOCs catalytic oxidation remains fundamentally challenging due to the inherent trade-off between activity and selectivity. Herein, we demonstrate that this trade-off can be overcome by applying a mechanochemical strategy coupled with electronic band modulation to construct a novel heterojunction catalyst, in which MnCe oxides are integrated with and piezoelectric BaTiO 3 to form a heterojunction interface. The optimized TB-MnCe catalyst exhibits remarkable synergistic performance, achieving the synergistic removal of o-dichlorobenzene (>80%) and NOx (100%) within a broad temperature range of 250–350 °C. Combined experimental and theoretical investigations reveal an interfacial charge transfer of approximately 4.6 electrons from BaTiO 3 to MnCe during mechanochemical treatment. This charge redistribution, mediated by the engineered interface, significantly enhances the redox capability of the active sites and promotes cooperative reactions. This work highlights that atomic-level interfacial electronic modulation induced by mechanochemical processing provides a powerful route to resolve the activity-selectivity dilemma in bifunctional catalysis. Download: Download high-res image (128KB) Download: Download full-size image
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ENVIRONMENTAL RESEARCH
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2026
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IF 8.2
Zhuoyi Xie,Keying Li,Xiaomai Zhou,Qiuchen Wu,Xiangrong Zhou,Ping Zeng,Jing Li,Qiao Niu,Zhipeng Qi,Xinying Zhao,Weiyi Song
Epidemiological evidence has linked early-life exposure to estrogenic endocrine-disrupting chemicals (e-EDCs) to craniofacial malformations. Benzophenone-2 (BP2), a representative e-EDC, is frequently detected in environmental media and biological samples. However, the developmental effects of BP2 on craniofacial chondrogenesis and the underlying mechanisms remain unclear. Here, we demonstrate that early exposure to environmentally relevant concentrations of BP2 induces orofacial cleft-like craniofacial defects in zebrafish larvae, characterized by jaw flattening and anterior neurocranium shortening. Using Tg (sox10: EGFP) zebrafish, we traced these abnormalities to disrupted cranial neural crest cell (CNCC) development. Morpholino knockdown and genetic knockout further identified estrogen receptor signaling as a key mediator of BP2-induced craniofacial toxicity, with esr2a exerting the predominant effect. Mechanistically, esr2a activation suppresses endothelin signaling, thereby disrupting CNCC-dependent craniofacial development, and pharmacological activation of the endothelin pathway markedly alleviates these defects. Together, these findings identify an esr2a -endothelin signaling axis underlying BP2-induced disruption of CNCC-derived craniofacial cartilage development. This work highlights craniofacial chondrogenesis as a sensitive developmental target of e-EDCs exposure, and provides new mechanistic insight for environmental health risk assessment.
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Advanced Science
·
2026
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IF 14.1
Guangmeng You,Jingdan Lei,Kai Xu,Yuntian Fu,Xueke Gu,Chengxiao Peng,Zhen Wang,Jing Chen,Kunpeng Zhao,Chao Wang
Mg 3 (Sb,Bi) 2 has emerged as one of the most promising thermoelectric materials with the potential to complement commercial bismuth telluride. However, its performance is still hindered by pronounced carrier grain-boundary scattering, relatively high lattice thermal conductivity, and poor chemical stability. In this work, we reveal the multifaceted role of Ta in enhancing the thermoelectric performance of Mg 3 (Sb,Bi) 2 -based materials. The incorporation of Ta not only increases carrier concentration through the donor effect, but also boosts carrier mobility by promoting grain growth and reducing the potential barrier. Meanwhile, Ta point defects together with metallic Ta precipitates induce strong phonon scattering, leading to a substantial reduction in lattice thermal conductivity. These synergistic effects yield outstanding TE performance, with a remarkably high zT plateau of 1.8 between 573 and 723 K, surpassing the performance of most previously reported Mg 3 (Sb,Bi) 2 systems. Moreover, a TE module constructed by both p-type and n-type Zintl phases achieves a high conversion efficiency of 9.6% at ΔT of 460 K. This work takes an important step toward the practical application of Mg 3 Sb 2 -based TE materials and devices.
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JOURNAL OF POWER SOURCES
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2026
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IF 8.4
Yuqian Gao,Haotian Tan,Wenxue Chen,Jinlin Wang,Fan Luo,Hongfu Gao,Maierwaiti Jimosi,Xiaoyuan Zeng
The development of highly efficient and low-cost bifunctional catalysts is pivotal for the large-scale commercialization of water electrolysis technology. A solvothermal method was used to fabricate the bifunctional Ir 0.1 Ni/Ni(OH) 2 electrocatalyst, utilizing Ni(OH) 2 which served as both the support and the nickel (Ni) source for the in-situ formation of IrNi alloy nanoparticles via co-reduction. The significant electronegativity difference between iridium (Ir) and Ni induced electron transfer from Ni to Ir at the alloy interface, resulting in substantial interfacial electronic reconstruction. This electronic synergy optimally regulated the bifunctional activity: the electron-rich Ir sites facilitated the adsorption of hydrogen intermediates, enhancing the hydrogen evolution reaction; whereas the electron-deficient Ni sites strengthened the adsorption of hydroxyl and oxygen intermediates (OH, OOH*), significantly lowering the energy barrier for the oxygen evolution reaction. Therefore, this catalyst exhibits excellent activity and stability in both the OER and the HER. In a 1.0 M KOH solution at a current density of 10 mA cm −2 , the HER requires an extremely low overpotential of only 31 mV, while the OER requires 270 mV. Moreover, Ir 0.1 Ni/Ni(OH) 2 serves as an electrocatalyst for overall water splitting in alkaline media. This research provides a simple and effective strategy for designing advanced alloy catalysts for sustainable energy conversion.
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PHYSICA B-CONDENSED MATTER
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2026
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IF 3.2
Chang Feng,Qian Jing,Li Tang,Jiangping Jing,Ruiling Wang,Zhuoyuan Chen
S-C 3 N 4 /Mg(OH) 2 heterojunction photocatalyst was synthesized via a simple ball-milling method. • S-C 3 N 4 /Mg(OH) 2 exhibited significantly enhanced photocatalytic performance. • S-C 3 N 4 /Mg(OH) 2 demonstrated stable photocatalytic activity in complex ionic environments. • The photocatalytic reaction mechanism of S-C 3 N 4 /Mg(OH) 2 was proposed in this work. This work fabricated a type II 2D/2D S-doped graphitic carbon nitride/magnesium hydroxide (S-C 3 N 4 /Mg(OH) 2 ) heterojunction photocatalyst via a straightforward ball-milling method. The Mg(OH) 2 nanosheets are uniformly dispersed on the surface of S-C 3 N 4 , forming a well-developed heterojunction structure. The S-C 3 N 4 /Mg(OH) 2 composite material was employed as a photocatalyst and exhibited high efficiency in degrading tetracycline and methyl orange in an aqueous environment. The optimized S-C 3 N 4 /Mg(OH) 2 -30 composite demonstrated superior photocatalytic performance, achieving 100% removal of tetracycline within 45 min and 93% degradation of methyl orange within 60 min. Its performance was significantly superior to that of the single-component photocatalysts, and it exhibited stable photocatalytic activity even in complex ionic environments. The formation of Type-II heterojunction between S-C 3 N 4 and Mg(OH) 2 facilitates charge separation/migration and thus significantly enhanced pollutant removal efficiency. The S-C 3 N 4 /Mg(OH) 2 composite material fabricated in this work shows great promise for practical wastewater treatment applications. The S-C 3 N 4 /Mg(OH) 2 heterojunction photocatalyst was successfully fabricated. It not only exhibits outstanding photocatalytic performance in degrading organic pollutants but also maintains stable photocatalytic degradation ability even under complex ionic conditions. Download: Download high-res image (368KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Mingcong Tang,Li Wu,Zichu Li,Heng Gao,Hao Zhang,Zijian Wang,Dongzhi Zhang,Zhaofeng Wu
The dynamic reaction process of HCHO, encompassing its adsorption onto the surface of CuO nanosheets, subsequent oxidation to formic acid, and further oxidation to carbon dioxide, was elucidated using in-situ infrared spectroscopy and Gibbs free energy calculations. • Surface-induced preparation facilitates the formation of high-energy (110) crystal planes and (20−2) twin defects in CuO nanosheets, which synergistically enhance their performance for ultra-sensitive formaldehyde detection. • The CuO nanosheet sensor exhibits an extremely low detection limit of 0.1 ppb, along with rapid response and recovery times, enabling long-term and continuous detection. Long-term exposure to an environment above the formaldehyde threshold poses a serious threat to human health. In this study, by adjusting the concentration of the surfactant polyvinylpyrrolidone, CuO nanosheets with high-energy crystal planes (110, 20−2) twinning defect structures were successfully prepared for the first time. Through operando infrared and theoretical calculation of Gibbs free energy and adsorption energy, the dynamic process of HCHO adsorption on the surface of CuO, oxidation to formic acid and ultimately to carbon dioxide was revealed for the first time. The results of the gas sensitivity test show that the response value of the CP-4 sensor to formaldehyde reaches 129.95 (5 ppm) at the low operating temperature (100 °C), with a detection limit as low as 8.4 ppb. The response/recovery time were 6 s/14 s. This sensor demonstrated excellent stability during 50 cycles and 90 days of continuous operation. Its outstanding performance stems from the fact that high-energy crystal planes increase the active sites for oxygen adsorption, and twinning defects accelerate electron transfer. The examination system based on the STM-32 platform verified the feasibility of practical application. This study provides a new strategy for optimizing the performance of CuO-based HCHO sensors, which has significant guiding significance for the development of high-performance semiconductor gas sensors. Download: Download high-res image (131KB) Download: Download full-size image
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TOXICOLOGY
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2025
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IF 4.6
Jing Zhang,Yan Zhao
Glutamate is the principal excitatory neurotransmitter in the central nervous system. It is essential for neurotransmission and synaptic plasticity; however, excessive glutamate leads to neuronal toxicity, which is considered as a key mechanism contributing to neurodegeneration. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in ethanol metabolism, which converts the toxic alcohol metabolite acetaldehyde to acetate; meanwhile, ALDH2 is also important for the detoxification of other reactive aldehydes such as lipid peroxidation product 4-hydroxy-2-nonenal. ALDH2 deficiency has been associated with the acceleration of neurodegeneration and cognitive impairment accompanied by increased brain oxidative damages. However, there is a lack of reports on how ALDH2 deficiency affects glutamate-induced cytotoxicity. In the present study, it was found that ALDH2-deficient N2a cells exhibited heightened susceptibility to glutamate, displaying aggravated oxidative stress, mitochondrial dysfunction, and calcium imbalance in response to glutamate. ALDH2 deficiency led to reduced antioxidant capacity and elevated intracellular calcium concentration at basal state, thus predisposing the cells to a higher sensitivity to glutamate. Further analyses showed that ALDH2 deficiency elevated the expression of GluN1 subunit of N-methyl-D-aspartate receptors (NMDARs), which are major ionic glutamate receptors allowing the passage of calcium. Consistently, treatment with the NMDAR channel blocker MK-801 (100 μM) or knockdown of GluN1 reduced the susceptibility of Aldh2 -/- cells to glutamate, suggesting that the elevation of GluN1 was a key determinant for the increased sensitivity of ALDH2-deficient cells to glutamate-induced cytotoxicity. The results revealed that ALDH2 plays a critical protective role in glutamate-induced neuronal cytotoxicity, while blocking the overactivation of NMDARs might be beneficial for preventing glutamate-induced neuronal toxicity in individuals with defective ALDH2.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Kuan Gao,Qin Geng,Changbao Hu,Wenhui Zhang,Xin Li,Ping Tong,Anshu Yang,Zhihua Wu,Hongbing Chen
Interactions between food allergens and polyphenols can provide a method to alleviate food allergies. This study investigated the effect of differently structured polyphenols complexed with Ara h 2 based on high-throughput virtual screening, utilizing a spectroscopic, thermodynamic, bone marrow-derived dendritic cells (BMDCs) model, BMDCs-T cells coculture model, KU812 cells model, and molecular simulation analyses for the allergenicity evaluation. Hesperidin (HSD), neohesperidin (NH), and neohesperidin dihydrochalcone (NHDC) exhibited a high binding energy and interacted with Ara h 2 through hydrogen bonding, primarily at two additional binding sites. This interaction led to protein unfolding and reduced hydrophobicity, particularly in the NH–Ara h2 complex. In addition, NH-bound Ara h2 has a lower potential for sensitization due to its reduced immunoglobulin E (IgE) binding capacity compared with Ara h 2 during gastrointestinal digestion. This is further supported by the decreased expression of costimulatory factors in BMDCs, the reduced release of allergenic cytokines, and the maintained balance of Th1, Th2, Th17, and Treg. The same trend was followed by the HSD and NHDC complexes. These findings suggest that glycosidic bond positions play a more significant role in reducing sensitization than does the flavonoid structure. Therefore, this study can assist in developing oral-specific immunotherapy of individuals with peanut allergies under the potential interaction mechanism of polyphenols and Ara h 2.
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BIOSENSORS & BIOELECTRONICS
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2025
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IF 10.5
Qisheng Luo,Chuanhua Zheng,Yongning Huang,Linghuan Liang,Yuanxun Gong,Jiayi Zhang,Qianli Tang,Kai Zhang,Xianjiu Liao
Lead-halide perovskites offer bright electrochemiluminescence (ECL) but suffer from aqueous instability and Pb 2+ safety concerns. We construct a CsPbBr 3 @PDA–Au nanointerface that couples polydopamine (PDA) passivation with Au-assisted charge transfer, integrated into a peptide-to-CRISPR/Cas12a amplification scheme for ultrasensitive detection of matrix metalloproteinase-2 (MMP-2). PDA conformally coats CsPbBr 3 , suppressing trap-mediated quenching and mitigating Pb 2+ release, while providing catechol/amine anchors for a tetrahedral DNA scaffold bearing a ferrocene-labeled hairpin. Upon MMP-2 cleavage of a GPLG↓VRG peptide–DNA chimera, the released strand activates Cas12a trans-cleavage, removing the proximal quencher and switching the interface from “off” to “on.” Under unified processing (baseline subtraction and renormalization), the platform achieves a 5.6 aM detection limit with high selectivity over non-target proteases and excellent inter-device reproducibility (triplicate error bars reported). TEM/HRTEM visualize uniform nanocubes; XPS/FTIR evidence PDA catechol/quinone/amine coordination; XRD confirms phase-pure CsPbBr 3 ; and corrected CV/EIS analyses verify accelerated interfacial kinetics after Au decoration. The sensor retains ∼98 % intra-day and ≥91 % 7-day signal, supporting operational robustness. By integrating interfacial stabilization, catalytic electron transfer, and molecular amplification, this modular design advances eco-conscious, perovskite-based ECL diagnostics for low-abundance protease monitoring and broader clinical bioanalysis.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Yanqiu Xu,Jiaju Lu,Xuanli Chen,Yin Li,Keyu Zhang,Shaoze Zhang,Yaochun Yao,Junxian Hu
Sodium-ion batteries (SIBs) are the highly promising rechargeable batteries for large-scale energy storage systems, offering advantages such as low cost, high safety and fast charging capabilities. Important research work on SIBs has focused on exploring high-performance electrode materials and their mechanism in depth. With benefits of low cost, good thermal stability and small volume strain, Na 3.12 Fe 2.44 (P 2 O 7 ) 2 (NFPO) is a potential cathode material. However, the inherent poor conductivity of the material leads to polarization, consequently compromising electrochemical reversibility. Therefore, we synthesized NFPO composites with porous structure (P-NFPO) by sol-gel method which exhibited excellent electrochemical performance. The diffusion path of sodium ions during charging and discharging can be effectively shortened by the three-dimensional pore structure, which also promotes electrolyte penetration and absorbs volume expansion. P-NFPO exhibits a reversible specific capacity of 108.13 mAh g −1 at the rate of 0.1 C. Additionally, NFPO exhibits superb long-term cyclability and rate capability. Its specific capacity was found to be 95.94 mAh g −1 at a current density of 1 C. Impressively, even after 400 cycles at a rate of 5 C, it retains 95.1 % of its initial capacity, maintaining a reversible specific capacity of 74.6 mAh g −1 . Furthermore, when operated at 0.2 C, the P-NFPO//hard carbon full cell demonstrates a reversible capacity of 100.9 mAh g −1 . This study presents new ideas for modified cathode materials and promotes the practical application of cathode materials.
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MICROCHIMICA ACTA
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2025
·Vol. 192
·期 7
·1-14
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IF 5.3
Gao Yueming,Weng Guojun,Li Jianjun,Zhu Jian,Zhao Junwu
A flexible silver triangular nanoplate (Ag TNPs)@m-phenylenediamine (mPD)@polyacrylonitrile (PAN) skin patch based on electrospinning is fabricated and applied to detect human beta-defensin 2 (HBD-2) by using surface-enhanced Raman scattering (SERS). First, PAN was used as the base material to create a fibrous membrane through electrospinning. The fibers were then modified with Ag TNPs by mPD endowing positive charges, forming a flexible Ag TNPs@mPD@PAN substrate. The flexible substrate features advantages of simple preparation, low cost, and convenient portability, which are suitable for in situ rapid detection on irregular surfaces. The combination of the flexible Ag TNPs@mPD@PAN substrate with Ag TNPs probes enabled the specific detection of HBD-2. It demonstrated satisfactory sensitivity and reproducibility with a wide detection range of 100–10 ng/mL and a limit of detection (LOD) of 59.57 fg/mL. Eventually, the flexible substrate was applied to HBD-2 detection on the surface of contaminated chicken skin. This study provides a simple and highly sensitive method for the detection of HBD-2, offering a novel approach for the non-invasive rapid diagnosis of psoriasis and the monitoring of disease progression. Graphical
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