Nanoscale
·
2023
·
IF 6.7
Xia Zhang,Like Ning,Hongshuai Wu,Wenhong Wang,Suisui Yang,Ziyi Hu,Yuandong Cao,Hongliang Xin,Chaoqun You,Fan Lin
Despite aggressive treatments, including surgery, chemo- and radio-therapy, the prognosis of glioblastoma (GBM) remains poor and tumor recurrence is inevitable. The FDA-approved CDK4/6 inhibitor palbociclib (PB) showed interesting anti-GBM effects, but its brain penetration is limited by the blood-brain barrier. The hypothesis of this project is to find whether the cellulose-based hydrogel via in situ injection could provide an alternative route of PB brain delivery and generate sufficient drug exposure in orthotopic GBM. In brief, PB was encapsulated in a cellulose nanocrystal network structure crosslinked by polydopamine via divalent Cu2+ and hexadecylamine. The formed hydrogel (PB@PH/Cu-CNCs) exhibited sustained drug retention and acid-responsive network de-polymerization for controlled release in vivo. Specifically, the released Cu2+ catalyzed a Fenton-like reaction to generate reactive oxygen species (ROS), which was further enhanced by PB, and consequently induced irreversible senescence and apoptosis in GBM cells. Finally, PB@PH/Cu-CNCs demonstrated a more potent anti-GBM effect than those treated with free PB or PH/Cu-CNCs (drug-free hydrogel) in cultured cells or in an orthotopic glioma model. These results prove that the injection of PB-loaded hydrogel in situ is an effective strategy to deliver CDK4/6 inhibitor into the brain and its anti-GBM effect can be further enhanced by combining Cu2+-mediated Fenton-like reaction.
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Materials
·
2023
·Vol. 16
·期 10
·3642
·
IF 3.4
Lina Zhang,Xiaomin Huo,Jin Zhu,Changbin Liu,Lianfeng Wang
Dye is an anionic common pollutant in industrial wastewater and poses a great threat to the environment and human health. Owing to its advantageous adsorption capacity, nanocellulose is widely used for wastewater treatment. The cell walls of Chlorella mainly comprise cellulose instead of lignin. In this study, residual Chlorella-based cellulose nanofiber (CNF) and cationic cellulose nanofiber (CCNF) with surface quaternization were prepared through homogenization. Moreover, Congo red (CR) was used as a model dye to measure the adsorption capacity of CNF and CCNF. The adsorption capacity was almost saturated when CNF and CCNF contacted CR for 100 min, and the adsorption kinetics coincided with the pseudo-secondary kinetics model. The initial concentration of CR considerably affected its adsorption on CNF and CCNF. Below the initial concentration of 40 mg/g, the adsorption on CNF and CCNF considerably increased with the increase in the initial concentration of CR. Based on the sorption isotherms analysis of CNF and CCNF, the Langmuir model fitted best with the experimental data. Thus, CNF and CCNF surfaces were uniform, and monolayer adsorption occurred. The adsorption of CR on CNF and CCNF was greatly affected by the pH value, and the acidic medium favored the adsorption of CR (especially for CCNF). CCNF showed a more advantageous adsorption capacity, with a maximum value of 1657.89 mg/g, compared to that of CNF (190.0 mg/g). According to the findings of this study, residual Chlorella-based CCNF could be a very promising adsorbent candidate for removing anionic dyes from wastewater.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Qingcheng Wang,Xinyu Zhang,Jing Tian,Chenyu Zheng,Mohammad Rizwan Khan,Jiaqi Guo,Wenyuan Zhu,Yongcan Jin,Huining Xiao,Junlong Song,Orlando J. Rojas
We introduce a strategy to disintegrate cellulose microfibrils present in the cell walls of plant fibers. The process includes impregnation and mild oxidation followed by ultrasonication, which loosens the hydrophilic planes of crystalline cellulose while preserving the hydrophobic ones. The resultant molecularly-sized cellulose structures (cellulose ribbons, CR) retain a length of the order of a micron (1.47 ± 0.48 μm, AFM). A very high axial aspect ratio is determined (at least 190), considering the CR height (0.62 ± 0.38 nm, AFM), corresponding to 1–2 cellulose chains, and width (7.64 ± 1.82 nm, TEM). The new molecularly-thin cellulose proposes excellent hydrophilicity and flexibility, enabling a remarkable viscosifying effect when dispersed in aqueous media (shear-thinning, zero shear viscosity of 6.3 × 10 5 mPa·s). As such, CR suspensions readily develop into gel-like Pickering emulsions in the absence of crosslinking, suitable for direct ink writing at ultra-low solids content.
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ACS Catalysis
·
2023
·
IF 12.9
Yuting Zhu,Yuhe Liao,Luying Lu,Wei Lv,Jing Liu,Xiangbo Song,Jingcheng Wu,Lei Li,Chenguang Wang,Longlong Ma,Bert F. Sels
Facile oxidation is a promising technology to valorize lignocellulosic biomass toward high-value chemicals and cellulose. However, the carbon efficiency is restricted by inevitable dissolution and conversion of carbohydrates and the condensation and degradation of lignin and monophenolics. Herein, we report the use of CuO nanoparticles (NPs) to oxidatively fractionate lignocellulose with O2 in aqueous NaOH under mild conditions, achieving over 80% carbon efficiency. Lignin was converted to aromatic aldehyde monomers (up to 48.6 wt %, mainly vanillin and syringaldehyde), and the yield can surpass the theoretical value (on the basis of the β-O-4 bond content) due to cleavage of other bonds. This was proven by several model compounds with different interlinkages. All hemicelluloses were transformed toward water-soluble small acids (mainly oxalic acid). As it was protected by the complexation of Cu cations, up to 80% cellulose was obtained as a white crystalline residue with high purity (>95%), which has potential applications in the production of materials and chemicals.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Junfeng Cheng,Hualin Wang
The goal of this study was to develop new biocomposite films that can better protect and prolong the shelf life of food. Here, a ZnO: eugenol@yam starch/microcrystalline cellulose (ZnO:Eu@SC) antibacterial active film was constructed. Because of the advantages of metal oxides and plant essential oils, codoping with these can effectively improve the physicochemical and functional properties of composite films. The addition of an appropriate amount of nano-ZnO improved the compactness and thermostability , reduced the moisture sensitivity, and enhanced the mechanical and barrier properties of the film. ZnO:Eu@SC exhibited good controlled release of nano-ZnO and Eu in food simulants. Nano-ZnO and Eu release was controlled by two mechanisms: diffusion (primary) and swelling (secondary). After loading Eu, the antimicrobial activity of ZnO:Eu@SC was significantly enhanced, resulting in a synergistic antibacterial effect. Z 4 :Eu@SC film extended the pork shelf life by 100 % (25 °C). In humus, the ZnO:Eu@SC film was effectively degraded into fragments. Therefore, the ZnO:Eu@SC film has excellent potential in food active packaging.
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CELLULOSE
·
2023
·Vol. 30
·期 7
·4469-4484
·
IF 5.7
Wang Qin,Wang Ning,Zhu Ge,Lin Ning
Membranes organized by rigid cellulose nanocrystals (CNCs), the highly crystalline nano-objects, exhibit a wide range of potential applications attributed to their numerous advantages including excellent hydrophilicity, biocompatibility, high crystallinity, and superior strength. However, the correlation between mechanical stiffness and structural arrangements for CNC-based membranes is still a challenge, particularly in a predictive manner for the tailored macroscale performance. This study proposes a strategy of regulating the surface properties, charges and stiffness of CNC composite membranes with the incorporation of the zwitterion and chitin nanofibrils (ChNFs) components. The synthesized zwitterion ( n , n -dipropionate methyl ester octadecylamine) endows the modified CNCs with a pH-sensitively charged surface, displaying the cationic form in the acidic condition while converted to anionic surface in the alkaline state. The ionic “bridge” between semi-flexible nanofibrils and rigid CNCs can effectively reduce the nanohardness of the composite membranes, taking the uniform surface and microstructural morphologies. Graphical Abstract
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Miaoyu Gan,Caoyu Guo,Wenying Liao,Xiaoli Liu,Qi Wang
A natural biopolymer bilayer film based on chitosan and bacterial cellulose with a protective layer of pullulan was developed by a two-step solution casting method. Curcumin was incorporated as an active antioxidant and antibacterial agent into the inner layer. The films with different curcumin concentrations were systematically characterized. Fourier transform infrared spectroscopy and X-ray diffraction analyses showed high compatibility between curcumin and the polysaccharide matrix through intermolecular interactions, which was verified by enhanced mechanical and barrier properties. The curcumin incorporation improved the thermal stability by >35.4 %, along with lower visible and ultraviolet light transmittance (< 8.6 %) and water solubility (< 25.1 %). The film had both antibacterial and antioxidant properties, and the sustained release of curcumin was largest (> 58.8 %) in the fatty food simulant lasting for over 155 h. The results suggested that the film containing 0.2 % curcumin had ideal physical and functional properties, suggesting its potential as a novel packaging material for the preservation of high-fat food.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
An Liu,Jia Liu,Shu He,Jie Zhang,Wei Shao
Due to the increasingly serious antibiotic-related pollution, it is crucial to develop novel green bioadsorbents to effectively remove antibiotics from aqueous solutions. In this study, Fe doped zeolitic imidazolate frameworks-8 loaded cellulose (Fe/ZIF-8@cellulose) aerogels were prepared. The synthesized Fe/ZIF-8@cellulose aerogels were characterized experimentally including morphology observation and chemical compositions determination. The effects of bioadsorbent dosage, solution pH, adsorption time, initial TC concentration and adsorption temperature on the TC adsorption behaviors were systematically studied. Due to the introduction of Fe in the ZIF-8, the maximum adsorption capacity of Fe/ZIF-8@cellulose for TC could reach as high as 1359.2 mg/g, which is higher than the reported ZIF-8 loaded polysaccharide based adsorbents. The adsorption kinetics and isotherm of TC adsorption were also determined. With the cellulose as the matrix to load Fe/ZIF-8, the obtained Fe/ZIF-8@cellulose aerogels exhibited good reusability. Most importantly, the TC adsorption mechanism was proposed. The results of our finding suggest that the Fe doping into MOFs is an effective strategy to improve the antibiotics adsorption performance and the application of cellulose as the matrix is a valuable method to increase the cyclic utilization. This study highlights the potentials of applying the Fe/ZIF-8@cellulose aerogels in the antibiotics removal for practical wastewater.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Xinyi Xie,Canxin Li,Di Fan,Jian Zhong,Qiyu Liu,Xueqing Qiu,Xinping Ouyang
Traditional pretreatment of lignocellulose is usually conducted under higher acidic and high temperature conditions, which leads to both the degradation of sugar and the condensation of lignin, hindering the subsequent conversion. An effective approach to fractionate lignocellulose into 93.9% of noncondensed lignin, 99.4% of cellulose, 17.8% of xylose, and 66.7% of xylooligosaccharides under mild conditions was developed using the formic acid solution at 80 °C for 100 min. The β-O-4 bond content of lignin fractionated with formic acid (54.6 per 100 C9 units) was higher than dioxasolv lignin (48.4 per 100 C9 units), indicating that formic acid pretreatment well protected the ether bonds in lignin. Therefore, the hydrogenolysis of fractionated lignin contributed to 28.0% of aromatic monomer yield, which was comparable to dioxasolv lignin. As cellulose possesses a large amount of porosity because lignin was separated from lignocellulose, the hydrolysis of fractionated cellulose by molten salt hydrates gave a 96.4% of glucose yield.
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JOURNAL OF POROUS MATERIALS
·
2022
·Vol. 30
·期 3
·989-997
·
IF 2.523
Sun Weihao,Fang Yinchun,Wu Lingshuang,Liu Xinhua
Cellulose aerogel as the third generation of aerogel materials has become a hotspot. However, the poor mechanical property and dimensional stability of cellulose aerogel restrict its application. In this study, the micron down feather fibers (DFF) was used as the reinforcing material to prepare the cellulose composite aerogels by dispersion DFF in the carboxymethyl cellulose (CMC) matrix. The prepared CMC/DFF composite aerogel with low density (0.0389–0.0428 g/cm 3 ) and high porosity (about 97%). The effects of down fiber mass fraction on the mechanical and insulation properties of cellulose composite aerogel were studied. The addition of down feather fibers in the CMC aerogels could improve the mechanical property by increasing the compressive stresses at the 80% compressive strain about 75%. The CMC/DFF composite aerogels also could obtain excellent acoustic and thermal insulation properties with the sound absorption coefficient of 0.991 and thermal conductive of 0.06012 W/mK. The reinforcing mechanism of down fiber on cellulose aerogel was studied. The improvement of mechanical property of CMC aerogels by down feather fibers was due to the physical reinforcement by broadening the layers space of composite aerogels and the chemical reinforcement by forming the cross-linking system with CMC matrix and DFF through glutaraldehyde. Therefore, this research provides a novel strategy for preparation of cellulose composite aerogels with excellent acoustic and thermal insulation, and reinforced mechanical property by using the waste bio-based micron down feather fibers.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Haibo Huang,Long Mao,Wei Wang,Zhihan Li,Chengrong Qin
As a traditionally used packaging material, natural cellulose-based paper has poor barrier properties to water and oxygen, which severely limits its wide application in food packaging. In this study, we report a new sustainable approach to producing hydrophobic, high-barrier, and antibacterial packaging materials from cellulose paper. In this process, commercially available microcrystalline cellulose was first modified by long-chain stearic acid to form hydrophobic microcrystalline cellulose ester and then mixed with stearic acid as filler in the subsequent surface coating of bagasse fibre paper. The microcrystalline cellulose ester/stearic acid-coated paper (MSP) exhibited good water repellency and oxygen barrier activity due to a continuous hydrophobic film that formed, which completely covered the pores of the original bagasse fibre paper. The coated MSP sample also showed excellent dimensional stability in water and a good wet tensile strength of 16 MPa. In addition, poly(hexamethylene guanidine) (PHMG) was chemically grafted onto the free carboxyl groups of the MSP surface layer, and the resulting MSP- g -PHMG samples exhibited excellent antibacterial activity against Escherichia coli and Listeria monocytogenes . The biodegradable cellulose-based MSP- g -PHMG sample significantly delayed the decay of raspberry during storage, indicating its potential application in food packaging.
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CELLULOSE
·
2022
·Vol. 30
·期 4
·2597-2610
·
IF 6.123
Liu Hongxia,Fan Wei,Miao Yaping,Dou Hao,Shi Yang,Wang Shujuan,Zhang Xinqing,Hou Lin,Yu Xichen,Lam Su Shiung,Ge Shengbo
Worldwide, 45 million tons of waste cotton textiles are produced annually, of which 75% is burned and buried, leading to serious environmental pollution. In this study, a method for directly preparing colored regenerated cellulose fibers (CRCFs) from dyed cotton textile waste (DCTW) was demonstrated. The tensile strength of CRCFs reached 226 MPa, which was equivalent to that of commercial viscose fibers. CRCFs exhibited excellent color fastness and hydrophilicity. In addition, CRCFs can be reprocessed into secondary CRCFs. The tensile strength of secondary CRCFs was 14.64% less than that of the primary CRCFs due to the reduction in the polymerization degree of secondary CRCFs; however, it also can be woven into fabrics. The exploration of the secondary utilization of CRCFs provides an experimental basis for prolonging the service life of DCTW. This approach of preparing CRCFs achieves closed-loop recycling of waste colored cellulose textiles and prevents environmental pollution caused by decoloring and dyeing.
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