Cell Reports Medicine
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2026
·Vol. 7
·期 3
·
IF 14
Weihao Yang,Chunjie Wang,Chao Yu,Nan Jiang,Bin Yu,Yicheng Ni,Caifang Ni,Liangzhu Feng,Lei Zhang
Transcatheter arterial chemoembolization (TACE) faces limitations in hepatocellular carcinoma (HCC) due to suboptimal drug pharmacokinetics and immunosuppression post-embolization. This study develops iron nanoparticles (FeNPs) with pH-responsive Fenton activity as surfactants for a Lipiodol Pickering emulsion (LPE) to deliver cariporide, targeting tumor acidity. Cariporide inhibits plasma membrane sodium-hydrogen exchangers, reducing intracellular pH to amplify FeNP-induced ferroptosis while suppressing extracellular acidosis by blocking proton extrusion. The cariporide-loaded FeNP-LPE (CFe-LPE) promotes immunogenic cell death and reverses immunosuppressive tumor microenvironments by alleviating acidity. In multiple orthotopic HCC models, CFe-LPE-based transarterial embolization outperforms conventional doxorubicin-Lipiodol TACE, demonstrating that dual modulation of intra/extracellular pH enhances Fenton-catalytic embolic agents by synergistically activating antitumor immunity.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Zhuorong Fan,Xiaojing Xu,Jixian Luo,Zimeng Lei,Wenjuan Dong,Wenting Liang,Shengmei Song,Xiaojuan Gong
Background Red-emitting carbon dots (R-CDs), characterized by their long-wavelength fluorescence in the red spectral region, offer significant advantages as fluorescent probes due to their capacity to effectively mitigate light scattering and suppress autofluorescence interference from biological matrices. This inherent optical property positions them as one of the most promising candidates for high-contrast bioimaging and sensitive sensing applications. Herein, a novel type of highly luminescent R-CDs was synthesized via a tailored precursor design and doping strategy. Their potential as advanced fluorescent probes was systematically evaluated, focusing on their exceptional optical properties, photostability, and responsiveness to specific substances. Results The emitting of R-CDs exhibits strong pH sensitivity in the range of 1.5-4.0, enabling monitoring of extremely acidic environments. Additionally, R-CDs were employed as probes to develop a multi-mode sensing platform integrating ratiometric fluorescence, ratiometric colorimetry, and smartphone-based imaging for Ag + detection. Fluorescence mode: Ag + selectively quenches the red emission of R-CDs, while yellow emission of Cu-CDs remains stable. Quantification detection relies on the I 624 /I 550 ratio, with a linear range of 0–185.3 μM and LOD of 0.266 μM. Colorimetry mode: Ag + -induced aggregation of the R-CDs weakened the original absorption band and generates a new peak at 680 nm, enabling detection via the A 680 /A 610 ratio with a linear range of 0–208.0 μM and LOD of 0.398 μM. Moreover, the R-CDs solution undergoes a distinct color change under exposure to Ag + ; by leveraging smartphone-based color recognition, a portable visual sensing platform has been successfully constructed. Significance In this work, the synthesis of R-CDs provides a strategic reference for developing high-performance, multicolor-tunable, and function-oriented doped CDs. The multi-mode sensing platform achieves functional complementarity and data cross-validation, thereby improving the reliability, anti-interference capability and on-site applicability of detection. Analytical robustness is further enhanced by the ratiometric strategy's built-in reference signal, which effectively compensates for instrumental, environmental, and operational variables. This design strategy features universal principles and demonstrates strong potential across a wide range of applications.
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Food Packaging and Shelf Life
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2026
·
IF 10.8
Peng Shan,Jian Du,Zhihang Xu,Chenglong Fu,Jinwen Hu,Yehan Tao,Chao Li,Jijuan Cao,Dong Lv,Haisong Wang
The proliferation of halophilic bacteria severely shortens the shelf life of high-salt foods. However, in emulsion-based active packaging systems, abundant salt ions can readily destabilize the emulsion structure through ionic complexation, resulting in the burst release of active agents and ultimately weakening preservation efficiency. Here we reported an ion-shielding strategy for salt-resistant emulsions in which tea polyphenol-grafted sodium polyacrylate (PNa@TP) forms robust interfacial stabilizing shell, while curcumin (Cur) serves as an active model. Molecular dynamics simulations showed that hydrophobic aromatic rings of tea polyphenol (TP) assemble into continuous hydrophobic domains at the oil–water interface, effectively preventing hydrated ions from approaching and disrupting interfacial structure. Consequently, PNa@TP–Cur emulsions maintain a unimodal size distribution and excellent macroscopic stability for over 30 days under high-salinity conditions up to 2.0 M in NaCl, KCl, and CaCl 2 solutions, whereas pristine PNa emulsions undergo rapid phase separation within 24 h. Moreover, reversible interactions between ammonia and sodium carboxylate groups dynamically modulate polymer interchain associations, enabling synergistic pH-responsive release of the encapsulated agent. As proof of concept, composite films containing these emulsions effectively extended the refrigerated shelf life of salted pork and sea shrimp during storage. This work establishes a general ion-shielding design paradigm for emulsion-based smart materials operating in high-ionic-strength environments.
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ACS Applied Nano Materials
·
2026
·Vol. 9
·期 35
·16823-16837
·
IF 5.8
Wang Jiayu,Yan Herui,Li Fan,Chen Zhuoming,Xin Binjie,Wu Yu
Diabetic wounds remain difficult to treat due to bacterial
resistance,
a localized weakly acidic microenvironment, imbalanced oxidative stress,
and poor dressing conformity. To address these challenges, this study
developed an injectable pH-responsive nanocomposite hydrogel using
phenylboronic acid-modified chitosan (PBCS), tannic acid (TA), and
porphyrinic metal–organic framework PCN-224 nanoparticles,
featuring with superior tissue adhesiveness, self-healing, and pH-responsiveness.
The hydrogel was fabricated using PBCS as the matrix and TA as the
cross-linker, establishing a dual-cross-linked network sustained by
dynamic boronate ester bonds and multiple hydrogen bonds, into which
the porphyrinic metal–organic framework (MOF) PCN-224 was subsequently
loaded. This hydrogel precisely senses and exploits the endogenous
weakly acidic microenvironment of the infected wound, triggering the
dissociation of boronate ester bonds to achieve the on-demand release
of TA, as well as the smart regulation of the network’s swelling
behavior. The synchronously released polyphenol component, TA, imparts
excellent antioxidant activity to scavenge excess free radicals and
re-establish oxidative stress balance. Meanwhile, under 660 nm laser
irradiation, PCN-224 generated reactive oxygen species and a mild
photothermal effect, enabling combined photodynamic and photothermal
antibacterial activity. Collectively, the PBCS-TA/PCN-224 nanocomposite
hydrogel integrates pH-responsive behavior, antioxidant activity,
and light-triggered antibacterial functionality, supporting its potential
application in infected diabetic wounds.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Xixi Zhu,Ying Feng,Haiqi Zhang,Jinfeng Wang,Qian Wang,Shaoyu Chen,Xungai Wang
A biobased hydrogel film was fabricated using sodium alginate and anthocyanin. • The film exhibits sensitive color changes for visual wound infection monitoring. • Antibacterial activity is achieved without additional drugs. • On-demand dissolution triggered by EDTA enables pain-free removal and recycling. Wound status monitoring has emerged as a promising strategy to enable timely intervention for effective wound infection management and promote wound healing. Herein, a recyclable alginate hydrogel film with pH-sensing and antibacterial functions was developed as a smart wound dressing. The hydrogel film (SA-Anth) was fabricated via a two-step process, i.e., an evaporation-induced self-assembly of sodium alginate solution doped with anthocyanin and glycerin, followed by Ca 2+ -mediated ionic cross-linking using CaCl 2 . Taking advantage of the pH-responsiveness of anthocyanin, the hydrogel film exhibited distinct color changes from red-purple at pH 5.0 to violet-blue at pH 7.3 and further to green at pH 9.0, suggesting its potential for visual monitoring of wound pH variations associated with infection. The incorporation of anthocyanin endowed the film with antibacterial activity, achieving bacterial reduction rates of 90.48% against E. coli and 98.10% against S. aureus . The hydrogel film also exhibited wound-dressing-relevant properties, including appropriate physicochemical performance, a low hemolysis ratio, and good in vitro cytocompatibility. In an S. aureus -infected rat full-thickness wound model, SA-Anth treatment enhanced wound closure and improved histological features of tissue repair compared with the control treatments. Furthermore, the de-crosslinking of the ionically crosslinked network was triggered by the addition of EDTA, enabling the recovery of the alginate component. The SA-Anth hydrogel film integrates pH-responsive visual indication, antibacterial activity, favorable biocompatibility, infected-wound repair performance, and EDTA-assisted material recovery, providing a promising platform for intelligent wound-dressing applications.
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Communications Chemistry
·
2026
·
IF 6.9
Zhang Chengyu,Wang Longyu,Ndayisenga Fabrice,Jalil Anam,Zhang Yiming,Yu Zhisheng
The hydrogen evolution reaction (HER) is critical for clean energy conversion, yet achieving efficient and durable electrocatalysis across a wide pH range remains a major challenge. Modulating the electronic structure of metal single atoms has shown promise, but is often constrained by weak metal–support interactions in conventional carbon matrices. Here, we report a pH–universal HER electrocatalyst comprising atomically dispersed Ru sites and carbon–confined Ru nanoparticles, synthesized via one–step pyrolysis of biomass–derived precursors. The catalyst delivered low overpotentials of 176 mV (Tafel slope: 23 mV dec –1 ) in acidic and 241 mV (40 mV dec –1 ) in alkaline media at 200 mA cm –2 , along with outstanding operational stability exceeding 500 hours—outperforming commercial Pt/C. This performance arises from electron–rich Ru single atoms (RuN 4 ) modulated by neighboring Ru nanoparticles, synergistically embedded within a hydrophilic and porous carbon scaffold. Density functional theory (DFT) calculations revealed a near–optimal hydrogen adsorption free energy (ΔG H* = –0.25 eV) in acidic conditions and a moderate water dissociation barrier (0.94 eV) in alkaline media. Our findings demonstrate a viable strategy for integrating nanoparticles and single atoms to achieve both high activity and durability, while highlighting the upcycling of biomass into advanced HER catalysts via rational interface engineering.
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Biomaterials Advances
·
2026
·
IF 6.7
Junhui Jiang,Junbo Dang,Minna Ma,Qiaochu Fan,Tianhao Zhao,Nan Zuo,Yu Su,Dahui Sun,Mei Zhang
DMSN/Ca/Ce/GSH exhibits pH responsiveness and excellent osteoconductivity. • Ce 3+ /Ce 4+ and GSH achieved pH-responsive release under high glucose conditions and targeted the improvement of mitochondrial function. • Hydrogel modulates the inflammatory microenvironment through ionic effects and GSH. • Hydrogel accelerates angiogenesis and bone regeneration in diabetic bone defects. Diabetes is a chronic disease characterized by persistent hyperglycemia, which creates a pathological microenvironment that impairs bone regeneration. In diabetic conditions, inflammation, excessive reactive oxygen species (ROS) and mitochondrial dysfunction disrupt angiogenesis and hinder bone regeneration homeostasis. To address these challenges, this study developed an injectable hydrogel specifically designed to modulate the diabetic microenvironment and facilitate the repair of diabetes-related bone defects. The hydrogel is composed of pH-responsive drug-loaded dendritic mesoporous silica nanoparticles, hydrazide-modified carboxymethyl chitosan and oxidized hyaluronic acid. During the initial treatment phase, the acidic diabetic microenvironment destabilized the hydrogel network (crosslinked via Schiff base bonds), triggering the release of drug-loaded nanoparticles into the high ROS microenvironment. Subsequently, pH-responsive amide bonds and acid-degradable nanoparticles enabled the sustained release of Cerium ion (Ce 3+ /Ce 4+ ) and reduced glutathione (GSH). The synergistic antioxidant activity of Ce 3+ /Ce 4+ and GSH effectively scavenged ROS, mitigated oxidative stress induced by high glucose levels and restored mitochondrial function in the diabetic microenvironment. At later stages, the hydrogel transformed into a regenerative scaffold, accelerating angiogenesis and promoting osteogenesis. In summary, this pH-responsive hydrogel facilitates the targeted release of Ce 3+ /Ce 4+ and GSH under high glucose conditions and improves mitochondrial function, establishing a multi-component synergistic intervention strategy to disrupt the pathological cascade of diabetic bone defects. By combining ion-based action with drug delivery, this innovative hydrogel accelerates angiogenesis and bone regeneration, offering a promising therapeutic avenue for repair of bone defects in diabetic patients. Download: Download high-res image (306KB) Download: Download full-size image
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Journal of Macromolecular Science Part B-Physics
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2026
·
IF 1.7
Cheng Guo,Ziyi Dang,Hongying Yang,Shuibo Yang,Dehua Wen,Ying Li,Hao Liu,Yin He
Sweat contains a rich repertoire of biomarkers that can reflect physiological health statuses, such as electrolyte imbalance, stress levels, and certain diseases. This makes it an ideal biofluid for continuous, noninvasive monitoring via miniaturized wearable electrochemical biosensors. Herein, we developed a wearable sweat pH-sensing patch. The patch incorporates a polyaniline (PANI)-based pH-sensing electrode fabricated via screen-printing technology, which features a high specific surface area, enabling the simultaneous and real-time monitoring of sweat pH. The as-fabricated pH sensing patch demonstrates a high sensitivity of 45.8 mV·pH−1, a good linear response (R2 = 0.9732), excellent cycling stability, a rapid response time (20 s), and a broad detection range (pH 3 ∼ 8). Furthermore, when integrated with a self-developed miniaturized acquisition system, the patch successfully captured the dynamic variations in sweat pH during human physical exercise, thereby validating its stability and reliability in real-world scenarios. This work provides an effective wearable solution for personalized health monitoring and scientific exercise assessment, showcasing considerable application potential.
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Small
·
2025
·
IF 12.1
Bocong Zou,Hulin Wang,Runchao Dong,Jia Zhang,Zhiheng Liu,Yan Lin,Zhicheng Zhu,Xiangyang Hu,Weijun Li,Dongdong Zhang,Xiaoxiao Li,Lin Wang,Huan He,Weiyou Yang,Fengmei Gao,Shanliang Chen
The precise control of the surface properties of low-dimensional nanostructures is a prerequisite for preserving the intrinsic material quality and manipulating the carrier transport behavior to enhance optoelectronic device performance. Herein, a high-responsivity photoelectrochemical (PEC) ultraviolet (UV) photodetector (PD) based on SiC/TiO 2 heterojunction nanowires is developed. The surface of SiC nanowires is decorated with high-quality TiO 2 nanoparticles through a simple hydrothermal process, and a type-II heterojunction is established. The fabricated SiC/TiO 2 heterojunction nanowire PEC PD exhibited excellent photoresponsivity with high responsivity (50.97 mA W −1 ), detectivity (1.07 × 10 12 Jones), and external quantum efficiency (16.85%) under 375 nm ultraviolet illumination. Response and decay times are as low as 0.3 and 0.1 ms, respectively—these values are within the state-of-the-art range for semiconductor nanostructure–based PEC PDs reported thus far. The device also exhibits excellent photoresponsivity and long-term stability under different light intensities, even in harsh universal-pH liquid environments, including acidic, neutral, and alkaline solutions with different concentrations. The elevated photodetection performance of the device is primarily attributed to the effective synergistic effect of the formation of a type-II charge transfer pathway in the SiC/TiO 2 heterostructure, the optimal load capacity of TiO 2 nanoparticles, and the excellent inherent corrosion resistance of SiC and TiO 2 .
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Regenerative Biomaterials
·
2025
·
IF 8.1
Lu Xianwen,Hu Sitong,Zhang Zhaowenbin,Bao Jing,Cao Bangping,Xie Jian,Chang Jiang,Yang Chen,Wang Xiaohong,Su Jiansheng
Periodontitis, a chronic inflammatory disorder primarily induced by bacterial infection and exacerbated by excessive oxidative stress, leads to the destruction of alveolar bone. Diabetes mellitus intensifies this oxidative stress in periodontal tissues and disrupts the oral microbiome, thereby aggravating periodontal conditions and complicating the management of periodontitis. The development of materials that possess comprehensive therapeutic effects, including antibacterial, antioxidant, and osteogenic properties, for the treatment of diabetic periodontitis (DP) remains at the forefront of research. In this study, we introduced a copper hydrogen phosphate (CuHP) composite hydrogel, which exhibited multi-enzymatic activities at varying pH levels. This hydrogel was synthesized by encapsulating CuHP within a commercially available sodium alginate (SA) matrix. In vitro analyses explored the pH-responsive enzymatic activities, biocompatibility, and the antioxidant, osteogenic, and antibacterial properties of the resultant SA/CuHP composite hydrogel. At neutral pH, the hydrogel primarily exhibited catalase-like activity, providing it with antioxidant capabilities that reduced the inhibitory effects of oxidative stress on osteogenesis in bone marrow mesenchymal stem cells. In mildly acidic conditions, the hydrogel displayed peroxidase-like activity, catalysing the production of more potent reactive oxygen species and exhibiting significant antibacterial efficacy against Aggregatibacter actinomycetemcomitans. Furthermore, the SA/CuHP hydrogel continuously released copper ions, which synergistically enhance its osteogenic and antimicrobial efficacies. In vivo studies demonstrated that this composite hydrogel significantly inhibited bacterial growth and promoted bone regeneration in a rat model of DP. These findings suggest that the SA/CuHP hydrogel holds substantial potential for the treatment of periodontitis in patients with diabetes.
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REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Dandan Yan,Yuanfeng Pan,Pingxiong Cai,Huining Xiao
s Insecticides play a crucial role in promoting crop growth and boosting crop yields. However, they also contribute to environmental pollution and pose risk to human health. To increase the utilization rate of insecticides and minimize their pollution of the soil and water environment, it is imperative to develop a green material or carrier for the controlled-release of agrochemicals including insecticides. In this study, composite hydrogel beads were successfully prepared using dialdehyde starch and sodium alginate as green-based raw materials, cystamine dihydrochloride as a cross-linking agent, and meanwhile sodium alginate was ionic cross-linked with calcium ions. As-prepared composite hydrogel beads possess pH/redox dual-responsive properties, enabling the controlled release of the insecticide dinotefuran (DIN). The properties, structure and morphology of the hydrogel beads were comprehensively characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Additionally, the release behavior of DIN from the composite hydrogel beads under various conditions was extensively investigated. The results showed that the incorporation of dialdehyde starch significantly enhanced the encapsulation efficiency of DIN within the hydrogel bead. Moreover, the cumulative release of DIN can be precisely modulated by adjusting the release conditions or environmental stimuli; the release kinetics align with the Korsmeyer-Peppas model well. Specially, DIN release is accelerated under neutral conditions and in the presence of the reducing agent glutathione (GSH). The findings of this work are anticipated to exert a positive influence on agricultural production while also contributing to the alleviation of insecticide-related adverse environmental impacts.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Tianhao Zhang,Junjie Fan,Xinyu Yuan,Jianwen Hu,Haotian Gao,Wenqing Xie,Jingwen Wang,Jian Yang,Chunling Li,Shuangqing Sun
This study presents a novel responsive carbon dot-based surfactant system that exhibits catalytic activity at the interface of an oil-in-water Pickering emulsion microreactor containing reactants. Nickel nitrate was employed to dope carbon dots via a microwave-assisted method, imparting catalytic functionality to the resulting nanomaterials. Subsequently, poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) was grafted onto the surface of the nickel-doped carbon dots through electron transfer radical polymerization, yielding the catalytically responsive solid emulsifier Ni@CD-NH-Met-PDMAEMA (Ni@CD-3). Owing to the metal doping of carbon dots and subsequent emulsification functionalization, Ni@CD-3 demonstrates exceptional ability to stabilize reactive droplets in Pickering emulsion while exhibiting intrinsic catalytic activity at the oil–water interface. Notably, Ni@CD-3 exhibits high catalytic activity, with an extremely short reduction reaction time required to achieve a conversion efficiency exceeding 99%, attributed to the advantageous interfacial properties of the emulsion. Its catalytic efficiency is 560% higher than that of Fe@CD-3 under comparable conditions. Furthermore, the cyclic response property of Ni@CD-3 enables in situ separation and emulsion-breaking recovery by adjusting the pH at the end of the reaction. This property facilitates the recovery and reuse of the catalyst for up to five cycles, with the catalytic efficiency maintained above 99% for the first three cycles. These results suggest that the Ni@CD-3-based emulsion microreactor system holds great promise as a high-performance catalyst for diverse organic chemical reactions.
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