CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Guoqing Chen,Zhongchen Ma,Wenli Gu,Pu Liu,Tian Lan,Yong Lu
The direct production of sustainable aviation fuel (SAF) through Fischer−Tropsch synthesis (FTS) has garnered significant interest within the energy and petrochemical sectors. However, attaining high SAF selectivity remains a critical hurdle, as the inherent maximum selectivity for the C 8 −C 16 hydrocarbon fraction in traditional FTS process hovers around 41%. Here, we report a promising bifunctional catalyst system for FTS to SAF, featuring cobalt nanoparticles (Co NPs) embedded within amorphous silica (Co@ x Si) integrated with ZSM-5 zeolite. The optimal catalyst system was identified by combining Co@ 3 Si derived from an APTES-infused ZIF-67 (with a 3:1 mass ratio of APTES to ZIF-67) with two mass fractions of a ZSM-5 (Co@ 3 Si& 2 Z5). This formulation achieved a 75.2% selectivity to C 8 −C 16 hydrocarbons with an iso-paraffins proportion of 24.3%, while effectively minimizing CH 4 formation to 6.3%. It also sustained a high CO conversion of 85.1% and was stable for at least 168 h. The Co@ 3 Si, leveraging its abundant active cobalt sites and distinctive confined structure, not only improved CO adsorption and activation but also extended the residence time of −CH x intermediates on the surface of Co NPs, thereby efficiently facilitating the formation of long-chain hydrocarbons. The ZSM-5 zeolite facilitated the selective catalytic cracking and isomerization of long-chain hydrocarbons, effectively converting them into SAF-range paraffins. The collaborative synergy between the two core components forms an efficient catalytic process akin to an assembly line, enabling the highly selective direct transformation of syngas into SAF.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Li Cui,Rongling Zhong,Wanqiu Peng,Zhenhai Zhang,Zhentao An,Hui Li
Current clinical management of diarrhea-predominant irritable bowel syndrome (IBS-D) faces substantial challenges due to the limited efficacy of existing therapeutic strategies. This study aimed to synthesize and characterize the hyaluronic acid-ethylenediamine-cinnamic acid conjugate (HA-EDA-CA), investigate its oral bioavailability and colonic tissue distribution, and validate its therapeutic potential along with underlying mechanisms of action in IBS-D models. Following oral administration of free CA or HA-EDA-CA, the colon concentration of CA released from the derivative was significantly higher than that of free CA alone. Both free and conjugated forms of CA likely contributed to the therapeutic effects against IBS-D. The IBS-D model was established by a combination of senna decoction administration and physical restraint stress. After HA-EDA-CA intervention, IBS-D model mice showed marked improvements in stool consistency, fecal water content, stool output, body weight, visceral hypersensitivity, and colon length. ELISA results indicated significant reduction in enteric neurotransmitter levels, including 5-hydroxytryptamine, substance P, and vasoactive intestinal peptide, after oral gavage administration of HA-EDA-CA. Additionally, intestinal permeability assessment and immunofluorescence analyse revealed that HA-EDA-CA improved intestinal barrier function. Western blot analysis indicated HA-EDA-CA inhibited 5-hydroxytryptamine signaling pathway. Furthermore, HA-EDA-CA modulated gut microbiota composition. These findings suggested the potential of HA-EDA-CA as a promising therapeutic candidate for IBS-D treatment. Key novelties: (i) First colon-targeted CA-HA conjugate: We developed and characterized the first hyaluronic acid-based conjugate specifically designed for colon-targeted delivery of cinnamic acid. (ii) Multi-mechanism rescue: The conjugate simultaneously restores gut homeostasis by modulating the 5-hydroxytryptamine signaling pathway, enhancing intestinal barrier function, and rebalancing gut microbiota. (iii) Enhanced therapeutic efficacy: HA-EDA-CA demonstrates superior colonic drug accumulation and integrated therapeutic outcomes compared to free cinnamic acid or simple drug mixtures. (iv) Open-source data availability: All relevant data and analysis scripts supporting the findings are publicly accessible to ensure reproducibility and further research.
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Sustainable Materials and Technologies
·
2026
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IF 9.7
Meng Xu,Yu Wang,Lang Wei,Simin He,Ruibin Guo,Nijuan Liu,Zunli Mo
Microbial adhesion and biofilm formation pose persistent threats to marine industry, healthcare, and food safety, often resulting in severe economic losses and structural failure. Although superhydrophobic surfaces offer a physical barrier by trapping air layer, their practical application remains limited by intrinsic mechanical fragility; moreover, once the air layer becomes unstable, the surface lacks an active defense mechanism. Here, we report a multistrategy biomimetic design that enables the engineered fabrication of a highly robust MOF-5/HGM/PPS composite coating, integrating passive physical repulsion with active chemical killing in a synergistic manner. By tuning the hierarchical ratio of micron-sized hollow glass microspheres (HGM) and nanoscale metal–organic framework particles (MOF-5) within a chemically inert polyphenylene sulfide (PPS) matrix, multilevel hierarchical roughness was successfully constructed. The optimized surface exhibited excellent superhydrophobicity, with a static water contact angle of 151.2° and a sliding angle of only 4 ± 1°. Importantly, thermal crosslinking of the PPS network ensured outstanding mechanical and chemical durability. Even after 50 rigorous sandpaper abrasion cycles, prolonged exposure to extreme pH conditions, or 180 h of corrosive salt spray, the coating retained its near-superhydrophobic integrity. Electrochemical measurements showed that the composite reduced the corrosion current density of the metal substrate to 1.406 × 10 −8 A·cm −2 , corresponding to a corrosion inhibition efficiency of 99.994%. In addition, the sustained release of Zn 2+ ions from the MOF-5 framework provided potent biochemical activity, achieving bactericidal efficiencies of over 99% against Escherichia coli and Staphylococcus aureus , while also effectively suppressing colonization by Chlorella vulgaris . This dual-defense strategy, combining a stable air-cushion barrier with localized chemical killing, establishes a new paradigm for the development of intelligent, long-lasting protective materials for harsh marine and clinical environments.
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RSC Advances
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2026
·Vol. 16
·期 27
·25131-25143
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IF 6.1
Yaling Wu,Peipei Xu,Jing Lin,WanJing Li,Qing Lin,Hanhao Lu,Jingbo Chen,Zhenhua Liu,Yudong Lu
Colorectal cancer chemotherapy often faces challenges such as rapid drug clearance, non-specific biodistribution, and burst release, leading to systemic toxicity and reduced therapeutic efficacy. To overcome these limitations, this study developed a colon-targeted sustained-release hydrogel bead system based on β-cyclodextrin (β-CD) and biocompatible polymers (CMCS/CMCNa/SA). The results demonstrated that the incorporation of β-CD significantly enhanced the drug loading capacity through host–guest interactions. Under the optimal mass ratio of drug complex to wall material (15 : 35), the encapsulation efficiency reached as high as 81.23%. Drug release kinetics showed high correlation coefficients (R2 > 0.9) in zero-order, first-order, Higuchi, and Korsmeyer–Peppas models, indicating a diffusion-controlled release mechanism. The β-CD-modified hydrogel matrix effectively sustained the release of 5-fluorouracil (5-Fu) within the therapeutic window while minimizing the initial burst release. In conclusion, this intelligent delivery system takes advantage of the host–guest inclusion of β-CD and the pH-responsive properties of the polymers, showing promise for localized treatment of colorectal cancer.
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PHYTOMEDICINE
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2026
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IF 11.3
Xu Gao,Xiaofeng Zhu,Yibin Lin,Chengkuan Liu,Qingwen Wang,Xian Lin
Background Developing novel therapeutic targets and innovative drugs for rheumatoid arthritis (RA) remains highly challenging. Despite the involvement of 5-methylcytosine (m5C) RNA methylation in various biological processes, its specific roles in RA and potential applications in drug development remain unclear. Additionally, the role of CX26 in RA progression and its inflammatory effects on fibroblast-like synoviocytes (FLSs) have not been elucidated. Salvianolic acid B (SAB), a bioactive component derived from Salvia miltiorrhiza , possesses anti-inflammatory properties, but its potential in RA treatment has not been completely explored. Purpose This study aimed to clarify the role of m5C-methylated gene CX26 in RA-FLSs and evaluate the therapeutic potential of SAB for RA therapy. Methods Multi-omics analysis was used to determine the contribution of m5C RNA methylation to RA pathogenesis and characterize m5C-methylated genes during RA progression. Methylated RNA immunoprecipitation sequencing and RNA sequencing were employed to analyze the effect of SAB on m5C methylation of CX26 in RA-FLSs. Immunohistochemistry, quantitative real-time PCR, Western blot, Cell Counting Kit-8, 5-Ethynyl-2′-deoxyuridine, and Transwell assays were applied to assess the effects of CX26 and SAB on RA-FLSs. The anti-arthritic activity of SAB was validated in a collagen-induced arthritis (CIA) mouse model. Results This study demonstrated a vital role of m5C RNA methylation in RA progression. CX26 was identified as an m5C-methylated gene that was selectively overexpressed in RA-FLSs. The CX26 levels in the synovium of patients with RA demonstrated significant associations with an activated immuno-inflammatory phenotype, clinical features, and treatment outcomes. Moreover, the CX26 mRNA m5C methylation, stability and expression were elevated by TNF. CX26 augmented inflammation-induced proliferation, migration, and invasion of RA-FLSs via activating the IκBα/NF-κB signaling. SAB reduced m5C methylation of CX26 mRNA and impair CX26 expression, thus abrogating CX26/IκBα/NF-κB signaling–induced pathological phenotypes of RA-FLSs. Furthermore, computational modeling and the CIA model confirmed that SAB alleviated RA progression. Conclusions This cross-validated study, based on multi-omics analysis, outlines the potential of CX26 as a highly selective target and SAB as a novel therapeutic candidate for RA treatment.
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Inorganics
·
2026
·Vol. 14
·期 6
·163
·
IF 3.4
Shuo Yan,Qing-Xu Fan,Jun-Peng Liu,Fen-Lian Wang,Yu-Ji Gao
The selective photocatalytic oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) into high-value 2,5-diformylfuran (DFF) under green conditions is a promising route toward carbon neutrality. However, achieving high efficiency and selectivity in pure water remains challenging due to limited oxygen solubility and nonselective radical reactions. In this study, a series of amorphous MoS3-modified Zn3In2S6nanoflowers (x%MS/ZIS) with varying MoS3loadings were successfully synthesized via a one-step hydrothermal method and served as the photocatalysts for the highly selective oxidation of HMF to DFF. The incorporation of MoS3significantly enhances visible-light absorption, promotes efficient separation of photogenerated carriers, and accelerates surface reaction kinetics. Under visible light irradiation, the optimized 2.4%MS/ZIS catalyst achieves 64.7% HMF conversion and 89.5% DFF selectivity in pure water within 6 h, ~39-fold enhancement in DFF yield compared to pristine Zn3In2S6. Radical scavenging experiments and electron paramagnetic resonance analyses suggest that superoxide radicals (·O2−) and photogenerated holes are the main reactive oxygen species governing the selective oxidation, while the absence of ·OH radicals suppresses overoxidation. This study demonstrates a viable and green strategy for the valorization of biomass platform molecules through visible-light-driven photocatalysis in pure water.
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DRUG METABOLISM AND DISPOSITION
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2026
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IF 3.6
Qianqian Zhang,Jingyi Hu,Yangbo Liu,Dongzhao Xie,Linyue Bai,Zhuang Hu,Yanjun Tang,Siqi Feng
The therapeutic efficacy of 5-fluorouracil (5-FU), a cornerstone of gastric cancer chemotherapy, is predominantly limited by its catabolic inactivation in tumors. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme responsible for 5-FU inactivation, and its tumor-specific overexpression constitutes a primary mechanism of 5-FU resistance. Here, we report a novel strategy to increase the sensitivity of 5-FU by targeting the post-translational regulation of DPD. We demonstrate that the NEDD8-activating enzyme (NAE) inhibitor MLN4924 significantly enhancesthe antitumor activity of 5-FU in both cellular and animal models of gastric cancer without augmenting systemic toxicity. Mechanistically, MLN4924 treatment inhibits the neddylation of DPD, which is dependent on the NAE1/UBC12 axis. This inhibition triggers the ubiquitination and subsequent proteasomal degradation of DPD, thereby reducing intracellular 5-FU catabolism and augmenting its cytotoxic effects. Our findings identify neddylation as a previously unrecognized regulatory mechanism governing DPD protein stability and activity. This work identifies the neddylation-DPD axis as a novel therapeutic target and provides a strong rationale for combining NAE inhibition with 5-FU-based chemotherapy in gastric cancer.
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EUROPEAN POLYMER JOURNAL
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2026
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IF 6.8
Jialiang Zhong,Yue Wang,Wenjie Mo,Rongji Shen,Yanning Zeng
Bio-based polyimine networks derived from renewable 5-hydroxymethylfurfural (HMF) were successfully fabricated via curing two newly designed HMF-based dialdehydes (HMF-MDI and HMF-HDI) with melamine. The resulting networks exhibit tunable mechanical properties, with HM-1.0 achieving a tensile strength of 73.1 MPa and a Young’s modulus of 128.7 MPa. Notably, these materials demonstrate intrinsic flame retardancy (UL-94 V-0 rating, LOI up to 29.2%) without any added flame retardants, attributed to the formation of a continuous and compact carbonaceous barrier. Benefiting from dense furan rings and conjugated structures, HM-1.0 shows a photothermal conversion efficiency of 85.9% under 808 nm NIR irradiation, enabling photothermal self-healing with high self-healing efficiency (97.4%) in terms of tensile strength recovery. All networks exhibit ≥85% DPPH radical scavenging activity and water contact angles up to 94°. Moreover, the dynamic imine linkages impart outstanding reprocessability (95.6% efficiency), weldability (81.6% efficiency), and closed-loop recyclability under mild acidic conditions with 96.8% tensile strength retention after first cycle. This work provides a sustainable design strategy for HMF-based high-performance polyimine networks integrating multiple functions, with promising applications in flame-retardant coatings, electronic packaging, and smart materials.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2026
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IF 3.5
Dongyang Liu,Liang Zhao,Yuen Bai,Jianxin Zhang,Jingjing Wang,Jiaojiao Wang,Haifeng Li,Jinsen Gao,Chunming Xu
Hierarchical HZSM-5 with integrated micro–mesopore structure is promising for boosting light olefin yield in light paraffin catalytic cracking, yet conventional alkali etching creates disordered large mesopores and rough crystal surfaces that degrade light olefin selectivity. Herein, this work adopts NaHCO 3 –TPAOH composite alkali treatment and pos-surface silanization treatment were used to regulate the micro-mesopore spatial distribution of hierarchical HZSM-5, for investigating the re-distribute of the hierarchical HZSM-5 and the effects of pore structure and its spatial arrangement on product selectivity. It was found TPA + in composite alkali system possesses large steric hindrance, which inhibits excessive local OH - corrosion, and avoids the formation of irregular large defective mesopores. On the optimized catalyst, the selectivity of light olefins is elevated by 8.7%. After surface silanization of zeolite, precisely passivates external acidic sites without blocking internal micropore channels, concentrating mesopores inside the zeolite framework. This structure greatly promotes the monomolecular cracking pathway of alkanes and achieves an improvement in ethylene production. This study clarifies the regulatory mechanism of spatially differentiated mesopores in HZSM-5 catalysts on the n-hexane catalytic pyrolysis reaction and their modulation effect on light olefin selectivity. It deepens the fundamental understanding of the structure-performance correlation of hierarchical porous zeolites and provides reliable guidance for the rational design and targeted fabrication of high-efficiency pyrolysis catalysts. Download: Download high-res image (254KB) Download: Download full-size image
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Materials Today Chemistry
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2026
·
IF 7.4
Guohao Xu
A facile desilication-recrystallization strategy is developed to fabricate b-axis oriented hollow nanosheet ZSM-5 zeolites. • Optimal catalyst achieves 94.4% propane conversion, 8.2% methane conversion and 80.1% aromatic selectivity in MPC reaction. • The catalyst exhibits a 100 h catalytic lifetime (10-fold that of commercial ZSM-5) with excellent regeneration stability. • In-situ IR and DFT calculations reveal the synergistic mechanism of methane-propane co-aromatization. A nanosheet ZSM-5 (∼100 nm thick) was synthesized via a facile desilication-recrystallization approach using silicalite-1 as a precursor for methane and propane co-aromatization (MPC). The Si/Al feed ratio was tuned by varying NaAlO 2 dosage to direct the structural evolution of the zeolite. The acid strength and acid amount gradually increased with decreasing the Si/Al ratio from 100 to 25. Under the suitable Si/Al ratio of 50, the resulting Zn-bZSM-5(50) catalyst possessed the proper acidity and the largest average pore diameter of 6.16 nm, which endowed it with optimal catalytic performance: achieving 94.4% propane conversion, 8.2% methane conversion, 80.1% total aromatics selectivity, and an extended catalytic lifetime of 100 h. Additionally, the catalyst displayed outstanding regeneration stability, with no significant decline in reactant conversion and aromatics selectivity after five consecutive reaction-regeneration cycles. The exceptional stability originated from the chemical anchoring of Zn species as isolated [ZnOH] + sites within the framework, which effectively suppressed Zn volatilization. In-situ infrared spectroscopy analysis revealed that the presence of methane, combined with the acidity and Zn species, promoted the formation of adsorbed reaction intermediates, thereby improving the reaction performance. Control experiments with varied feed compositions further confirmed the synergistic effect between methane and propane. Density functional theory (DFT) calculations demonstrated that the co-aromatization of methane and propane was more thermodynamically favorable for the conversion of methane, corroborating the experimental observations. These findings establish a rational design strategy for developing nanosheet ZSM-5 zeolites with the superior performance and a long lifetime for MPC reaction. Download: Download high-res image (269KB) Download: Download full-size image
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MICROPOROUS AND MESOPOROUS MATERIALS
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2026
·
IF 4.5
Rui Feng,Runxi Zhang,Dejun Shi,Hongyue Yu,Kebin Chi,Peng Peng,Xinlong Yan,Shijian Lu
Seed type controls the physiochemical properties of template-free DGC ZSM-5. • S1 seeding affords mesoporous nanocrystallite aggregates with moderate acidity. • S2 seeding favors Al occupation at straight and intersecting channels. • S2-derived catalyst achieves 94.1% conversion with >90% stability after 36 h. • S1-derived catalyst exhibits ultralow coking rate (0.056 h −1 ) and coke content (∼2.2 wt%). The template-free dry gel conversion (DGC) synthesis of zeolites typically suffers from poor crystallinity and limited structural tunability. In this study, we demonstrated that these limitations can be effectively overcome through a seed-assisted DGC strategy, employing colloidal S1, self-synthesized S2, and commercial ZSM-5 as seeds to direct ZSM-5 crystallization. Comprehensive characterization revealed that seed type critically influences crystallite size, mesoporosity, framework silica-to-alumina ratio (SAR), aluminum siting, and the distribution of Brønsted and Lewis acid sites. Specifically, S1 seeding afforded nanocrystallite aggregates with abundant mesopores, moderate acidity, and the highest SAR (106). S2 seeding resulted in intermediate crystallite dimensions, preferential Al occupation at straight and intersecting channels, and the highest Brønsted/Lewis ratio (6.1). In contrast, the seed-free system yielded dense, large-block crystallites with a lower SAR (65). In n-hexane cracking at 550 °C, the S2-derived catalyst (S2-DG-Z5) achieved the highest initial conversion (94.1%) and light olefin selectivity, while maintaining >90% conversion after 36 h, whereas the seed-free counterpart (DG-Z5) dropped from 90% to <80%. Meanwhile, the S1-derived catalyst (S1-DG-Z5) exhibited the lowest coking rate (0.056 h −1 ) and coke content (∼2.2 wt%), attributable to its moderate acidity, nanocrystallite morphology, and mesoporosity, which synergistically suppress coking and enhance mass transport. Collectively, these findings establish seed type as a pivotal parameter for tuning Al siting and acidity in template-free DG-synthesized ZSM-5, and highlight this seed-assisted route as an effective strategy for producing high-crystallinity, stable zeolite catalysts for hydrocarbon cracking. Download: Download high-res image (288KB) Download: Download full-size image
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
·
IF 4.8
Jin-Xian Luo,Qing Fan,Qing Tang,Zhu Tao,Ying Huang
A supramolecular gel was constructed based on chitosan (CS) and cucurbit[5]uril (Q[5]) through self-assembly via hydrogen bonds and ion-dipole interactions. This gel possesses a dense three-dimensional network structure that provides a rigid microenvironment for encapsulating 6-bromo-2-methylquinoline (6-Br-2-MQ), successfully inducing room-temperature phosphorescence (RTP) emission at 511 nm with a phosphorescence lifetime of 1.537 ms and a quantum yield of 6.72%. Mechanistic studies indicate that the RTP emission originates from the synergistic effects of the rigid gel matrix, host-guest interactions at the Q[5], and the bromine-induced heavy-atom effect. The RTP system exhibits reversible temperature-responsive “on-off” behavior. Furthermore, based on a resonance energy transfer mechanism, the system serves as a phosphorescence probe for the detection of doxorubicin (DOX) in complex biological matrices with a detection limit of 0.65 μM, utilizing a PRET-based dynamic quenching mechanism. The probe shows good recovery (96.08–100.75%) and high anti-interference capability in artificial urine samples. This study provides a new strategy for developing RTP materials using naturally derived and biocompatible components, and demonstrates their potential as a simple, cost-effective platform for point-of-care biosensing applications in complex biological fluids.
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危险品化学品经营许可证（带存储）