Frontiers in Medicine
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2021
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IF 5.093
Guo Liting,Zhang Hongming,Liu Ping,Mi Tianai,Ha Da,Su Li,Huang Lei,Shi Yan,Zhang Jun
Objective: The purpose of this study was to investigate the anticancer activity and the potential imaging use of the innovative combination of magnetic nanoparticles (MNPs)-Fe3O4, paclitaxel (PTX), and trastuzumab (Herceptin) in HER2-positive breast cancer.Methods: MNPs-Fe3O4 was synthesized and underwent water phase transfer and hydrophobic molecular loading, and its surface was then coupled with Herceptin mono-antibody. The morphological characteristics of MNPs-Fe3O4 were observed under transmission electron microscopy (TEM). Effects of PTX-Herceptin-MNPs-Fe3O4 on breast cancer cells were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,4-diphenyltetrazolium bromide assay and the flow cytometric apoptosis assay. To establish a xenograft model, we injected breast cancer SK-BR-3 cells into the left thighs of nude mice. We measured the effect of PTX-Herceptin-MNPs-Fe3O4 on tumor growth by measuring tumor size and calculating inhibition rate with immunohistochemistry analysis further performed, and analyzed MNPs-Fe3O4 accumulation in tumor lesions using in vivo magnetic resonance imaging and in vivo fluorescence imaging.Results: Most MNPs were in spherical shape of about 10 nm in diameter observed under TEM. PTX-Herceptin-MNPs-Fe3O4 showed greater cytotoxic effects, and induced a higher apoptosis rate of SK-BR-3 cells than all the other groups, with corresponding changes of apoptosis-related proteins. Meanwhile, the in vivo tumor xenograft model showed that tumor inhibition rate in the PTX-Herceptin-MNPs-Fe3O4 group was higher than in the PTX-Herceptin group. Furthermore, PTX-Herceptin-MNPs-Fe3O4 enhanced the T2 imaging contrast enhancement effect on tumors in tumor-bearing mice.Conclusion: The novel PTX-Herceptin-MNPs-Fe3O4 combination may represent a promising alternative breast cancer treatment strategy and may facilitate tumor imaging.
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Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Yanhua Cui,Jian Zheng,Zengkai Wang,Binrong Li,Yongsheng Yan,Minjia Meng
How to endow the photocatalytic membrane with excellent efficiency and high permeability has always troubled scientific researchers. Herein, this work proposed an alternative strategy to controllably induce magnetic core-shell structured Fe 3 O 4 @TiO 2 nanoparticles to move towards the membrane surface under magnetic field, significantly maintaining a high-water flow rate and enhancing the photocatalytic degradation efficiency. The presence of Fe 3 O 4 in Fe 3 O 4 @TiO 2 facilitates the electron-hole separation efficiency and maintains the high redox ability of photogenerated electrons in TiO 2 . The characterization results indicated the Fe 3 O 4 @TiO 2 nanoparticles were successfully migrated to the membrane surface. As expected, the FTM(Y) had higher porosity (85.56%), higher pure water flux (1536.47 L m −2 h −1 bar −1 ) and better antifouling performance (5.24% of BSA static adsorption) than that of FTM(N) (1054.26 L m −2 h −1 bar −1 , 6.62%). Meanwhile, the FTM(Y) exhibited excellent photocatalytic and self-cleaning activity, the FTM(Y) showed 1.3 times enhancement in visible light (λ > 420 nm) driven photocatalytic degradation efficiency of tetracycline compared to that of the FTM(N) without magnetically induced. The ·O 2 - and·OH radicals and photogenerated h + played the primary role in photocatalytic degradation process. This work provides new insight into the design of highly efficient photocatalytic membrane to treat wastewater and enhance water purification .
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Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Songtao Cai,Jinman Wu,Yaokun Mo,Yuxuan Dai,Peng Liu,Jianxin Luo,Chunyan Zhang,Yifei Liu,Jianjun Liu,Qingwen Zhang,Fuming Du,Yi Wang,Hu Chen
A two-pot method is reported for the synthesis of ferric oxide-gluconic acid/β-cyclodextrin (Fe 3 O 4 -GA@β-CD). The proposed approach is a green one as the raw material is a natural product (sucrose) and no organic solvent is involved. Meanwhile, this novel composite was demonstrated for catalytic degradation of p-nitrophenol (PNP), a prototype toxic with high toxicity and low degradability. This is realized by H 2 O 2 activation induced by the heterogeneous Fenton-like catalysis of the as-prepared Fe 3 O 4 -GA@β-CD nano-microspheres. The results showed that the reaction rate constants of PNP degradation catalyzed by Fe 3 O 4 -GA@β-CD and Fe 3 O 4 -GA were 0.0879 and 0.0514 min −1 , respectively, suggesting improved catalytic performance of Fe 3 O 4 -GA@β-CD compared with Fe 3 O 4 -GA. This can be attributed to the cavity of β-CD, which can capture and include PNP molecules. The effects of pH value, H 2 O 2 concentration, catalyst load and hydroxyl radical quenching on the Fenton-like catalysis were explored and the optimized conditions (pH value = 2.0, H 2 O 2 concentration = 50 mM, and catalyst load = 1.0 g/L) were determined. Additionally, Fe 3 O 4 -GA@β-CD exhibited excellent reusability (catalytic degradation rate = 95.1% after five recycling times) as it can be recycled under external magnetic field owing to its good magnetic response (up to 18.41 emu/g).
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Analytical Methods
·
2023
·
IF 3.1
Gang Qu,Yuxin Zhao,Qiaoli Zhang,Ji Na Wu,Xiao Sen Li,Yang Yang,Shi-Lei Liu
Rapid and accurate detection of hydrolyzed products of organophosphorus nerve agents (OPNAs) is an important method to confirm the use of organophosphorus nerve agents effectively. OPNAs are rapidly hydrolyzed to methyl phosphonates (MPs), which act as environmental traceability marker for OPNAs. In this study, magnetic mesoporous materials combined with real-time in-situ mass spectrometry were used to achieve high throughput detection of MPs. A novel magnetic mesoporous nanoparticles Fe3O4@nSiO2@mSiO2 were synthesized through co-condensation of tetraethyl orthosilicate (TEOS) and cetyltrimethylammonium bromide (CTAB) on the surface of nonporous silica-coated Fe3O4 at alkaline conditions, CTAB templates were removed by the reflux of ethanol (0.0375 mM ammonium nitrate) to form a mesoporous SiO2, which has a large specific surface area of 549 m2/g and an excellent magnetization strength of 59.6 emu/g. A quick cheap, effective, rugged and safe magnetic preparation method (M-QuEChERS) was established with magnetic mesoporous nanoparticles (Fe3O4@nSiO2@mSiO2) as adsorption materials for real-time direct analysis and tandem mass spectrometry (DART-MS/MS) of MPs in environmental samples. The method exhibits a good linearity (R2 > 0.992) in the range of 20.0 ng/mL-4.00 µg/mL, the limits of detections (LODs) were less than 5.00 ng/mL, the limits of quantifications (LOQs) were less than 20.0 ng/mL, the extraction recoveries were 70.2%-98.1%, with relative standard deviation (RSD) ranged from 1.97 to 10.6%. In addition, the method analysis of 70 environmental samples could be completed within 20 min. What’ more, it was applied to the 52nd OPCW environmental spiled samples analysis, the accuracy ranged from 95.2-116%, and the RSD ranged from 1.16-7.83%. The results demonstrated that Fe3O4@nSiO2@mSiO2 based on QuEChERS method can quickly and efficiently remove the matrix of environmental samples and coupled with the DART-MS/MS technique can achieve the throughput determination of MPs in environmental samples.
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Journal of Water Process Engineering
·
2023
·
IF 7
Meng Zhang,Shu Jiang,Xishou Guo,Xiaobin Tang,Langming Bai,Jinlong Wang,Han Zhang,Daliang Xu,Rui Wu,Luming Liu,Heng Liang
Membrane fouling increases operational expenses and limits the application of ultrafiltration technology in water treatment . To mitigate the membrane fouling, this study incorporated Fe 3 O 4 nanoparticles (NPs) into the polyethersulfone (PES) membrane casting solution, and developed a non-solvent induced phase separation (NIPS) method assisted by a magnetic field (MGF) to fabricate the Fe 3 O 4 NPs composite ultrafiltration membrane. The combination of MGF and Fe 3 O 4 NPs synergistically enhanced the permeability and separation performance of the composite membrane. The performance of the membrane was determined by its structure. With the involvement of MGF, Fe 3 O 4 NPs were enriched on the surface layer of the membrane, resulting in enhanced hydrophilicity of the composite membrane. The membrane permeability increased to 913.39 LMH·bar −1 , and the rejection performance rose to 93 % due to the formation of tiny pores on the membrane surface that facilitated solvent diffusion during phase separation, thereby counteracting the adverse effects of heightened viscosity in the casting solution. Moreover, the Fe 3 O 4 NPs composite membrane fabricated with MGF induction exhibited significantly enhanced antifouling capability in multi-cycle fouling tests, resulting in a 27.5 % increase in specific flux compared to the pure PES membrane. Additionally, the preparation procedures for the matrix membrane were optimized to include 15 wt% PES, 3 wt% PVP, and a pre-treatment time of 30 s. These findings have significant implications for advancing the widespread application of membrane technology .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Ahmed M. Omer,Mohamed El-Sayed,Eman M. Abd El-Monaem,Gehan M. El-Subruiti,Abdelazeem S. Eltaweil
The aggravated problem of lead pollution, especially in aquatic environments, necessitates the development of eminent adsorbents that could radically solve this environmental problem. Hence, a new composite was constructed based on iota carrageenan ( i .Carr), graphene oxide (GO) and magnetite (Fe 3 O 4 ) for removing noxious Pb 2+ ions. The GO@Fe 3 O 4 - i .Carr composite was characterized by VSM, SEM, XPS, XRD, FTIR and Zeta potential . The removal of Pb 2+ ions attained a quick equilibrium of almost 30 min with a removal efficiency reaching 93.68 %. The removal of Pb 2+ was boosted significantly, in the order of GO@Fe 3 O 4 - i .Carr(1:1) > GO@Fe 3 O 4 - i .Carr(1:3) > GO@Fe 3 O 4 - i .Carr(3:1). Moreover, acquired experimental data fitted the pseudo 2nd order kinetic model and Freundlich isotherm model with a maximal monolayer adsorption capacity reached 440.05 mg/g. Notably, after five adsorption runs, the composite maintained its removal efficiency exceeding 74 %. The assumed adsorption mechanisms of Pb 2+ onto GO@Fe 3 O 4 - i .Carr were complexation, precipitation, Lewis acid-base, and electrostatic attraction forces. Overall, the GO@Fe 3 O 4 - i .Carr composite elucidated the auspicious adsorbent criteria, comprising fast adsorption with high performance, ease-separation and tolerable recyclability, advising its feasible use to decontaminate water bodies from hazardous heavy metals.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Siqin He,Bin Xu,Ying Liu,Xiaoshuang Yin,Wenzhong Yang,Yun Chen
Polyaminoamide (PAMAM) dendrimers with different generations from 1 G to 5 G were grafted on magnetic core-shell Fe 3 O 4 -SiO 2 composite particles , respectively. Using Fe 3 O 4 as a magnetic center and SiO 2 as the connecting layer, the PAMAM dendrimers with amino functional groups were modified on SiO 2 successfully, while laccase was immobilized to the surface of Fe 3 O 4 -SiO 2 -PAMAM x by covalent cross-linking using amide bond. Under the optimal conditions, the loading capacity of laccase reached 65.5 mg/g, and about 62.8 % of its initial activity of free laccase was reserved. Immobilized laccase degradated 2,4-dichlorophenol (2,4-DCP) with a degradation ratio of 91.5 % after 24 h. The degradation ratio of 82.9 % was maintained after 5 cycles of the operation, and when enhanced to the 10 cycles degradation, the degradation rate was still remained close to 80 %. Compared with free laccase, the comprehensive stability of immobilized laccase was improved significantly, and it displayed the excellent catalytic degradation ability for 2,4-DCP.
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FUEL
·
2023
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IF 7.4
Xue Bai,Zhipeng Yang,Xiaolan Wang,Guangyin Fan
The sluggish kinetics for oxygen evolution reaction (OER) significantly impede the practical applications of electrocatalytic water splitting technology for renewable energy source. The facile design of self-supporting electrocatalysts with high activity and stability for OER catalysis at industrial-grade current density is of paramount significance to mitigate the above bottlenecks. We report herein the construction of iron foam (IF) self-supported Ir-magnetite (Ir-Fe 3 O 4 /IF-T-x) electrode via galvanic replacement between IrCl 6 2− ions and Fe 2+ in Fe 3 O 4 nanosheet arrays, which is simply synthesized by annealing IF in air and subsequent thermal treatment in reducing atmosphere. Such pre-treatment enables the growth of leaf-like Fe 3 O 4 nanosheet arrays with rich Fe 2+ species and oxygen defects, which facilitate the depositing of Ir on the surface of nanosheet arrays and thereby promote the electrochemical OER performance in basic electrolyte. Impressively, the optimized Ir-Fe 3 O 4 /IF-400-2 delivers the highest electrocatalytic activity with a low overpotential of 316 mV to obtain industrial-grade current density of 500 mA cm −2 for alkaline OER. Meanwhile, the catalyst still shows good long-term stability after 36 h V-t test at 100 mA cm −2 . This study offers a simple and efficient pathway to prepare self-supporting electrode for alkaline OER at industrial-grade current density.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
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IF 7.312
Liangzhong Li,Chang Liu,Ruixue Ma,Yunjiang Yu,Zhaofeng Chang,Xiaohui Zhang,Chenyu Yang,Da Chen,Yang Yu,Wei Li,Yongdi Liu
In this study, Fe 3 O 4 @TiO 2 decorated reduced graphene oxide (RGO) nanosheets were synthesized by loading iron oxide on the surface of RGO nanosheets and subsequently coating by titanium oxide, which can be employed as the persulfate (PS) activator and high-performance adsorbent toward thallium (Tl). PS could be effectively activated by the Fe 3 O 4 @TiO 2 decorated RGO nanosheets due to the presence of RGO and Fe(II), resulting in the rapid oxidation of Tl(I) to Tl(III). The removal of Tl(I) was found to be pH-dependent, with the removal efficiency of more than 88.5% in the pH range of 8.0–12.0 at the optimal PS dosage of 10 mM and material dosage of 0.2 g/L. The surface precipitation of Tl 2 O 3 and enhanced adsorption affinity toward Tl were deduced to be main mechanisms for the extremely efficient removal of Tl(I) ions during the oxidation and adsorption hybrid process. The maximum removal capacity of the material at pH 8.0 was estimated as 673.2 mg/g based on the fitting result from the Langmuir model. Approximately 94.7% of ultimate removal capacity could be accomplished within the first 10 min at the initial Tl concentration of 8.5 mg/L. The PS catalytic oxidation coupled with the adsorption technique using the prepared Fe 3 O 4 @TiO 2 decorated RGO nanosheets were proven to be a promising approach for Tl(I) removal from water.
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CHEMOSPHERE
·
2021
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IF 7.086
Yunbo Liu,Xuemei Zhang,Jinhua Deng,Yong Liu
A novel composite (CNTs-Fe 3 O 4 ) was synthesized by a ball-milling strategy and characterized by BET, SEM, FTIR , XRD and VSM. The as-fabricated CNTs-Fe 3 O 4 was used to remove six sulfonamides by a Fenton degradation process, including sulfanilamide (SAM), sulfamerazine (SMR), sulfadimethoxine (SMX), sulfadiazine (SDZ), sulfamethazine (SMT) and sulfametoxydiazine (SMD). The degradation behaviors of six sulfonamides in CNTs-Fe 3 O 4 /H 2 O 2 system and the relationship between molecular structure of sulfonamides and their degradation behaviors were investigated systematically. Batch experimental results showed that the as-fabricated CNTs-Fe 3 O 4 had excellent Fenton catalytic activity for the degradation of sulfonamides due to its unique porous structure and the good combination mode of CNTs with Fe 3 O 4 particles. The first-order kinetic mode could better describe the degradation behaviors of six sulfonamides in CNTs-Fe 3 O 4 /H 2 O 2 system, and the degradation rate constant could be ordered as: SAM < SMT < SDZ < SMR < SMD < SMX. The quantitative relationship between the Mulliken charge of sulfonamides (x) and their degradation rate constant (y) in CNTs-Fe 3 O 4 /H 2 O 2 system could be described as: y = - 28.719x + 15.67 (R 2 = 0.957). Finally, the possible synthesis mechanisms of CNTs-Fe 3 O 4 and the degradation mechanisms of sulfonamides in CNTs-Fe 3 O 4 /H 2 O 2 system was proposed.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 13
·3529-3540
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IF 4.157
Li Xiangdong,Chen Yihui,Chen Shubing,Hou Chunyan,Xuan Rongrong,Gao Yajie,Ren Shuaijun,Yao Lihui,Wang Tingting,Zhang Lihua,Zhang Yukui
Fluoroquinolone (FQ) residues in foods of animal origin may threaten public health but are challenging to determine because of their low contents and complex matrices. In this study, novel polyethyleneimine-functionalized Fe 3 O 4 /attapulgite magnetic particles were prepared by a simple co-mixing method and applied as hydrophilic sorbents for the magnetic dispersive solid-phase extraction (MSPE) of three FQs, i.e., ciprofloxacin, norfloxacin, and enrofloxacin, from chicken muscle samples. The preparation of the magnetic particles was of high reproducibility and the products could be reused many times with high adsorption capacity. The key experimental factors possibly influencing the extraction efficiencies, including sample solution, extraction time, sample loading volume, desorption solution, desorption time, and elution volume were investigated. Under optimum MSPE conditions, the analytes in chicken muscle samples were extracted and then determined by RPLC-MS/MS in MRM mode. Good linearity was obtained for the analytes with correlation coefficients ranged from 0.9975 to 0.9995. The limits of detection were in the range of 0.02–0.08 μg kg −1 , and the recoveries of the spiked FQs in chicken muscle samples ranged from 83.9 to 98.7% with relative standard deviations of 1.3–6.8% ( n = 3). Compared with the traditional MSPE methods based on hydrophobic mechanism, this hydrophilic interaction-based method significantly simplifies the sample pretreatment procedure and improves repeatability. This method is promising for accurate monitoring of FQs in foods of animal origin. Graphical abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 28
·6941-6949
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IF 4.157
Gu Chunchuan,Chen Xiang,Liu Hongying
In this report, portable, quantitative, and sequential monitoring of copper ions and pyrophosphate (PPi) with a single sensor based on a DNAzyme-Fe 3 O 4 system and glucometer readout was performed. Initially, streptavidin was functionalized on the surface of magnetic Fe 3 O 4 spheres through glutaraldehyde. Then, an invertase-modified DNA Cu substrate was connected to the magnetic Fe 3 O 4 spheres by a specific reaction between streptavidin and biotin. The sensing system was formed by a hybridization reaction between the Cu substrate and Cu enzyme. In the presence of Cu 2+ , Cu 2+ will recognize the Cu DNA substrate and form an “off-on” signal switch, thereby resulting in the separation of invertase from the Fe 3 O 4 nanospheres. PPi recognizes Cu 2+ to form a Cu 2+ -PPi complex, resulting in an “on-off” signal switch. Under optimized conditions, linear detection ranges for Cu 2+ and PPi of 0.01–5 and 0.5–10 μM, and detection limits for Cu 2+ and PPi of 10 nM and 500 nM, respectively, were obtained. Good selectivity was achieved for the analysis of Cu 2+ and PPi. Satisfactory results were achieved for this biosensor during the determination of Cu 2+ in real tap samples and PPi in human urine samples. This verified that the sensor is portable and low cost, and can be applied to the sequential monitoring of multiple analytes with a single point-of-care biosensor. Graphical abstract
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高影响因子
危险品化学品经营许可证（带存储）