INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Yu Liu,Jie Chen,Chunyan Hu,Baojiang Liu
Adhesive conductive hydrogels have a broad application prospect in the field of flexible sensors, but existing adhesive hydrogels often struggle to balance adhesion performance and mechanical strength, and their adhesion stability is poor, which limits their long-term applications. In this study, a dual-network-structured hydrogel with durability, conductivity, and adhesion was prepared using a photoinitiated polymerization process, and its potential application in flexible sensors was explored. The hydrogel is based on thiosemicarbazone-modified chitosan (CS-SCM) as the backbone, introducing a reducible group into the system, acrylic acid (AA), tannic acid (TA), and Fe3+ are incorporated, endowing the hydrogel with excellent electrical conductivity and adhesion durability through multiple hydrogen bonds, electrostatic interactions, and metal-phenol complexation effects. The experimental results show that the hydrogel is able to maintain stable and long-lasting adhesion on the surface of various substrates, and its adhesion to plank remains above 90 kPa after 5 days of storage and more than 20 kPa after 13 days, which is significantly better than traditional hydrogels. Moreover, the durable adhesion of this hydrogel is highly valuable for research and applications in flexible sensors, smart wearables, and bioelectronic devices.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wentao Qu,Zhikun Wang,Jiaqi Feng,Xupeng Li,Liqiang Yang,Li Wang,Jie Guo,Huiling Su,Miantuo Li,Yu Fu,Songqing Hu
This work presents a dual-adsorbent strategy for enhanced phosphate removal via chitosan-based materials with molecular-level mechanistic elucidation. Two complementary adsorbents are designed: spherical bimetallic beads (CSQ@Zr/Fe) and a porous hydrogel (CSQ@Zr). The CSQ@Zr/Fe beads demonstrate outstanding cyclic stability, retaining 84.2 % adsorption capacity after 5 regeneration cycles, while achieving a maximum adsorption capacity of 122.51 mg/g under optimized conditions. The CSQ@Zr hydrogel exhibits superior single-cycle performance with a capacity of 126.50 mg/g and rapid uptake kinetics, reaching adsorption equilibrium within 240 min. Both materials maintain high removal efficiency over a broad pH range (3–9) and show remarkable selectivity in complex ionic environments, with phosphate removal exceeding 90 % even in the presence of competing anions (Cl − , NO 3 − , SO 4 2− ). Comprehensive characterization and simulation studies reveal a synergistic adsorption mechanism dominated by electrostatic interactions (85–92 % contribution to binding energy), complemented by outer-sphere coordination (P–O–Zr: 2.25 Å; P–O–Fe: 1.85 Å) and hydrogen bonding networks. The hydrogel exhibits stronger phosphate confinement (diffusion coefficient: 0.544 × 10 −12 m 2 /s) compared to the beads (0.685 × 10 −12 m 2 /s), which correlates with its enhanced adsorption performance. This work provides not only high-performance adsorbents but also fundamental insights into the design of chitosan-based materials for sustainable phosphate removal and recovery applications.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Huanyu Zheng,Ji Zhang,Zhouliang Sun,Mengqi Wang,Yufei Zhang,Mingming Zheng
Nature employs non-catalytic scaffold proteins to achieve precise enzyme positioning and enhanced catalysis. However, mimicking this approach with food-grade macromolecular materials remains a significant challenge. Herein, we introduce a pH-tunable gliadin-chitosan matrix designed to act as a bioinspired scaffold. It spontaneously self-assembles with lipase into stable ternary complex, gliadin-chitosan-lipase (GCL), through robust hydrogen bonding and hydrophobic interactions (∆G_binding = −331.7 kJ‧mol −1 ) immobilize lipase AYS in an optimally active conformation. Upon addition to an oil-water mixture at pH 7, GCL particles adsorb at the interface, creating a highly efficient Pickering interfacial biocatalysis (PIB) system. When applied to the synthesis of sterol esters via interesterification with flaxseed oil, the GCL-stabllized PIB system achieved an 81.4 % yield within 6 h, a relative conversion rate of almost three times that of free lipase (31.8 %), and maintained 73.4 % of its initial activity after five consecutive cycles. Its compatibility extended to six commercial oils. Molecular dynamics results indicated that lipase acts as a regulatory element, suppressing global fluctuations to generate stable structures with high catalytic activity, thereby preparing the interface for biocatalysis. This work establishes a sustainable, scalable platform for functional lipid production and provides a blueprint for next-generation biomacromolecular enzyme carriers.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Jie Chen,Hui Zhang,Yuxin Lin,Jinyu Liu,Yisong Chen,Xiaoyan Zhang,Hetong Lin,Da-Peng Yang
Food preservation technologies that combine antimicrobial activity with controlled-release functionality are essential to mitigate postharvest losses. Herein, chitosan (CS)-based coatings incorporating S-nitroso- N -acetyl-DL-penicillamine (SNAP) as a nitric oxide (NO) donor were developed for sustained antimicrobial release and fruit preservation. The CS/SNAP coatings showed high transparency (79.5–79.9 %), strong UV-blocking (T 350 nm < 1 %), and rapid water solubility, with flexibility increasing alongside SNAP loading. The coatings released NO over 15 days, exhibiting potent antibacterial effects against E. coli (24.64 mm inhibition zone), S. aureus (28.86 mm), and antifungal activity against B. cinerea (20.20 mm). When applied to tomatoes, the CS/SNAP12 coating reduces weight loss, maintains fruit firmness and inhibits ethylene production, thereby extending shelf life to 15 days. Cytotoxicity and seed germination tests confirmed biocompatibility. This scalable, eco-friendly solution synergistically controls respiration, microbial growth, and moisture loss, offering a promising approach to perishable food preservation.
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TALANTA
·
2025
·
IF 6.1
Lifang Gao,Yuheng Wang,Jixuan Zhang,Haoran Wang,Yue Zhang
Herein, a zwitterionic hybridization approach is engineered to develop a functional hybrid framework (MPC) for the efficient separation of immunoglobulin G (IgG). The in-situ polymerization of octa-carboxyl polyhedral oligomeric silsesquioxane (OCPOSS)-chitosan polymer on Ti 3 C 2 T x MXene effectually enables the formation of local zwitterionic hydrophilic microregions in MPC, and meanwhile actuates its affinity ability and recognition selectivity toward IgG. When 1 mg of MPC serves as adsorbent to treat IgG solution (100 mg L −1 , 1 mL), an adsorption efficiency of approximately 99.0 % is facilely reached. Superior adsorption performance of MPC is well demonstrated by satisfactory enrichment factor (119.3) and high binding capacity (866.4 mg g −1 ). MPC is further employed for the separation of IgG from complex biological samples, achieving a protein purity of 97.9 %. Experimental characterization and molecular docking simulation successfully affirm the prominent role of multiple components in MPC in the collaborative contribution to the selective affinity separation of IgG. This study not only affords a highly efficient pretreatment platform for specific biomarker detection and antibody purification, but also illuminates the huge prospects of zwitterionic MXene-based frameworks in the field of proteomics research.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xuan Wang,Xu Meng,Tao Liang,Jiachun Song,Kamal Eldin Afaf,Hong Duan,Lingyan Zheng,Gang Chen
γ-Cyclodextrin (γ-CD) is one of the most widely used materials for encapsulating hydrophobic functional molecules due to its distinctive structural features, especially an internal hydrophobic cavity surrounded by external hydrophilic surface. However, its limited loading capacity, adsorption efficiency, and poor stability hinder its broader applications. To address this issue, γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) was formed by anchoring potassium ions with γ-CD through hydrothermal self-assembly. After loading different hydrophobic small molecule active substances, a multifunctional composite coating was prepared by embedding them into the chitosan (CS) matrix. The release kinetic model analysis confirmed that the release behavior of Cinnamaldehyde (Cia), 2-methoxycinamaldehyde (2-MCA), and Curcumin (Cur) from γ-CD-MOFs conformed to the Ritger-Peppas equation. Compared with CS, CS/γ-CD-MOF@Cia has a strong inhibitory effect on E. coli O157: H7 and S. aureus . Sprayed on green grapes, the shelf life is extended to 21 days. CS/γ-CD-MOF@2-MCA can significantly reduce the spoilage of milk caused by photooxidation. Furthermore, compared with CS, the oxidation and browning of banana peels were effectively delayed by CS/γ-CD-MOF@Cur, and complete blackening is not observed even after 11 days of storage. By combining the advantages of chitosan and γ-CD-MOF, the active molecules with different functions were encapsulated on the platform of γ-CD-MOF to achieve antibacterial, light-blocking, and antioxidant effects on food. The novel functional coating materials presented in this work offer a promising approach to effectively prolonging the shelf life of fresh foods products.
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RSC Advances
·
2025
·Vol. 15
·期 14
·10816-10824
·
IF 4.6
Qifei Ma,Huaizhou Jin,Weihong Wang,Shangzhong Jin
Emulsions stabilized by protein/polysaccharide complexes have attracted great interest. However, the emulsion properties and interactions between droplets at the microscale require further investigation. In this work, the interaction forces between two rice bran oil droplets stabilized by casein–chitosan complexes, with a diameter of 3 ± 0.1 μm (pH 5.54 and no-salt), were measured under different aqueous conditions (pH and ionic strength) using optical tweezers. The measured force curves exhibited consistency with the interfacial layer conformation and interfacial charge, as determined through fluorescence spectroscopy and zeta-potential analysis. Furthermore, atomic force microscopy (AFM) and optical microscopy were employed to characterize the morphology and structural evolution of the emulsions under varying environmental conditions. Our results provide a useful method for studying the interaction forces between Pickering emulsion droplets with pN force resolution and reveal the correlation between interfacial layer properties and physical stability, offering deep insights into the stabilization mechanism of Pickering emulsions.
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Journal of Biomedical Nanotechnology
·
2024
·Vol. 20
·期 3
·551-559
·
IF 2.9
Che Xun,Wu Yu-Ling,He Qing-Ling,Wu Zhen,Wang Shi-Bo,Zhang Han,Zubair Iqbal M.,Liu Fei,Lu Jia-Ju,Kong Xiang-Dong
The wound healing in the presence of bacterial infections is a complex process and prolonged challenge with severe implications for human health. To address this issue, injectable thermo-sensitive hydrogels as wound dressings have garnered considerable attention as a potential solution.
In this study, we have developed an injectable and antibacterial thermosensitive hydrogel for wound healing, based on chitosan (CS) and β-glycerophosphate (β-GP) and modified with a range of cinnamaldehyde (CA). The CS/β-GP/CA gels demonstrate a phase transition
at body temperatures, and exhibit good biocompatibility. Compared with the unmodified CS/β-GP hydrogels, incorporating CA can promote endothelial cell growth and the antibacterial property of the hydrogel system, which may lead to faster wound healing and tissue regeneration. Our
findings suggest that the CS/β-GP/CA thermosensitive hydrogel emerges as a promising candidate for an injectable wound dressing in wound treatments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Ye He,Mingming Zang,Jinting Zhang,Hui Cheng,Yong Cui,Da Wang,Haotian Zhang,Xinyao Guan,Siling Wang,Yue Yuan,Yikun Gao
In this study, we constructed a novel powder-laden core–shell crosslinked chitosan microneedle patch for high-dose and controllable delivery of various drugs, including both macromolecular biological drugs and small-molecule chemical drugs. Direct loading of drug powders greatly improved drug loading capacity and minimized degradation. The results of the in vitro drug release study suggested that the release behaviors of the most tested drugs (both macromolecular drugs and small-molecule drugs) can be tuned by adjusting the crosslink density of the microneedle shell to achieve either rapid or sustained release of the loaded drug. The in vivo hypoglycemic efficacy test in streptozotocin-induced diabetic mice further proved that the onset and duration of the insulin-laden patch can be customized by adjusting the crosslink density. Furthermore, a combination of microneedle patches with different crosslink densities not only rapidly reduced blood glucose levels to normoglycemic levels (within 1 h) but also maintained normoglycemia for up to 36 h. The insulin loaded in the patch also showed good stability during storage at 40 °C for 6 months. Our results suggest that this powder-laden patch represents a strong candidate for addressing the multiple challenges in the preparation and application of polymeric microneedles and shows promise in clinical applications.
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Polymers
·
2018
·Vol. 10
·期 6
·664
·
IF 2.935
Qiongqiong Liu,Qingtao Li,Sheng Xu,Qiujian Zheng,Xiaodong Cao
Three-dimensional (3D) printing holds great potential for preparing sophisticated scaffolds for tissue engineering. As a result of the shear thinning properties of an alginate solution, it is often used as 3D printing ink. However, it is difficult to prepare scaffolds with complexity structure and high fidelity, because the alginate solution has a low viscosity and alginate hydrogels prepared with Ca2+crosslinking are mechanically weak. In this work, chitosan powders were dispersed and swelled in an alginate solution, which could effectively improve the viscosity of an alginate solution by 1.5–4 times. With the increase of chitosan content, the shape fidelity of the 3D printed alginate–chitosan polyion complex (AlCh PIC) hydrogels were improved. Scanning electron microscope (SEM) photographs showed that the lateral pore structure of 3D printed hydrogels was becoming more obvious. As a result of the increased reaction ion pairs in comparison to the alginate hydrogels that were prepared with Ca2+crosslinking, AlCh PIC hydrogels were mechanically strong, and the compression stress of hydrogels at a 90% strain could achieve 1.4 MPa without breaking. In addition, human adipose derived stem cells (hASCs) adhered to the 3D printed AlCh PIC hydrogels and proliferated with time, which indicated that the obtained hydrogels were biocompatible and could potentially be used as scaffolds for tissue engineering.
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Food Bioscience
·
2023
·
IF 5.2
Xiaowei Ding,Dekun Cheng,Lingyu Zhao,Xuerong Luo,Lin Yue,Yin Zhang,Zhouping Wang
Curcumin (CCM) is a natural photoinitiator with antioxidant, antibacterial and anti-inflammatory properties. However, hydrophobicity and low stability limit its application. In this study, CCM was coupled with carboxymethyl chitosan (CMCS) by an esterification reaction to obtain a water-soluble derivative (CMCS-CCM). A series of characterization techniques demonstrated the synthesis and aggregation properties of CMCS-CCM. The derivative exhibited good stability, antioxidant properties, and photodynamic antibacterial activity . Under the blue light irradiation of 450 nm, the minimal inhibit concentration (MIC) of CMCS-CCM against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were 128 and 512 μg/mL, respectively. Reactive oxygen species (ROS) assay and Scanning electron microscope (SEM) results indicated that the photodynamic antibacterial activity of CMCS-CCM was attributed to the disruptive effect of the generated ROS on the bacterial structure. Furthermore, the derivative did not show significant cytotoxicity and hemolytic activity. These results suggest that the derivatives can be used as a potential antibacterial agent and applied in the food industry.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Die Wang,Luminita Marin,Xinjian Cheng
The detection of heavy metals, such as Hg 2+ and Fe 3+ , is of great significance. In this work, fluorescent small-molecule BODIPY (BY-3) bearing C C group was synthesized firstly. And then, the chitosan-based polymer sensor CY-1 was synthesized through the spontaneous NH 2 /C≡C click reaction. The synthesized CY-1 can effectively bind and recognize Hg 2+ /Hg + by the –C=N groups formed in the click reaction. Moreover, the macromolecular sensors CS-1 and CS-2 were synthesized by incorporating another recognition sites to CY-1. These synthesized macromolecular sensors can not only recognize Hg 2+ /Hg + , but also effectively recognize Fe 3+ /Fe 2+ . All of them exhibited significant quenching effect, visible to the naked eye under UV irradiation. The detection limit of CY-1 for Hg 2+ was 1.51 × 10 −6 mol/L, and the detection limit of CS-2 for Fe 3+ was 2.30 × 10 −6 mol/L. The BODIPY-chitosan sensors synthesized in this work have the functions of removing heavy metal ions besides the identifying ability. The maximum adsorption capacity of 1 g chitosan to Hg 2+ was 108 mg as the best one. This article provides a new method to prepare macromolecular sensors for the detection and removal of heavy metal ions. As a useful natural polymer, chitosan's application scope was enlarged.
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