MATERIALS CHEMISTRY AND PHYSICS
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2026
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IF 5.2
Mengwen Hu,Piyu Gong,Jumiao Shi,Shuo Tao,Haibo Li,Suyuan Zeng,Lei Wang
In this work, Zn 3 (VO 4 ) 2 @Fe 3 O 4 composites were constructed and utilized as the anode materials for lithium-ion batteries. The formed Zn 3 (VO 4 ) 2 @Fe 3 O 4 composites with a Zn 3 (VO 4 ) 2 /Fe 3 O 4 weight ratio of 1:1 and 1:2 delivered the discharge capacities of 925.6 and 684.4 mA h g −1 respectively. The introduction of Fe 3 O 4 enhances the electronic/ionic transport and structural stability of the Zn 3 (VO 4 ) 2 microstructure, improves the charge transfer kinetics and pseudocapacitive behavior and stabilizes the cycling performance, thereby boosting the lithium storage capacity of the Zn 3 (VO 4 ) 2 based electrodes.
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Reaction Kinetics Mechanisms and Catalysis
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2026
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IF 2.1
Hu Yanan,Yang Dawei,Li Qiaoling,Yu Chengcheng
Herein, a Cr-doped Ni-Cu/(NiOH) 2 coating supported on nickel foam (Ni-Cu-Cr/NF) was fabricated via a facile one-step electrodeposition strategy and employed as an efficient electrocatalyst for the hydrogen evolution reaction (HER) in alkaline media. In 1 M NaOH, Ni–Cu–Cr/NF requires an overpotential of 30 mV to reach a current density of − 10 mA cm⁻ 2 and exhibits a Tafel slope of 55 mV dec⁻ 1 . These electrochemical results are associated with the combined effects of the multicomponent composition and an increased electrochemically active surface area (ECSA). The ECSA of Ni–Cu–Cr/NF is approximately 23.6 times that of Ni–Cu/NF. In addition, the catalyst maintains stable operation for 60 h during continuous electrolysis. This work presents a simple preparation method for the novel Ni-Cu-Cr/NF catalyst and systematically investigates the impact of Cr doping on enhancing catalytic performance, providing an effective strategy for the development of nickel-based alloy electrocatalysts. Graphical
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 9
·118223
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IF 6.3
Lan Gao,Yun Zhang,Xi Jiang,Shihua Ding
Ga 3+ heterovalent substitution for Zn 2+ was beneficial for modifying ZnZrTa 2 O 8 ceramic. The enlarged Q × f was caused by a combination of grain size and total lattice energy U Total increase. The improvement of τ f was attributed to the increase in Ta-O bond energy. Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 ceramics exhibited optimal Q × f of 103,236 ± 2155 GHz (@7.38 GHz) and τ f = -17.65 ± 1.61 ppm/℃. The improved τ f provided great convenience for gaining temperature stable dielectric ceramics. Afterward, ZnTa 2 O 6 as a temperature compensator was added to adjust the τ f to zero. The Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 dissolved into ZnTa 2 O 6 lattice. As a result, 0.4Zn 0.99 Ga 0.01 ZrTa 2 O 8.005 -0.6ZnTa 2 O 6 ceramic sintered at 1350 ℃ obtained the desirable dielectric properties: ε r = 28.18 ± 0.01, Q × f = 81,919 ± 394 GHz (@6.70 GHz), τ ƒ = -0.51 ± 0.06 ppm/℃.
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ORGANIC PROCESS RESEARCH & DEVELOPMENT
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2026
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IF 3.5
Jinnai Liu,Jiawei Tang,Hao Chen,Li Zhang,Ganlan Li,Fuli Zhang,Shaoxin Chen,Jun Yu
(S)-3-Bromo-2-(1-methoxyethyl)pyridine 1 is a key intermediate of RMC-6236. In this report, we detail the development and optimization of a highly enantioselective chemoenzymatic and kilogram-scale process for 1. The developed process for intermediate (S)-1-(3-Bromopyridin-2-yl)ethanol 3 was performed on 1 kg scale with a substrate concentration of 70.0 g/L, achieving a yield of 93.0% and an ee value of >99.9%. Subsequently, a simple and effective NaHMDS/CH3I methylation system afforded the title compound 1, in 95.0% yield and with >99.9% ee, achieving 88.4% overall yield from intermediate 1-(3-bromopyridin-2-yl)ethanone 2. This represents a notable increase compared to the early stage process (overall yield 55.5%). This optimized highly efficient and sustainable process was demonstrated during kilogram-scale production of 1.
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ANTIVIRAL RESEARCH
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2026
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IF 4.3
Ting Zhang,Zi-Ling Wang,Xi-Ya Li,Rong-Hua Luo,Lu-Xi Zhang,Hong-Yi Zheng,Si-Dong Xiong,Wen-Lan Yang,Yong-Tang Zheng
The continuous emergence of new SARS-CoV-2 variants limits the effectiveness of current vaccines and monoclonal antibodies, highlighting the urgent need for complementary antiviral strategies. Targeting host proteins that are exploited by the virus represents a promising approach to achieve broad-spectrum inhibition. Given the recently established proviral role of METTL3-dependent RNA m 6 A modification in SARS-CoV-2 replication, we conducted a structure-based virtual screening to repurpose compounds with acceptable safety profiles. Subsequent biochemical validation identified onvansertib and vilazodone as direct METTL3 binders and potent inhibitors of its methyltransferase activity. Notably, both compounds effectively suppressed the replication of ancestral SARS-CoV-2 and Omicron BA.2 variant in vitro . Mechanistically, each compound potentially enhanced the innate antiviral response of the host and repressed the expression of viral entry-associated host factors during infection; this observation is consistent with the established proviral role of METTL3. In summary, these findings not only substantiate METTL3 as a viable antiviral target but also lay the foundation for further research on the therapeutic potential of onvansertib and vilazodone against COVID-19.
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Nanoscale
·
2026
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IF 5.2
Tingting Cai,Shuangshuang Zhao,Qin Fang,Huixin Chen,Xiuli Jia,DONGXU YU
Vanadium (III) oxide (V2O3) has emerged as a promising cathode material for aqueous zinc-ion batteries owing to high theoretical capacity based on reversible two-electron redox chemistry. However, the cycling stability and reaction kinetics are highly sensitive to its microstructural characteristics, which remain insufficiently understood. Here, we report a facile and scalable synthesis of V2O3 via combining oil-bath reaction and controlled calcination process, enabling precise regulation of particle morphology and microstructure through calcination time. Systematic microstructural evolution is correlated with Zinc-ion storage behavior, revealing that optimized architectures effectively promote ion transport kinetics and structural stability. Coupled with a high-concentration water-in-salt electrolyte to suppress parasitic reactions, the optimized V2O3 cathode delivers a high specific capacity of 453.8 mA h g -1 at 0.05 A g -1 , exceptional rate capability with 180 mA h g -1 retained at 10 A g -1 , and prolonged cycling stability of 210 mAh g -1 after 1000 cycles at 1 A g -1 . This work elucidates the underlying structure-property relationship governed by microstructure but also provides valuable insights into the design of highperformance cathode materials for advanced energy storage systems.
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YONSEI MEDICAL JOURNAL
·
2019
·
IF 1.759
Huaxin Wang,Xuan Peng,Yayi Huang,Yeda Xiao,Zhuo Wang,Liying Zhan
Purpose The aim of this study was to investigate whether propofol could attenuate hypoxia/reoxygenation-induced apoptosis and autophagy in human renal proximal tubular cells (HK-2) by inhibiting JNK activation. Materials and methods HK-2 cells were treated with or without propofol or JNK inhibitor SP600125 for 1 hour and then subjected to 15 hours of hypoxia and 2 hours of reoxygenation (H/R). Cell viability and LDH release were measured with commercial kits. Cell apoptosis was evaluated by flow cytometry. The expressions of p-JNK, cleaved-caspase-3, Bcl-2, and autophagy markers LC3 and p62 were measured by Western blot or immunofluorescence. Results HK-2 cells exposed to H/R insult showed higher cell injury (detected by increased LDH release and decreased cell viability), increased cell apoptosis index and expression of cleaved-caspase-3, a decrease in the expression of Bcl-2 accompanied by increased expression of p-JNK and LC3II, and a decrease in expression of p62. All of these alterations were attenuated by propofol treatment. Similar effects were provoked upon treatment with the JNK inhibitor SP600125. Moreover, the protective effects were more obvious with the combination of propofol and SP600125. Conclusion These results suggest that propofol could attenuate hypoxia/reoxygenation induced apoptosis and autophagy in HK-2 cells, probably through inhibiting JNK activation.
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FOOD CHEMISTRY
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2026
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IF 10.4
Jialin Hu,Xinxin Xu,Xiaoling Wu,Hua Kuang,Chuanlai Xu,Lingling Guo
Melatonin (MT) is a popular ingredient in food and supplements due to its health benefits. However, unregulated use and labeling inaccuracies in commercial products pose safety risks. Establishing reliable monitoring methods is therefore essential for consumer protection. In this study, haptens were screened through computer simulations based on structural, charge, and electrostatic potential properties. Using the selected optimal hapten, a monoclonal antibody capable of simultaneously recognizing MT and 2-hydroxymelatonin (2-MT) was successfully developed. The half-maximal inhibitory concentrations for MT and 2-MT were 47.89 ng/mL and 185.09 ng/mL, respectively. Furthermore, a colloidal gold immunochromatographic assay was established to detect MT and 2-MT in milk, wine, and tablets. The visual limit of detection was 20–100 ng/mL for MT and 50–200 ng/mL (or μg/kg) for 2-MT, respectively. The method demonstrated reliable results when validated by LC-MS/MS. Meanwhile, the developed strips exhibited good stability.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Chao Chen,Meng-Han Li,Ya-Yun Ma,Guo-Zhi Han
Photo-deposition method has the advantages of simplicity, environmental friendliness, and high efficiency, and has been widely used in the field of materials preparation. In this paper, we firstly prepared hollow black TiO 2 microspheres by template method, then using the mesoporous hollow microspheres as a carrier, NiCl 2 ·6 H 2 O as raw material, a novel kind of hollow Ni(OH) 2 @TiO 2 composite microspheres was prepared by photochemical deposition. Characterization of X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), fluorescence spectrophotometry (PL), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FT-IR) indicated that the two units of TiO 2 and Ni(OH) 2 in the composite hollow microspheres form tightly chemical connections. More importantly, this chemical connection endowed the two functional units with mutually enhanced catalytic performance for reduction of aromatic nitro compounds and photocatalytic degradation of emerging organic pollutants. For example, it can catalyze the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) by NaBH 4 with a k value of 0.8457 min −1 , as well as degrade tetracycline hydrochloride (TCH) with a degradation rate of 92.29% within 60 min with a k value of 0.0606 min −1 , which is superior to most previous reports. Finally, based on a series of control experiments, a plausible mutually enhanced catalytic mechanism was proposed.
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Journal of Water Process Engineering
·
2026
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IF 6.6
Zengjin Fu,Yan Hao,Tingrui Lin,Huiling Ma,Huazheng Sai,Hui Yang
A novel adsorbent (PHPM) was synthesized through the functionalization of N -(2-Hydroxyethyl) acrylamide (HEAA) with phytic acid (PA) and applied for the adsorption of La(III) and Ce(III) ions. The material was characterized by means of FTIR, TGA, SEM, and XPS. The present study systematically investigated the effects of contact time, adsorbent dosage, initial La(III) or Ce(III) concentration, and pH value on the adsorption capacity. The maximum theoretical adsorption capacities of PHPM for La(III) and Ce(III) were determined to be 198.0 and 186.2 mg·g −1 , respectively. The adsorption process followed the pseudo-second-order kinetic model and the Langmuir isotherm model, as further confirmed by nonlinear fitting with low RMSE and χ 2 values. Thermodynamic analysis revealed negative Δ G values, positive Δ H and Δ S values, indicating a spontaneous, endothermic, and entropy-driven process. Furthermore, PHPM demonstrated high adsorption efficiency toward La(III) and Ce(III), even in the presence of competing ions. A preliminary cost analysis indicated that the preparation of PHPM was economically feasible with low cost. The adsorbent maintained approximately 50% of its initial adsorption capacity after ten consecutive adsorption-desorption cycles. The findings demonstrate that PHPM was a promising adsorbent for the recovery of La(III) and Ce(III) from aqueous environments.
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Frontiers in Public Health
·
2026
·
IF 4.1
Qizhi Diao,Sha Tang,Xin Liu,Jiajia Li,Xiangmin Zhou,Yuanyu Chen,Qiongyuan Zhang,Fangyu Yang
Background This study aimed to establish a rapid detection method for SARS-CoV-2 by integrating loop-mediated isothermal amplification (LAMP) with lateral flow dipstick (LFD) technology. Method Specific primers targeting the nucleocapsid (N) gene and open reading frame 1ab (ORF1ab) gene of SARS-CoV-2 were designed and labeled with 6-FAM and biotin, respectively. After systematically optimizing key reaction parameters, including primer selection, primer concentration, and LAMP reaction time, the sensitivity, specificity, and clinical applicability of the method were evaluated. Results The proposed LAMP-LFD assay enables rapid detection within 30 min with high specificity, accurately identifying the N and ORF1ab genes of SARS-CoV-2 without cross-reactivity with influenza A hemagglutinin gene, influenza B neuraminidase gene, and respiratory syncytial virus M gene. The limit of detection reached 1.892 × 10 1 copies/μL, showing comparable sensitivity to agarose gel electrophoresis and real-time quantitative reverse transcription PCR (RT-qPCR). The results were consistent across different batches of primers and probes, demonstrating good reproducibility. When compared with RT-qPCR using 114 inactivated throat swab samples, the diagnostic agreement rate reached 95.61%. Discussion This study provides technical support for the surveillance and control of SARS-CoV-2 infection.
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DALTON TRANSACTIONS
·
2026
·
IF 3.3
Xing-Yu Bi,Yuting Gao,Chenyuan Ma,Zhi Fang,Mei-Hong Duan
Designing birefringent crystals with wide band gap presents significant challenges, especially within chalcogenide systems. Herein, motivated by the high structural anisotropy of thiourea, along with the ultraviolet compatibility and birefringence activity of halogenated tin(II)-based anionic groups, SnCl2[SC(NH2)2], a novel molecular crystal, was discovered. SnCl2[SC(NH2)2] was characterized by a bench-shaped molecule structure which is formed by the sharing of sulfur anion between a distorted SnCl2S trigonal pyramid and a planar π-conjugated thiourea unit. Through the synergistic interactions among multiple functional groups and the auxiliary regulation of hydrogen bonds, SnCl2[SC(NH2)2] succeeded in breaking the “3 eV wall” with a band gap of 3.362 eV and achieved a large birefringence of 0.20@546 nm, demonstrating a facile design strategy for the development of chalcogenides with dual optical enhancement.
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