Advanced Healthcare Materials
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2026
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IF 9.6
Xueqin Wang,Hong Chen,Chuan Liu,Mengna Wan,Shangyi Zhao,Na Li,Shaofeng Duan,Shaobo Duan
Diabetic wound infection remains a devastating threat to human health, largely due to bacterial colonization and increased antibiotic resistance during conventional treatments, and alternative therapeutic strategies are thus urgent to improve diabetic wound healing. Herein, we developed a multifaceted nanoplatform (CuO@SiO 2 @NO@Au, CSNA NPs) consisting of a cupric oxide (CuO) core, a mesoporous silicon nanoshell loaded with nitric oxide (NO), and in situ grown ultrasmall Au nanoparticles (NPs) for improved diabetic wound treatment. The results showed that the prepared CSNA NPs exhibited remarkable dual-enzyme mimic activity of glucose oxidase (GOx) and peroxidase (POD), effectively oxidizing glucose to generate gluconic acid, thereby reducing the glucose levels and reversing the acidic wound microenvironment. In addition, the fabricated nanoplatform generated abundant H 2 O 2 , which was converted into highly toxic hydroxyl radical ( · OH), leading to efficient bacterial eradication that was subsequently. Under near-infrared (NIR) light irradiation, the CSNA nanozyme also triggered the release of NO gas and aided in the removal of bacterial biofilms, collectively improving the wound microenvironment. By integrating chemodynamic therapy (CDT), photothermal therapy, and NO gas therapy, this self-activatable NIR- augmented nanozyme provides a promising antimicrobial strategy for diabetic wound treatment.
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高影响因子
ADVANCED MATERIALS
·
2026
·
IF 29.1
Xiachu Xiao,Yutao Yang,Jianru Wang,Yuxiang Xin,Yujie Jiang,Xingyou Wu,Kun Zhang,Hengyang Xiang,Haibo Zeng,Jiang Tang,Zhuolei Zhang
High-brightness photonic platforms driven at high currents self-heat beyond 400 K; under such conditions, colloidal emitters (II–VI, III–V, I–III–VI 2 , group-IV semiconductors, and both leaded and lead-free halide perovskite nanocrystals) typically lose efficiency and drift in color. Extrinsic passivation offers limited thermal gains with trade-offs such as organic-matrix degradation or oxide-shell phonon bottlenecks. Here we establish a lattice-encoded chemical strategy that imparts intrinsic thermal resilience to colloidal nanocrystals via defect–phonon–exciton coupling in a zero-dimensional Sb 3+ -doped Cs 3 LnCl 6 lattice. A controlled-ramp synthesis co-modulates site occupancy and defect chemistry, creating rigid, low-phonon [BX 6 ] 3− octahedra that localize lattice expansion and suppress multiphonon relaxation. Ångström-scale engineered deep traps (∼0.6–1.2 eV) recycle thermally activated carriers, enabling trap-compensated anti-thermal quenching and stabilizing emission through Ln 3+ 4f cascade coupling. Tunable from deep violet to ultra-narrow green and yellow, these nanocrystals show enhanced photoluminescence at elevated temperatures (Cs 3 LnCl 6 :Sb 3+ reaches 160% intensity at ∼410 K while retaining >93% photoluminescence quantum yield). High-power devices retain >90% luminous flux after 50 h at 1.4 A (junction temperature ∼410 K) with <1% chromaticity shift. This work turns thermal robustness from extrinsic protection into intrinsic bonding, providing a molecular design framework for high-flux photonics.
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高影响因子
Advanced Optical Materials
·
2026
·
IF 7.2
Yujia Peng,Zhimin Yu,Liang Zhao,Yuhang Zhang,Hai Lin
The demand for advanced luminescent perovskites with tunable emission and excellent thermal stability is rapidly growing in secure optical encryption and high-precision temperature sensing. Herein, we develop a multifunctional Cs 2 NaLuCl 6 : Sb 3+ /Ho 3+ /Yb 3+ (CNLC: Sb-Ho-Yb) perovskite that achieves coordinated control of color modulation and thermal robustness. By enabling efficient Sb 3+ →Ho 3+ energy transfer in downshifting (DS) and simultaneously suppressing Ho 3+ nonradiative losses in upconversion (UC), the Sb 3+ -doped strategy significantly enhances both Ho 3+ DS and Ho 3+ -Yb 3+ UC emissions, serving as a foundation for color-coded encryption. The CNLC: Sb-Ho-Yb system further enables dual-mode thermometry by exploiting the contrasting thermal behaviors of its UC (enhanced) and DS (quenched) emissions, allowing for temperature sensing tailored to the specific thermal responses of the respective luminescence mode through two independent fluorescence intensity ratio (FIR) methodologies. Specifically, excitation-wavelength-controlled color switching enables high-security and multi-dimensional optical encryption with strong anti-interference capability, while the high luminescence sensitivity and reversible thermal response ensure high-precision temperature sensing with excellent signal fidelity. Overall, this work establishes a new design paradigm that bridges thermal stability and tunable luminescence in perovskite systems, paving the way toward next-generation intelligent optical encryption and reliable thermal sensing technologies.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
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IF 19.9
Sen Zhang,Dan Zhao,Shuang Wu,Hao Cui,Yanhui Wang,Weiping Qin
Non-contact luminescence thermometry featuring high resolution and high sensitivity represents a crucial application of lanthanide upconversion materials. Nevertheless, primarily due to the thermal quenching (TQ) effect, traditional fluorides continue to present significant challenges in attaining real-time, high-sensitivity temperature sensing across a broad temperature spectrum. In this study, two thermometers are developed based on the thermal coupling energy levels (TCLs) and non-thermal coupling energy levels (NTCLs) of CaZrF 6 :3%Yb; 2%Er. Benefiting from the luminescence thermal enhancement induced by lattice thermal contraction, these ratio-type thermometers demonstrate the ability to operate within an extensive temperature range, spanning from relatively low to high temperatures (193 ∼ 793 K). TCLs and NTCLs display extraordinarily comparatively large relative sensitivity of 1.53 and 1.45% K −1 at room temperature. Most notably, based on NTCLs, the absolute sensitivity value consistently remains above 4.00 × 10 − 2 K −1 within the high-temperature range (393–793 K), and attains a maximum of 5.08 × 10 − 2 K −1 at 543 K, which is significantly higher than those of the vast majority of Yb 3+ /Er 3+ -doped optical temperature-measurement materials. These results offer a novel approach for the advancement of high-sensitivity and high-resolution sensor devices across a wide temperature range (Especially in high-temperature).
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
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IF 19.9
Haitao Deng,Ziquan Cao,Jianmin Yang,Maosong Yin,Chuanghui Yu,Dianyu Wang,Jianning Yu,Guoliang Liu,Weihua Gao,Xianhe Yu,Jiantao Yao,Ye Tian
Engineering soft conductors that simultaneously offer high strength, extreme stretchability, and environmental stability remains a central challenge for next-generation wearable electronics. Here, we incorporate an electrospun polyurethane (PU) nanomesh rich in hydrogen bonding sites into a eutectogel matrix. Benefiting from designable interfacial interactions, the thin hybrid gel (≈45 µm) exhibits high tensile strength (12.6 MPa), remarkable stretchability (1376%) and fatigue resistance. Based on its good sensitivity, the hybrid gel can serve as a strain sensor for wide range human motion monitoring, as well as a multifunctional sensor for humidity and temperature detection. Moreover, its high water vapor transmission rate (1176 g·m −2 ·d −1 ) and robust anti-freezing and anti-drying properties enable reliable recording of physiological signals such as electromyography (EMG) and electrocardiography (ECG). By coupling the EMG output with a convolutional neural network (CNN), the system attains a high gesture recognition accuracy of 98.7%. This work demonstrates great potential for next-generation wearable healthcare and human-machine interfaces.
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高影响因子
Advanced Science
·
2026
·
IF 14.1
Sijia Sun,Dong Jiang,Hengsong Zheng,Shuai Zhang,Ziyuan Cheng,Changtong Mei,Dan Tian,Shilong Yang,Yusuke Yamauchi,Mingzhu Pan
Efficient solar-driven interfacial evaporation requires coordinated photon absorption, heat confinement, and directional water delivery, yet current directional evaporators rarely achieve materials-level anisotropy to regulate photon-phonon-water coupling. Here, we report a 3D-printed anisotropic channel architecture (a-BTCG) that co-engineers directional geometry with preferential alignment of Ti 3 O 5 nanoparticles, boron nitride (BN) nanosheets, and chitosan to form an integrated transport framework. The a-BTCG delivers a high evaporation rate of 5.43 kg m −2 h −1 under 1 sun and maintains stable performance for over 200 h in 20 wt.% NaCl, enabled by fast water flux (1.13 × 10 −2 µm 3 s −1 ) and enhanced in-plane thermal conductivity (2.73 W m −1 K −1 ). Mechanistic investigations reveal that aligned BN establishes continuous phonon-guided thermal pathways for heat localization, while the Ti 3 O 5 –BN hybrids enhance broadband absorption via reduced reflectance and multireflection in oriented channels. Chitosan mediates interfacial water structuring, lowers effective evaporation enthalpy, and sustains salt-resistant replenishment. The combined structural and materials-level anisotropy, therefore, overcomes conventional trade-offs in light absorption, heat dissipation, and water supply. This work demonstrates the potential of 3D printing–assisted alignment engineering for high-performance solar evaporators and provides a generalizable platform for advanced desalination and environmental thermal-management technologies.
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高影响因子
Advanced Science
·
2026
·
IF 14.1
Xuefeng Zhang,Yujia Wu,Huayu Xu,Jinyi Ye,Yanfang Yang,Haohan Wu,Jiayi Lu,Hao Li,Dongxiao Kan,Jingfeng Wang,Hui Kang,Zhimin Fan
Titanium carbide (Ti 3 C 2 T x ) MXene has attracted broad interest owing to its versatile functional properties. However, its intrinsic instability in aqueous environments drives spontaneous surface oxidation to insulating TiO 2 , resulting in pronounced performance degradation and posing a major obstacle to practical utilization. Here, we propose an erasure-purification strategy that selectively targets surface-derived oxide phases on oxidized MXene. By constructing an ion-confined interfacial environment followed by a brief acid-washing step, further oxidation is mitigated while pre-existing TiO 2 is selectively removed. The recovered MXene exhibits restored colloidal stability and can be reassembled into conductive films delivering high volumetric capacitance and favorable rate performance. In addition, the purified MXene demonstrates competitive low-frequency electromagnetic attenuation and low infrared emissivity in assembled forms. This approach is applicable to MXene with different morphologies and oxidation states, offering a practical and generalizable route for reclaiming and reusing oxidized MXene materials.
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高影响因子
ADVANCED MATERIALS
·
2026
·
IF 26.8
Xiafeng He,Jian Wang,Yuxiao Du,Kun Zhao,Dongliang Shan,Yunya Liu,Chao Xu,Zhenyong Cen,Xiaoyi Gao,Rui Huang,Xiyong Chen,Zhonghui Shen,Dawei Wang,Limei Zheng,Haibo Zhang,Jing-Feng Li,Shujun Zhang,Nengneng Luo
Achieving both high energy storage density and excellent thermal stability in lead-free multilayer ceramic capacitors (MLCCs) has long been a critical challenge for advanced electronic systems. To address this issue, we propose an innovative strategy to simultaneously improve both properties by constructing ordered heterogeneous interfaces through embedding parallel-aligned Al 2 O 3 plates in 0.6SrTiO 3 -0.4Bi 0.5 Na 0.5 TiO 3 (0.6ST-0.4BNT) lead-free ceramics. This approach effectively suppresses the charge carrier injection and transport, yielding an ultrahigh recoverable energy storage density of 16.0 J cm −3 with a giant breakdown strength of 1140 kV cm −1 in Al 2 O 3 modified 0.6ST-0.4BNT based MLCCs, which outperforms most state-of-the-art dielectric ceramics. Furthermore, the MLCCs exhibit superior thermal stability with variation less than 3% across a broad temperature range of 20–160 °C. The overall superior performance underscores the potential of the ordered heterogeneous interface engineering in advancing the thermally stable high-density energy storage materials for next-generation MLCC applications.
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高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Lu Han,Yingying Gong,Fangliang Luo,Zhengchao Yuan,Hao Feng,Shutao Ma,Mohamed EL-Newehy,Meera Moydeen Abdulhameed,Nurbiya Abduriyim,Xinyi Lai,Xiumei Mo,Qinghua Qiu
Obstructive lacrimal duct disease has long been a clinical challenge due to the limitations of traditional silicone stents, which are functionally simple, non-degradable, and prone to fibrosis-induced restenosis. In this study, we present a breakthrough approach in the development of a multifunctional, drug-loaded, biodegradable lacrimal duct stent based on electrospinning technology. By integrating mesoporous polydopamine nanoparticles loaded with dexamethasone (MPDA@DEX) into a PLCL/Gel composite matrix, we successfully fabricated a biomimetic stent that exhibits desirable mechanical properties, hydrophilic surface characteristics, and controlled drug release capabilities. In vitro, the stent demonstrated excellent anti-inflammatory and antioxidant activities, being associated with a shift of macrophages toward an M2-like phenotype, significantly reducing intracellular ROS levels, and contributing to an inflammation-repair balance via modulation of the MAPK/Hippo/FoxO signaling pathways. Transcriptomic sequencing further confirmed its ability to coordinate the regulation of the cellular transcription network, simultaneously suppressing pro-inflammatory pathways while activating repair mechanisms. In vivo experiments further validated the stent's capacity to significantly reduce inflammation at the implantation site, inhibit collagen deposition, and promote angiogenesis. This research provides an innovative solution for lacrimal duct repair with active regulatory functions, representing a promising transition from “passive support” to “active repair” in therapeutic strategies.
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高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Dongqiu Li,Bingyi Xu,Feifei Ren,Jiajing Yu,Yan Tong,Shiwu Deng,Hezhong Jiang
Diabetic wound healing is substantially impaired by biofilm infections, oxidative stress, and persistent hypoxia, which present major challenges for timely diagnosis and treatment. In this study, theranostic nanoparticles (NPs) were engineered to facilitate lipase-triggered biofilm theranostics and accelerate wound healing. Theranostic Mn-TC NPs were prepared by grafting a fluorescent sonosensitizer, meso-tetra (4-carboxyphenyl) porphine (TCPP), onto manganese dioxide (MnO 2 ) nanoflowers, quenching the fluorescence emissions of TCPP. Upon encountering biofilms in vivo, the elevated lipase hydrolyzes ester linkages within the Mn-TC NPs, liberating TCPP to restore its fluorescence emission and enabling the real-time visualization of biofilm-infected wounds. MnO 2 nanoflowers offer abundant reaction sites for TCPP grafting while enhancing the catalysis of hydrogen peroxide to generate oxygen. The boosted oxygen evolution promoted the sonodynamic therapy effect of ultrasound-activated TCPP, achieving 94.0% reduction in biofilm biomass and 99.9% bacterial clearance. Engineering NPs accelerate wound healing by simultaneously eradicating biofilms, modulating inflammatory states, enhancing collagen deposition, and promoting angiogenesis. This study presents a novel theranostic strategy for biofilm-triggered visual imaging and an antibiotic-free therapy for diabetic wounds.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Hao Chen,Jiayao Li,Wenjing Li,Yuting Dai,Xuejie Yue,Dongya Yang,Tao Zhang,Fengxian Qiu
Solar-driven interfacial evaporation offers a promising route to mitigate global freshwater shortage scarcity. Nevertheless, achieving efficient management of water, salt, and heat remains a critical challenge in designing photothermal evaporation systems. Inspired by the hierarchical structure of tree root–stem–leaf systems, we propose a three-level biomimetic strategy to fabricate a trilevel photothermal fibrous membrane that enables highly efficient and stable solar desalination of seawater. This membrane features a spatially and functionally decoupled architecture: a hydrophilic polyacrylonitrile (PAN) fibrous substrate serves as a root-like layer for rapid water uptake; a sulfobetaine methacrylate (SBMA)-modified PAN (PAN@SBMA2) intermediate layer mimics stem vasculature, synergistically regulating water retention and salt rejection through strong hydration and electrostatic screening; and a 2.0 wt% of molybdenum sulfide (MoS 2 ) loaded polyvinylidene fluoride (PVDF) (2.0MoS 2 @PVDF) top layer acts as a leaf-inspired photothermal zone for localized solar–thermal conversion and vapor generation. Benefitting from the synergistic water-salt-heat enhancement afforded by this ‘root-stem-leaf’ cooperative interlayer design, the resulting 2.0MoS 2 @PVDF-PAN@SBMA2-PAN (2.0MP-PS2-P) membrane achieves a high evaporation rate and an efficiency. This work not only presents an efficient solar-driven evaporation membrane for solar desalination but also demonstrates a systematic biomimetic structure paradigm for synergistic resource management in interfacial evaporation systems.
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高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Xin Chen,Zhongxue Lin,Hao Lei,Yuan Qin,Feng Xu,Lei Xie,Zuolin Jin
Periodontitis, a chronic inflammatory disease driven by bacterial dysbiosis and oxidative stress, remains a major clinical challenge due to its complex pathogenesis and the lack of effective regenerative therapies. Here, we engineer an intelligent pH-responsive MXene-based nanosystem (MPDM) integrating polyethyleneimine (PEI) for pathogen-derived cfDNA capture, methyltransferase-like 3/14 (METTL3/14) for m6A-mediated osteogenic reprogramming, and 2,3-dimethylmaleic anhydride (DMMA) for dynamic charge-shielding to enhance targeting of inflammatory sites targeting. In vitro studies reveal that MPDM exhibits synergistic antibacterial activity, potent reactive oxygen species (ROS) scavenging capacity, and inflammation-triggered payload release. In a murine ligature-induced periodontitis model, micro-CT analysis revealed that MPDM reduced alveolar bone loss and increased the bone volume fraction by 32% (from 53% to 85%) compared to the diseased (Untreated) group. Transcriptomic analysis further reveals that MPDM downregulates toll-like receptor (TLR) and neutrophil extracellular trap (NET) formation signaling pathways, while suppressing osteoclast differentiation. By concurrently neutralizing pathogenic triggers and activating tissue repair, this work establishes a framework for next-generation nanotherapeutics in inflammatory bone disorders, with potential applicability to other multifactorial diseases.
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高影响因子
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